Season 7, Ep 9: Baricitinib for Pediatric Alopecia Areata: Promising Results and Future Directions

Welcome to another episode of the Evidence-Based Hair Podcast. In this episode, Dr. Donovan delves into an insightful study by Zhao and colleagues, published in the Journal of the European Academy of Dermatology and Venereology, titled "Baricitinib Therapy for Pediatric Patients with Severe Alopecia Areata."
This episode continues the June series dedicated to JAK inhibitors. Dr. Donovan highlights the increasing global use of these medications for treating severe alopecia areata, including the recent approvals of baricitinib and ritlicitinib.
The featured study examines the effectiveness and safety of baricitinib in treating children with severe alopecia areata, focusing on a small group of 10 patients aged between under two years to 13 years. The results reveal promising regrowth and mild side effects, underscoring the potential of baricitinib for younger patients.
Dr. Donovan discusses the broader implications of these findings, including the likelihood of future approvals for younger age groups and the importance of long-term safety data. He emphasizes the need for ongoing research and real-world studies to better understand the prolonged effects of JAK inhibitors.
Join Dr. Donovan next week for the final episode of the June series, where he will explore a study on the use of topical tofacitinib for treating lichen planopilaris and frontal fibrosing alopecia.
STUDIES REFERENCED
Zhao M et al. Baricitinib therapy for paediatric patients with severe alopecia areata. J Eur Acad Dermatol Venereol. 2024 May 22.
Zhan J et al. Real-data on the use of baricitinib in adolescents with severe alopecia areata. J Eur Acad Dermatol Venereol. 2023 Apr 17. doi: 1
Moussa A et al.Treatment of moderate-to-severe alopecia areata in adolescents withbaricitinib: a retrospective review of 29 patients. J Am Acad Dermatol.2023;88(5):1194-6.3.
Asfour L et al.Treatment of moderate-to-severe alopecia areata with baricitinib in preadolescent children. Br J Dermatol. 2023;189(2):248-50
- See more at: donovanmedical.com/hair-blog#...

Пікірлер: 10

  • @carson8527
    @carson8527Ай бұрын

    Hi Doctor Donovan, do patients with scarring alopecia show hair miniaturization, or is this something that usually only happens in patients with androgenic alopecia or alopecia areata?

  • @donovanmedical9780

    @donovanmedical9780

    Ай бұрын

    Miniaturization can be seen in several different conditions. I’ll attach a helpful link here for you. donovanmedical.com/hair-blog/miniaturization

  • @carson8527

    @carson8527

    Ай бұрын

    @@donovanmedical9780 Thank you Doctor, I’ll take a look at this.

  • @carson8527
    @carson8527Ай бұрын

    Doctor, have you seen men with androgenic alopecia who don’t have any family members or relatives with the condtion?

  • @donovanmedical9780

    @donovanmedical9780

    Ай бұрын

    Yes, it’s possible. Granted it’s not the typical story but absolutely it can occur. Be sure to see an expert to exclude all the hair and scalp disorders that mimic male balding.

  • @carson8527

    @carson8527

    Ай бұрын

    @@donovanmedical9780 Yes, that is exactly what I plan on doing. I’ve been having diffuse thinning and anisotrichosis all over my scalp, including the sides and back, since late September 2023. Back then, I thought it was telogen effluvium because I had COVID a month prior, but later realized that telogen effluvium should not cause individual hairs to become thinner. More recently, the corners of my hairline have started thinning out more aggressively, so I believe these are early signs of a receding hairline. I’ve been to a couple of dermatologists and have gotten mixed opinions from them, and have been told to wait a bit longer. Even though my hair thinning is not cosmetically visible to others yet, I can definitely feel and see a difference compared to how it was a year ago. If I do have a chronic hair loss condition, it is still in its early stages, which is why it might be hard for an accurate diagnosis right now. I would definitely start medical treatment soon (if that is required) to prevent further loss. If you were still accepting new patients, I would definitely visit you, but completely understand why this is not possible for you at this time. I will be moving to Seattle next month, so Whistler would not be too far away (I visited Whistler last summer and it is beautiful). Anyway, maybe I can see a good alopecia specialist soon and get an accurate diagnosis before my hair gets worse. I look forward to more videos on this channel Doctor, they are very informative.

  • @carson8527

    @carson8527

    Ай бұрын

    Yes, I completely agree that an accurate diagnosis is crucial, especially in early stages of hair loss. The thing is I’ve been having diffuse thinning and anisotrichosis all over my scalp, including the sides and back, since late September 2023. At first, I thought this was telogen effluvium because I had COVID a month prior. However, I realized that telogen effluvium should not cause individual hairs to become thinner. More recently I started noticing more aggressive thinning at the corners of my hairline, which seem like the early signs of a receding hairline. I went to a couple of dermatologists, but have gotten mixed opinions from them and have been told to wait longer to see what happens. If I do have a chronic hair loss condition, it is definitely in its early stages, which is why an accurate diagnosis might be difficult right now. I would start treatment ASAP if it were required, because it is always better to prevent hair loss early on. I would visit you if you were still accepting new patients, but completely understand why this is impossible for you at this time. I will be moving to Seattle next month, so Whistler would not be too far away (I visited Whistler last summer and it was beautiful). Anyway, I hope I can get an accurate diagnosis from an alopecia specialist soon and see where I can proceed from there. I look forward to more videos on this channel Doctor, they are very informative.

  • @carson8527

    @carson8527

    Ай бұрын

    @@donovanmedical9780 Yes, I completely agree that an accurate diagnosis is crucial, especially in early stages of hair loss. The thing is I’ve been having diffuse thinning and anisotrichosis all over my scalp, including the sides and back, since late September 2023. At first, I thought this was telogen effluvium because I had COVID a month prior. However, I realized that telogen effluvium should not cause individual hairs to become thinner. More recently I started noticing more aggressive thinning at the corners of my hairline, which look like the early signs of a receding hairline. I went to a couple of dermatologists, but have gotten mixed opinions from them and have been told to wait longer to see what happens. If I do have a chronic hair loss condition, it is definitely in its early stages, which is why an accurate diagnosis might be difficult right now. I would visit you if you were still accepting new patients, but completely understand this is impossible for you at this time. I will be moving to Seattle next month, so Whistler would not be too far away (I visited Whistler last summer and it was beautiful). Anyway, I hope I can get an accurate diagnosis from an alopecia specialist soon and see where I can proceed from there. I look forward to more videos on this channel Doctor, they are very informative.

  • @carson8527

    @carson8527

    Ай бұрын

    @@donovanmedical9780 Yes, I completely agree that an accurate diagnosis is crucial, especially in early stages of hair loss. The thing is I’ve been having diffuse thinning and anisotrichosis all over my scalp, including the sides and back, since late September 2023. At first, I thought this was telogen effluvium because I had high fever (from the illness that starts with a C that I can’t write in youtube comments) a month prior. However, I realized that telogen effluvium should not cause individual hairs to become thinner. More recently I started noticing more aggressive thinning at the corners of my hairline, which look like the early signs of a receding hairline. I went to a couple of dermatologists, but have gotten mixed opinions from them and have been told to wait longer to see what happens. If I do have a chronic hair loss condition, it is definitely in its early stages, which is why an accurate diagnosis might be difficult right now. I would visit you if you were still accepting new patients, but completely understand this is impossible for you at this time. I will be moving to Seattle next month, so Whistler would not be too far away (I visited Whistler last summer and it was beautiful). Anyway, I hope I can get an accurate diagnosis from an alopecia specialist soon and see where I can proceed from there. I look forward to more videos on this channel Doctor, they are very informative.