Season 6 Episode 1 (Baricitinib Response Timing, Real World Study of Baricitinib)
The Evidence Based Hair Podcast was created by dermatologist & hair loss specialist Dr Jeff Donovan to highlight new, hot off the press, world-class research in the field of hair loss. The podcast was created for hair loss practitioners around the world who care for patients with all different types of hair loss. Each week, different hair loss research topics are covered in the podcast including new research related to androgenetic alopecia, alopecia areatea, telogen effluvium, traction alopecia, tinea capitis, trichotillomania, chemotherapy induced hair loss, lichen planopilaris, frontal fibrosing alopecia, dissecting cellulitis, folliculitis decalvans, discoid lupus, central centrifugal cicatricial alopecia, erosive pustular dermatosis.... and a whole lot more.
THIS WEEK'S STUDIES (SEASON 6, EP 1)
King B et al (starts at 3:46). When to expect scalp hair regrowth during treatment of severe alopecia areata with baricitinib: insights from trajectories analyses of patients enrolled in two phase III trials. Br J Dermatol. 2023 Sep 14:ljad253.
Gargiulo L et al (starts at 31:55). Effectiveness and safety of baricitinib in patients with severe alopecia areata: a 36-week multicenter real-world experience. J Dermatolog Treat. 2023 Dec;34(1):2268764.
NEXT WEEK'S STUDIES (FOR THOSE INTERESTED! SEASON 6, EP2)
Krauss A. Why all randomised controlled trials produce biased results. Ann Med. 2018 Jun;50(4):312-322.
Carlisle JB. False individual patient data and zombie randomised controlled trials submitted to Anaesthesia. Anaesthesia. 2021 Apr;76(4):472-479.
Van Noorden R. Medicine is plagued by untrustworthy clinical trials. How many studies are faked or flawed? Nature. 2023 Jul;619(7970):454-458. Listen at • Audio long read: Medic...
Пікірлер: 3
Thank you Dr. Donovan! Great as always. Are patients always compliant with the one line treatment for 9-12 months? Especially when they're investing in JAK inhibitors with hopes of superior results.
@donovanmedical9780
8 ай бұрын
Not always! It’s easy to feel down when you have such high hopes and don’t see any results after 1 month, 2 months, 3 months, 4 months, 5 months, 6 months. It takes alot of up front counseling as well as guidance along the way. It takes a good amount of reassurance that what patients may be seeing could be normal. The tough thing is that there is so much excitement around the JAks but 1 out of 3 patients with severe AA will be really disappointed by their results. So we need to keep a balanced view. I think the thing that matters most is an open dialogue and to carry hope if there is reason to carry hope! Sometimes the patient will carry the flashlight to navigate these dark times and sometimes it’s up to someone else to carry the flashlight and help the patient through the journey. The new JAK inhibitor era is not quite as easy and straightforward as many make it out to be!
@melkurls4034
8 ай бұрын
@@donovanmedical9780 Are you confident in recommending JAK inhibitors, considering the limited long-term side effect data available? I feel like I need to learn A LOT more before I start suggesting it. Specially for my teenage clients.