All Sam Bankman proved is that good barbershops don't accept crypto.

@christiancolossus5165

Жыл бұрын

Clothes companies too apparently.

@teddy.rose.88

Жыл бұрын

He's actually been quoted saying getting his hair cut would be 'negative EV' (expected value) with regards to what his role was in "tech" lol so apparently it was a calculated look.

@njmxjunkie3128

Жыл бұрын

Broo

@ariyune7007

Жыл бұрын

@@teddy.rose.88 That's a fancy way of saying he was lazy lol

@lunkynicky2466

Жыл бұрын

I don’t understand how people trusted him. I would NEVER trust that dude to babysit my kids let alone my entire life savings. Mans a creep

SBF seems to be describing mania when he writes about his mental state. I've known plenty of people who developed mania from substance abuse. They become convinced that they are operating on a "higher level" than other people while simultaneously doing profoundly dumb things.

@bowdlerise

Жыл бұрын

adam neumann

@OsmosisJones-0925

Жыл бұрын

Agreed. I’ve been diagnosed with Bipolar and have learned to recognize the signs of mania really quickly. It’s a tough world to navigate because you can’t always trust yourself.

@PedroTRamos1

Жыл бұрын

He´s just a con man.

@philbert006

Жыл бұрын

The man stole 11 billion dollars and has still got half the world making his excuses for him and are not even considering beating him to death, much less prosecuting him. I don't see how you could convince him that he wasn't operating on a higher level than everyone else. That's exactly what he is doing. He's definitely not profoundly dumb. The people who let this happen and aren't taking steps to make sure it doesn't happen again are the profoundly dumb ones.

@mikemor6005

Жыл бұрын

Conor Murphy

I like how Derek's idea for what he would use a limitless drug for is leg day.

@ElusiveEyes

Жыл бұрын

Where he mention that

@KhanSphere

Жыл бұрын

​@@ElusiveEyes did you watch the fucking video?

@ElusiveEyes

Жыл бұрын

@@KhanSphere somebody thumbs up my comment so obviously I’m not the only one.

@ElusiveEyes

Жыл бұрын

@@KhanSphere he just mentions leg day cognitively draining in the vid that’s it.

@KhanSphere

Жыл бұрын

@@ElusiveEyes and says he takes nootropics as a preworkout specifically for such a day. Listening comprehension. Also, whoever thumbs-up'd your comment also didn't watch the video. Not relevant.

Amphetamines, the talmud and a strange polyamorous relationship with the weird squirrel looking girl. Sam really knows how to live it up

His limitless drug was so potent he tanked FTX lol

@yoss4r1an

Жыл бұрын

Cz tanked it.

@mtnentertainment3454

Жыл бұрын

Just like in the movie, he picked a fight he shouldn't have picked. Unlike in the movie, he lost the fight.

@woaken

Жыл бұрын

It was a crypto Heist. Tanked on purpose

@bigzachful

Жыл бұрын

@@woaken He was super by rich powerful people to do that. It was an inside job. I hope that they lower all crypto and then allow it to skyrocket back up next year and we can get rich those of us who missed out the last few years.

@Gatesunder

Жыл бұрын

@@yoss4r1an SBF was siphoning client funds from FTX to Alameda research where they were losing hundreds of millions on their epic Quant strategy of buying shitcoins and praying the market turned around.

What a good way for him to blame something else in anticipation of his guaranteed court proceedings. Very well orchestrated on his part. It wasn’t me, I was addicted to drugs

@JeffreyBenjaminWhite

Жыл бұрын

Three points.

@thehoov6672

Жыл бұрын

He was well advised by his parents... Who there entire professional careers have been spent concocting bs schemes and escape Plans.

@buddhastl7120

Жыл бұрын

He’s not doing any jail time

@mmgr2k196

Жыл бұрын

Jail Lol, lmao

@umarb7325

Жыл бұрын

"I was addicted to illegally procured prescription drugs"

Self confidence sometimes isn't a good thing - especially when it's artificially induced. For instance it would be a bad thing for me to have a sudden feeling of confidence that I could land an airliner or disarm a thermonuclear device.

@DeKosta

Жыл бұрын

For sure. It is a very shallow confidence that will break down and show its cracks if pushed enough or let it run its course. Confidence should come from within oneself otherwise its just what it is - artificial.

@stokkejanraggio9091

Жыл бұрын

Thats where lunacy starts.

@rynperry

Жыл бұрын

I agree with you in part... but think of how self confidence looks to a person who's never had it, or only had it in small doses / short duration.. to feel good about yourself is sometimes more important then the potential downsides

@genghiskhanschubbycheeks2170

Жыл бұрын

I've spoken about this a lot in my personal life. There is a difference between genuine self confidence and arrogance.

@Graterstuuf

Жыл бұрын

The confidence is always fleeting.

It's interesting that you can't eat meat while taking this drug. I wonder if this was the real reason SBF turned vegan and then tried to mask it as some moral calling to promote his brand. In a leaked private conversation he already admitted to essentially acting out a role in order to appeal to potential investors and regulators.

@usernamemlgdoge

Жыл бұрын

Maybe that s why so many celebrities are turning vegan 🤔

@Aquietdreamer11

Жыл бұрын

You can eat most meats. Generally it’s aged cheese that’s the problem. These medications are not used for good reason because combined with tyrosine rich foods they cause a hypertensive crisis

@charmando641

Жыл бұрын

@@Aquietdreamer11incorrect tyramine. It’s not even a concern anymore unless you eat an insane amount of high tyramine containing cheese.

@Ben-pv3hu

Жыл бұрын

@@Aquietdreamer11 aged/fermented things in general but yeah. im on a MAOI and i dont have to limit anything i eat but i avoid aged/fermented things

@CharleyGriffin

Жыл бұрын

you can't eat meat while on it??

Who knew MIT entrepreneurs could be ‘fake nattys’ 😂

@HereForTheComments

Жыл бұрын

Sometimes we forget the brain is worth building too.

@mattlars89

Жыл бұрын

@@HereForTheComments The brain is not a muscle though, but a complex network made up of fat and proteins. Quite delicate stuff, i would not take any kind of inhibitor. Unless prescribed by a Psychiatrist. "If it ain´t broke, don´t fix it" Build it by studying, doing stuff like Sudoku and Crossword puzzles. Mental workouts.

@yayayayya4731

Жыл бұрын

@@mattlars89 brain plasticity. The bioneer has some videos on it

@RR-et6zp

Жыл бұрын

they should do kinobody

@mattlars89

Жыл бұрын

@@yayayayya4731 Thank you Yayayayya, i can read books just fine :) Another way to increase mental acuity. Reading

What happened to good ol days of CEO’s racking up lines of coke and dominating the industry. Now there’s all these fancy designer prescription drugs and billionaires are declaring bankruptcy.

@Kaizen747

Жыл бұрын

Lmao

@michaeld9999

5 ай бұрын

Lmao. This is actually a great point.

@CraigJonesFluffer

3 ай бұрын

Watches Wolf of Wall Street once

@SmoltingWassie

3 ай бұрын

@@CraigJonesFluffer making a sarcastic joke when the sarcasm of the initial statement has gone over your head, is just too rich.

Derek and Coffeezilla the dream team YT deserves

@dowscrypto

Жыл бұрын

not me

@nikkolomakaveli8295

Жыл бұрын

You wouldn’t watch them expose fake fitness gurus who sell fake supplements, fake naturals, or set up scandalous personal training?

@hansolo631

Жыл бұрын

Yea probably the only 2 youtubers I trust to not be lying about 99% of their content. Two different worlds though.

So you're saying that if I take this I will lose billions of dollars too? Sign me up

@JosephTurcotte117

Жыл бұрын

It's meth for dementia.

@trepridgen

Жыл бұрын

Gotta have billions to lose billions 🤷‍♂️ give it to me.

@KK001

Жыл бұрын

Someone sell me this shit cuz idk how to get the prescription without dementia or alzheimers.

@unicestwiacznoworodkow7

Жыл бұрын

@@KK001 just tell the doctor you forgot what you came for. He'll know what to prescribe you

@Xighor

Жыл бұрын

@@unicestwiacznoworodkow7 prescribe what?

No better way to finish off thanksgiving than throwin on a MPMD vid. Much love Derek

@CptCupcake5

Жыл бұрын

Finish? It’s not even 4:00 yet brother

@mousepurple1713

Жыл бұрын

@@CptCupcake5 timezones my friend

@sqweems3297

Жыл бұрын

@@CptCupcake5 different time zone g

@CptCupcake5

Жыл бұрын

@@sqweems3297 no such thing

@ThisHandleWasTheOnly1Available

Жыл бұрын

Derek is Canadian. He celebrated Thanksgiving about a month ago.

Can you do a video on Propranolol? When I was in the Marine Corps I started having crippling ocular migraines that essentially caused blindness and neurological effects such as feeling infinitesimally small or infinitely large in proportion to my environment and I was prescribed Propranolol 40mg. After about 2 weeks of taking it I found myself talking to large groups of Marines and instructing them. I literally could not stutter. The words just continued to roll off my tongue like magic. I wasn’t making things up it’s just like the knowledge that I had in my head didn’t have to translate to fit a social situation so there wasn’t a barrier to saying what I meant. My charisma went up to level 100. I even began giving high level briefs to officers and even Lt Colonels and Colonels during deployments and large international multi-departmental training Ops. I was a Corporal (E-4) and a combat engineer, but within 2 years I literally became the go-to person for everything. Eventually propranolol starting dropping my BP too low and I had to stop taking it, but I would love to hear your input on it and other beta-blockers regarding its use as a cognitive/confidence enhancer from a scientific point of view.

@williamshears9953

Жыл бұрын

Was it the drugs or did you just finally find some of that good old Marine Corps spirit

@evobe

Жыл бұрын

that's cause it's a beta blocker, your nervous response was just depressed. Lucky for you, all it did was remove the nerves, if you work on calming yourself normally you'd be the same as with the drugs. it's pretty known that there are tons of ways to overcome stuttering.

@ElusiveEyes

Жыл бұрын

Being in the marines you prob have a high likelihood of a overactive sympathetic nervous system which causes a cumulative build up adrenaline , norepinephrine, cortisol which causes anxiety and ptsd. Beta blockers are used off label for producing too much adrenaline I would stay away from them honestly.

@MG-hx3ym

Жыл бұрын

@@williamshears9953 it was the propranolol. LMAO.

@Kaizen747

Жыл бұрын

Propanolol is a Beta Blocker that has the capacity to pass the blood brain barrier, From what i understand Beta Blockers block Cortisol, adrenaline and other hormones responsible for stress, anxiety , so theres that Must investigate this drug further..

Your explanations are refreshing. It's always nice to hear pharmacology discussed intelligently, in an easy to relate with manner.

@raylopez99

Жыл бұрын

Yeah I thought the host was a doctor or bio-researcher.

@charlesbrown1628

Жыл бұрын

I thought I were being sarcastic, then I looked at your profile picture 😂

@faeancestor

Жыл бұрын

This guy doesn’t seem especially bright

@SwimDeeep

Жыл бұрын

@@raylopez99 I’ve wondered what his background is. He covers drugs, bloodwork, etc very well

@MrLemonMedia

10 ай бұрын

@@SwimDeeepA meathead.

"eeroh....wid" kinda shocked that Derek had never heard of Erowid considering his age and interests. Millennial psychonauts cut our teeth on that site

@Will-uf9nd

Жыл бұрын

Derek's never done any psychedelics

@MMAneuver

Жыл бұрын

Psychonaught wikia is a great v2 but can't compete with the volume of experience reports in errowids experience vaults! Some of them are wild...

@Ryan-xq3kl

Жыл бұрын

erowid has been captured for over 10 years now dont post experiences there

@IAmYourReflection

Жыл бұрын

Man I used to live on erowid lycaeum and other similar websites. Those were the days. I even remember the alt.drug groups 😂 what a waste of time

@SrbijaFail

Жыл бұрын

@@Ryan-xq3kl captured? Every single digital activity of yours is captured nowdays.

Fried is a well connected con artist, no way he's going to prison, his ties to the establishment is beyond comprehension

@alejandrogn4

Жыл бұрын

Yeah he’ll just get offed

@oshbar7922

Жыл бұрын

naaah , he did "payed" his way out ... but then when all went BOOM ... they found out he paid them very "cheap" , now that makes them very angry .

@afromanftw

Жыл бұрын

connections with the biggest con artists in the world, government

@Bob-fj7lr

Жыл бұрын

I don't know about this. Dude is already looking at enough points to put him in jail for 150 years at the moment. Maybe if he gets pardoned, but highly doubt that at this point tbh.

@ronfroehlich4697

Жыл бұрын

@@Bob-fj7lr he won't spend a single day in prison. The law does not apply to our ruling class.

I liked the coffeezilla shout out, I've been following him for a while as he's grown from just covering these cases to being a legit journalist with sources who breaks stories. I've learned a lot from watching his channel, I second Derek's recommendation.

@xxxxxboxfan

Жыл бұрын

He’s the best!!!

@EternalNico1

Жыл бұрын

He's an L

@infini.tesimo

Жыл бұрын

Absolutely hate coffeezilla

@jessegilmore3009

Жыл бұрын

​@@infini.tesimoWhy are you scared he's going to expose whatever scam you're involved in. I don't understand how you hate a guy that has done so much good and saved so many people from getting scammed.

@bobbyhillthuglife

Жыл бұрын

@@jessegilmore3009 everyone loves coffeezilla until he comes for their particular scam

as someone who currently who enjoyed a copious amount of exposure to the academic route of learning biochemistry and pharmacology, currently going to med school, just starting out on what you may call Md/PhD track in the US, focusing on therapeutic monoclonal antibodies (lotsa immunology and biochem), i can safely say your grasp on these topics is easily on par or surpassing the level most physicians leave their training with. Your unpretentious approach is very refreshing and fun, thank you for your work :)

@tifKh

Жыл бұрын

Enjoy! My partner is a little further on the same route while at Pfizer, the world is your oyster. Keep up the good work, it’s worth it! You won’t get bored.

Derek, you talk a lot about your genes. Especially recently with the Hemsworth Alzheimer’s video and about your MTHFR gene. Would u do a video sometime on key genes/SNPs to look at and how to interpret them for optimal health?

@manonamission2000

Жыл бұрын

Consider the Promethease service after getting a DNA test from FTDNA

The real issue is if he was mixing MAO inhibitors with other stimulants - which makes it much stronger through a synergistic effect. His GF Caroline Ellison has tweeted about liking stimulants in deleted tweets, so it's possible Sam was mixing MAOI with stims just to make his stimulants even stronger.

@JamesR23

Жыл бұрын

Agreed. This drug would have super enhanced any stimulants he took.

@Seasniffer69

Жыл бұрын

Why wouldn't one do this? Definitely sounds like something me and everyone I know would do.

@justinscaffidi3570

Жыл бұрын

@@Seasniffer69 sounds like a recipe for neurotoxicity to me.

@threestans9096

Жыл бұрын

@kevamor435 or the fact he’s CIA backed? look at his parents jobs and etc. hired to regulate crypto and launder money.

@BoostDriftTeam

Жыл бұрын

@@Seasniffer69 MAOIs mixed with some stimulants can cause cerebral bleeding, cardiac arrest and death. Besides Methylphenidate, no stimulants are 100% safe when combined with MAOIs. Some non-selective MAOIs, like Parnate and Nardil, mixed with amphetamines, can cause serotonin syndrome (slow and painful death, in some cases). Having taken MAOIs, there's nothing "limitless" about these drugs. They are powerful antidepressants with sometimes horrible side effects.

Derek dropping gems with this phenylethyl dmc thank you sir

Hearing you talk about these things is crazy. You clearly know exactly what you are talking about and understand it deeply. It’s amazing to hear you talk lol.

@chrisreale4326

Жыл бұрын

U ain’t lying.

Honestly with all the insight into this scandal from a finance perspective, this is gold and tells so much more about the story

this is a limitless drug for people who havent worked a day in their life

@_JS96

Жыл бұрын

Seriously, I'm a software workaholic and it's not for any money or fame incentives. I just get a huge rush when I crack that darn bug, or put up that whole framework in a night, or build something that works right first try. The only way to achieve these things (WITH the dopamine reward) is to work enough that you have the skillset, and the knowledge to make it happen, then be motivated to get yourself there. Giving yourself pretend meth to get the dopamine while not really doing much is literally conning yourself, and slaughtering your ability to actually do it yourself without the chemicals.

@rickmort27

Жыл бұрын

@@_JS96 this guy gets it ^

@chigbungus5257

Жыл бұрын

@@_JS96 I understand, but the idea that your way is better is simply an opinion. Depending on your philosophy, one could make a compelling argument that using exogenous chemicals to achieve the same feeling is equally valid

@thegoodobserver

Жыл бұрын

@@chigbungus5257 Are you a real human?

@ticktockbam

Жыл бұрын

Just sleep 8 hours a day and you should be good.

I’m a paramedic. I’d heard of this channel. First time viewer. Wow. Very impressive. Great info! Thanks

@jordonpumpin

Жыл бұрын

He has many many great videos check out his other vids! Welcome :)

@lachyj8344

Жыл бұрын

You’re the first double spacer I’ve ever seen

@jonvia

Жыл бұрын

When I read "Wow" I thought of Owen Wilson

@mtmatt8958

Жыл бұрын

Thank god we have a paramedic in the comments, just incase of a medical emergency lol

@lachyj8344

Жыл бұрын

@@mtmatt8958 thank god we have a weirdo on the comments, just to make us all look normal

Man I no longer have to go to pharmacology lectures now that I found your channel

@boobybuyer127

Жыл бұрын

Satire I hope

@3bet316

Жыл бұрын

@@boobybuyer127 real

@jonahandersen632

Жыл бұрын

Seriously, like how tf is this guy so knowledgeable

@titanattackbee1985

Жыл бұрын

mpmd is a fraud unfortunately. this is a clickbait video hyping up an ssri like drug KEK

@isomilo

Жыл бұрын

and there's ninja nerd and human anatomy institute tho

Come to think of it, Derek is the Coffeezilla for fitness influencers

@Rok1900

Жыл бұрын

except coffeezilla never scammed his fans

@christophegroulx7816

Жыл бұрын

@@Rok1900 What are you talking about?

@alexcarlone7967

Жыл бұрын

Collab

@kimchipanda7678

Жыл бұрын

Philion used to be that guy but has expanded to influencers in general.

@Avogadros_number

Жыл бұрын

@@kimchipanda7678 Philion is a tool

my man i'm new to this channel and idk if you are a physician or pharmacist or something but your knowledge of chemistry and pharmacology is incredible. I am in medical school and you understand this better than most people I know. Kudos to you for knowing your stuff and if this is self taught, my god bro you are a good learner

@Rickycob

Жыл бұрын

First off hats off to you for being in medical school. I agree, his knowledge of pharmacology, biology, and organic chemistry is top notch. Definitely gonna be keeping up with this channel more. Makes me want to brush up on my neuropharm!

@skateking959

Жыл бұрын

Derek’s favorite word is pharmacology.

@yesnt2801

Жыл бұрын

@@skateking959 supraphysiological

@yehheapsmadaybut

Жыл бұрын

I mean he's literally talking about an antidepressant. It's not that complicated.

@drewnielson6472

Жыл бұрын

Self taught

I love the deep pharmacological dives. Derek is king for this. Its amazing. Much love man.

When Derek zooms in twice, you know shit is about to get real

I understood about 3 words total in whole video explaining drug uses/effects....holy shit

I love your videos! Your thought process and presentation are top notch. Keep up the great work!

Does anyone else remember that true life episode with the guy that was addicted to neurotropics? He started on neurotropic medications and vitamins because he wanted to be the best of the best but became dependent on it thinking it made him smarter and more productive and ignored the fact that it was doing the opposite... At the end of the episode it shows him taking his arsenal of pills before going in for a very important, huge test and he failed it even though he was a straight A student his entire life up to this point before he was on neurotropics. I felt horrible for his girlfriend too.

@liudehua5742

Жыл бұрын

I did! They also had the dude that injected something from a pigs intestines into himself

@NotWatchingTV

Жыл бұрын

yea we think we can f**k with the brain and we don't know anything about it LMAO ancient Egyptian would have laughed at us and still are

@ElusiveEyes

Жыл бұрын

@@liudehua5742 what episode is that never seen that true life episode. I’m assuming the medication your referring to is cerebrolysin which comes from porcine brain 🧠

@liudehua5742

Жыл бұрын

@@ElusiveEyes I don't remember I was camping in the woods and downloaded it before hand plus I was really stoned lol

@ElusiveEyes

Жыл бұрын

Cerebrolysin is sourced from porcine brain was really hyped up on the longecity nootropic forums back then. I’ll have to look into that true life episode

30 years ago I took a similar oral drug for depression and I remember that semester as my best ever. I was at least hypomanic but did not go "over the top" per se. I do know what drug induced mania is after taking a very strong course of dexamethasone to reduce the swelling in my brain due to a tumour that was subsequently removed. Motivation is at the very least a trait that can be sharpened or blunted in many ways, chemically or by lifestyle too.

@FBFTheRagingWarrior

Жыл бұрын

dexamethasone gives mania? I was on it 5 days a few months ago, due to a brain swelling, didnt feel anything.

@manny45629

Жыл бұрын

You need to take more of it for longer. You only took for 5 days. Not long enough for withdrawal symptoms.

@bearpunss9389

Жыл бұрын

You need to wean off. Was on it for a long time due to brain tumour and it took me months to wean off.

@ebarr9476

Жыл бұрын

@@FBFTheRagingWarrior A very well know side effect for that med. I was taking 16mg/day tho.

@ronfox5519

Жыл бұрын

My neurosurgeon was always looped out on something. I assumed since he was 'in the bizz' that it was neotropics. Is there such a thing as harmless neotropics? Are they all versions of anti-depressants?

Even Derik is jumping on the FTX bandwagon now 😂

Love this type of content on dopaminergic drugs

I wish I was more versed in these topics, a lot of what you said went over my head, but it looks like I’ve got something new to learn in the world

@st33Npuist

Жыл бұрын

Same thoughts

@360Fov

Жыл бұрын

PLEASE be careful. It's so much easier to slip up than you'd ever expect and the problem is, it takes months and years to realize you've been going down a super hard path to reverse yourself out of. Not saying nootropics are bad or preaching some frigid mindset type stuff...just saying the learning process can be nefarious; it can feel like walking around a field of grass and you don't notice how far into the thorns you've gone type thing.

All our comments for "boosting the alogrithm" when he just had 10k subs have been fruitful. Happy for you man, you always deserved these many subs.

@burtmcgurt3584

Жыл бұрын

What does that mean? I came here after JRE. Seems like a great channel. So did he just get 1.5 mil?

@brobocops

Жыл бұрын

Classic here for the algo comments

@fastlifebmx9292

Жыл бұрын

@@burtmcgurt3584 I was around like 4 or 5 years ago he had like 50k and then he started getting traction and in the past year or two he's really took off I think he hit a mil last year.

Love how you break it down bro! Get the same urge as you do to dig deep and really understand the ins and outs of these chemicals. It takes a long time to gain the type of knowledge that you retain. Great job man ,keep it up!!

Limitless jail time.

Every time I get Chinese food here, the cookie fortune has the FTX logo on the back. Makes me laugh every time lol.

Sounds like Sam might be trying to set up the Ambien defense strategy.

As a Pharmacist, I appreciate your depth of knowledge on pharmacokinetics/pharmacodynamics and biochemistry.

@matthewhurst5910

Жыл бұрын

In your opinion do you think he's as knowledgeable as the average average pharmacist, or more possibly?

@patrickl5290

Жыл бұрын

^also curious

@1u8taheb6

Жыл бұрын

@@matthewhurst5910 I am a pharmacist for 50 years and I can confirm I do not know any other pharmacists named Tyler F do NOT trust this man

@Gsg-xh3th

Жыл бұрын

@@matthewhurst5910 I mean yes in certain areas he certainly is because he's spent hours and hours researching it. But I'm the broad spectrum of medicines probably not. (Pharmacist myself)

@Make-Asylums-Great-Again

Жыл бұрын

Answer us Tyler!

I took this drug for about a year thinking it was a panacea. It destroyed my life. I've since recovered, but that year was the lowest point in my life. I've yet to see an example of it being used productively long-term.

@KT-sl4js

Жыл бұрын

​@@DannerWellness It didn't "destroy" my dopamine, but definitely caused a drastic change in my behavior and actions. I became increasingly paranoid, was unable to eat & sleep much, and disturbed my baseline mental/emotional health to a great degree. Towards the end of it, I was incredibly anxious around anyone including family. It was as if my awareness was hyper-vigilant, and I perceived literally every single movement and action by those around me as a slight against me. Every seemed like an enemy and I lashed out. The scariest part was I was completely unaware of the change in my behavior and genuinely thought I was right and everyone else was wrong. It was only after tapering off the patches and a few months of recovery for my MAOI enzymes that I could look back with clarity at the strange creature I had become. I had alienated many relationships during that short year, and had to make amends over the following years. Everything is good now though, but let this be a cautionary tale to anyone who thinks any one drug or substance will be the solution to their problems. It's best to take an organic approach where you cultivate a stock of healthy lifestyle practices. Only then can you make real, lasting progress.

@DannerWellness

Жыл бұрын

@@KT-sl4js My response was deleted. Thanks for the reply. I had a similar experience with stims. You're right about there being no magic pill.

@MichaelMerritt

Жыл бұрын

@@KT-sl4jsit’s interesting you mention that. I’ve recently been arguing with my spouse for the first time and yet constantly feel I’m being positive and not the instigator yet she’s telling me I’m always negative and she’s not used to it. I can’t see or feel the change. Thank you for posting your detailed experience.

@Ozzy254

Жыл бұрын

@@KT-sl4js Thanks for sharing this experience. Too many people assume that the effects of these drugs are consequence free. Few think about the downregulation on the receptors through constant use and stimuli that worsens the very same baseline you were trying to improve in the first place. Remember kids, there's is no free lunch in biology.

When it comes to anything you consume that affects mood, focus, energy……what goes up must eventually come down. These drugs are not sustainable long term.

I'm not touching crypto until Deltcoin is released.

@Ryan-xq3kl

Жыл бұрын

stop pushing scam tokens bitcoin is the only true cryptographic currency

@lionbear7078

Жыл бұрын

I think Deltcoin is backed in Ireland. The price is Dublin!

Derek I appreciate the pharmacokinetic information you present. When using supplemental substances, people often forget to research the mechanism of action along with the bioavailability/half-life.

Derrick is a freaking genius when it comes to this stuff. A never ending cascade of information on any of these topics .. 😳

@rogerfatcocc7343

Жыл бұрын

Yea but what is he saying

Reminds me of modafinil in its upregulation of dopamine, but moda works at the dopamine synapse preventing the re-uptake of dopamine and increasing its concentration there. For both of these drugs, I worry about negative feedback from the dopamine stimulated neuron reducing the body's production of natural dopamine.

@jimbob4456

Жыл бұрын

There is always a price to be paid.

@levidestin6783

Жыл бұрын

ohh that might explain why i feel depressed all the time maybe i fried my dopamine receptors with moda abuse

@zergenzerg6853

Жыл бұрын

Wait can you elaborate? What is considered abuse of these dopamine drugs? And what if you actually have ADHD?

@snipinstrisand

Жыл бұрын

@@levidestin6783 this is what I noticed last year when I was experimenting with moda. I also feel like it reinforced some addictive behaviors because I'd be on moda while doing them - giving my brain additional reinforcement.

@Demoralized88

Жыл бұрын

Adderall is the one of the ONLY drugs I've NOT experienced withdrawal effects from. And I've been on a LOT, including almost all drugs marketed for depression, many opioids, etc. I feel the exact same as baseline, which was very much not expected. I'm not sure Dopamine suffers from the same degree of persisting downregulation as other mechanisms, but then again my neurochemistry is very much fucked up and probably not representitive. Also, don't recall any withdrawal from NRIs or MAOIs, but SSRI/SNRI withdrawal is typically bad.

Shout out to Erowid that’s a throwback for me!

@chill00000

Жыл бұрын

bluelight and erowid were lowkey like gold mines back in the days

@irishjoe9195

Жыл бұрын

@@chill00000 hell yeah they were

@haydenchristensen9278

Жыл бұрын

erowid convinced me not to take DMT 💀

@myronbourne6937

Жыл бұрын

high school was lit

I could easily see you making videos decades from now. I hope you get to 10 million subs.

Selegiline is a very old drug that was used a lot back in 90's... Known mostly for it's "possible" life extending properties (tested in lab animals), not so much as a nootropic.... It's main use is as an anti Parkinsons drug... It's an MAO inhibitor that slows aging of the substantia nigra by lowering 6-hydroxydopamine levels, a toxic metabolite of dopamine that ages that part of the brain...MAO inhibitors are also antidepressants, they all increase dopamine, and have a "stimulant effect".... Not exactly a "limitless drug" but I guess could be part of a nootropic "stack" that may be far more potent.... The real interest is that after the age of 30 as humans we lose about 13 percent of out dopamine production per decade. If we don't die from vascular disease, cancer, or kidney failure first , we'll eventually die from dopamine loss.... Dopamine is a very important neurotransmitter and neuro-endocrine molecule... Slowing down the damage to the substantia nigra by 6-hydroxydopamine could theoretically increase life span and has in animal models..

@Patchkt1998

Жыл бұрын

So Is selegiline not that harmful to take if done responsibly?

@theterribleanimator1793

Жыл бұрын

@@Patchkt1998 dont even think about it.

@bengaliinplatforms1268

Жыл бұрын

@@theterribleanimator1793 Why?

@ratfacekick

Жыл бұрын

ok but it also makes you think committing fraud is a good idea lol

@ThePdog3k

Жыл бұрын

@@ratfacekick so?

This explains SBFs behavior talking down to people. Telling people he could buy their family and that if people would just do what he wants nothing would be wrong

@chrisawesome3091

Жыл бұрын

So ur saying this will make me funny too

@Sentient.A.I.

Жыл бұрын

@@chrisawesome3091 Maybe delusional i dont know about funny

@pluto8404

Жыл бұрын

@Sentient AI will be funny like that old german guy that did those things. Kicked off a whole sub genre of dark comedy.

@Sentient.A.I.

Жыл бұрын

@@pluto8404 I don't know what your talking about. I don't have my subroutines trained on old germans.

I've been on SSRIs for 23 years. Always saw the "don't mix MAOIs with this drug" warning on every bottle. Now I know what they do. Amazing.

@johnwall7190

Жыл бұрын

this is terrifying you can vote

@John-mh9ty

Жыл бұрын

Yep, they make you a billionaire with billionaire problems. Very dangerous stuff

@Bryce_C.

Жыл бұрын

@@johnwall7190 voting is a scam

@Naptosis

Жыл бұрын

@@johnwall7190 it's terrifying you want to disenfranchise someone because they take a monitored medication.

@nikhayes3396

Жыл бұрын

@@Naptosis Who wants to Disenfranchise anyone? I don't see what you are responding to. The person that says its terrifying that they can vote?

Hope you're doing well brother. We appreciate your time and work.

Gorilla Mind Smooth: had a one day extreme boost, then it gives you better focus even when you are off it. Also, if you did not sleep well the effects are invisible.

I’ve done a lot of drugs(all the good ones at least) and it seems like regardless of what the drug does to you, once you quit taking the drug or can’t get it anymore, your brain isn’t able to produce certain chemicals anymore or as much as before. There’s always a high, a low and then you level back out.

@tomahawk297

Жыл бұрын

Preach it.

That blue bottle on his desk was Nootropic Depot's Adrafinil, I'm like 90% certain. They're the most popular nootropics vendor so this is a pretty safe bet if he was using other very obscure things, which is such a weird thing to take when he had more than enough money to just get real Modafinil from a doctor

@serebbi

Жыл бұрын

Yep, it's Nootropic Depot and most likely Adrafinil.

@orion10x10

Жыл бұрын

@@serebbi RIP Adrafinil though 😭😭😭 it’s not coming back, neither is Piracetam RIP

@Serrotonin

Жыл бұрын

Omg it is

@serebbi

Жыл бұрын

@@orion10x10 I know 😭

On an interview he did for some news channel, he was super jittery and twitchy. Might be because of this neutropic or severe stress over the current mishap he has experienced in his business, or both things combined.

@some_g333

Жыл бұрын

There are leaks of him encouraging drug use for his employees. They were all on speed etc. Also the main group were poly and Jewish. Apparently a sex tape is going to be released on Friday kek.

Selegiline is also known as Deprenyl. It's an anti aging drug. Look up the book "Deprenyl: The anti aging drug" by Alistair dow.. this drug is used by people to promote longevity. The inventor was Joseph Knoll from the country of Hungary.

@moonmerchant7148

Жыл бұрын

yo does this actually work dude

@dyslexicstoner2408

Жыл бұрын

@@moonmerchant7148 I recommend reading Life Extension's report on it on their website. It's promising at low doses, but more research needs to be done due to contradictory study results and a lack of knowledge about long-term side effects. But still, promising, but not enough to commit to taking it. When you take drugs that permanently alter a part of your brain you better be 100% sure it does exactly what it should.

That selegiline story sounded like me when I first found Adderall. Over time, the feelings diminish and side effects stack up. 1.5 years off Adderall now and wouldn't ever want to go back

@JupiterLXIX

Жыл бұрын

Do you regret going on it? Many times I’ve heard “I don’t regret taking it in the first place but I wouldn’t do it again”

@simonnilsson5356

Жыл бұрын

How much were you taking and what was the side effects? Appreciated

@heavensent4362

Жыл бұрын

Did you even get a diagnosis?

@josephhertzberg2734

Жыл бұрын

Adderall is almost evil, not quite but close

@monty1691

Жыл бұрын

@@JupiterLXIX from my experience it really helped me build a strong routine and do more in life. But once I stopped I was still easily able to keep up with my day to day life. I would say it helped me build the foundation but wouldn’t use it again.

Sam's a good person, he's still looking for the guy who did all of this... 😗

@NomadicFreediver

Жыл бұрын

LMAO

@carlosk8103

Жыл бұрын

He found him and even tried to bring him in but he was too high at the time and didn't realize he was looking at his own reflection....

@j4genius961

Жыл бұрын

Just like OJ Simpson🤐

Can you do a video about a recommended nootropic stack? Your own or theoretical? Something I’m personally into

The Behind the Bastards most recent podcast about this dude was really intriguing. I encourage folks to take a listen.

The effort this channel makes to create content is amazing!!!

@memegazer

Жыл бұрын

Thanks You posted this on the wrong video but I knew you meant to say this about me

@NutBusta

Жыл бұрын

@@memegazer You are so funny!

@JK8

Жыл бұрын

@@memegazercringe

Love the shout-out. Real recognise real

I just don't want to have to take drugs to be superphislogicslly motivated to do the dishes

@clay38391

Жыл бұрын

real

@shivinpokemon

Жыл бұрын

I have ADHD so I need meds

@deezy8226

Жыл бұрын

@@shivinpokemon No you don't. The big pharma lies

@shivinpokemon

Жыл бұрын

@@deezy8226 I lived over 20 years without it. I need them to function optimally

@RoxusRemo

Жыл бұрын

@@shivinpokemon How did it change your general motivation and getting stuff done. I'm 30 and still on a 2 year waiting list to get diagnosed but I just struggle with doing literally anything unless it's going to be really fun and rewarding. Work and just generally looking after myself is hard work most of the time unless I'm taking over half a g of caffeine a day.

Knowing that Derek watches Coffeezilla is crazy

@Izzy-ww1vh

Жыл бұрын

Fr , I thought he would be a Tech Lead kinda viewer

@_baller

Жыл бұрын

KZreadrs watch KZread....crazy isn't it

@RR-et6zp

Жыл бұрын

KZread isn’t that big lol

@rodrigozanabria2978

Жыл бұрын

Why would that be crazy

@Replicant2600

Жыл бұрын

The KZread multiverse.

If you have huge task or project that you have to complete. I have taken 32.5 mg (Instant Release Tablets) of Dextroamphetamine, it takes longer to kick then levoamphetamine to get things moving and to get a positive and upbeat type of mood. It give you such a real strong sense of focus, being able focus on different tasks all at the same, becoming talkative, having a positive outlook on life. It is a great high, but then you crash later in the day, make sure you have something neutralize the final weak lingering stimulatory effects that remain, but are too weak to do anything great and anyway the effect attenuates because of time. Like you can have a couple Valiums and when take effect, it neutralizes the stimulatory effects are within a few minutes. Once the Valiums take effect, you will hungry again, your muscles will relax, and you feel sleepy. So eat and drink your fill and go to sleep and the day to back to normal. On a side note: You cannot or should do this procedure everyday, it will too much for the mind and body. It is good to do it one week once every two weeks.

Great vid!! would be cool to get time stamps going forward.

Almost everyone is on something and it's been like that for a while. People have been raising the bar, and now it's almost impossible to keep up unless you're willing to also get you're hands dirty.

@NeanderthalDogma

Жыл бұрын

You can compete naturally all these drugs lose their effects.

@ghost-user559

Жыл бұрын

Yeah that’s why everyone is numb and ineffectual, not creative or empathetic, have no social skills and low grit and tolerance for adversity. In other words that is why everything is going to sht

@jacquelinepayne2012

Жыл бұрын

this is all a pharmacologists wet dream.

It’s an antidepressant and due to it’s impact on decreasing the breakdown of dopamine it’s efficacious for treating Parkinson’s disease (dopamine deficiency). Most of the antidepressants work the same way by inhibiting the re-uptake of dopamine, serotonin, and noradrenaline or by inhibiting the breakdown of the neurotransmitter’s. Very interesting stuff

@Demoralized88

Жыл бұрын

Very few antidepressants are dopaminergic. The few that do are stigmatized as they have abuse potential. In practice, only treatment-resistant depression will ever see an MAOI and most doctors are afraid to prescribe them.

There were so many big words used here I feel like an idiot, and I love it

My theory has always been that, all the most successful people are on something steroids, drugs, high grade supps, medications etc.

@X8X8X6X4X

Жыл бұрын

You're correct.

@Onegamex

Жыл бұрын

High grade medication + drugs yes. And they probably have bio-chemiste work with them.

The thing I like about Derek is he says what we’re all thinking.

@Northern_Star

Жыл бұрын

HAHAHHA I felt like he was rapping all episode😂 loved it 💪🏼

@nb-eq6rw

Жыл бұрын

Trust me I'm definitely not thinking "monoamine oxidase"

@Calebanton

Жыл бұрын

@@nb-eq6rw I mean, if you stop and think about it, not that he really gives you the chance to, but monoamine oxidase is kinda self explanatory. Mono - one, amine meaning the nh2 group which is removed (the word deamination is just removing amine) and oxidase, meaning it replaces the amine group with a Oxygen. The 'ase' just specifies that it's an enzyme. The name as with most biological terms is just a short hand description of what it does

@homelessman3483

Жыл бұрын

Yes I was totally thinking about the breakdown of serotonin and norepinephrine that is indicative of moai-b inhibition

@homelessman3483

Жыл бұрын

Especially from transdermal administration

lmao that first guy just became a full narcissist "everyone is now looking up to me" lmao

@ConnorH.

Жыл бұрын

Meh I can sort of see what he's saying. Stims do give some people a more alpha/dominant vibe

@etakarinae248

Жыл бұрын

@@ConnorH. BUT only in their minds. There was this guy in my college time. He thaught he was a genius, talked like he was a 'supreme' human being. All the others thaught he was an arrogant a***ole

I've heard low dose naltrexone (LDN) mentioned a few times on your channel. I've been using LDN for some months now and have found great results. The boost in my endogenous opiod system is great but I'm still coming to understand its interaction with dopamine and motivation.

@johnnylego807

Жыл бұрын

How’s that working for you, i’ve considered trying it multiple times for health issues, heard some amazing stories from it. How do you feel on it? any noticeable negatives?

@jordanstokes3392

Жыл бұрын

Id like to know too

I don't know if you mentioned it but the metabolite of selegiline is amphetamine like which is also a part of the focusing aspect of the drug.

@colinforaker1143

Жыл бұрын

The metabolite is (R) -methamphetamine also called levomethamphetamine. It is the major metabolite of selegiline.

side effects include impulsive or risky behaviour? Derek may have just found the perfect dense for SBF

@umarb7325

Жыл бұрын

illegal or recreational drug abuse isn't an accepted defense for most crimes. Otherwise half of wall street would have a built in defense

@MrMalzers

Жыл бұрын

Drugs are reason for my behavior has never been a good defense.

@hodlcrypto6026

Жыл бұрын

It's all part of the plan

@hodlcrypto6026

Жыл бұрын

@@MrMalzers that's not the point, they are already saying he had downsyndrom

@umarb7325

Жыл бұрын

@@hodlcrypto6026 that's now how defenses work. You need to show you were low functioning to scale the bar for diminished responsiblity defenses to work. Taking stimulants and doing crazy shit isnt a defense. and not from a lack of trying. Idiots have been trying this defense from the beginning of time

25 years ago my brother brought these pills back from Mexico. It was meant for Alzheimer’s or something like that maybe Parkinson’s but it was an off label mind enhancement drug. I only took it for a month. The medication took about a week to really take affect. I felt like my ability to process things and learn became enhanced to superhuman capabilities during the time of use. I really want more of that!

@GldnBlnk

Жыл бұрын

Let me know when you find out what that stuff was haha

@levidestin6783

Жыл бұрын

shit let me get a years supply broo

@shitmandood

Жыл бұрын

Superhuman capabilities…lmfao 😂 obviously it didn’t do anything useful, like elevate your social class, bank account, or getting women, but hey, you got to be Superman! 😅

@retrogamer2548

Жыл бұрын

I take this stuff before fapping. Makes me Kum much faster!!!!

@retrogamer2548

Жыл бұрын

@Golfjoshd I take this before I FAP. Makes ME Kumm so haard.

Been subscribed to both MpMd and Coffeezilla for ages now. Must see TV.

This is going to help him get away with much more due to his “drug problems”

@g13n4

Жыл бұрын

He is going to get away no matter what happens let's be real

EMSAM is a MAOI. If you read the interaction warnings on basically any OTC or prescription drug MAOIs are listed. They interact with everything and most in a bad way. This is not the kind of drug you want to experiment with as a nootropic. You are probably safer doing stimulants which is saying a lot.

@aeonikus1

Жыл бұрын

Nah, in theory you're right. Many MAOIs could be potentially dangerous when missused or in combo with some drugs but selegiline is rather safe substance, it can be helpful in certain situations, like quick acting antydepresant (positive effects can be felt in 1h, not weeks like most/all SSRI/SNRI needs), mood modulator/enhancer, slight cognitive enhancer, it is said that selegiline enhances neuroplasticity/CNS regeneration so one may get long term effects too. I've seen cases of simultaneous selegiline and tramadol use in doses like Sele.20mg + 300~400mg of tram. without any MAOI's related side effects. BUT!!! I DO NOT encourage anyone to take above as medical advice nor to take any drugs without prior consultation with a specialists ;)

5 min into the video i was calling my psych to schedule an appointment to change my antidepressant 😂

@derekr2233

Жыл бұрын

Its decent.. but NOTHING like they are making it out to be. Ive been on EMSAM for around 10 years. Honestly I can barely tell Im on it but it helps me feel less depressed and a bit more focused.. BTW it cost about $3,000 a month.

@T4xEvader

Жыл бұрын

@@derekr2233 nah bro MAOI's are generic at this point if you get a psych script, so with insurance they should be cheap (in the US), or if in the EU then generally drugs are really cheap in europe

@derekr2233

Жыл бұрын

@@T4xEvader I dont think there is a generic of Emsam, my insurance covers it.. but I see the cost. right about $3,000 for 30 days

@T4xEvader

Жыл бұрын

@@derekr2233 bro of course there is a generic the drug was synthesized in the 60's, maybe not for the transdermal patch but your ignorance is a you problem. Took me 60 seconds of research

@seaSwann

Жыл бұрын

@@T4xEvader took me 10 seconds of research to know that there is NO generic version of the transdermal patch, which if you watched the video or read up on this drug is a major factor in its effectiveness as well as effects and side effects

Derek went through an entire roll of word of the day toilet paper in this one.

The whole team at Alameda used adderall on a regular basis, you just have to watch some videos with sam trabucco or sam bankman fried. This has already been known for years in the space, also not that surprising considering they were absolute workaholics and getting very little sleep and always being proud of it lmao

@jhtsurvival

Жыл бұрын

Adderall is a staple to many many people... everyone i know that works nights and oncall at my job takes it. I stopped taking it when not at work and on my own because I just ended up watching porn for hours... didn't help me be Productive on my own lol. Also stopped taking it at work because I was scared of long term heart issues. I also know quite a few people in the medical field that have prescriptions for their sudden on set ADHD

I used to be so huge into Nootropics, looking back it was crazy how much money I spend on them. Few of them worked, and when they did it was amazing. I had some "limitless" experiences, but most of my nootropic use always came at a long-term cost (I was taking them for months/years). Either, when I would get off of them, my motivation to work on things that previously went effortless took a huge drop, or my mood did. There were some nootropics which I did which just made me misbehave, and sometimes this wouldn't happen until being on them for weeks or months. Like Modafinil, turned me into a primal sex animal, after taking it for 6 months. Prior to that, insane focus, and insane motivation. Lifted me out of depression. Then suddenly, boom I wanted to fuck everything that moved. And let's just say it ended up in quite some risky behavior. I couldn't imagine, being on nootropics, having such a paradoxical reaction and then having to manage billions of user funds, ouch.

@hedgehoge90

Жыл бұрын

How much where you taking? I started taking 50 mg 5 times a week, 2 weeks ago. So far I like it because I dont feel wired and can actually concentrate.

@NutritionPolice

Жыл бұрын

I never like modafinil compared to adderall... but once I took Moda before a flight to try to get some work done and it caused me like 6-7/10 anxiety the whole flight, NEVER AGAIN. Turned me off nootropics altogether. I stick with adderall low to medium dose and that's fine.

@__-bz7wh

Жыл бұрын

Which ones actually worked

@hedgehoge90

Жыл бұрын

@@NutritionPolice Really? I find adderall way more anxiety-inducing lol. Its funny how dif drugs affect dif people

@GamesonQ

Жыл бұрын

@@__-bz7wh caffeine

the fact this guy was hardstuck bronze in league tells me everything i need to kno

OLD DEREK IS BACK BOYS! Amazing video!

Been waiting for this one! thanks derek

Vyvanse is amazing vs Adderall IR for me. Adderal IR destroys my mood when it comes down an hour later. The "long half life" of something like vyvanse (it's not a half life, they are just released slower due to digestion) attenuates that emotional crash and is amazing for me.

@John-mh9ty

Жыл бұрын

For me, Provigil wrecks stimulants. Protect your heart bro. Provigil is super neat if you're a responder.

@HeyhitmeBAM

Жыл бұрын

Both are horrible for you

@Ketannabis

Жыл бұрын

I totally agree

@stephenbrody2717

Жыл бұрын

Both create life! Give my creation life! That means my work😂💪

@dougclendening5896

Жыл бұрын

Sometimes there isn't a perfect answer for someone like me. It's all a balance. I try to take as little of anything as needed which is a far cry from what I used to think. 10 years ago I refused to take anything because it wasn't "natural" or "meant to be". If I did that these days I wouldn't be able to keep a good job and support my family. I've accepted that my brain is different than it needs to be for modern society and moved on.

Pretty sure SBF was not taking that to help him stay motivated during workouts...

I didnt watch you for almost a year. What did you do to make your beard look that good?

In all my time I've found Modafinil to be the best for actual function, I'm a big believer on the idea of no biological free lunches, anything that leads to a heavy increase of dopamine, or an increase in how much you are maintaining without breakdown, if used in the long term, will have long lasting consequences. Modafinil doesn't really help with motivation, but at least I'm awake and If I apply other strategies for motivation, I can utilize what it does effectively without becoming a mess, people on Adderall in the long term, if you think It's not going to have consequences, well, I hope you're right, for me, it was a bad decision, especially considering the consistent use over a long period.

Dude finally subscribed. You’re a beast

Is that an old school intercom in the background? Im old (45) and new to the channel 😂 Love the content!!!

You didn't mention this but I think it's quite interesting, Selegiline is also a pro-drug to levoamphetamine & levomethamphetamine. It doesn't increase the levels enough to contribute to the effectiveness of Selegiline but it would still make you fail an amphetamine drug test.

@Demoralized88

Жыл бұрын

Can confirm, failed several UA while on Selegiline via oral admin. Detection threshold >1000ng/ml. Edit: It also shows up positive for Amp and Meth on confirmation testing.

@6DonnieDarko

Жыл бұрын

@@Demoralized88 you can blame it on your vicks inhaler

Jeez bro you've grown so much this past year

@Will-uf9nd

Жыл бұрын

damn I just realized he's already almost at 1.5M

Never thought I’d see Derek do a video on someone in the crypto market but here we are.