A leading researcher on the efficacy of antidepressant drugs to treat depression, Dr. Joanna Moncrieff joins Chris on this episode of Revolution Health Radio to discuss her newest landmark paper debunking the widespread belief that an imbalance of neurotransmitters, particularly serotonin, in the brain causes depression. Dr. Moncrieff explains how the “chemical imbalance theory” of depression originated, whether there is any scientific evidence to support this theory, and how the use of drugs to treat depression has caused a ripple effect in mental healthcare.
In this episode, we discuss:
--The origins of the chemical imbalance theory of depression and whether there is scientific evidence to support this theory
--How human bias has perpetuated the myth of the serotonin theory and the use of antidepressant drugs to treat depression
--Our approach to understanding and treating depression prior to the chemical imbalance theory and how this theory has altered approaches to depression in the mental health profession
--Why the pharmaceutical industry sought to override the dominant conceptualization of depression
--Whether we can say that there is a true biological basis to depression
--What happens to people with and without depression when levels of neurotransmitters in the brain are altered in clinical trials and the role of the placebo effect in antidepressant drug trials
--The long-term negative effects of selective serotonin reuptake inhibitors (SSRIs) on the human body, particularly in adolescence
Show notes:
--“The ‘Chemical Imbalance’ Myth” by Chris Kresser
chriskresser.com/the-chemical...
--“The serotonin theory of depression: a systematic umbrella review of the evidence” by Joanna Moncrieff, et al.
www.nature.com/articles/s4138...
--Blaming the Brain: The Truth About Drugs and Mental Health by Elliot Valenstein
www.amazon.com/Blaming-Brain-...
--“Placebo Response of Non-Pharmacological and Pharmacological Trials in Major Depression: A Systematic Review and Meta-Analysis” by André Russowsky Brunoni, et al.
journals.plos.org/plosone/art...
--Dr. Joanna Moncrieff’s website
joannamoncrieff.com/
--Follow Dr. Moncrieff on Twitter @joannamoncrieff
--If you’d like to ask a question for Chris to answer in a future episode, submit it at chriskresser.com/podcastquest...
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Chris Kresser M.S., L.Ac. is the co-founder of the California Center for Functional Medicine, the founder of Kresser Institute, the host of the top-ranked health podcast Revolution Health Radio, the creator of ChrisKresser.com, and the New York Times best-selling author of The Paleo Cure and Unconventional Medicine. He is one of the most respected clinicians and educators in the fields of Functional Medicine and ancestral health and has trained over 2,000 clinicians and health coaches from more than 50 countries in his unique approach. Chris was named one of the 100 most influential people in health and fitness by Greatist.com and has appeared as a featured guest on Dr. Oz, Time, The Atlantic, NPR, Fox & Friends, and other national media outlets. Throughout his career, Chris has been devoted to exploring the deeper questions surrounding health and wellness. His most recent work is focused on helping people to thrive and flourish even in the midst of chronic illness or other challenging circumstances. He recently launched Adapt Naturals, a supplement line designed to add back in what the modern world has squeezed out and help people perform and feel their best.
The Revolution Health Radio Show is brought to you by ChrisKresser.com and 14Four.me.