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@jonathanberry1111

11 күн бұрын

If you watch a recent Kurzgesagt video on Exercise, you will find that apparently exercise reduces inflammation as it uses energy on something other than inflammation! This would then explain why Exercise helps with NAD levels are reducing inflammation would naturally increase NAD, but the Doctor did not mention and perhaps wasn't/isn't aware of what the video explains, worth checking out!

Lots of value in here. Would love to see a bit of more engagement between the interviewer and the guest. Apart from that, thumbs up!

@ModernHealthspan

10 ай бұрын

Hi thanks for your comment and the feedback. I will work on that!

@davidjordan2011

10 ай бұрын

Or possibly, if she has new and more information, just let her speak and provide that new information. Modern Healthspan hasn't invited her on because MH already knows everything she's going to say.

One of the best interviews I’ve heard in years

It's been said you need to take TMG along with your NR, NMN. I have long wondered how the body deals with all these supplements we take. Believe you dont have this issue with natural sources. A lot of folks are just walking, talking chemistry experiments. Nice interview. Lovely lady.

@ModernHealthspan

10 ай бұрын

Hi Scott, thanks for sharing!

awesome holistic approach to NAD....we need more people like dr Conlon

She may be on to something, but all the ingredients contained in her formulation are readily available at a fraction of the price. I'm not convinced that nicotinamide does much to increase NAD levels, at least not according to the research I've seen. Also, some actual research or studies involving her products would be appreciated.

@lawnmower11

10 ай бұрын

I prefer nicotinic acids flushing niacin as it is very effective at increasing NAD and it reduces LDL and increases good HDL cholesterol. Whereas nmn and Nicotinamide has opposite effects on chol levels, per my understanding

@toniedwards8462

10 ай бұрын

How mu h nicotonic avid do ypu take to accomplish all 3?

@ModernHealthspan

10 ай бұрын

Hi Jon, thanks for your comment. They have done a trial, which we talk about a bit later. It is currently in peer review.

@lawnmower11

10 ай бұрын

@@toniedwards8462see Conquer Aging channel’s videos in past couple months in regard to his NA niacin dosing. He used around 600-700mg daily IIRC. I use 300mg currently

Thank you. A lovely video. Answered many of my doubts.

@ModernHealthspan

10 ай бұрын

Thanks!

Thanks Richard.

@ModernHealthspan

10 ай бұрын

Hi Ron, thanks!

Dr Conlon, Are you currently taking this particular product? Do you have a list of your current supplement routine?

🎯 Key points for quick navigation: 00:00:00 *🧬 Dr. Conlon's background and motivation for founding Neo Labs* - Dr. Conlon discusses her scientific background in bioavailability and drug development. - She explains her transition into longevity research due to the potential impact on age-related diseases. - Highlights frustrations with the slow pace of drug development and the underutilization of natural compounds in research. 00:06:26 *🌿 Understanding the role of NAD in aging and Neo's approach* - NAD's crucial role in cellular energy production and repair processes. - Discussion on the decline of NAD with age and its impact on cellular health. - Neo's strategy focuses on addressing the root causes of NAD decline through the Salvage pathway and optimizing nicotinamide recycling. 23:31 *🧬 Nicotinamide Metabolism and Cellular Function* - Nicotinamide is regulated in cells through methylation enzymes like NNMT, which attach methyl groups and signal its excretion to prevent cellular buildup. - Studies indicate that physiological levels of nicotinamide do not inhibit NAD synthesis under normal conditions. - Understanding cellular pathways holistically is crucial, as isolated findings in vitro may not reflect physiological processes accurately. 24:52 *📊 Limits of NAD Precursors in Humans* - NR supplementation shows an initial increase in NAD levels in humans, but this increase plateaus despite continued dosing. - Excessive NR can lead to increased excretion of methyl nicotinamide, indicating saturation of the salvage pathway. - Balancing methyl donors becomes crucial to avoid methylation issues when supplementing with NAD precursors. 26:31 *🌱 Clinical Implications of Methyl Group Deficiency* - Methyl groups are essential for DNA repair and epigenetic regulation, influencing gene expression and cellular health. - Symptoms of methyl group deficiency can vary widely but often include fatigue, reduced recovery, and immune system challenges. - Maintaining adequate methyl groups supports overall cellular function and health. Made with HARPA AI

What are the food Methyl donors? I'm seeing changes... I'm taking Time+ and alternate with DON NMN and TMG. Seeing Hair, nail growth, lack of desire for alcohol, huge appetite increase, deep dreamy sleep. This one is different: I'm a big meditator and noticed this too I'm more able to be in the moment! I'm taking Sert 6 activator in the evening so that may play a part as well. I'm 62 and do HIIT a couple times per week in addition to a walking and body weight exercises. I also do IF and some multiday fasting periodically. Any Food Methyl donors we can eat?

@timratcliff6590

10 ай бұрын

How are you alternating Time + and DNO and how many GM are you taking sert 6 thanks

@Frogman214

10 ай бұрын

Taking some days and not and never together.

❗️👍 Very helpful/useful information! Thanks!

@ModernHealthspan

10 ай бұрын

Hi Thanks, I hope that you enjoyed the video.

🎯 Key points for quick navigation: 00:19 *🧬 Background and Motivation* - Dr. Nichola Conlon discusses her scientific background in bioavailability, drug development, and her transition to focusing on longevity and NAD. - Highlights the gap between groundbreaking research in labs and its translation into accessible treatments. - Emphasizes the importance of dietary supplements in bringing scientific advancements to the public quicker. 02:07 *🌱 The Importance of NAD in Aging* - NAD's role in cellular energy production and repair is crucial for maintaining cellular health. - Decline of NAD levels with age impacts energy production and cellular repair pathways. - Boosting NAD levels through supplements can potentially mitigate multiple hallmarks of aging. 06:41 *🛠️ Neo's Approach to Boosting NAD* - Neo's strategy focuses on addressing the root causes of NAD decline, specifically targeting the NAMPT enzyme in the Salvage pathway. - Utilization of ingredients like alpha-lipoic acid and rutin to activate AMPK and increase NAMPT levels. - Emphasis on fixing cellular mechanisms rather than simply supplying precursors to NAD. Made with HARPA AI

Before taking things to suppress CD38, do we know all the reasons it goes up with age?

@Always-xl9db

9 ай бұрын

Primary reason is inflammation

Well, I went on Conlon's company's website and tried ti figure out what the supplement cost was. I could not find it anywhere. I sent a message and asked the question of cost and no one ever got back to me. Not impressesd.

@ModernHealthspan

10 ай бұрын

Hi Linda, thanks for your comment. The pricing is clear on the website that I can see, $65 for a one time purchase. Am I misunderstanding your comment?

@lindaabernathy4876

10 ай бұрын

Thanks, I am now impressed, sir@@ModernHealthspan

Do you have a list of the supplement that you take?

Wow, simply brilliant.

@ModernHealthspan

10 ай бұрын

Hi James, thanks!

Do you need to take TMG with these?

@lawnmower11

10 ай бұрын

I thought her product included TMG

@ModernHealthspan

10 ай бұрын

Hi Sean, thanks for the question. According to the biochemistry, the idea would be that you would not need to. The activation of NAMPT should convert the NAM back into NAD and so it would not build up and require methylation to get it excreted.

@seanobrien9676

10 ай бұрын

@@ModernHealthspan Thanks for the explanation!

Hi guys. Another question from me. I'm trying to get an idea how much this new NAD booster increases NAD compared to the 700mg of NMN I take. From the clinical trial it was reported to be 18ng/ml from baseline but that doesn't seem very much. I'm sure I'm missing something. NMN doubles blood NAD levels which I believe is 200ng/ml. Thanks again!

I get the idea that NAD supports work of Sirtuins, but has anybody proved NAD boosting does anything at all?

Which acid she said?

@user-xv5sn9gn5n

10 ай бұрын

R alpha lipon acid

@ModernHealthspan

10 ай бұрын

Hi Anna, thanks for your question. R alpha lipoic acid.

Summary please

@estebanroussel1618

10 ай бұрын

Just supplementing NAD precursors (NR, NMN, nicotinamide) is like pushing on a string. You need to consider the holistic system, which includes the salvage pathway (activating NAMPT, which she covers in the video). Google the NAD salvage pathway and you can find visual representations.

Capers full of quercetin and it is better apsorp

@MixtrisUFOimages

10 ай бұрын

yup. have it frequently

@ModernHealthspan

10 ай бұрын

Hi thanks for sharing.

She has so right isolated ingredients are not apsorb that’s why I paire my supplements always with spirulina it has everything in it except of vitamin c and this I put in

@ModernHealthspan

10 ай бұрын

Hi thanks for sharing.

She still doesn't fully understand NAMPT. She is getting close, though. Instead of using biomimetics or their stimulators, I'd rather go straight to the epigenetic signalling molecules that directly controls NAMPT, pulsed glycololysis, and demethylation.

Niacin noflush 4x 500 mg per day SOLGAR

@lindaabernathy4876

10 ай бұрын

She's not talking about Niacin, exactly, though when you see Niacin as an ingredient in a multi vit. some of it may be "as Nicinamide".

@user-xv5sn9gn5n

10 ай бұрын

With milk thistle Copper spirulina Vitamin c

@ModernHealthspan

10 ай бұрын

Hello Gianni, thanks for sharing. Niacin is an NAD precursor but without the other components, to activate NAMPT then it will cause an increase in nicotinamide in the cell.

@Frogman214

10 ай бұрын

No Flush is said to be bad on the liver. Search.

Who’s the drunk incompetent host?

Key takaway - she's adding sugar to your supplements now

@ModernHealthspan

10 ай бұрын

Hi Elwyn, the sugar Dr Conlon referred to is attached to the quercetin and just serves to stabilize it and increase bioavailability.

@elwyn14

10 ай бұрын

@@ModernHealthspan thanks for responding, love your videos, I apologize for my terrible sense of humor 😭

Nushido contains alpha lipoic acid, and I have seen that Novos prefered not to include it in their product because they fear too much anti-oxidant might shorten lifespan. They mention a study in which ALA shorten mice lifespan by a third. It is this one: DOI: 10.3233/JAD-2012-120130 ALA is interested though, hard to know whether to take it or not..

@ModernHealthspan

10 ай бұрын

Hi thanks for sharing and including the paper. I will have a look at that. I have seen that NOVOS are not positive on antioxidants although they generally seem to be viewed as positive. Is it a question of dose? Some ROS is required for hormeses but too much is not good?