Rethinking Psychedelics, Octopuses on MDMA, and The Master Key of Metaplasticity | Dr. Gül Dölen

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Resources from this episode: tim.blog/2023/04/19/gul-dolen/
Dr. Gül Dölen is an associate professor of Neuroscience at the Johns Hopkins University School of Medicine and a pioneer and world leader of psychedelics research. Her laboratory has discovered a novel mechanism that could account for the broad range of therapeutic applications that psychedelics are currently being tested for. Her lab has discovered a novel critical period for social reward learning and shown that this critical period can be reopened with psychedelic drugs, such as MDMA, LSD, psilocybin, ketamine, and ibogaine. Building on this discovery, she has formulated the hypothesis that psychedelics may be the long sought “master key” for unlocking critical periods across the brain. To test this hypothesis, she has initiated a nationwide collaborative effort to determine whether psychedelics reopen critical periods for ocular dominance plasticity, bird song learning, anatomical plasticity in the barrel cortex, serotonergic neuronal regeneration, dendritic spinogenesis, and motor learning.
Importantly, understanding psychedelics through this framework dramatically expands the scope of disorders (including autism, stroke, and allergies) that might benefit from adjunct therapy with psychedelics, an approach she has dubbed the PHATHOM project (Psychedelic Healing: Adjunct Therapy Harnessing Opened Malleability).
Dr. Dölen earned her MD, PhD at Brown University and the Massachusetts Institute of Technology (MIT), where she carried out seminal work on critical periods, learning and memory, and the pathogenesis of autism.
Please enjoy!
[00:00] Start
[02:14] How Gül designed her own major as an undergrad.
[05:11] Philosophy of mind and theory of mind.
[09:58] What theory of mind in non-human species suggests.
[13:23] The origin of Gül’s interest in autism.
[18:24] Autism facts vs. fiction.
[25:41] Critical periods.
[35:32] How critical periods apply to therapies for autism.
[39:56] Why might psychedelics allow us to reopen shut critical periods?
[46:01] MDMA and the octopus.
[49:25] Challenging popular notions about psychedelic research.
[51:41] Plasticity.
[57:25] Favorite neurotransmitter receptors.
[1:03:20] Can psychedelics cure allergies?
[1:11:33] Seeking a common pathway for the therapeutic effects of psychedelics.
[1:13:32] Potential applications for kappa-opioid agonists.
[1:14:45] Beta-arrestin developments.
[1:18:24] On Sasha Shulgin.
[1:24:05] Strokes.
[1:28:11] Cross-cultural considerations.
[1:31:49] What do these therapies look like 10 years from now?
[1:35:30] Gauging minimum effective dose.
[1:41:55] The funding frustrations that almost made Gül give up science.
[1:48:00] Taking risks.
[1:52:34] What would Gül change about the way research is funded today?
[1:55:11] Books most gifted.
[1:59:10] Parting thoughts.
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Пікірлер: 58

  • @timferriss
    @timferriss Жыл бұрын

    Brought to you by LMNT electrolyte supplement drinklmnt.com/tim, Helix Sleep premium mattresses helixsleep.com/tim, and Athletic Greens’s AG1 all-in-one nutritional supplement athleticgreens.com/tim

  • @johntnguyen9917
    @johntnguyen9917 Жыл бұрын

    Psychedelic therapy is one of those great leaps in the mental health space. It’s wonderful and the fact that they serve recreational use and health purposes as well. It helped me get rid of depression and anxiety.

  • @george.beard2409

    @george.beard2409

    Жыл бұрын

    Yes, Doctor.coxx

  • @Karamayfield2043

    @Karamayfield2043

    Жыл бұрын

    Can Doctor.coxx send to me in AZ?

  • @roarodneal3390

    @roarodneal3390

    Жыл бұрын

    Sure. He delivers anywhere and also it’s discreet, if you’re worried about that

  • @shannonkeeth3094

    @shannonkeeth3094

    Жыл бұрын

    Just reach out to him. He also gives advice if you're entirely new to this.

  • @moniquemichelle7295
    @moniquemichelle7295 Жыл бұрын

    Love this! She has a great energy and curiosity. We need more women in science like her 🔥🔥🔥

  • @pierrejarthon4254

    @pierrejarthon4254

    Жыл бұрын

    HA oui ... I was caught since she began to explain her tri Majors dilemma & her motivation to answer what is the mind ...

  • @dahnyul
    @dahnyul Жыл бұрын

    Absolutely love this interview! I have not heard so many female voices on the science side of psychedelic research. To hear her and her different understandings of the field was really informative and a much needed update for me. Beautiful interview and so much love, Tim! Also, the History of Everything was life-changing. Truly wonderful and deeply connects us to an updated look at an ever changing understanding of our past! 🔥🔥🔥

  • @justinbirkholz7814
    @justinbirkholz7814 Жыл бұрын

    Wow what an interesting interview! This gave me a lot to consider. It's a different perspective on psychedelics than I've ever heard before. I'm particularly fascinated by the potential to treat/cure allergies. I had not heard the story of Andrew Weil using psychedelics to cure his allergy. She needs to write a book! I would buy it.

  • @QuantumGoddess
    @QuantumGoddess8 ай бұрын

    Honoured to be alive for this movement and the research I've come into is profound. Thank you beings for sharing!

  • @josephparker3033
    @josephparker303310 ай бұрын

    I have watched this three times while taking notes. What an incredible amount of information interestingly presented. The conversational report between Mr. Ferriss and Dr. Dolen was amazing.

  • @paulaht
    @paulaht Жыл бұрын

    Wow what a effervescent powerhouse Dr Gul Dolen is, it was a great pleasure to listen & learn. Thank you Tim.

  • @pricklycats
    @pricklycats Жыл бұрын

    As someone with autism it's nice to know that there are people out there researching these things. I really want to have kids someday but I'm terrified of having an autistic child.

  • @NinaKatharinaWeber
    @NinaKatharinaWeber11 ай бұрын

    Even though I enjoyed the interview, the part about autism was hard to swallow. Especially to categorize it as „disease“. I suggest watching Yo Samedy Sam‘s video critiquing mice studies, for starters. We see more diagnoses because high-masking autism is now recognized as such and so previously ignored kids and adults (especially female) are diagnosed. As a mom of a high-masking kid: Hearing Dr Dölen speak dismissively about high-masking autism was hard. The struggle is still there, the feeling that everyone else got the memo but you didn‘t. The struggle to form friendships and later relationships. Executive dysfunction. And all the while, you work twice as hard as everyone else to keep the mask intact and pass for neurotypical.

  • @TwistedMesses
    @TwistedMesses Жыл бұрын

    Ok so doesn't this research also have implications into what causes PTSD? If a novel environment can reopen critical periods then a traumatic experience would likely elicit that state. Then you're basically undergoing a restructuring of your understanding of the world on a very deep level at a rapid rate. Just one experience can cause a "learned trait" similar to the way a child learns. So that makes sense that psychedelic therapy could reopen that critical period while revisiting the event in a safe environment and basically "unlearn" what you learned in that potentially singular traumatic experience. Fascinating

  • @infinitedurr

    @infinitedurr

    Жыл бұрын

    Well said, and practically speaking, that’s the idea of how to use psychedelics for PTSD

  • @justinbirkholz7814

    @justinbirkholz7814

    Жыл бұрын

    Yes, you are definitely on the right track here. I heard Robin Carhart-Harris talk about this in an interview with Jordan Peterson. I recommend looking that up here on KZread if you want to learn more about the use of psychedelics to treat PTSD.

  • @justmorenoise

    @justmorenoise

    Жыл бұрын

    Wow I wonder umm I once read a paper saying that people were way more susceptible to developing PTSD in war IF they already had a learning disability neurodiverse as a child. It was alarming because it made it look like someone with ADD or ASD level 1 was developing PTSD from war and not correlated with the actual big T trauma or severity of trigger event.

  • @JeoffreyDiggs
    @JeoffreyDiggs Жыл бұрын

    There's a lot of potential in psychedelics, I can't wait to try any of them mushroom specifically but it's just so hard to find a reliable source over here, l'll be glad if anyone can be of help

  • @CarltonWill

    @CarltonWill

    Жыл бұрын

    I've tried a lot and since the first time i tried it, I said "it's a crime against humanity to make psychedelic illegal"

  • @AllenRobert-oe6ox

    @AllenRobert-oe6ox

    Жыл бұрын

    [myco_carson] (Got psychs:)

  • @GrantSimmons-ne4og

    @GrantSimmons-ne4og

    Жыл бұрын

    Tripping is not a bad idea but having a Mycologist who will recommend you the dosage is the best option

  • @JeoffreyDiggs

    @JeoffreyDiggs

    Жыл бұрын

    ​@@AllenRobert-oe6ox Where to search? Is it on IG?

  • @AllenRobert-oe6ox

    @AllenRobert-oe6ox

    Жыл бұрын

    ​@@JeoffreyDiggs YES.He's got shrooms, lsd, magic mushrooms, chocolate bar, dmt and other psychedelics products

  • @CashMoneyMoore
    @CashMoneyMoore Жыл бұрын

    Seems like a very exciting field. Can't wait to see more research being done here, it seems like especially for autism, opening the critical windows of learning could be a game changer.

  • @Beederda
    @Beederda Жыл бұрын

    So when i did psilocybin mushrooms last year i jumped into john vervaeke’s awakening from the meaning crisis series and half way through I thought to myself how tf am I understanding most of this or it’s atleast making a bunch of sense? I later found out about neuroplasicity and how psychedelics open up this in the brain i was a firestorm for my friends to say the least as i tried to talk about what i was now learning and of course none of them could grasp any of it but now im like super intrigued by mycology and psychology and philosophy fell into c.g jung and Jordan Peterson. But this episode is super helpful with information i am missing still trying to grasp the whole of my experience that happened. Let the psychedelics renaissance snowball roll! ❤️🍄

  • @phoenixreborn21
    @phoenixreborn21 Жыл бұрын

    Glad the difference between autistics and psychopaths in regards to theory of mind was pointed out so clearly. However, consciousness is a right hemisphere state, not a left hemisphere state (from my own experience) - because in a right hemisphere state, you zoom our of filtering out of the reductionist thinking, and you see the overall picture, and it might be similar to dreaming, you can;t quite grasp it, once you wake up and are back to left hemisphere perception. You just remember your dreams vaguely, if you don;t write them down, you tend to forget them quite quickly. Late Donna Williams (the UNLOST instinct) argues, that we all originate in the right hemisphere state before language and As a Mother of a now adult autistic son, Linguist Dr.Olga Bogdashina has done a lot of research in terms of differences in language and sensory perception and what is called spontaneous non ordinary states of consciousness in her books Autism and the Edges of the Known World - Autism & Spirituality. (She would be great to interview) - and it makes clear, that autism is NOT a disease. But a different state of perception. You can't "cure" a different state of consciousness perception. Compare that to Dr. Jill Bolte Taylor and her famous viral TED talk, where she describes her state of consciousness during her left brain stroke (Left brain is where Broca's and Wernickes are are) where she lost the sense of who she was and the loss of understanding and speaking language, but instead felt expansion and MERGING with the environment, she called it NIRVANA for the DEEP PEACE she felt, while in this state. If you look into Interspecies Communicator Anna Breytenbach, who argues, that this way of interacting with the environment has been lost to our Western Society but Indigenous Folks (Australian Aborigines, African tribes) have still at their disposal.

  • @timothyrae9145
    @timothyrae9145 Жыл бұрын

    Great conversation!

  • @drnicolaschongks
    @drnicolaschongks11 ай бұрын

    Been on shroom for several months . Weekly to biweekly use . Feels great . improve smell , improve hearing and vision . Loving it ...

  • @cag1
    @cag1 Жыл бұрын

    How does a channel with over 1mio subscribers get barely 9k views?!

  • @40somethingvlogger74
    @40somethingvlogger74 Жыл бұрын

    This interview is platinum

  • @robfield2302
    @robfield2302 Жыл бұрын

    Good one!

  • @carolspencer6915
    @carolspencer6915 Жыл бұрын

    Good afternoon to you both Thankyou for your shared conversation. Fab brain gym. Love science and octopus.😀 Think we need to do more to create a new paradigm within my own profession, too. If not think I might jump ship, but to leave nursing behind NOT an easy decision! After eighteen years of mental health nursing our patients are deserving of much more (better outcomes, measurement of!) to say the least. Reasearch and Development departments and strategists do seem to be hindered in their creativity almost mixed up, entangled in politic and self serving drama. Professionally frustrating at times. In short.. Anyways thankyou for sharing. 💜

  • @dianera2571
    @dianera2571 Жыл бұрын

    Thank God research is being done on these things. I hope we can find an end of life care replacement for morphine and Ativan. There’s nothing divine about the dying experience with those medicines-just sluggishness and inability to communicate with family. Hospice care needs to be revamped.

  • @vespahandle

    @vespahandle

    Жыл бұрын

    Exactly

  • @vespahandle
    @vespahandle Жыл бұрын

    Such important data that is needed to better understand the therapeutic uses of psychedelics. Thank you dr. Dole and Tim..

  • @sarahhughes1505
    @sarahhughes150511 ай бұрын

    As an autistic person, i found a lot of the facts vs fiction section to be untrue and offensive. First of all, autism isn't a "disease" that can be cured. Its a developmental disorder. It is a form of neurodivergence, i.e. having a brain that is different from the norm. Autistic brains are structurally different from neurotypical brains. The diagnostic definition of autism got expanded to include symptoms normally seen in the drastically underdiagnosed female population, including the ideas of masking and social mimicry. Another reason why diagnoses seem to be increasing is because everyone now has access to the internet, we have access to information about autism, information which was previously only accessible to psychologists. Therefore these psychologists can no longer gatekeep autism diagnoses to a select few (cis, white males). Autism is not something that we as a society should aim to eradicate. Many historically great minds were autistic (Albert Einstein, Nikola Tesla, ect). Maybe instead of trying to cure autistics, we as a society should be adapting the world to be more inclusive of neurodivergent people.

  • @BasedChadman

    @BasedChadman

    8 ай бұрын

    You could say the same about depression, but autism is unfortunately a setback in modern life. I'd give anything to enjoy the comfort of not feeling like an oddball in every social setting or to not have some of the cognitive struggles I do. I can recognize autism has its perks, but I can't pretend having it has made my life easier in any way.

  • @danokhlopkov
    @danokhlopkov Жыл бұрын

    need a timecode to listen about Octopuses on MDMA

  • @imondtitanic

    @imondtitanic

    Жыл бұрын

    10:30

  • @Amy-nu4cc
    @Amy-nu4cc Жыл бұрын

    Thank you for having a woman on your podcast. It sure has been a while! I'm sure you know women make up half the population and you are missing out on HALF THE MARKET by not including them on your podcast quests in the same and equal way as men....

  • @TheGuyMidkiffShow
    @TheGuyMidkiffShow Жыл бұрын

    I need an aspirin.

  • @stephaniehoile8762
    @stephaniehoile8762 Жыл бұрын

    autism isn't a disorder. it's just a way of seeing/thinking.

  • @justmorenoise

    @justmorenoise

    Жыл бұрын

    It’s a disorder. If you can’t communicate adequately to live independently or survive on your own it’s disorderly. I get it that many people with Level 1 might not think it’s a disorder and have a job or partner but there’s a big difference between being on the spectrum and still functioning in life and being on the spectrum and being extremely limited in life.

  • @trismegistus3461
    @trismegistus3461 Жыл бұрын

    MDMA is neurotoxic

  • @ryanmadlener

    @ryanmadlener

    Жыл бұрын

    The studies that showed that MDMA is neurotoxic are false because the experiments were actually testing methamphetamine, not MDMA.

  • @vespahandle
    @vespahandle Жыл бұрын

    What is the most helpful book for understanding how DMT helps WITH PSYCHOSPIRITUAL DEVELOPMENT.? whoops sorry for the all caps. Thanks for the thoughts here Diane.

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