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Video Summary:
Most of the receptor tyrosine kinases are single-pass transmembrane proteins with the extracellular ligand-binding site and the intracellular tyrosine kinase domain. Receptors for insulin and some growth factors are Receptor tyrosine kinases. Under an inactive state, receptors are in monomeric form. Ligand binding causes dimerization. Some receptors like those for insulin are present as dimer even under resting conditions. In the dimer, the tyrosine kinase domain of each receptor phosphorylates tyrosine residues on the other one. Resultant phosphotyrosine motifs attract SH2 domain-containing proteins. In MAPK pathway, downstream signal molecules are GRB2, SOS, Ras, Raf-1, MEK, MAPK, proteins involved in cytoskeletal assembly and transcription factors. PI3k pathway, involves PI3K, PIP3, then PDK1, PKC or guanine nucleotide exchange factor Vav and downstream to PDK1 we have Akt or PKB and glycogen synthase kinase 3-β.
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Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.