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Video Summary:
Nuclear receptors are located inside the cell. They bind with a lipophilic ligand molecule. They are transcription factors. They have a ligand-binding domain, DNA binding domain, and transactivation domain. Under resting state, glucocorticoid receptors are located in the cytoplasm and are bound with chaperone protein HSP-90 that prevents its activity. Binding of glucocorticoid causes release of chaperone protein, dimerization, entry into the nucleus, binding with coregulator, binding with DNA, and modulation of transcriptional activity. Because of the involvement of protein synthesis, their effects are slow to appear and slow to disappear.
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Dr Vipul Navadiya
DISCLAIMER: This video is for education purposes only. Although every effort is made to ensure the accuracy of the material, viewers should refer to the appropriate regulatory body/authorized websites, guidelines, and other suitable sources of information as deemed relevant and applicable. In view of the possibility of human error or changes in medical science, any person or organization involved in the preparation of this work accepts no responsibility for any errors or omissions, or results obtained from the use of information in this video.