Thanks Eleanor for helping to fundraise for the rapamycin trial. This was a fun discussion and I hope your audience finds it useful :-)

@surfreadjumpsleep

2 жыл бұрын

Brad, maybe pick up the phone and call Sergey Young? There are little pockets of money interested in testing these drugs. Seems to be mid-life people with money. The good news is there are a lot of those people out there who are also technically inclined. Unfortunately most of the computer programmers I know are not too concerned with their health. Also.. how about arranging trials in a place like India where conducting the research is perhaps less expensive than in Western countries?

@LanceHitchings

2 жыл бұрын

I agree with Matthew. Sergey Young is, I believe, a venture capitalist with a strong interest in longevity. If he's not willing to invest in your trial, I'm sure he could point to investors who would be.

@LanceHitchings

2 жыл бұрын

Do you feel that there might be any added benefit from taking spermadine on the same days as you're taking rapamycin? Do you feel that it might boost autophagy?

@petermalmgren1207

2 жыл бұрын

Dr. Standfield I am 70 ; we do 2.5-3 hours of hiit training 3days a week, I have gained lots of lean muscle weight in my late 60’s , I have a 10% body fat % have a video on Facebook doing 40 real pushups, I am doing fisetin and others . I would love to share more details with you guys.

Really, very interesting! I"ve been following the news surrounding rapamycin for a while now and find it fascinating. I'm currently signed up for the PEARL trial, but haven't started yet. As a 72 year-old, who both exercises and engages in excellent nutrition, I'm at a point in my life where I'm looking for validated protocols beyond nutrition and exercise. Were I younger, I'd wait, but at my age, I'm willing to take a calculated risk with bio-hacking.

@TheIgnacio777

2 жыл бұрын

Why not do metformin or berberine in the meantime? If we purposefully switch on mTOR with resistance training and more protein, then we can switch it off w metformin/berberine and intermittent fasting mediated autophagy?

@imanudinanita361

2 жыл бұрын

Are you really 71 year old......wooow....👍👍👍

@PaulThomas-qb9cx

2 жыл бұрын

Three of my favorite channels, two in the interview and one commenting. Love it!!

@bill9989

10 ай бұрын

Are you aware of any info/research about "too old to start" rapamycin? I'm 74, male, in very good health and have been taking metformin for 2 years for longevity (I'm not diabetic). I've been notified that I can get rapamycin through my metformin provider and I can afford it but wonder if it is of any benefit at my age.

@LanceHitchings

10 ай бұрын

@@bill9989 It's my understanding that trials have been done using middle-aged mice and they were very successful. The general thinking is that rapamycin provides benefits regardless of your age.

My two favorite health-hosts in one show!

I am 70 we do 2.5 to 3 hours of Hiit training 3 days a week. I take fisetin and others. I have a 10% body fat percentage; and have developed plenty of lean muscle weight in my late 60’s ; I would definitely like to share some more details with you guys

@herveduchemin2139

Жыл бұрын

Amazing body composition and health profile -- just to clarify, HIIT can't be done for 3 hours a week, it's simply not possible to do that level of intensity for 3 hours in a week and if you are then it might be healthy cardiovascular activity, but not High Intensity Intervals. Should be 7-10 minutes maximum per session with somewhere between 4 to 10 sets of 30 second work/30 second rest, and doing that too many times in a week would surely be detrimental as it's extremely taxing on the body and demands proper recovery. Peter Attia says to not do it more than 1-2x per week, if you can do 31 seconds or longer it's not at that HIIT intensity :)

"Benevolent pseudo-diabetes" occurs when fasting as well as with rapamycin therapy. It might be important to check both glucose and insulin levels.

@scottclark6674

2 жыл бұрын

Specifically glucose tolerance and insulin sensitivity

I was curious about the 30 second chair test, because I’m two moths out from chemotherapy and 70 years old, (female) so I thought I would see how weak all this made me. According to the CDC guidelines a female my age should be able to do 10, but chemo is known to cause muscular deterioration. I have been exercising all throughout chemo when I felt up to it, and all throughout my life. I have definitely noticed significant fatigue, though, days after the chemo treatments and even now feel some weakness in my legs on the stationary bike as opposed to last Spring when I could easily ride 25 miles. Still, I succeeded in 17 rises, well over the 10 required and even over the 12 required in females a decade younger, I think perhaps the expectations are too low. (But I still got cancer, so there is that…..)

@toomanymarys7355

Жыл бұрын

I think you underestimate how disabled so many people are by 70. :(

Worth mentioning, on chart at 27:45.. I read that the doseges they used for curcumin were very vety high and not sure if humans can tolerate those doseges.. Keep that in mind.

Thanks, everyone, for working on this and supporting the field. Centenarians have shown to have very low inflammation and very low fasting blood sugar IGF etc. They have perfect arteries and organs well into their hundreds. We are currently putting a fund together for research, but we are nowhere near ready to fund anything.

Thanks a lot to you both for the work you are doing.

I was taking Metformin but believe I was getting bloody noses from it, so took your advice saying stop.Thank you

This is a great interview from two highly knowledgeable people and regarding Dr Stanfields delivery in his videos - Brad I think your delivery is great, you get the right information across without any unnecessary fluff. I’ve been a subscriber for a very long time. Thank you both for this video

Thank you for this interesting interview.

Great interview Sheeky. Very informative.

The use of functional tests, as opposed to using DNA methylation tests, is a good idea to track effectiveness.

Very interesting to listen to as I'm currently writing my dissertation on longevity in centenarians vs health and disease. It would be an interesting part to mention.

@lifesrealityis

2 жыл бұрын

Oh exciting! I’m curious what is your thesis for the dissertation?

@Shanti_S

2 жыл бұрын

@@lifesrealityis Hiya, so I'm British and haven't really used the word 'thesis' before but it's apparently the same as dissertation. The question I chose for my diss was "Does our modern understanding of epigenetics challenge the principles of Neo-Darwinism?" Basically I am looking at longevity in populations and especially centenarians to see if they have certain genes that are more influential in their lifespan or if their methylation patterns are different compared to other populations etc. I'm looking into diet and methylation patterns there, environmental attributes to health and other factors etc. It is really interesting that's for sure and certain genes like APOE are significant in my review too. Thanks for asking :)

I’m using Rapamycin it has cleared some skin problems ;with it ,I am taking Curcumin ,my muscles are growing through training. I truly think I might benefit immensely

In 2023, Rapamycin costs around $1/mg when ordered overseas, $3/mg when ordered in the US, but has an insane copay from typical insurance plans (because it's only used in transplant patients).

you should do episodes interviewing Drs. Alan Green and Blagosklonny

Good strategy for promoting phased autophagy/m-TOR activation is taking spermidine on rest days or at least 5 hours after exercise

My doctors prescribe me sirolimus rapamycin for shrinking tumors as NEUROFIBROMATOSIS

Hi I'm a recent fan of you both.

curcumin increases fat adaptation and acelerates autophagy which in turn does increase longevity.similar to olive oil. only totally different pathways.

Why not use metformin or berberine to periodically suppress mTOR and also intermittent fasting to stimulate autopgagy while also do resistance trainings to switch mTOR on for muscle growth?

@Scottlp2

2 жыл бұрын

I like and take berberine. Alas berberine messes with P450 (liver enzymes which metabolizes drugs), so taking berberine and eg rapamycin not good idea.

@elizabethk3238

Жыл бұрын

Good question. I'm taking BERBERINE, with good outcomes.

I’m 65 my body is resting responding resembling something I thought not possible

Another question on senylotic plz.. Does sulforaphane has any effect on senescence cells?

Thanks for the video. Q: for people who do not have access to rapamycin, what are the alternatives? comments on this article? A computer modeling study has identified ashwagandha and ginseng as among the top dietary ingredient candidates that mimic the anti-aging effects of two common drugs. The study, titled “​Towards natural mimetics of metformin and rapamycin,​”​ was published recently in the journal Aging. Dec 1, 2017

@joshuaeisenberger4975

2 жыл бұрын

i would suggest you to reaserch ashwagandha a little bit bc i heard of some plenty donwsides (numbs emotions, is hard on the liver...) Also the best metformin alternative is called berberine which is an over the counter herbal supplement which dosent has the downside on wheightlifting like metformin has.

Have you read the latest paper by Steve Horvath regarding healthspan increase potential using HGH, Metformin, and DHEA?

How does Rapamycin compare with Urolithin A?

Hi Doctor - do u think maybe good to look at few physical parameters at start and end other than just stand test which is mainly looking at lower body strength? Maybe grip strength which in many other studies shows some correlation to lifespan? And maybe pull ups, for upper body testing, with this at your clinic site at start and end. Here could use a weighted assist pull up machine as many have issues for just one pull-up?

@michael-qp9xd

2 жыл бұрын

Hi Doctor - near end of podcast mentioned other tests besides sit test - walk and grip. You think pull-ups for upper body measurement change might be good too? Here would have from assisted pull-up machine so could get more differentiation and data spread.

Where can you get it

Trials need to be cheaper. I'm wondering what the cost breakdown is for this? Where could money be shaved off?

Have Dr. Sam Bailey on

How can I participate in the test? I"m 70 years old, good health and I don't do much exercise, just walk for 4 or 5 miles 3 or 4 times a week.

I am not from the English speaking country, so understanding what Eleanor is speaking due to her accent is a huge challenge for me! 😀

@BR-hi6yt

2 жыл бұрын

Agree, she is not clear for some reason.

@toomanymarys7355

Жыл бұрын

Her mic is bad. It's not her Aussie or NZ accent (sorry can't reliably tell the difference). Or her echo-y room.

Where I can find doctor in US give me Rapamycine ? Please help

@emaginate1

4 ай бұрын

Dr Alan Green, NY. USA. He's my MD via telehealth

Id rather eat a high protein diet and build more muscle now so that when im older I'll have a higher baseline strength

Superb information presented by Dr. Stanfield. I would respectfully encourage the interviewer to work on her diction, as she is no doubt intelligent, but does not speak clearly (as does Dr. Stanfield).

Why does it seem like all of the studies are focusing on those 65+?

@nikos4641

2 жыл бұрын

easier to pinpont changes

@BR-hi6yt

2 жыл бұрын

I am 73 and AKG supplement has a huge effect on me whereas it doesn't on a youngster. Almost pointless trying longevity therapies on them. The effect definitely peps me up BUT mentally I feel too pepped-up and have horrid dreams - not pleasant. The psychological effects are too often simply ignored. I wouldn't enjoy permanently feeling like that (AKG effects) even if it made me "younger".

I've taken supplements since I was a teen and still take them at age 73 .And also have not been to a doctor for a health checkup in 60 years. I've had no covid19 vaccine shot and been around strangers and no mask and no social distancing and been fine.

It's a shame it's a whopping $400K. I mean of course it's peanuts in the medical landscape of things, of course. But yeah I hope it gets funded.

@houndofzoltan

2 жыл бұрын

Someone definitely needs to be working on a way to bring the cost of trials down: where there's a will there's a way.

Honestly believe there's just huge propaganda against aspirin

@emaginate1

4 ай бұрын

Not really... reading more about problematic aspirin should be informative.

Let's do a pickleball superiority trial test with 60+ We will measure the improvement by their level of play in pickeleball. Would that work?

What about the yakimoto factors. Has there been any advance in the turning on and off of the factors in the process it'll take to do so. That is the true key to reversing aging. All these clinical trials is to distract us from the true proven keys to reverse an aging. In the process of cellular engineering to turn those factors on and off periodically through chemical triggers that can switch those factors on and off on and off.. You never hear any talk of that

@TheSheekeyScienceShow

2 жыл бұрын

I have many recent videos on yamanaka factors

Possibly I am getting paranoid about Omicron the new Sars-Co2 variant with over 50 mutations 32 on the spike protein. I am currently doing everything I know to boost my immune system, such as D3/K2/K4/K7, Zink with Quercitin&Bromelain,, Cod liver oil, Boron, Methylated B vitamins, Methyl Folate L-5 MTHF, Potassium, Vitamin C. Lemon/lime juice. I am age 70, self isolating not vaccinated. Hope this helps.

@anon5523

2 жыл бұрын

Vaccination is helpful to boost your immune system against the corona virus. It many countries vaccines are even available free of charge.

@nikos4641

2 жыл бұрын

a walking pharmacy that isnt vaccinated?

She's so adorable

I applaud the effort, but the study design fails to address a critical problem in most of the research on longevity. Testing subjects who didn't previously exercise artificially selects for people who are functionally "sick". Anyone who doesn't exercise is destined to live a shorter life (on average). In effect, you're stacking the study. You may only prove that Rapmycin is an analogue for exercise, not a drug that truly moves the needle on the maximum health or lifespan. It would be far more interesting to test a cohort who was in the peak of health. People who exercise, are vegan, get 8 hours sleep and don't engage in high risk activities like smoking. You're not really achieving anything until you extend the lives of people who were already going to live longer than the average person.

You look so cute here :D

He tries to present himself as an expert in the field, but he is so often wrong. Rapamycin can be used alone to reduce the incidence of acute rejection in organ transplants. It is more effective, however, when used in combination with other drugs. And this is someone who is designing a crowd funded clinical trial?

Dear lady, all good,,but I have difficulties understand what you say. I have to guess what you are saying. Can you improve your pronunciation, please?

Brad has a mostly a clickbait channel

@nikos4641

2 жыл бұрын

why do you say that brother