Biochemist explaining longevity, biotech, CRISPR and more...!!
So, hello and welcome to The Sheekey Science Show! My name is Eleanor and I graduated in Biochemistry from the University of Cambridge (2019). I am now doing a PhD at the Cancer Research UK - Cambridge Institute. (p53 & senescence)
Science communication is a really important aspect to scientific research. So I made this science channel. The channel covers topics from aging & longevity, gut microbiome, neuroscience, CRISPR, Biotechnology companies and book reviews + more.
I post frequently and like to cover the latest science news. I hope you will enjoy learning something from any of my videos :)
Пікірлер
You came to Japan? 😮 Now I plan to make two KZread channels (one for academic-level Japanese learning). If you have any advice on topics to cover, please let me know. I’ve been doing a literature review on elastogenesis as a part of my hobbies. Arterial aging has captured my interest. However, I also think skin aging is an inevitable viewpoint. Some leading scientists boast about their young biological age, but their skin looks like that of uncles.
Thoughts on Sunekos? It’s an injectable that’s said to actually build elastin
Supplement ...now is a drug...follow the money. LOL
As much as I am just barely scraping the surface of Longevity, LEV and biological immortality - I've always cringed whenever I read studies utilizing lab mice. Sure they're mammals like us. But how can you take those results and say the same would happen or not happen in humans? We could be using a more identical DNA make-up such as Primates or even condemned humans - not to say it's not already in the works.
I hear Dr. Vittorio Sebastiano's company is working on a topical treatment for skin aging he's also on the board of some big cosmetic company so I'm not surprised
You are very appreciated. Sorry on the entitled attacking ungrateful egoist post. There's a special place in Hell for judgemental attackers, don't worry your awesomeness on it.
Boohoo, did not move to San Diego :( We have Scripps, Salk, UCSD, SDSU and other great stuff. To be honest, human skin on robots does creep me out. Things are likely to get perverse, abusive and inhumane. I am vastly more at ease with germ line genetic modification, artificial twinning, and cloning. The other areas that creep me out are: putting a lot of human genes into animals, especially the ones that express in the brain, making mini brains with human cells to experiment on, and taking human embryos beyond some point. I am against technologies for which the main app is allowing people an outlet to be more barbaric, grotesque, sadistic, power tripping and abusive clearly imagining they are doing these acts to other people, or run the risk of torture and murder of what might be human in some meaningful way, for science and profit. Less, so, but also concerning would be adding animal genes that change personality, and/or make people appear or behave like animals. I am less concerned about borrowing mitochondria, more efficient genes, better lung function and other purely objective improvements borrowed from animals. Adding horns, weird hairy skin, hooves, tales, funky ears...I have a problem with. Though, I admit to coming up short on a solid rational justification for my objection to that.
love the theme song! Couldn't polymers attached to the skin cause some polymers to enter the body and possibly accumulate inside?
Hi Eleanor, another amazing video! Have you come across the story with the C15 fatty acids recently being discovered to be a necessary fat much like omega 3 and that its lack leads to fatty liver disease and cell death by compromised integrity of the cell membranes? What is up with this compound is the research legitimate? If so it could be important for longevity as well?
Best channel on KZread
Sheekey, you probably remember seeing a few much more realistic-looking robotic faces in the news over the past couple of years, such as Amica (search on KZread if you don't remember). To me, this is getting pretty close to mimicking at least the look of human skin on an applied robotic body already, even without needing to use actual human skin. So I guess the question I would ask is what are the advantages and disadvantages of using human skin for such applications? Perhaps synthetic skin could go beyond human skin function in certain care-abouts and applications. Maybe if we want to touch a robot, we want it to look and feel as much like a human as possible, to be sure, but if we're just trying to get along with a robot friend, it may not be necessary. Of course, using new skin on ourselves is a completely different ballpark.
I personally believe skin will fix itself IF you maintain the hormonal levels as they are in youth. This would require fixing the core hormonal drop with aging in the pituitary gland and removing the inflammation that accumilated with age. So understsnding the decline in the pituitary gland is key and then removing the accumilation of damage so the hormones can do there job without cancer concerns any other solution is just a patch not a cure. 😊
good overview. small glitch: the hyflick limit is oudated... it was deteremined only in one or 2 cell types, in vitro. On the level of tissues it is much higher and different tissues have a very different limit. Skin cells replicate much more often
Your accent and very long intros making your videos little bit hard to watch.
Enjoy Japan. I studied my PhD and lived in Japan for 10 years. Never wanted to leave but somehow my job life moved me to the UK
Love your content. That intro music is god awful.
Is that an AI created jiggle for your channel?
please go back to the old video format - more in-depth, less flashy... and covering NEW developments, not papers from 2016 (8 years ago). We're here primarily here for knowledge, and deciphering complex new papers; for entertainment, we have Netflix
Loved the short poem, pop music must Go! Aargh.
Yay, a Sheekey video!
I LOVE the intro!!! Thank you for your research.
Living here in Japan, I know some researchers at Shiseido are making some great advances. Ganbatte :)
That thumbnail is HORRIFYING
I would love to see some advances in skin technologies that will make “glass skin” possible for everyone to attain.
So, how can these discoveries contribute to anti-aging & skin repair? Can any of this be used to turn back the hands of time?
That intro is so exciting 🎉
"Cross-linking of proteins may also play a role in the hardening of collagen and cardiac enlargement, increasing the risk for cardiac arrest. Cross-linking is also associated with stiffening of blood vessel walls, delayed wound healing, reduced joint mobility, and changes in the lens of the eye. In addition to these potentially serious implications, many believe that cross-linking is responsible for age-related skin changes including wrinkles and reduced elasticity. It is believed that cross-linking within the body is enhanced when there is a high concentration of sugar in the bloodstream. Further bolstering this idea is the fact that diabetics often have two to three times more cross-linked proteins in their body in comparison to non-diabetics. If this theory is correct, then foods with a high glycemic index (those that release sugar into the body at a rapid pace) should be reduced as much as possible to retain one’s youthful appearance. By ditching the sugary sodas, simple carbohydrates, and processed foods, the onset of cross-linking molecules may be able to be slowed." Reducing glucose spikes will likely slow the aging process so a tablespoon of vinegar with a glass of water twenty to thirty minutes before a meal, and going for a walk after a meal will reduce these glucose spikes.
Amazing title song
i liked the older videos better. i don't need a poem at the start and super long tv show intro for an 8 minute video.
My thoughts exactly!
Wow, now we have the technology to get rid of lether. I see a human skin sofa in the near future. LOL Very interesting btw, thx!
Well worth the wait!! Very exciting news. Of course it could very well be like the “stem cells” I read about almost 30 years ago. So much promise, so much disappointment… 🤞🏼🤞🏼🤞🏼
Love your research. Thank you
That's coool ur moving to Japan :o are u in Tokyo?
tks u informative knowledge but until now can we reverse the aging process
It goes beyond then what is told to the public! What is and has been done behind closed doors would shake the world! There a reasons it's behind closed doors!
Aging is not one process, it is many. Some of those we can address. Others it appears we are close to addressing. But a few, are pure science fiction. And then there are processes which we haven't even discovered are happening, some of which may be perfectly capable of killing people like clockwork, even if everything else is addressed. Every year or two, we discover one more way we age. We are not even close to solving one each few years. The latest one I heard of was the cellular accumulation of glycerol and glyceraldehyde. Though, it looks like this will be readily solvable. I am not trying to say it is hopeless. There is every reason to think we can extend human life substantially, but meaningful broad spectrum reversal of aging, we just are not likely to see in the next 20-30 years in humans. Part of that is that we have no method of repairing autosomal DNA. There will be many different patterns of damage in every person. Finding your original undamaged DNA and multiplying an appropriate set of these chromosomes for each cell, and then replacing this in every cell? That sounds fantastically difficult. Alternatively, a nanite that inspects a cell's DNA, identifies each error and repairs them? Also, fantastically difficult. Growing all new organs from good DNA and replacing your aged organs with those? Very expensive and exclusive, and unlikely to include many systems that don't have fairly simple and few attachments. That also sounds very painful and unending. Continual renewal from stem cells at the correct stage with your undamaged DNA to replace things? Not far-fetched. And we can either multiply your stem cells you have or give you stem cells that are less mature, but are not yours. Each appears to do things. I doubt any of these can do what is theoretically necessary to substantially roll back DNA damage. DNA damage is not the only difficult puzzle. Another is the loss of order. Things can get pushed and pulled out of order. Structures can become more chaotic, dysfunctional, and obstructive. Elastin, for example, coexists with other proteins, making a 3-D lattice structure holding the skin and other tissues together. Trying to get this all put back together after many decades of destruction...when we never had a system to repair it? How?
this video was months in the making. was a lot of reading, much of which of course never gets mentioned, while i filter to find the more interesting content. thank you for the continued support!
are there any 2024 updates to XPL?
I love your voice and accent.
Ok, where do I get some?
loved it ! you rock
Teaching ability is zero
Aging to me is very interesting aswell, I think about it sometimes and I am interested in the siences, I love to theorise about it. If it is meant to be it is meant to be. But if it is something that can be avoided that would be wonderfull. Feel free to correct me in the things I have wrong! So let's have a little thought experiment! Embryo's at an early stage have totipotent cells, eventually they grow into different types. But what is the trigger of them dividing into different cell types, in what "state" does that happen and how is that communicated? Now with that in mind what would happen if you would keep taking the totipotent cells away? Would the cells keep dividing to reach a certain treshold of cells or would they eventually change? I believe this might be a fundamental insight into understanding why cells might degenerate as we get older. Cells communicate with each other and the "state" of the cell itself and the neighbouring cells are rather important, cause it might define what a cell does. Would cells keep dividing when it is not needed, that would be cancer cell behaviour it knows when to stop! The stem cells of our body turn into and replace the non stem cells right? But eventually they to do degenerate and die!? That makes no sense cause (Telomerase activity is present in most types of adult stem cells, though at substantially lower levels) they can regenerate telomeres! Altough very slowly, but my question is it slow because it is in a "state" with more urgent prioritys like replacing other cells etc. There must be some kind of priority, cause would embryonic stem cells at their earliest stage be like nah I am gonna change into some other cell type already instead of dividing for the propper amount of totipotent stem cells to continue the embryo's development. If cells behave according to different states, wich would also be heavily dependend on the environment of the cell! Would it be possible to enter a state of rejuvenation or in this case increased telomerase activity! Would this be possible if we reduce the amount of stress our body endures? During sleep our body replenishes energy and repairs itself, any activity requires energy and many cells have fallen during day times! If we put less pressure on our body and it not requiring as many repairs could we enter a state of restoration / rejuvenation, where cells focus on different things less important to keeping us working and alive. We don't live with society foccused on our body's, our body's live foccused on what society requires of us. Take an alarm clock for example either way I can't think of such things a s trully "healthy". Just like many other behaviours and habits we have from food to everything else. There is more I could say about this, but I am gonna keep it at this. Thanks for your video!
thank you... Can do this important topic again slowly with more detailed explanation ....But again thank you for this explanation.
WRONG 😢❤.
ALL MOUSE RESEARCH AND ST
Yes, one wonders if NMN and AKG work on the same pathways and if the effects are additive, synergistic, or neither.
What are the barriers from upscaling from frogs? Why I guess do these processes in drug creation take so long?
Therapy creation
I would ask if the Niacin for NAD+ precursors, was Niacin flush or non flush. I do do Niacin flushes. The supplements I take are AKG, Resveratrol, and NR. I gotta switch to CaAKG because I accidentally just bought 60 days of regular AKG.
Excellent! Thank you. Subscribed.
Very interesting, thank you.
Geat ! but need to slow down and talk American english , hard to understand what is being said here in California USA
Thank you very much!