Psychiatric side effects of Montelukast, Singulair

Ғылым және технология

Psychiatric side effects of Montelukast, Singulair
Montelukast is the generic name for a medicine that's also sold under the brand name Singulair. It's usually prescribed to treat asthma. It can also be prescribed to treat allergies.
Shortly after montelukast entered clinical practice, I started getting calls and messages -- usually from parents -- about the new onset of mood changes, suicidal ideas, or psychosis in people who took this medication.
Last spring (March, 2020), the FDA required a boxed warning be added to the montelukast (Singulair) prescribing information. (Boxed warnings are the most prominent form of warning in the FDA safety communication system).
The most likely explanation for the psychiatric side effect potential of montelukast (Singulair) lies in its unique mechanism of action. The drug prevents the conversion of an omega-6 fatty acid (arachidonic acid) into a signaling molecule known as leukotriene. Leukotrienes are inflammation molecules. So blocking their formation can be a good way to treat asthma.
But in blocking the path from arachidonic acid to leukotriene, the arachidonic acid is probably pushed into other pathways (like the prostaglandin pathway) whose products can interact with neurotransmitters that influence mood and behavior.
In this video, Dr. Sara Dugan reviews the psychiatric side effects of montelukast.
This lecture was given at the January 12, 2021 meeting of the SZconsult learning community.
SZconsult is a free consultation + education service offered by Northeast Ohio Medical University. It’s open to any clinician who wants to learn more about schizophrenia-spectrum illness, or who wants to tap into the collective wisdom of the learning community to find answers to clinical problems.
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#askapsychiatrist

Пікірлер: 101

  • @darealmr7931
    @darealmr79313 жыл бұрын

    I took this drug for years starting at 9 years old. Ever since then, even after stopping the medication, it has given me horrible anxiety. So much so that i cant have a normal life and have been on many different anti anxiety meds through out the years. I still battle with it today along with ocd and depression. I am now 26 years old.

  • @amymurr28

    @amymurr28

    2 жыл бұрын

    i started taking this at 10 , by 11 i had depression and anxiety- i’m 14 now and still on it- i’m worried that i’m in a similar situation to you now

  • @platypuz1702
    @platypuz17023 жыл бұрын

    I will never forget the first day I took it, took a nap and then proceeded to have some of the absolute worst nightmares and night terrors of my life, even though it was the middle of the day. Never touched it again.

  • @maxp6051

    @maxp6051

    2 жыл бұрын

    I take it every day I've had some weird ass dreams even some where I die but honestly it's kinda cool to me

  • @gooddoc8129

    @gooddoc8129

    2 жыл бұрын

    @@maxp6051 Please stop it I went throu like you It will get worst and you will be aggressive and do dangerous things

  • @maxp6051

    @maxp6051

    2 жыл бұрын

    @@gooddoc8129 yea I did get aggressive while using it

  • @gooddoc8129

    @gooddoc8129

    2 жыл бұрын

    @@maxp6051 How are you now

  • @maxp6051

    @maxp6051

    2 жыл бұрын

    @@gooddoc8129 much better now luckily

  • @expatnanay
    @expatnanay2 жыл бұрын

    This was prescribed to my then 3 years old son for what was assumed as reactive airway. my gut instinct as a mom kicked in as I immediately noticed behavioral changes such as agitation, irritability and uncontrollable screaming. It was like my son turned into a completely different person. The doctor dismissed it and so I changed doctors. I could not forget that.

  • @AskAPsychiatrist

    @AskAPsychiatrist

    2 жыл бұрын

    There is now a warning in the montelukast (Singulair) prescribing information. So hopefully discussions like that (where the doctor dismisses patient/parent reports) won’t happen again - at least where it concerns psychiatric side effects from motelukast. On the other hand, it’s still way to common (based on what I hear from patients) that the prescribing clinician dismisses side effect concerns. “Anybody can get any side effect from any medicine” is what I’ve come to learn during my work.

  • @noelavalos2558

    @noelavalos2558

    Жыл бұрын

    Is he ok

  • @kayomoreno4031
    @kayomoreno40313 жыл бұрын

    Hi Doctor Sara Dugan, how are you? I work in the pharmaceutical industry here in Brazil. I have montelukast as a product, and is propagated to doctors. In the past two years, I haven't heard reports from doctors, who have had problems with the montelukast prescription, although everyone is aware of the likely side effects. I would like to thank you for the video, in my case in particular, it will help a lot in talking to doctors, where we can clarify how the FDA studies on montelukast are doing. Congratulations on your work, God bless you!

  • @AskAPsychiatrist

    @AskAPsychiatrist

    2 жыл бұрын

    Thanks for the comment, Kayo. The psychiatric adverse effects are (fortunately) uncommon. But they do happen - more so in children. It’s good for everyone to be aware that things like mood changes, agitation, and psychosis are possible. Others in the comments section here have spoken about how they had reported these side effects to their doctors, only to have the doctors dismiss the concern. I’m glad this video can help in your work.

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    @@AskAPsychiatrist hello Does Montelukast cause withdrawal symptoms?

  • @willowbe4747
    @willowbe47472 жыл бұрын

    I have been on this medication for over 20 years. I've never linked my behavior with this medication. Just so happen to read the side effects from the manufacturer. I have taken them and then stop for years. I've had asthma since I was very small.

  • @danielamartinez8200
    @danielamartinez82003 жыл бұрын

    Hello. My little brother was prescribed with Montelukast. He passed away due to this medication's side effects and medical malpractice. We are looking forward to getting support on this matter.

  • @maudetongson9532
    @maudetongson95322 жыл бұрын

    My doctor prescribed this medicine and after taking it for 4 days, I've been having nightmares. The nightmares were realistic. I killed many people in my dream. It was like a horror movie😭😭😭

  • @killer_style007

    @killer_style007

    8 ай бұрын

    Seriously?

  • @crystalakabeavergamingsubs9549
    @crystalakabeavergamingsubs95493 жыл бұрын

    I am barely functioning. Extreme anadonia. It’s all I can do each day to keep Living. I’m in terrible frame of mine. My life is falling apart. I just heard about this and stopped yesterday. How soon will I feel a relief. Just the tiniest relief. I have been to psychiatric and doing anything to find the courage to live one more day.

  • @ckas1785

    @ckas1785

    2 жыл бұрын

    Hi, I know im 3 months late, but are you ok? 😣😔

  • @simonriley4180

    @simonriley4180

    11 ай бұрын

    You good now brother? Did the symptoms vanished? I'm going through similar phase. Please tell me how much time it might take

  • @crystalakabeavergamingsubs9549

    @crystalakabeavergamingsubs9549

    11 ай бұрын

    @@simonriley4180 yes!!

  • @crystalakabeavergamingsubs9549

    @crystalakabeavergamingsubs9549

    11 ай бұрын

    @@simonriley4180 I noticed a big difference after 10 days being off it.

  • @JournalismCCP
    @JournalismCCP3 жыл бұрын

    I am recovering from this medication. Please do not take these meds. It will turn out to be a lot nastier than it is

  • @Jxspur

    @Jxspur

    3 жыл бұрын

    What types of steps are you taking to recover?

  • @7vernessa

    @7vernessa

    3 жыл бұрын

    Yes could you let me know what I can do to help my son he almost died from suicide and he really still seem very empty inside

  • @7vernessa

    @7vernessa

    3 жыл бұрын

    Will this ever go away

  • @JournalismCCP

    @JournalismCCP

    3 жыл бұрын

    I’m sorry I didn’t see these you guys. It takes time. Please hang in there! We got to start small! Have you both joined the Montelukast support group on Facebook? Are you off meds? How long have you been on or off?

  • @gooddoc8129

    @gooddoc8129

    2 жыл бұрын

    @@JournalismCCP Will the mental symptoms go away?

  • @compulsiverambler1352
    @compulsiverambler13522 жыл бұрын

    The vast majority of people with symptoms would have just been diagnosed with anxiety or depression as standalone conditions, never linking them to the drug, not caring what the cause was, probably not even bothering to do blood tests. Even blood tests are woefully inadequate when someone reports psychiatric problems, few get the right types of tests for every possible cause of psychiatric symptoms, they just jump straight to the assumption that it starts and ends in the mind. People with asthma have higher rates of anxiety and depression. What if certain medicines used are the reason, never identified. Corticosteroids do the same thing but the vast majority of the time nobody asks what medicine you're on and even considers if they might be the cause, no doctor has EVER suggested any of my steroid or other medications could be the cause of any of my diagnoses, they just don't care what the medical cause of mental illness is, they want to tell you it's all in your mind, not a real medical problem. Same with my B12 deficiency causing psychiatric problems, it took nearly two years to get diagnosed and when I got the loading injections I was back to my old self within one week. They just can't WAIT to dismiss mental symptoms as all in the mind instead of looking for the medical cause. And you've still got people trying to treat schizophrenia with talk therapy instead of as a brain disease needing medication. Talk therapy is an insult in many cases, it's gaslighting. The only time any kind of talk therapy was appropriate was when I had OCD, really severely, and I got CBT, ERP, and mindfulness-based therapy combined. But even then, I needed medication so I could even engage with the therapy at all. Mental illness needs to be renamed because in very few cases is the mind the cause, it's just the victim of the real cause.

  • @familyofnguyeners7946
    @familyofnguyeners79462 жыл бұрын

    I’ve been on day 5 off montelukast and anxiety attacks are still going strong. While on the medication I’ve experienced anger, nothingness then spiraled to a deep depression until I found the linkage. Besides current constant anxiety my head has been very cloudy. How long should I expect to be back to normal? Was on the medication for 9 days

  • @SincerelyJean

    @SincerelyJean

    Жыл бұрын

    I am 4 days off after taking it for 6 days and am still feeling horrible anxiety and sleeplessness. Are you feeling better now? And how long did it take for you?

  • @noelavalos2558

    @noelavalos2558

    Жыл бұрын

    Are y’all good ? How long did it take to get back to normal

  • @simonriley4180

    @simonriley4180

    11 ай бұрын

    How y'all doing now? How long till it gets better? Please help

  • @amonaco11
    @amonaco113 жыл бұрын

    I've been taking this for one week shy of a year. I've felt many of the symptoms described, never considering it had any association with this drug. My question is... What about withdrawals? Is there data describing what could occur if use of this medication is abruptly stopped?

  • @7vernessa

    @7vernessa

    3 жыл бұрын

    Abruptly stopping can lead to suicide my son cannot get back to his normal self and I am very concerned he will never be the same

  • @maxp6051

    @maxp6051

    2 жыл бұрын

    I have the same situation/ question

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    Hello did you stop the medicine? Did you have any withdrawal symptoms when stopping?

  • @davidkropodra
    @davidkropodra3 жыл бұрын

    I've been too scared to take mine ...I was on strong antibiotics for a little over a year and it took about 2 years to recover from them...I would have anxiety and panic attacks 6 out of 7 days a week

  • @thetruthwillsetyoufree7912

    @thetruthwillsetyoufree7912

    2 жыл бұрын

    Did you take them in the end . How was it ?

  • @davidkropodra

    @davidkropodra

    2 жыл бұрын

    @@thetruthwillsetyoufree7912 stuck with flovent hfa price is lnsane at 220.00 a month

  • @yesikanarvaez5027
    @yesikanarvaez50272 ай бұрын

    Will the side effects and anxiety from it ever go away?

  • @Smyline

    @Smyline

    2 ай бұрын

    Ça fat 2semaines que j’ai arrêté,je ressens toujours quelques effets comme l’anxiété 😢

  • @pavanpyda
    @pavanpyda3 жыл бұрын

    Association doesn't equal causation. I think there is a confounding variable : Inflammatory milieu... You did not talk about risk - benefit analysis that you mentioned at 2:27. What was the hypothetical pathophysiology ? The aspirin video covered this concept. You did not even make such an attempt

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    Hello Does Montelukast cause withdrawal symptoms?

  • @shirleyreyes8991
    @shirleyreyes89913 жыл бұрын

    Too late for my son

  • @wellnesscanceradvocate8564

    @wellnesscanceradvocate8564

    Жыл бұрын

    🙏🙏🙏 I’m sorry. I was just prescribed this . I took one before seeing this video. I felt side effects immediately. I’m not taking it anymore especially know it is black box label.

  • @pancanman
    @pancanmanАй бұрын

    Been taking it for 30 years. I don't think that it does anything. No difference in my asthma, no difference in my mood. I have skipped doses many times by accident, but that also had no effect. Everyone is different. Why do I keep taking it? Habit.

  • @bigjoseph1876
    @bigjoseph18763 жыл бұрын

    Damn I’ve been on this for like a decade. I don’t think I’ve had psychiatric side effects but who knows

  • @AskAPsychiatrist

    @AskAPsychiatrist

    3 жыл бұрын

    Most people don’t have psychiatric side effects from it. We just want to make sure that the possibility is known so that the people who do get these side effects will be able to quickly recognize them (rather than suffer for months or years not knowing the cause).

  • @bigjoseph1876

    @bigjoseph1876

    3 жыл бұрын

    @@AskAPsychiatrist phew 😅

  • @lady4191

    @lady4191

    3 жыл бұрын

    @@AskAPsychiatrist you are wrong I know lots of people who had those effects including myself and my half sister.

  • @beautifulaffliction1742

    @beautifulaffliction1742

    2 жыл бұрын

    That Lady you're probably an anomaly

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    Ate you still taking it?

  • @hampshire2821
    @hampshire28212 жыл бұрын

    I have taken this drug for many, many years and now when I try to stop I have no inner voice.

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    What do you mean? Does Montelukast cause withdrawal symptoms?

  • @hampshire2821

    @hampshire2821

    2 жыл бұрын

    @@AJ88874 Idk, i am blaming the drug when it is probably not the reason. I do feel different when I am on it, like I am more myself when I take it.

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    @@hampshire2821 that’s weird I’ve taken it for months on and off and never get withdrawal or feel any different..I sometimes wonder if it’s even working bc I don’t feel anything lol

  • @jeraldlowe4370

    @jeraldlowe4370

    2 жыл бұрын

    @@AJ88874 I just got some. You didn't get any side affects or anything?

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    @@jeraldlowe4370 nope I’ve been on it for many months...I kinda wanna get off it tho bc I don’t feel anything lol like it’s not even helping

  • @shirleyreyes8991
    @shirleyreyes89913 жыл бұрын

    My son is going to prison because of this medication. This stuff is bad

  • @almightydrankhead3570

    @almightydrankhead3570

    3 жыл бұрын

    Aight bruh that’s just taking it too far😂

  • @Day2Night_

    @Day2Night_

    3 жыл бұрын

    @@almightydrankhead3570 LMAOOO

  • @DrBenson21

    @DrBenson21

    3 жыл бұрын

    What did he do?

  • @samirahmed175

    @samirahmed175

    2 жыл бұрын

    Same. Almost went to prison. Even my family noticed something was off. The aggression is REAL.

  • @KinLarkin513

    @KinLarkin513

    Ай бұрын

    Facts Arguments Hella Intense​@@samirahmed175

  • @Jxspur
    @Jxspur3 жыл бұрын

    Is this safe for me to stop taking ??

  • @Oilyhands

    @Oilyhands

    3 жыл бұрын

    Don't stop suddenly. Try skipping 1 day and take it the next day and so on. If you stop taking it suddenly you'll get restless and won't function properly.

  • @AJ88874

    @AJ88874

    2 жыл бұрын

    @@Oilyhands hi did this happen to you? Did you get withdrawal symptoms from Montelukast?

  • @shy6892
    @shy6892 Жыл бұрын

    Lost my job because of it

  • @pavochon
    @pavochon3 жыл бұрын

    You need Singulair LOL

  • @wellnesscanceradvocate8564
    @wellnesscanceradvocate8564 Жыл бұрын

    Wow , good to know. I was just prescribed this . I took it one day and I felt side effects immediately. I will never take it and especially know it crosses the blood brain barrier & black box warning ⛔️ . The side effects do not outweigh benefits. I’m really losing my faith in doctors 🥼 because they are prescribing this to millions including young children.

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