Lesson on Pre-Eclampsia: Symptoms, Pathophysiology and Treatment. Pre-Eclampsia is a serious obstetrical condition characterized by gestational hypertension with new onset proteinuria and/or other adverse conditions such as thrombocytopenia, new-onset headache and/or vision changes. Preeclampsia has a variety of risk factors including advanced maternal age, previous history of preeclampsia, family history, obesity and having pre-existing conditions such as lupus. Pre-eclampsia is important to recognize and treat due to adverse outcomes of non-treatment including fetal demise and maternal end-organ damage. Various causes have been proposed to explain why pre-eclampsia occurs, including abnormal placentation and failure to remodel spiral arteries. Upon diagnosis of pre-eclampsia, treatment involves the use of anti-hypertensives including labetalol.
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