Pharmacology - DRUGS FOR HYPERLIPIDEMIA (MADE EASY)
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Lipid-lowering agents, or hypolipidemic agents, are a group of drugs that are used in the treatment of high levels of fats, such as triglycerides and cholesterol, in the blood. Hyperlipidemia (also known as high cholesterol) is the key contributing factors to the development of atherosclerosis (hardening of the arteries), which can lead to stroke and heart attack. This pharmacology lecture covers topics such as pathophysiology of hyperlipidemia; lipids, cholesterol, triglycerides, phospholipids, bile acids, fatty acids, lipoproteins, apolipoproteins, chylomicrons, VLDL, LDL, HDL, lipoprotein lipase, atherosclerosis, and vascular inflammation; mechanism of action of lipid-lowering drugs and their side effects; HMG-CoA reductase inhibitors (statins), nicotinic acid, fibrates, bile acid sequestrants, cholesterol absorption inhibitors, pcsk9 inhibitors, omega 3 fatty acids. Drugs mentioned include; Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin, Niacin, Fenofibrate, Gemfibrozil, Colesevelam, Colestipol, Cholestyramine, Ezetimibe, Evolocumab, Alirocumab, Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Icosapent ethyl, and Fish oil.
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0:00 Pathophysiology of hyperlipidemia
4:18 HMG-CoA reductase inhibitors - Statins
6:20 Nicotinic acid - Niacin
7:39 Fibrates
9:25 Bile acid sequestrants
10:51 Cholesterol absorption inhibitors
12:24 PCSK9 inhibitors
13:27 Omega−3 fatty acids
Пікірлер: 256
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Just wanted to drop a mnemonic for niacin (Vitamin B3) - B3 stands for: "Beet" red (flushing), Big toe (hyperuricemia and gout), Blubber (acts on adipocytes) - Also "NIce Try" = NIacin liberates FFA from TRYglycerides. Also shout out to Speed. This is by far the best lipid lowering video out there.
@ArJun-id2gi
6 ай бұрын
Thanks guy 😃 for this
being 3 year of medical school speed pharmacology have been best pharmacological Lectures ever they way you explained is phenomenal Apricate your hard work
Thank you! 2hr lecture in class summed up 1000x better in less than 15 min!
HDL = H for Healthy LDL = L for Lethal Obviously this is just to remember which lipoproteins are good for you and which ones are bad for you and H and L doesnt actually stand for Healthy and Lethal respectively
@ushnar9346
4 жыл бұрын
But we must know the concept that high density means it is heavier aand can flow easily in the blood i e. it's plasma soluble but low density means that it is lighter than blood and it does not dissolve in the blood doesnot move and cqnbe deposited easily
@ASN_405
4 жыл бұрын
Well..I read an interesting article which claims that all this was crap of HDL being good and LDL being bad was spread by corporate companies (specially those who sell edible oils) who wanted to increase their buisness ! They claimed that their oils increased HDL and helped fight elevated cholesterol levels. Idk the real truth but that's what the article claimed🤷🏻♂️
@lilna7444
4 жыл бұрын
@@ASN_405 Numerous studies PROVED that high concentrations of HDL cholesterol has benefits in decreasing cholesterol levels, which means less cholesterol deposit in arteries.
@offrednatalie7887
4 жыл бұрын
Thanks 🙏
I'm studying dentistry and this is extremely helpful for learning patients' medications which aren't taught well in school. I really appreciate your work, please keep up the great job.
@humerxa
Жыл бұрын
Where are you working now?
We studied this lecture in class and it just went above my head but thankfully this video lecture saved my life
7:15 to minimise the side effect flushing. We can use aspirin concomitantly with niacin. Because asprin is a prostaglandin inhibitor.
@jaycastillo13
10 ай бұрын
you can also reduce the incidence of flushing by administration of aspirin 325mg shortly before niacin ingestion
Perhaps, the best video I have seen about antihyperlipidemic medications! Thank you!
this came just in time. . i have a pharmacology exam tomorrow and this video saved me so much time. . thanks a lot!
@zoheirboutaleb3358
3 жыл бұрын
How did it go?
Thank you very much for the effort. This really helps. This is really simplified for my report.
Your videos are so clear, straight forward, and thorough! Thank you! Please make more!
This is so amazing so handy in short perfect to the point explanations. The effort is fully appreciated, Sir. Thanks.
@flowersfranklin6722
3 жыл бұрын
To be able to enhance the existence of my “good” cholesterol and lessen the “bad” cholesterol I have, I applied making use of this specific cholesterol guideline t.co/Vm9XwBkfhi . I am unsure if it is performed like this way. Since that time I haven’t used it so I do not have any idea if this one is beneficial. I cannot delay to have my cholesterol tested again in a few weeks. I`m hoping this could help me. Therefore I`m con.templating certainly according to what exactly I have read. .
Thank you so much for making the concept so easy to understand 😊❤️
Your every videos are amazing! I have gone through each of them! You should make more of these! :)
Thank you so much! You explain so well. God bless you!
Excellent thanks for your time and expertise!🙏
Thank you so much...You are amazing...I really love your videos...You really make things easier to understand....Thanks to you i got an A this semester...Thanks man
@Mindofuche
3 жыл бұрын
May this be my story 😪
THANK YOU SO MUCH DOC!! GOD BLESS YOU
you helped me a lot, really... may god bless you
Very informative and easy to be understood Thank you 🙂
I saw this video for a test today, and I did fairly good. Forgot the statin drug with 19hr half-life, and the drug interactions of Bile-binding resins though. Thank you for your hard work.
You're amazing! Thanks a lot for all your video's, they are of great help. 🌠
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Explained in accordance with Lippincot Pharmacology.... Excellent job! Found this really helpful ☺
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One of the best video regarding Dyslipidemia drugs 😊👌
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Thank you for this very good video on Hyperlipidemia and its treatment
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Tu boht mast kaam karta hai speed pharmacology bhai
Thank you!
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Very Very nice explanation regarding statins and other inhibitors. Very easy to understand. Tks for sharing.
Excelent video, thank you!
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Thanks a lot!
YOU ARE WONDERFULL SIR!!! FINALLY I UNDERSTAND PHARMACOLOGY BECAUSE OF YOUR VİDEOS. PLEASE YOU BECOME MY TEACHER IN MED SCHOOL.
Thank you very much
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Jazakallah o khairen kaseera!
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Thank you for helping me
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