Pharmacology - DRUGS FOR HYPERLIPIDEMIA (MADE EASY)

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Lipid-lowering agents, or hypolipidemic agents, are a group of drugs that are used in the treatment of high levels of fats, such as triglycerides and cholesterol, in the blood. Hyperlipidemia (also known as high cholesterol) is the key contributing factors to the development of atherosclerosis (hardening of the arteries), which can lead to stroke and heart attack. This pharmacology lecture covers topics such as pathophysiology of hyperlipidemia; lipids, cholesterol, triglycerides, phospholipids, bile acids, fatty acids, lipoproteins, apolipoproteins, chylomicrons, VLDL, LDL, HDL, lipoprotein lipase, atherosclerosis, and vascular inflammation; mechanism of action of lipid-lowering drugs and their side effects; HMG-CoA reductase inhibitors (statins), nicotinic acid, fibrates, bile acid sequestrants, cholesterol absorption inhibitors, pcsk9 inhibitors, omega 3 fatty acids. Drugs mentioned include; Atorvastatin, Fluvastatin, Lovastatin, Pravastatin, Rosuvastatin, Simvastatin, Niacin, Fenofibrate, Gemfibrozil, Colesevelam, Colestipol, Cholestyramine, Ezetimibe, Evolocumab, Alirocumab, Docosahexaenoic acid (DHA), Eicosapentaenoic acid (EPA), Icosapent ethyl, and Fish oil.
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0:00 Pathophysiology of hyperlipidemia
4:18 HMG-CoA reductase inhibitors - Statins
6:20 Nicotinic acid - Niacin
7:39 Fibrates
9:25 Bile acid sequestrants
10:51 Cholesterol absorption inhibitors
12:24 PCSK9 inhibitors
13:27 Omega−3 fatty acids

Пікірлер: 256

  • @SpeedPharmacology
    @SpeedPharmacology9 ай бұрын

    🚀 Elevate Your Pharm Game! 📚 Join Patreon for A+ Study Notes! 👉 www.patreon.com/speedpharmacology 👈

  • @dunndenndonndinn
    @dunndenndonndinn11 ай бұрын

    Just wanted to drop a mnemonic for niacin (Vitamin B3) - B3 stands for: "Beet" red (flushing), Big toe (hyperuricemia and gout), Blubber (acts on adipocytes) - Also "NIce Try" = NIacin liberates FFA from TRYglycerides. Also shout out to Speed. This is by far the best lipid lowering video out there.

  • @ArJun-id2gi

    @ArJun-id2gi

    6 ай бұрын

    Thanks guy 😃 for this

  • @Yousafzaikamran2
    @Yousafzaikamran2 Жыл бұрын

    being 3 year of medical school speed pharmacology have been best pharmacological Lectures ever they way you explained is phenomenal Apricate your hard work

  • @ZadeBatarseh1
    @ZadeBatarseh16 жыл бұрын

    Thank you! 2hr lecture in class summed up 1000x better in less than 15 min!

  • @jonathanrankin7954
    @jonathanrankin79545 жыл бұрын

    HDL = H for Healthy LDL = L for Lethal Obviously this is just to remember which lipoproteins are good for you and which ones are bad for you and H and L doesnt actually stand for Healthy and Lethal respectively

  • @ushnar9346

    @ushnar9346

    4 жыл бұрын

    But we must know the concept that high density means it is heavier aand can flow easily in the blood i e. it's plasma soluble but low density means that it is lighter than blood and it does not dissolve in the blood doesnot move and cqnbe deposited easily

  • @ASN_405

    @ASN_405

    4 жыл бұрын

    Well..I read an interesting article which claims that all this was crap of HDL being good and LDL being bad was spread by corporate companies (specially those who sell edible oils) who wanted to increase their buisness ! They claimed that their oils increased HDL and helped fight elevated cholesterol levels. Idk the real truth but that's what the article claimed🤷🏻‍♂️

  • @lilna7444

    @lilna7444

    4 жыл бұрын

    @@ASN_405 Numerous studies PROVED that high concentrations of HDL cholesterol has benefits in decreasing cholesterol levels, which means less cholesterol deposit in arteries.

  • @offrednatalie7887

    @offrednatalie7887

    4 жыл бұрын

    Thanks 🙏

  • @aadriohno
    @aadriohno7 жыл бұрын

    I'm studying dentistry and this is extremely helpful for learning patients' medications which aren't taught well in school. I really appreciate your work, please keep up the great job.

  • @humerxa

    @humerxa

    Жыл бұрын

    Where are you working now?

  • @onestopmusic265
    @onestopmusic2653 жыл бұрын

    We studied this lecture in class and it just went above my head but thankfully this video lecture saved my life

  • @prashanthraju4013
    @prashanthraju4013 Жыл бұрын

    7:15 to minimise the side effect flushing. We can use aspirin concomitantly with niacin. Because asprin is a prostaglandin inhibitor.

  • @jaycastillo13

    @jaycastillo13

    10 ай бұрын

    you can also reduce the incidence of flushing by administration of aspirin 325mg shortly before niacin ingestion

  • @anthonyneira9740
    @anthonyneira97403 жыл бұрын

    Perhaps, the best video I have seen about antihyperlipidemic medications! Thank you!

  • @minadz1279
    @minadz12797 жыл бұрын

    this came just in time. . i have a pharmacology exam tomorrow and this video saved me so much time. . thanks a lot!

  • @zoheirboutaleb3358

    @zoheirboutaleb3358

    3 жыл бұрын

    How did it go?

  • @elliemarnie6430
    @elliemarnie64306 жыл бұрын

    Thank you very much for the effort. This really helps. This is really simplified for my report.

  • @shellylynn2450
    @shellylynn24507 жыл бұрын

    Your videos are so clear, straight forward, and thorough! Thank you! Please make more!

  • @AnjaliKumari-bt5go
    @AnjaliKumari-bt5go6 жыл бұрын

    This is so amazing so handy in short perfect to the point explanations. The effort is fully appreciated, Sir. Thanks.

  • @flowersfranklin6722

    @flowersfranklin6722

    3 жыл бұрын

    To be able to enhance the existence of my “good” cholesterol and lessen the “bad” cholesterol I have, I applied making use of this specific cholesterol guideline t.co/Vm9XwBkfhi . I am unsure if it is performed like this way. Since that time I haven’t used it so I do not have any idea if this one is beneficial. I cannot delay to have my cholesterol tested again in a few weeks. I`m hoping this could help me. Therefore I`m con.templating certainly according to what exactly I have read. .

  • @durganaik9511
    @durganaik9511 Жыл бұрын

    Thank you so much for making the concept so easy to understand 😊❤️

  • @sapanayonghang2951
    @sapanayonghang29517 жыл бұрын

    Your every videos are amazing! I have gone through each of them! You should make more of these! :)

  • @john.the.beloved
    @john.the.beloved2 жыл бұрын

    Thank you so much! You explain so well. God bless you!

  • @1cleandude
    @1cleandude Жыл бұрын

    Excellent thanks for your time and expertise!🙏

  • @nicholaslem6082
    @nicholaslem60827 жыл бұрын

    Thank you so much...You are amazing...I really love your videos...You really make things easier to understand....Thanks to you i got an A this semester...Thanks man

  • @Mindofuche

    @Mindofuche

    3 жыл бұрын

    May this be my story 😪

  • @kayefromthebay
    @kayefromthebay2 жыл бұрын

    THANK YOU SO MUCH DOC!! GOD BLESS YOU

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    @globuspallidus24573 жыл бұрын

    you helped me a lot, really... may god bless you

  • @salamkhashan4517
    @salamkhashan45173 жыл бұрын

    Very informative and easy to be understood Thank you 🙂

  • @muneebmohammed7893
    @muneebmohammed7893 Жыл бұрын

    I saw this video for a test today, and I did fairly good. Forgot the statin drug with 19hr half-life, and the drug interactions of Bile-binding resins though. Thank you for your hard work.

  • @karabomoloisi1134
    @karabomoloisi11344 жыл бұрын

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    @fatemaheldeeb42516 жыл бұрын

    Excellent video! Please keep them coming.

  • @abeenfatima3493
    @abeenfatima34932 жыл бұрын

    Explained in accordance with Lippincot Pharmacology.... Excellent job! Found this really helpful ☺

  • @saidgitta1548
    @saidgitta15487 жыл бұрын

    Superb pharmacology lectures.Thanks a million

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    @eulllight51416 жыл бұрын

    Y would someone dislike this!! Thanks alot

  • @toetovocaloid
    @toetovocaloid3 жыл бұрын

    Thanks for making this!

  • @hajrawaqas7557
    @hajrawaqas75572 жыл бұрын

    this was so so helpful! bless you!

  • @saharal_hili5305
    @saharal_hili5305 Жыл бұрын

    Thank you so much for this lecture. Easy to understand.

  • @soumyadeepdutta9542
    @soumyadeepdutta95426 жыл бұрын

    Thank you sir, your lectures are awesome!

  • @rutvikrana512
    @rutvikrana5124 жыл бұрын

    One of the best video regarding Dyslipidemia drugs 😊👌

  • @MAmeer-fr2hp
    @MAmeer-fr2hp6 жыл бұрын

    This video is awesome! now I love pharmacology beacuse of you! thanks

  • @user-pq6wz3yp1v
    @user-pq6wz3yp1v5 жыл бұрын

    This helped me a lot! Thanks!

  • @duocphamtruongtho4462
    @duocphamtruongtho44622 жыл бұрын

    Very informative and easy to be understood!

  • @he5457
    @he54576 жыл бұрын

    That’s amazing,thank you

  • @purushottamgarg5470
    @purushottamgarg54704 жыл бұрын

    Thank you for this very good video on Hyperlipidemia and its treatment

  • @salamkhashan4517
    @salamkhashan45175 жыл бұрын

    This video is so helpful Thank you ☺

  • @DRABENIDRLIDU-eh9yx
    @DRABENIDRLIDU-eh9yx11 ай бұрын

    Amaizing lecture thank you!

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    @sivaswaroop84375 жыл бұрын

    thank you speed pharmacology

  • @chessgold8768
    @chessgold8768 Жыл бұрын

    Well explained mechanisms with recent drugs too.. thanks a lot..

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    @hosseintoreyhi46983 жыл бұрын

    Very helpful!! thank you

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    @princecharming7315 Жыл бұрын

    Superb. Grateful to u💖

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    @ughsirius2 жыл бұрын

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    @irorereedith82463 жыл бұрын

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    @sandhyasingh1924 жыл бұрын

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    @carolinemarwan9119 ай бұрын

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    @daliamuhmod77475 жыл бұрын

    again and again you are amazing

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    @gopipatel25855 жыл бұрын

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    @mawaddashaban4776 жыл бұрын

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    @zhiyafarhad39 Жыл бұрын

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  • @sampathr2
    @sampathr23 жыл бұрын

    Very Very nice explanation regarding statins and other inhibitors. Very easy to understand. Tks for sharing.

  • @shiaragonzalez6903
    @shiaragonzalez69034 жыл бұрын

    Excelent video, thank you!

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    @safa9823 жыл бұрын

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    @pinkeu88213 жыл бұрын

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    @mohammedaldaraji88786 жыл бұрын

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    @juli11051 Жыл бұрын

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    @bitkigibiyetistirdi72546 жыл бұрын

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    @maalidirar51852 жыл бұрын

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    @bshayerahmad6 жыл бұрын

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  • @AshishSharma-eu8ps
    @AshishSharma-eu8ps Жыл бұрын

    Thank you for such a nice lecture ..awesome...

  • @dacommander
    @dacommander7 жыл бұрын

    good explanation. thanks

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    @melbaroma58333 жыл бұрын

    awesome lecture!

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    @bintehaider5288 Жыл бұрын

    Jazakallah o khairen kaseera!

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    @patchworkpig894 жыл бұрын

    So helpful, thank you

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    @cesarandreschg4 жыл бұрын

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    @aytakchichak74563 жыл бұрын

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    @nightbot90006 жыл бұрын

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    @dr.jeelkakadiya11115 жыл бұрын

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    @Shahnawazkhan-hh8er3 жыл бұрын

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    @mikhailfamily6 жыл бұрын

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    @Sara-tx9dw7 жыл бұрын

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    @Dr.Aqiikhan9 ай бұрын

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    @RahulTiwari-xz5pj7 жыл бұрын

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    @honestreviewsbym.f35653 жыл бұрын

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    @adlny13182 жыл бұрын

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    @heiitsme1823 жыл бұрын

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    @sivalakshmimarri5983 жыл бұрын

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    @malihaafridi1968 Жыл бұрын

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    @vijayareddy1967 Жыл бұрын

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    @ichaiszen50462 жыл бұрын

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    @nousheenrashid84707 жыл бұрын

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    @user-uo6ug9ie4x3 жыл бұрын

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    @Studyingwithmeeeee6 ай бұрын

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    @ritulhirwe33253 жыл бұрын

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    @mohammedrady50073 жыл бұрын

    really good explanation ... Thank u

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    @hansikamadumali122 жыл бұрын

    THANK YOU...........

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    @Drqazi247 Жыл бұрын

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    @drswetaruparel5 жыл бұрын

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    @nourassani55893 жыл бұрын

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    @dranildev6 жыл бұрын

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    @yourpainlessspine21815 жыл бұрын

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    @adandriollari34177 жыл бұрын

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    @njmkk2 жыл бұрын

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    @achinisenanayake63273 жыл бұрын

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    @raulparavisini13814 жыл бұрын

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    @rakeshranjan26645 жыл бұрын

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    @rahisadik63452 жыл бұрын

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    @SimdiChi3 ай бұрын

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    @ninounorino87167 жыл бұрын

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