Ozempic is a game-changer. Here’s how it works.
This diabetes drug could be the future of weight management.
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Ozempic, a medication developed to manage type 2 diabetes, has been in the news a lot lately because of one of its signature side effects: drastic weight loss. Both Ozempic and Wegovy, Ozempic’s counterpart approved specifically for weight loss by the FDA, are brand names of a drug called semaglutide. Semaglutide is one of several drugs that mimics a crucial digestive hormone called glucagon-like peptide 1, or GLP-1. It amplifies a process our bodies perform naturally.
GLP-1 is released in our intestines when we eat, and there are receptors for the hormone in cells all over the body. In the pancreas, GLP-1 promotes the production of insulin and suppresses the production of glucagon. This helps insulin-resistant bodies, like those with type 2 diabetes or obesity, manage blood sugar levels. In the stomach, GLP-1 slows gastric emptying, extending the feeling of being full. In the brain, GLP-1 suppresses appetite, which also promotes satiety and curbs hunger, so we eat less.
In late 2022, a rush to use Ozempic off-label for weight loss, likely prompted by its sudden rise in popularity in social media, led to a shortage of the drug for people who need it. But more drugs like semaglutide are currently in the process of being approved by the FDA to be prescribed for weight loss, likely signaling an end to the shortage and a promising new generation of medical treatment of obesity.
Further reading:
Mila Clarke's KZread channel: / thehangrywoman
The New Obesity Breakthrough Drugs, by Eric Topol
erictopol.substack.com/p/the-...
The Discovery and Development of Liraglutide and Semaglutide, by Lotte Bjerre Knudsen and Jesper Lau
www.frontiersin.org/articles/...
The pregnancy risks of Ozempic and Wegovy need more attention, Julia Belluz writes for Vox. Read more here: bit.ly/41znHCv
Note: The headline on this piece has been updated.
Previous headline: The game-changing weight loss drug, explained
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Пікірлер: 1 900
There's a lot about Ozempic we didn't have time to get into in this video, including more about medical discrimination around obesity and more context around recent drug shortages. This article from our website, written by Julia Belluz, provides more info: www.vox.com/science-and-health/23584679/ozempic-wegovy-semaglutide-weight-loss-obesity
@aprilmason1616
Жыл бұрын
Will you do an in depth video as well? It is so important for the public to have all the correct information. If I could I would love to help, but I study still and live else where. Im just so passionate about food and health related topics and got super excited for the video haha Okay bye 👋
@NadirAgha
Жыл бұрын
*including more about it's side effects, long term effects, indications, contra-indications, and how necessary it is to use it only if a doctor prescribes it.
@mysisterisafoodie
Жыл бұрын
Honestly this is a topic where there is just a lot of unnecessary outrage. There isn’t enough supply for the current demand. They should just make more. Done. Whoever wants to buy it, if they can afford it, should be able to. If not, lobby your insurance companies to do better. Better yet, why don’t you elect officials who will give y’all public healthcare? And whoever needs to prescribed it should be able to. I don’t hear anyone complaining about milk, because growing children need to drink it. There’s enough for recreational milk drinking and for children to drink it too.
@gwenstacyspidercat4294
Жыл бұрын
You "didn't have time to get into?" My siblings in christ, you decided the parameters of the video. The medical discrimination and context around drug shortages should not be considered secondary content, bc most ppl watching this are never going to read your article...
@CristinaNoujaim
Жыл бұрын
Why doesn't this video (or your article) cover the studies that show that weight is gained back and more statistically by those who *stop* taking ozempic? Or the long term effects on the body?
“Maybe you’ve heard the jingle” no, because medication isn’t advertised in my country!
@petar4onachev
Жыл бұрын
Bless your country! I am tired of seeing medical adds everyday, where are you from?
@StellaMariaGiulia
Жыл бұрын
Same
@jessealexander9074
Жыл бұрын
Its only legal in the U.S to advertise medications
@shana736
Жыл бұрын
@@jessealexander9074 Direct to consumer advertising for medical and pharmaceutical drugs is only legal in two countries which are the US and New Zealand
@Vonononie
Жыл бұрын
@@petar4onachev UK but I don’t think prescription medication is allowed to be advertised anywhere in Europe. Over the counter stuff, like basic painkillers and cold remedies, are allowed to be advertised but they aren’t heavily pushed. I can’t see a reason why medicine should be advertised, isn’t it given based on medical need not because you want it?
As someone who works in a pharmacy, I have seen how this hurts many patients who need this medication to control their diabetes. For almost 3 months straight we could barely receive this drug to dispense due to the unexpected increase in demand. I completely understand the want to lose weight and ozempic does help with this, but people with diabetes need medications like these to live their lives.
@steventhan93
Жыл бұрын
Are you saying T2D relies on this med to stay alive? Because that's not true at all, this med is FDA-approved in 2017, and T2D predates that by a long shot
@tdawg719
Жыл бұрын
Ditto
@Bassen97
Жыл бұрын
@@davidbjordan people w diabetes need it. People who are obese can stop eating junk food and start eating healthy and less and exercise. Not that hard
@stevethepocket
Жыл бұрын
@@davidbjordan So really the solution is to just ban processed food.
@jaguarrior
Жыл бұрын
@@stevethepocket banning processed food, would not do anything to make my diabetes better. Mine is caused by PCOS, a metabolic disease
You guys should really bring on a credentialed source like a doctor or pharmacist for videos like this
@tumblingrosesstudio
Жыл бұрын
Good idea
@firstprinciplesinvestor3464
Жыл бұрын
right, like they used some random lady off youtube as their primary source
@dominicrincker8280
Жыл бұрын
It felt like an ad
@allisonjoydahlen569
Жыл бұрын
I agree!
@phinsup402
Жыл бұрын
More like a passive aggressive sales pitch, shame on you Vox.... bring in a medical expert (scientist) next time.
Mila here! Thanks to everyone for your supportive comments and Vox for letting me share my experience. When I started Ozempic for diabetes management, few people talked about the effects, so I decided to document my progress. I'm so grateful that it has made diabetes management easier for me but disheartened that vanity weight loss has made it out of reach for patients who need it. Jimmy Kimmel even made a joke about it at the Oscars - that's what I meant by vanity weight loss and trivializing the medication. I hope this is a good solution for people living with diabetes and obesity, but even more so, that the long-term effects don't cause additional health challenges. That remains to be seen, and I'll be documenting it for as long as I need it (or can afford it or access it).
@katiemoreno3013
Жыл бұрын
@@crazyprophet3276?? She literally has T1 diabetes??
@FutureCommentary1
Жыл бұрын
Thanks for putting yourself out there so that people can have concrete examples. I struggle with weight myself. Very hard. Glad you are getting help both for diabetes and for weight management.
@KunalM-ec3pm
Жыл бұрын
Wish you great health 🤗
@drizztcat1
Жыл бұрын
I'm glad you told your story! As a fellow diabetic who has had success with Semaglutide, it's good to see the message getting out about the drug, even if it means occasional limited availability. I'm now on Mounjaro, and I've had even better luck with it, with fewer side effects.
@Vox
Жыл бұрын
It was so great talking with you Mila, thank you for sharing your experience and perspective on this story with us! -Coleman
I’ve been trying to lose weight after my dad ended up in the hospital due to diabetes, I had been hearing that ozempic from this is a quick fix to life long commitment but in the end the hype is causing a shortage for the people like my dad, who’s still here only thanks to his able to have access to these meds. I really hope that the supply issues improve but also doesn’t become out of reach due to expense too.
@toasted_.coconut
Жыл бұрын
Their lives matter, too.
@hjewkes
Жыл бұрын
The good news is that production has ramped up massively over the past 6 months, so I would expect the shortages to get a lot better soon (NovoNordisk is on record as saying late march)
@laurenconrad1799
Жыл бұрын
I feel you so much. I’m in the exact same scenario. Ozempic is a lifelong commitment and not a quick fix. The side effects are no joke. But it truly can help people whose genetics make it harder to lose weight than a person born with a faster metabolism. ❤️
@I_WANT_MY_SLAW
Жыл бұрын
They can make tons. They an unlimited supply. Its just the healthcare system is very corrupt.
@zjsz4954
Жыл бұрын
A drug is a drug how you use it is irrelevant. The problem is the labels we attach to drugs being a “weight loss drug” or a “diabetes drug”
I used to be 280 pounds, going blind due to a rare obesity complication called Intercranial Hypertension, but was able to take Ozempic for just 4 months and for the first time in my life felt full. I’ve kept up the initial weight loss and so far lost 80 pounds. Without this medication, I believe without a doubt I would be blind in my left eye by now.
@MsSarcasticity
Жыл бұрын
The reason why you cannot feel full is most likely due to eating carbohydrates which cause hunger hormones to increase. Completely remove carbohydrate sources and increase saturated fats from animal sources like butter or beef tallow. You'll feel a lot fuller on less food without without shooting yourself up.
@kidsdomath1330
Жыл бұрын
@@user-kr6jg6qb7l Ad.
@andreasamardzija1496
Жыл бұрын
I am not obese but I do have issues with binge eating and never feeling full, so I can't imagine how amazing it must have felt to be satieted. I'm so glad you've reached a healthier weight and saved you eye and possibly life.
@cat-.-
Жыл бұрын
Intercranial hypertension? so you have hypertension between your two skulls?
@ItsDanny91
Жыл бұрын
I also have this condition. Im 200 pounds so im at the point where its causing headaches and ear ringing. My optic nerves used to be swollen which i was told leads to the blindness
I've heard A LOT that challenges Ozempic as "safe". I'm a little wary of how we grazed over Mila's heart palpitations... I understand many drugs have side effects and for those living with diabetes, Ozempic really is a game changer BUT as we see it presented more and more as a weight management tool, I just worry about how positively it's framed in this video. I'm not gonna lie, this feels like an Ozempic promotion to me :(
@basmalawessam2488
Жыл бұрын
Yes! I expected them to go a little over the heart palpitations part, which sounds super dangerous to me. I think people need to wait until Ozempic is properly examined to be deemed safe for people using it for weight loss specifically.
@theuscivicsnerd7070
Жыл бұрын
The severity of heart palpitations and the frequency of them we'd need to look at. Heart palpitations from this doesn't surprise me but it's not a horrible side effect.
@Dan-uh9sg
Жыл бұрын
Heart palpitations are a common side effect of many medications. They also tend to be caused by medications that cause dehydration. GLP-1 agonists typically have a diuretic effect AND reduce thirst (as a side effect of increasing the feeling of fullness). Properly hydrating and getting electrolytes is a good first step to try in that case. With these medications, it's important to be proactive about hydration and frequently sip liquids. She likely had a conversation about it with her healthcare provider and decided on steps to ensure that it does not become an issue before she started using Ozempic again.
@jonathanodude6660
Жыл бұрын
keep in mind you take it once weekly. if its constant palpitations id be more worried. many people get worse symptoms from coffee.
@MsCorpora
Жыл бұрын
I agree! Calling it a game changer in the title is way too encouraging!
Vox, I’m disappointed that the abuse of this drug by Hollywood and influencers for a “quick-fix” to weight loss wasn’t emphasized as much as it should be. I have a family member that is dependent on it to stay healthy, yet shortages are making it difficult for them to obtain and afford it. And what about the long-term side effects for those just wanting to drop weight quickly? This video should have been a lot more cautionary.
@monkeylordofdoom14
Жыл бұрын
I was thinking the exact same thing!!
@justduro1527
Жыл бұрын
I dont think the drug has been around for long enough to see long term side effects
@thundercaaat
Жыл бұрын
100% AGREE!
@narnigrin
Жыл бұрын
@@justduro1527 The long-term/longer-term effects that have already been observed, afaik, are basically that if you use this drug to lose weight and then go off it when you've reached your target weight, you tend to very quickly gain all of the weight back. Which means that if this is a magic "get thin quick" drug, it's a get thin quick drug you'll have to keep taking for the rest of your life.
@laurenconrad1799
Жыл бұрын
I think this was the best explanatory video about what’s going on inside the body that I’ve ever seen. They could always do a part 2 to address the Hollywood issue. It’s tough to tackle everything in 7 minutes.
I have type 2 diabetes but I am far from obese, and my doctor put me on Ozempic for a while. It did a good job with what it's supposed to do, but I HAD to stop. I was felt nauseated CONSTANTLY and I finally decided that life on Ozempic wasn't worth it. Those side effects are just too much.
@kauntroap6339
Жыл бұрын
try intermittent fasting
@SomeDudeQC
Жыл бұрын
@@kauntroap6339is that good for diabetes?
@bria1660
Жыл бұрын
I stopped because my kidney functions were impacted ... also the side effects for me were horrible.
@inuhundchien6041
Жыл бұрын
The nausea make you not eat thus get skinnier
@starlett08
Жыл бұрын
Injecting it in your thigh instead of abdomen helps or eliminates the nausea.
I want to point out that this drug has been a game changer for several people I know in terms of weight loss. It's not just a few pounds - we're talking about 40-50 pounds on someone who used to be 200-210 pounds. It's a life changing amount that suddenly takes a lot of load off your body.
@nicholsonfile
Жыл бұрын
Stimulants work that way as well.
@windwhisprz
Жыл бұрын
Exactly and when people lose weight they feel better about themselves and then they are motivated to take care of themselves better and eat healthy because they finally see results. Losing 10 pounds can kick start someone into making other lifestyle changes for the better.
@C1azed
Жыл бұрын
@@windwhisprzstatistical 95% of peopl gain the weight back within a year of stoping the meds, drugs can't change bad habits
@peter.gorski
Жыл бұрын
And they rebound when they stop using it.
@Jerguu
Жыл бұрын
Maybe - maybe not. We don’t understand enough about obesity to know. It’s between the patient and their doctor. The more likely situation is they taper back down to a maintenance dose.
I lost 75 pounds on ozempic in 12 weeks!! I love it and I am a big guy with a type 2 diabetic this has been a life-saving game changer!!!!!
@joeytheestallion
4 ай бұрын
I know you commented this 7 months ago, but how are you doing now? How much did you lose, and how quick? I'm in the process of getting Ozempic for weight loss myself
@Fleetstreetbestone
3 ай бұрын
@@joeytheestalliondo not get this evil drug
@michellecrawbuck1198
3 ай бұрын
Did you have any side affects
@moya_moyz5471
2 ай бұрын
@@joeytheestallion I wanna know too. I’m abt to start this after my sleeve got reverse
@peachy4510
Ай бұрын
What strength did you take ??
In case people are wondering why the natural GLP-1 molecule has been changed, it is because in the body it has a very short half-life, to be used as a medication it would need to be in a permanently attached pump device, impractical and expensive. Hence longer acting forms were developed that resist DPP-IV the enzyme that breaks it down.
@gilessteve
11 ай бұрын
I was. Thank you.
In Australia diabetics are missing out on this medication due to the weight loss crowd creating shortages.
@zXPeterz14
Жыл бұрын
Imagine being so lazy that you would rather take a diabetic’s medication instead of eat less and move more
@stuartclifton4764
Жыл бұрын
@@zXPeterz14 this could be something useful to me, as I have an extreme sweating/overheating condition where even low levels of physical exercise can lead me to pass out :( struggled with it since I was around 13 and I'm now 26, not insanely overweight but this could help me massively!
@noname-zp1yh
Жыл бұрын
@@zXPeterz14 if it was that easy they would have already done it.
@PhilfreezeCH
Жыл бұрын
@@zXPeterz14 did you watch the video? You still need to do that, semaglutide just makes it easier through things like supressing appetite and so on. It helps you to eat less.
@Kamikazeesouled
Жыл бұрын
@@stuartclifton4764 then just eat less.
I was prescribed Ozempic for diabetes 2. I loved it because I no longer had to take 3 pills a day. The side effects for me were horrible ..stomach pains, gas, diarrhea, constant burping, heartburn ..but I did lose 15 pounds in 2 months. My Doctor took me off medication because it also had negative impact on my kidney functions. The downside was as soon as I stopped using the medication, my food cravings came back and I gained all the weight back within 4 weeks.
@allisonscanlan4144
Жыл бұрын
Most people who move to europe lose weight and it stays off
@JR-90
11 ай бұрын
Maybe if you changed your eating habits, this wouldn’t have happened. It doesn’t matter if you take something like this and lose weight, if you’re gonna keep eating junk food afterwards.
@bria1660
11 ай бұрын
@@JR-90 No, I try to eat healthy and only eat junk food occasionally. Whenever I would try to eat, I would frequently get nauseous. Foods I love did not taste or even smell the same. I found myself taking a few bites and then throwing away my food. Also, I found that I could not eat anything late at night. I could not drink alcohol or soft drinks or I would pay for it for about 4 hours with constant burping and gas. For me, Ozempic was not a pleasant experience and I do not miss it.
@supergg07
4 ай бұрын
I have been taking Ozempic for a while I’m over the side effects and I have lost 50 pounds. I am at a standstill though with the weight loss but that’s OK for now. I have chronic kidney disease and it has never did anything to hurt my kidneys in fact with that, and my pill I take, my kidney functions have been going up
@bria1660
4 ай бұрын
@@supergg07 Good to hear you are having positive experience. Continued good luck. I will say when I stopped taking Ozempic, my appetite came back with a vengeance along with the weight gain. Just curious but did your doctor say you will need to continue taking this medication to retain the weight loss?
This sounds too good to be true, and when you take into consideration the long history of pharmaceutical companies' predation on the most vulnerable, the whole thing makes me very skeptical.
@patriciacsapo
Жыл бұрын
This video sounds like an ad
@rcs3681
Жыл бұрын
It definitely is considering all the side effects it comes with. Nausea, digestive issues.
@CarSVernon
Жыл бұрын
yyyyep
@yaeli_i_guess
Жыл бұрын
you're right. i worked in a pharmacy and the pharmacist told me exactly this- nothing good is ever without a 'catch'
@sarachaya
Жыл бұрын
Yeah they forgot to mention that ozempic created thyroid tumours on rodents
Weight loss is not a trivial or superficial desire, it is a medical need that can drastically improve people's lives and save lives. We should not be pitting T2D against obesity, we should be asking for additional production of this drug.
@Tonixxy
Жыл бұрын
Only smart comment here
@celery7810
Жыл бұрын
Eat healthy, dont resort to drugs to lose weight.
@DivineGoddessOnEarth
Жыл бұрын
@@celery7810 eating healthy has so many layers to it, what is deemed as healthy could possibly not be America has to unlearn and relearn so much
@celery7810
11 ай бұрын
True, but drugs are not the answer unless you actually have a disease
@Tonixxy
11 ай бұрын
@@celery7810 obesity is a disease
I was diagnosed type 2 on October '22 with an aic of 7.2 and I weighed 240 lbs. I was started on Mounjaro and lost twenty pounds over two months. Due to insurance not covering anymore I was switched over to ozempic and although the weight loss is slower my recent aic as of March 10 is now 5.6! I needed help with controlling my hunger and cravings and this definitely helped with that. Yes you still have to eat right and exercise to really see the benefits. As of today I'm 203 lbs (slow but steady). Ozempic and other drugs like it have made a huge difference.
@shaanchaudhry5719
3 ай бұрын
If you don’t mind me asking what is your age and height? Did ozempic put your diabetes in remission or is it still something that is always there?
@OrianaZ5
3 ай бұрын
@@shaanchaudhry5719 Hey so for reference I was 38 years old when I started and 5'5". Now im 39 with my last aic of 5.3 and weigh 155lb. Doctor said diabetes is in remission. Hope that helps and good kuck!
In Canada they're not allowed to advertise the specific use of medications or use jingles, so we get a lot of extremely vague "[drug name]: ask your doctor" commercials and I never knew what Ozempic was used for
Semaglutide has been a game changer for me, currently I am down 71 pounds and almost to my goal with 34 pounds to go! I have tried for years to loose weight but struggled. With being able to loose weight I have more energy to exercise.
@JazzParrott
3 ай бұрын
Ik you commented this awhile ago, but how fast did you see results with the semaglutide?
I struggled with my weight most of my adult life and finally had an solution with the Gastric Bypass. It’s important to understand obesity has a physical and mental aspect, so being in therapy for almost 4 years as well. So many people change one addiction to another or worse don’t follow all medical protocols and end up sometimes in a worse shape.
@livelongandprospermary8796
Жыл бұрын
I havent gained anything back since stopping wegovy (same med as ozempic, different dose). I went from 212-185. That was late 2021-early 2022. I have fluctuated a little, losing some and gaining a little back but ive been holding close to that 185 or so. I havent made any changes either, since i weighed my heaviest. Like im eating the same i did at 212 and its been almost a year off the meds. Weird that back then i was just climbing and climbing on the scale with the same exact diet that is allowing me to maintain a much lower weight. Idk 🤷♀️
@FlabbyTabby
Жыл бұрын
IMO gastric bypass is a bad idea. Main reason people have trouble losing weight is because almost all of them don't know the real science behind it (hint: insulin is the key). Or because of medical conditions. It should be a last option. Surgery in general is risky.
@FatNebraskaMom
Жыл бұрын
Straight up true. 100%
@azca.
Жыл бұрын
Did you first trying eating in a calorie deficit or attempt to exercise at least 30 minutes a day? No one ever talks about working out and goes straight to weight loss meds
@laurenconrad1799
Жыл бұрын
@@FlabbyTabby Sounds like the opinion of someone who isn’t a doctor.
Here in Brazil quite often you meet upper class women who make use of Ozempic. Many doctors will prescribe it just for aesthetics, not for health reasons.
@rafinha7081
Жыл бұрын
E eu achando que esse remédio não existia aqui.
@JL_Lux
Жыл бұрын
Weight loss is health reasons 😊
@gilbertodemelo
Жыл бұрын
@JL-xf2zh upper class people in Brazil are already a lot thinner than average
@JR-90
11 ай бұрын
@@gilbertodemeloIs it easier to get your hands in this medication in Brazil?
@vir_rm
4 ай бұрын
@@JL_Lux It strongly depends. For obese people, probably. For people with no complications, it's an unnecessarily risky choice.
I remember trying this, losing ten pounds because my doctor gave me a simple dose for a month, and then hearing my insurance refused to cover it. It's $1,100 a month without insurance.
@itspossible2015
Жыл бұрын
I'd do it. Think of it as spending $300 for a gym membership over 3 months - except with a near guaranteed outcome within a month!
@SolSister10596
Жыл бұрын
Ah. So it’s a choice between this or my rent. I’m going to choose my rent.
@hicknopunk
5 ай бұрын
Metformin is really good to make you have nausea and generally not want to eat. Cheap too. Heck, talk to diabetics, many will throw the hated nausea pills at you.
My mom uses Ozempic weekly for type 2 diabetes that she's had for almost 30 years now and we live in Pakistan, so it's great to hear this drug is FDA-approved, and to be able to just learn more about my mom's symptoms and how the drug works.....Thanks Vox!
@stejannaone4141
Жыл бұрын
FDA has lost its credibility with the Opioid menace - both with Oxycontin and Fentanyl.
@JR-90
11 ай бұрын
Question: how do you get this without prescription?
@ranaka007
4 ай бұрын
@@JR-90 in a lot of South Asian countries, we can get most of the medicine off the counter, without a prescription ✌️😬
Let's be cautious. New miracle drugs come out all the time and then 10 years later, there's a class action lawsuit.
@puppppppies
Жыл бұрын
Yup. I'm willing to bet 50 bucks that this is gonna be the next phen-fen
@nilnil7325
Жыл бұрын
Thank you for having some sense! This drug doesn't have sufficient long-term data to show it is safe in the long run. The hype that is being created around it is due to marketing and people need to take a step back and look at this whole situation with a healthy dose of skepticism.
@wolfsbane1991
Жыл бұрын
This drug has been used for YEARS for diabetes. It's not new, and it's not a miracle drug. It's literally been on the market for decades. Stop spreading misinformation.
@holistichealthhacksinfo
Жыл бұрын
Why aren't more people realizing this. This comment should have 5,000 likes. Let's revisit this in 2 years and see how all these people are doing. I was borderline type 2 diabetic until I changed my lifestyle. Now there is no diabetes in sight. Wake up! These "quick fixes" will always have side effects and yo yo weight loss/gain is terrible for your health. Learn to get to the root of the problem!
@waltpowell7254
5 ай бұрын
Actually this is not true
Thank you for choosing to focus on how this drug is SOO lifechanging for those living with diabetes and obesity. That's really important and not enough are spreading that message.
As a type 1 diabetic I’ve been vocal about leaving diabetic medications for those with type 2 and obesity. These are important medications to help them get back on track not because they have 10lbs to loose.
@Pastacrest
Жыл бұрын
While it definitely should be prioritized for those with diabetes, if production can lead to enough supply for both diabetics and the overweight, why not give to both? If anything, the reduction in overweight people takes demand off of diabetic treatments for those risking type II
@thesupergreenjudy
Жыл бұрын
I am sure they will bump up production - The issue is that many view the idea of treating obesity with medication as a vanity project when it's just as much of a disease as Diabetes Type 2 is. You could reverse Type 2 Diabetes naturally as well - so to say that people should just lose weight with willpower doesn't work. And weight loss will also bring down the amount of Diabetes Type 2 cases. Edit: I just realised that you don't object to using Ozempic for Obesity although some have objected that. Many who use it are probably obese. I think there are few people who are skinny who will want to use it and from what I understand, private companies check their clients weight first, at least in the UK
@Call-me-Al
Жыл бұрын
Only rich people with 10lb to lose get ahold of this during shortage, people who get ahold of this now are more likely to fall into the 100lb or even closer to the 1000lb category. Especially because invasive surgery (lapband, etc) is way riskier than taking this. I do find it outrageous that there isn't a priority queue for medications when there are shortages though, millionaires and billionaires who want to lose 10lb shouldn't be able to get it more reliably than actual diabetics. Healthcare cannot be a for profit industry.
@AnymMusic
Жыл бұрын
@@Pastacrest because let's be real, just giving someone a drug to lose a bit of weight doesn't do anything for the underlying problem of those people, the fact that they eat too much calorically dense food
@hjewkes
Жыл бұрын
@Anym the big difference with the drugs is adherence. In the weightloss study, all groups were put in a calorie defecit and worked out for 150 minutes per week, but over a year the control group only lost a few pounds where the groups on the drug lost 30-40. Its not that everyone didnt want to or have to diet and exercise, its that it is a lot harder to stick to the program when your body is constantly sending you hunger signals
My Dad uses this product for diabetes management and it has really helped him. After 2 interviews with the VA I will be taking my first dose next week. I look forward to the help it will give me.
I am at the 9 months mark now on compound semiglutide (Ozempic but not name brand) and I lost 44 pounds so far. From a BMI of 35 to a BMI of 28 so far. Still going strong ahead. I can move so much easier now and work out 4 days a week. I wish everybody the best in their journey to complete health
At least their commercial is catchy 😂
@Johnsonsvideos
Жыл бұрын
I hate that people have to watch commercials. I would pay anything to never see another ad in my life
@Utsav_Viradiya
Жыл бұрын
@@Johnsonsvideos "anything"? - Then pay one million dollars now!
I am glad for the positive effects it has for people with diabetes. For someone who struggles with PCOS, it sounds like these drugs could be helpful for that community as well
@LillibitOfHere
Жыл бұрын
I've been struggling to lose weight my entire adult life. Even when I was counting out 1700 calories a day, full time breast feeding a baby, and cycling hard an hour a day on the road weight was still very slow to come off. The entire older generation of my family is diabetic, I'd be thrilled to take this before becoming diabetic as a preventative.
@rubia12gilable
Жыл бұрын
That’s why I’m on it. I’m insulin resistant because of the PCOS. I haven’t necessarily lost a lot of weight but I am fuller quicker and my sugars have been better.
@cherylferrer6916
Жыл бұрын
I just got diagnosed with pcos and insulin resistant as well. I hope my specialist may help me with what I’m going through. Thank you for this video
@triceyb1363
10 ай бұрын
I have PCOS, and it has helped tremendously. I'm at least 30 lbs down in about 5 or 6 months.
@sattineez
5 ай бұрын
I really wish for it 😢 as a person who has it+hashimoto it could be a great tool
It really does make everything easier. Quick advice, inject into your thigh to minimize any nausea, and make sure to drink more water than you usually do.
The larger-scale implications of this drug (and future superior drugs like it, which are currently in development) could be _massive_ . We are on track for a majority of the worlds population being overweight or obese. All the focus on individuals (either to shame them or celebrate/affirm them) distracts from the fact that this has massive public health implications, which we're dealing with on top of an aging population. The fact is, at a population level, recommending diet and exercise is not an effective strategy. Heath experts have been doing it for decades, and the public health problem is still getting worse. So we need to either radically reform the food industry or our lifestyles (which also won't realistically happen, at least to the extent it would have to), or try to come up with some other method of addressing the fact we aren't biologically wired to live the lifestyles we have. Honestly, this is the most hopeful I've been about actually addressing obesity at scale.
@salioneradam
Жыл бұрын
@Zaydan Alfariz even Europe doesn't have rules strict enough. We have problems with obesity too. Industry needs to change globally to stop selling calorie-dense addictive foods.
@sizzurpr7608
Жыл бұрын
Exactly
@tomashgrey5510
Жыл бұрын
Yeah, let's shift the responsibility for our health to a magical pills. Let's get hooked on em. Genius solution 👌
@brickmack
Жыл бұрын
Most functioning adults don't have these problems. Its not as though everyone under 500 pounds is chaining themselves to a radiator to keep themselves from compulsively eating a whole donut shop, they just... don't have a desire to eat that much. Maybe the correct question, as for drug use, is "why does such a large chunk of the population have such miserable empty lives that eating themselves to death is their only coping mechanism?"
@LafemmebearMusic
Жыл бұрын
@@tomashgrey5510 that’s not what was said here or in the video but I also hear the validity in your points hyperbolic nature. We definitely shouldn’t be putting our dates in the hands of pharma. AND there’s a real issue that isn’t being solved so this could be a step towards a solution but certainly not the whole solution by a long shot.
That's amazing to see innovations from side-effects.
@aprilmason1616
Жыл бұрын
It is! It think thats why we can use one drug for a variety of diseases
@laurenconrad1799
Жыл бұрын
I agree. ❤
@icomment4692
Жыл бұрын
Listerine
@SomeDudeQC
Жыл бұрын
@@icomment4692glycerine
I have lost 110lbs in 12 months and it has changed my life.
@nyc1655
Ай бұрын
Just got this today I’m 285lbs and diabetic
@Djjdkfjfkfn
Ай бұрын
Any side effects?
@phillipteems6617
28 күн бұрын
Feeling better is a side effect of losing 110lb. Good for you!
I'm amazed it really does work, I been on it for a month and lost 12 pounds already
Video did a good job explaining the MOA. Just note that this requires a prescription from a doctor because of some contraindications associated with use. Not a panacea for good health, it will reduce your weight but you also have to improve lifestyle.
I have found that it also helps with cravings. I'm very glad it exists.
A friend is on it, and the results are phenomenal. It works.
Tried this. Terrible Gastro symptoms that led to panic disorders. Gutted (pun intended) my immune system. Still dealing with side effects two months later. No free ride.
@RebelleFlo
Жыл бұрын
So sorry to hear that. I hope you’re on the road to recovery ❤️🩹. Would you mind expanding on what happened to you? I’m thinking of taking it so would be grateful to hear about firsthand experiences. I wish you all the best 😘
@hicknopunk
5 ай бұрын
Metformin is a great nausea pill
Thanks for the informative & positive video! I wish you the best! 🌻
I'm obese and have bad knees and take Semaglutide shot #7 tomorrow, have so far lost 9% of my starting weight, no extra exercise and not dieting at all, i simply feel full all the time, nauseous 2 or 3 times per day everyday but it only last a half hour or so, loose bowel movements almost everyday, i can only afford the next pen as I'm paying full price, but that should be enough to see me to a 12% weight loss - thus will be no longer be technically obese.....Semaglutide is an amazing drug.
My father (67 yo, kidney and liver transplanted) is also diabetic, and one doctor made him take ozempic rather than regular insulin. He almost rejected the kidney because of that, vomiting every day, no strength at all, could not drink any liquids.
Ozempic really IS A GAME CHANGER. im serious for anyone who struggles with the food issues it actually changed my life, not only did i stop eating a ton of unhealthy food, it made me NOT EVEN WANT the food i desperately craved before, like big time. It’s a fantastic addition to a good diet/lifestyle, it may not be the right decision for everyone, i knew one person where it made them gain weight, but for me and everyone else i know who went on it, it really changed everything. I couldn’t recommend this more.
Love ozempic. Where has it been all my life?!!❤
I look at it this way. I was borderline diabetic. I went to my doctor and asked for it for weight loss. He gave it to me. I’m two shots in. First was 0.25, second last night was 0.50. I had no side effects week 1. I am feeling a little nauseous today. If this is day 1 week 2 and this is the worse it gets and I lose weight…hopefully my stomach shrinks and I make better habits…I’ll stop taking it when I reach 10 lbs less than my goal weight. I’ll stand on a scale every day and make adjustments accordingly. Also I am on a low carb diet. What can go wrong. I might as well give it a go.
Drake
Ozempic is expensive. It’s about $1000 a month out of pocket, only a few insurances cover it completely.
I trust your channel and the production value is great. But this one feels off. There is a gap in balance of pro and con. A bit like advertisement. As someone unfamiliar with the subject I might not grasp the full picture here, but that's just the way I felt watching/listening.
Awesome video! Incredibly useful tips and optimistic tone are truly motivating. Many thanks for sharing your knowledge! 😀
i need this for my insulin resisstance and i hope it helps with that and my weight
I'm naturally skinny and have been my whole life. It's great. I am super lucky. I want this drug researched even more because everyone should be healthy and comfortable in their bodies!
Even outside of just diabetes management and weight loss, ozempic and other similar injections (like Saxenda) are really great for PCOS since it’s functionally like being pre-diabetic!!! Saxenda was just approved by the FDA for use in patients with PCOS, and I have a feeling that Ozempic will be next.
@samanthablevins8009
Жыл бұрын
Eating healthy does NOT prevent PCOS! Get educated before you comment to the world on stuff you don't know about
@XhumpersX
Жыл бұрын
@@samanthablevins8009 You're not wrong there, but you're also incorrect for saying that PCOS is NOT caused by obesity. The two are strongly correlated, but there haven't been any studies that definitively show if PCOS causes obesity, or if obesity can cause or exacerbate the PCOS cyst growth in the first place. The latter would certainly explain the massive rise in PCOS alongside the similarly massive rise in obesity over the past 30 years.
@samanthablevins8009
Жыл бұрын
@Afterglow Beats there are many women out there that have pcos and are otherwise healthy and are not obese. I do believe eating healthy helps with every aspect. I just don't want someone speaking out of what seems to be hatred for obese people.
@hicknopunk
5 ай бұрын
As a T1D I am telling you not to play with drugs as dangerous as insulin. Just don't. There are better, more obscure meds to make you lose weight. Just limit yourself to 70 to 100g of carbs a day.
Ty so much for sharing your story
Great video thank you makes so much sense now!
Thank you for this. My endocrinologist prescribed this to me in February 2020. It’s been a wild ride. It definitely did exactly what it was supposed to do, though those side effects are no joke. ❤
@andreymor5201
Жыл бұрын
What thyroid issues do you have?
@JayPersing
Жыл бұрын
@Andrey Mor yooo why are you asking for someone's medical information like it's your business?
@laurenconrad1799
Жыл бұрын
@@JayPersing Thanks. Sometimes in comment threads like this one, I’m not sure whether to answer or not.
@PuffleFuzz
Жыл бұрын
Now the jingle is stuck in my head.
It's a repeating Patten , happened many times in history . This kind of drugs get popular very quickly with only temporary effects ,but cause unknow side effects which are mostly long term or permanent .
Thank you for sharing this video! 🙂
I lost 20 pounds in 120 days using ozempic and insulin 3mg im not diabetic i said let me try it . After 2 weeks i wasn't getting appetite but i was eating 3 x a day apple and watermelon for breakfast and boiled eggs for lunch and salad for dinner.
If almost all people who are obese are at risk of diabetes, then perhaps it would be good to prescribe drugs like Wegovy or Ozempic that can help as a preventative medicine to help obese people lose weight.
@hicknopunk
5 ай бұрын
Metformin
This is so popular in Bulgaria, that we have a shortage, making Diabetes patients struggle to find it when influencers are abusing it for weight loss.
@petar4onachev
Жыл бұрын
@Zaydan Alfariz Yes, years ago we had 24/7 pharmacies at every street corner, after some eu regulation they are non-existant.
@cherrywilson6267
Жыл бұрын
What did they do before 2017? Since that’s when this was FDA approved 😂
I’m so grateful
I’m 275 and I’ve been on it for 3 weeks. Haven’t had a chance to weigh myself yet, but I will say I’m not as hungry anymore and don’t feel the need to snack.
Despite the few caveats at the end, it still felt like video was trying to sell me on a new weightloss drug
When my endocrinologist prescribed ozempic to help me with my type 1 diabetes, I was told that there’s a shortage because non-diabetics are taking it for weight loss. While I’m glad that there’s finally something for that, I’m also furious that the medicine isn’t being prioritized for diabetics first! Anything that can help prevent diabetes burnout and at the same time help me lose weight is unbelievably helpful. The idea that this medication is being trivialized into being “just a weight loss drug” is infuriating!!!
@scottanos9981
Жыл бұрын
The type 2 diabetics literally got their disease from obesity, the same disease the obese people are trying to treat with ozempic. Diabetics do not have the moral high ground on this.
@jessijoweb
Жыл бұрын
I was thinking about this too, but if we can cure obesity in people before it becomes diabetes at all, it feels like a win.
@kjkj4725
Жыл бұрын
A lot of obese people have pre-diabetes. You can’t blame them for trying to stop developing the actual diabetes.
@royw-g3120
8 ай бұрын
Unless you are overweight Ozempic is not licensed for type 1 diabetes. Your doctor can prescribe it off- license but he should have made that really clear to you at the time.
Been trying to lose weight all my life. I am finally at a healthy weight through intermittent fasting, regular exercise and yoga. I’m hoping to fast longer eventually for the additional medical benefits as I get older. It’s been a tough tough road.
@SomeDudeQC
Жыл бұрын
What are the additional benefit?
@tomashgrey5510
Жыл бұрын
Good job. Keep it up. Warm hugs from Ukraine
@smallmalaysianboy8025
Жыл бұрын
Fasting can be bad for you, all you really need is a calorie deficit. Mathematically you just lose weight if you're in a consistent calorie deficit.
@ASAMB12
Жыл бұрын
@@smallmalaysianboy8025 in what way can it be bad for you?
@ASAMB12
Жыл бұрын
@@SomeDudeQC the main one I know about is autophagy
who else got recommended this video after listening to the drake kendrick disses
The effects summarized: Makes you feel fuller for longer thereby reducing the amount of food you eat. Pros: Helps you lose weight as you are not eating as much food. Very similar to a diet except now you don't wanna eat the extra food as you are not as hungry
@stc.martin822
Жыл бұрын
So the solution was eating less food all along.
@mathemat3939
Жыл бұрын
@@stc.martin822 Well it doesn't solve the problem of them eating junk and processsed food. Diseases from that will still persist.
@aprilmason1616
Жыл бұрын
@@stc.martin822 all of the above and many other factors.
@ZOCCOK
Жыл бұрын
@@stc.martin822 economics and knowledge play a key role. People who are not economically stable are statistically less likely to have afford healthy foods in developed nations. Also knowledge is a simple one as the lack of nutritional knowledge simply means that one won't choose healthy foods even if one can afford it
@jeremiahromagnoli7389
Жыл бұрын
@@stc.martin822 I mean yeah, it's always been cico. The problem is that some people's bodies are resistant to entering calorie deficits bc of homeostatic feedback loops in the body run amok. Their body might slow down their metabolism in order to prevent them from losing weight. If they enter a deficit at all, they feel completely horrible which does not bode well for the sustainability of the diet. What we are looking for is a way to make caloric restriction feasible for the long term.
I feel it's so important to remember that Ozempic treats the symptoms. It does NOT solve the root of the problem.
@aprilmason1616
Жыл бұрын
💯👆
@studyboy6201
Жыл бұрын
@@julm7744 the root of the problem is clearly how you eat in america
@melindasmith3713
Жыл бұрын
@@julm7744 well facts are facts , they must change their diet and at least walk for exercise. If your health is at risk and you take no responsibility for it , why should a doctor even care ?
@Sol_Invictus_
Жыл бұрын
@@julm7744 people should stop eating unhealthy foods and stop pretending fatphobia is real
@0900McShizzle
Жыл бұрын
@@julm7744 but overeating and not exercising is the root cause in most, but not all, cases of obesity. Hormones are the other factor
Nice i am buying me some, this makes weight loss so much easier :] Will probably use half the dose though. This makes life so much easier for everyone, really a miracle drug it seems.
My A1c 11.0 went down to 5.1 in just 4 months only through weight loss (40 pounds) without any meds. Do whatever you can and lose that flab for better t2 management
Man, I really think this video misses an important point. While it can help you lose the weight, once you get off it the weight really wants to come back. It’s still mainly up to large life style changes to prevent the weight from coming back. I fear that more and more people are going to become dependent on this for keeping the weight off & won’t be able to get off with out weight gain. Of course this is great news for the drug manufacturers but poor for the normal person that uses it.
The video doesn’t mention the more serious side effects of Ozempic, such as thyroid tumours, but the overview is good. I am a candidate for Bariatric surgery, and I am about to start my prescription of Ozempic. I will just be sure to monitor myself closely for side effects. I tried a trial round of Saxenda (liraglutide) but couldn’t afford to stay on it as insurance doesn’t cover it. Ozempic is a viable alternative and has the advantage of it being a weekly injection instead of a daily one.
@lyndiskenny-howell1323
Жыл бұрын
good luck to you as you start your ozempic journey! i recommend having either a zofran prescription or gravol/dramamine on hand, as the nausea in the beginning can be very unpleasant. make sure you drink a lot of water, it reduces your appetite but you also don't really feel thirsty. it's super super important to drink water, (stay hydrated) so don't forget! This medicine has been a life changer for me. i hope you will get to enjoy the same experience as i and many others have had. take care!
Pcos women also are seeing great improvements with this medication however alberta blue cross wont pay for it because of the weight loss craze.
Best explanatory video I’ve seen anywhere online. Thank you Vox.
Great video! Thanks for putting this out. I am considered morbidly obese and I started Ozempic, today. I was wondering what to expect.
@celinemara565
11 ай бұрын
Are you seeing any good results?
@Maxaldojo
11 ай бұрын
@@celinemara565 The first 4 weeks I am on the 0.25 dose to see how I feel and react (side effects...). So far, rather mild... I was in the hospital twice since November with diverticulitis, so that's my measuring stick. I should know more in a month.
I tried this for my Type 2 diabetes and I was SO SICK on even the lowest dose. If you have IBS, pelvic floor dysfunction, lack of a gallbladder or any other gut struggles, please DO NOT take this if you can help it. They say the side effects go away after a few months, but they don't. This drug permanently worsened my other health conditions and despite my own research suggesting this was not the drug for me and lengthy conversations with my doctor, Ozempic was pushed and my concerns ignored, and I regret letting it happen.
very informative video, thank you
Semiglutide works wonders for diabetes!! I think diabetics deserve priority with this prescription.
The jingle, if you're under 30, sounds familiar because it's from the Wizards of Waverly Place soundtrack (Selena Gomez song). If you're older, you might know it as the 1974 Pilot song
@FOJO27
Жыл бұрын
Ah yes, "Magic" by the band Pilot. How apropos...
Ozempic was in the news in my country recently because of a shortage
@FOJO27
Жыл бұрын
Which country? Just asking since it seems to be in short supply everywhere. (Was assuming you're in the US or Canada)
@vox: "Caution with the rivals the effects of metabolic bariatric surgery" minute 4:45. Expected short-term weight loss following bariatric surgery Operative procedure :: Excess weight loss (percent) Gastric bypass :: 60 to 85 Adjustable gastric band :: 45 to 55 Sleeve gastrectomy :: 55 to 80
this video has one of the best hooks i’ve ever seen
Will be interesting to see what kind of long term side effects manifest once this is widely used for application of weight loss
@inuhundchien6041
Жыл бұрын
Yup, you can't stop this the same way you can't stop injecting insulin if you are diabetic, IF you don't change your lifestyle. So for diabetics this is good they just change from one medication to another. For others they are just adding more expenses. I do think it's still good for the initial weight loss but certainly at the same time going to therapy, go to cooking class or enroll in gym to become a 'skinny' person intrinsically.
@edkwon
Жыл бұрын
@@user-kr6jg6qb7l I'm referring more to unexpected adverse side effects with prolonged use, not the expected effects from stopping use
What a great time to live!
this is extraordinary
I've been covering a lot of this on my channel- always good to get more perspective!
As a soon to be dietician im tuning in for this video (I study in the Netherlands though) Edit: love the video. Good information, short clear and simple, Thank you for making it. I hope people are a bit better informed because of it! Edit 2: the video did miss a couple of important points, other have described it pretty well
I got diagnosed with thyroid cancer in 2020 and subsequently got a thyroidectomy. My endocrinologist said it would now be nearly impossible for me to lose any weight, so he prescribed ozempic to help me get my bmi down. Super weird I keep seeing videos and news articles about it now…. I hope it works 🤞🏻 😅
I'm prediabetic, this is a miracle drug for me but it's hard to get a hold of right now.
I’ve just learnt about GI tract and endocrine pathways and this video popped up on my feed I’m so not being monitored lol 😅
Truly a game changer
Hey Vox, was this video sponsored by any pharmaceutical companies at all? It was informative, but the writing (I think) gave a weird advertising vibe.
@aprilmason1616
Жыл бұрын
Oh why did get that vibe? (Curious, because i didnt, and I want to learn from your answer to improve my own cummication skills during consults)
@danielkjm
Жыл бұрын
Yeap, this is an AD
@danielkjm
Жыл бұрын
@Zaydan Alfariz A lot of channels dont even bother to disclosure ADs, because its a rule that is not enforced.
@danielkjm
Жыл бұрын
@Zaydan Alfariz Again, a rule that is not enforced its useless. There is a reason why "Content Ads" (Ads in form of content that hides the fact its an Ad) are huge right now, they are not enforced, and by hiding the information that X is an AD they sell more.
@RandomStreak-eo
Жыл бұрын
@@aprilmason1616 Assuming the facts are all correct (which I don’t doubt per say) the language used was generally positive and supportive of the drug despite the side effects. The tone didn’t feel neutral. And when interviewing they picked one user of the drug who had a good experience, but usually in a video like this, they’d get both sides, or have a neutral party (university researcher or something) to weigh in on things, but they didn’t. It really felt like an extended subtle ad.
This was very good for me as we just got a memo at work that Medicaid is not covering Wegovy because they don't cover weight loss in general.
@Sophie-ge7ti
Жыл бұрын
I hope that changes soon.
How long can you take it is there a limit?
I’m here mid-beef don’t mind me yall
My mom and her friend recently got on it. I was soooo skeptical… but It actually really works, her appetite has gone down and she’s lost weight (she works out three times a week, and does cardio every day, but hasn’t changed her diet even though her portion sizes decreased). She lost 10 pounds in a month
@Ardante11
7 ай бұрын
I’ve got a roommate that’s got only a month’s worth. I told him he should start exercising to speed up the weight loss because Diabetics need those drugs more. He’s been trying to get more but I dont think it’s needed if he simply starts working out.
Me knowing nothing about the drug yet immediately recognizing the jingle from watching Judge shows with my grandma. Not one commercial break goes by without the Ozempic Ad lol
This is awesome for diabetics and obviously there are people that really need this for medical reasons. That said though using this for vanity reasons on otherwise healthy people is kind of a cop out and maybe you should limit your consumption first.
now the jingle is stuck in my head.. again.. Thanks Vox
@aprilmason1616
Жыл бұрын
I heard it in this video for the first time, Im not going in a second time hahaha i feel you though ❤️