Ozempic and Wegovy: All you need to know

Ғылым және технология

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Did you know that 40% lot of the weight you lose on Ozempic is muscles, not fat? The weight-loss drugs Wegovy and Ozempic seem god-sent solutions for everyone who’s been struggling to lose weight, a miracle cure for a problem that befalls billions of people, even Elon Musk. But what makes the drug so effective? What do we know about it?
This video comes with a quiz which you can take here: quizwithit.com/start_thequiz/...
Many thanks to Jordi Busqué for helping with this video jordibusque.com/
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00:00 Intro
01:31 Celebrate Spooky Season with Galaxy Lamps!
02:52 What is semaglutide and how does it work?
06:04 How well does it work?
07:29 Side-effects and Downsides
09:57 Money
12:46 Morals
14:15 Summary
#science #ozempic #quizwithit

Пікірлер: 1 100

  • @SabineHossenfelder
    @SabineHossenfelder7 ай бұрын

    This video comes with a quiz which you can take here: quizwithit.com/start_thequiz/1698217936376x713111202058947200

  • @Einyen

    @Einyen

    7 ай бұрын

    There is another similar product from Novo Nordisk I took around 2017: "Saxenda" (containing "Liraglutide"). It is also an injection pen, but you have to take it daily instead of weekly. I'm not sure if it is prescribed anymore after the success of Wegony. They have 2 other products containing "Liraglutide" exclusively for type 2 diabetes: Victoza and Xultophy.

  • @jeetsom9659

    @jeetsom9659

    7 ай бұрын

    @@Einyen is it wise to tinker with biochemistry when the mechanism of action is not well understood ? The body is a homeostatic system where input and output of the metabolic engine regulated based on demand, and there is some evidence showing that refined sugar is addictive through the gut brain axis, essentially it changes microbiome bacteria making you crave sugar beyond your bodily requirements. So why not spend research money to understand sugar consumption it’s biochemistry throughout the body?

  • @MisterEMystery

    @MisterEMystery

    7 ай бұрын

    I’ve taken Victoza and Mounjaro for my diabetes with many side effects. I’ve been on Ozempic for years now with fluctuating weight when I was increased from 0.5 to 1.0 mg injections, but haven’t actually lost ANY weight. My doctor has been trying to get me on the highest approved mg for a year now. I think she believes my weight will go down. My A1c dropped to 5.0 after the other increase but my ophthalmologist has noted I’m beginning to suffer from retinopathy, my take is I won’t lose weight but may go blind if I increase the dosage, also my A1c could go dangerously low. I wonder if my endocrinologist is falling for the advertising and my health may suffer as a result. After all I’ll most likely be on Ozempic for the rest of my life, so why not guinea my pig.

  • @babyoda1973

    @babyoda1973

    7 ай бұрын

    There we go using stuff we don't understand

  • @anthonylosego

    @anthonylosego

    7 ай бұрын

    Coincidentally, cocaine and meth are good for losing weight also. Not recommended. The best method is self-control. It's a skill that will last you a life-time.

  • @goodisanoun
    @goodisanoun7 ай бұрын

    I had been overweight or obese for 15+ years and then went on Ozempic. Ive lost 60lbs and gone from 35% to 15% BF%. All the while finally getting on a heathy diet and forming good eating habits. I didnt have any side effects and feel the I have since my teens. I am incredibly grateful for Ozempic for helping me turn my life around.

  • @SabineHossenfelder

    @SabineHossenfelder

    7 ай бұрын

    Thanks for sharing, very interesting!

  • @dr_flunks

    @dr_flunks

    7 ай бұрын

    are you in the USA? how much are you getting it for? did your doctor give you grief for requesting it?

  • @MARILYNANDERSON88

    @MARILYNANDERSON88

    7 ай бұрын

    My daughter is prescribed Oz for pre diabetes, she is not obese. The side effects are horrid and frightening. She is less tired.

  • @MARILYNANDERSON88

    @MARILYNANDERSON88

    7 ай бұрын

    You look fantastic, Sabine. Great job for your work keeping yourself and family in great condition.

  • @brianjonker510

    @brianjonker510

    7 ай бұрын

    Says the PR from corporate

  • @jwrosenbury
    @jwrosenbury7 ай бұрын

    An important side effect is slowed digestion. My mother went in for surgery and they refused to operate on her until she had been off the drug for 8 days. They said sometimes people had food still in their digestive tract due to the drug seven days later. People need to know.

  • @abydosianchulac2

    @abydosianchulac2

    7 ай бұрын

    How did your mom get up to the point of arriving for surgery without the team checking her medication list?

  • @jwrosenbury

    @jwrosenbury

    7 ай бұрын

    @@abydosianchulac2 The team seems to have checked. But the written instructions said 48 hours. She had been off Ozempic for 7 days, but the surgeon said 8 at the time for which the surgery was scheduled. I think the requirement was new.

  • @kuroinokitsune

    @kuroinokitsune

    7 ай бұрын

    You know.. that's sounds actually good. Seems like your docs prioritized patients in front of them then written recommendations. In my place it the other way around, and caused me a lot of pain - docs never listen to me when I say that anesthesia and painkillers ain't working. So.. I am glad that you guys seem to be in a good hands.

  • @brianjonker510

    @brianjonker510

    7 ай бұрын

    I have never heard this and it is such an extreme GI residency period.

  • @psyringe5627

    @psyringe5627

    7 ай бұрын

    When I was prescribed Ozempic, I went 3 weeks without any bowel movement, and even after stopping taking it, it took several more weeks for my digestive tract to resume normal operations. I can absolutely see how this might cause problems for surgery, and I think it's great that doctors care about this possible complication.

  • @davidpaulcarlson8763
    @davidpaulcarlson87637 ай бұрын

    Sabine, this was REALLY a good explanation of not just the talking points, but the whole situation. My compliments to your team (and you). THANK YOU!

  • @vtr8427

    @vtr8427

    7 ай бұрын

    What team ?? She is the team

  • @abj136

    @abj136

    7 ай бұрын

    @@vtr8427 She is the leader, particularly for physics stuff, but she’s not the only one involved.

  • @SabineHossenfelder

    @SabineHossenfelder

    7 ай бұрын

    Thanks, I will pass this on to the team!

  • @SabineHossenfelder

    @SabineHossenfelder

    7 ай бұрын

    @@vtr8427 I work with about a dozen other people who help do the research and the videos.

  • @ArmadilloGodzilla

    @ArmadilloGodzilla

    7 ай бұрын

    ​@@vtr8427😂

  • @Sonnell
    @Sonnell7 ай бұрын

    I do not care how people eat less, if they do. Meaning: eating less is great for the environment, and perhaps to the whole society as well.

  • @wighar
    @wighar7 ай бұрын

    as a type 2 diabetic that is on Ozempic, have been really annoyed with people that misuse the medication and take it when they do not need it, I have had to go the last 6 months without the medication because there is not stock and the apothecary expect to have some in stock at earliest by december, I have many expletives I could say about this issue but have censored myself greatly in this post.

  • @positronundervolt4799

    @positronundervolt4799

    7 ай бұрын

    I have ADHD, & because of people abusing stimulant medication, it makes it extremely difficult for me to even try to be prescribed the medication by a psychiatrist. I have to be treated like a criminal and take drug tests before I'll be allowed to be prescribed medication that can drastically improve my quality of life.

  • @4203105

    @4203105

    7 ай бұрын

    @@positronundervolt4799 I have never had any problems getting ADHD medication, but it doesn't work very well for me. Mostly only helps with the emotional symptoms of my ADHD. You win some, you lose some, I guess. Also I wouldn't blame people abusing the medication, I'd blame our Draconian drug laws. Dexamphetamin should just be free to buy. It's a drug with relatively low addiction potential and very few side effects. It's just so highly controlled because god forbid somebody might have fun taking it.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    You should probably switch to Mounjaro.

  • @4203105

    @4203105

    7 ай бұрын

    @@VernCrisler The availibility of that is even worse.

  • @coppercore6287
    @coppercore62877 ай бұрын

    Thank you for adding the moral section into this. It's extremely important to point out these things.

  • @gl0bal7474
    @gl0bal74747 ай бұрын

    I really appreciate your blending of proper science and humour. your channel is gold

  • @sagecoach
    @sagecoach7 ай бұрын

    After seeing the needle my fasting works just fine. Thank you.

  • @Sweetthang9

    @Sweetthang9

    23 күн бұрын

    Congratulations you are part of the extreme minority for which fasting is an actual solution!

  • @chrisdonovan8795
    @chrisdonovan87957 ай бұрын

    I'm a 54 year old PE teacher with above average physical fitness. There's no jealousy here for people who need the help, but you all have to understand that physical fitness does not solely mean having low body fat.

  • @alanblack5112
    @alanblack51127 ай бұрын

    Another interesting and balanced video. Of course, my main takeaway from this video, was to order the Galaxy Lamp.

  • @Thomas-gk42

    @Thomas-gk42

    7 ай бұрын

    🙃🖖

  • @richardcoughlin8931
    @richardcoughlin89317 ай бұрын

    Thanks for a very clear description of the semaglutides. As someone who has struggled with my weight for 30 years, I have followed weight loss, regimes and treatments with great interest. In the past year I lost 10% of body mass by following a very low carb diet. It took a some getting used to (and I do miss my pasta, bread, and potatoes) but the diet is both tolerable and sustainable. My doctor said that she would prescribe a semaglutide if I wanted to lose another 10 to 20% of body mass but since I am in my 70s and insured through Medicare the monthly cost would be prohibitive. Do I feel cheated that I have to rely on continuing a diet that denies me foods that I love while others take the easy way out? Not really. First, all medications have side effects, which I prefer to avoid whenever possible. Second, following a sustainable diet over a long period of time I feel the risk of regaining weight is fairly low. The real test of my willpower would be if Medicare covers semaglutides for weight loss 😂.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    Unfortunately, low or zero carb diets are not very healthy in the long run, not without taking compensatory supplements such as Vitamin C, B12, etc. [As corrected below, that should have been VEGAN diets.] You can eat anything you want on semaglutide -- in moderation -- and still lose weight.

  • @ayoCC

    @ayoCC

    7 ай бұрын

    ​@@VernCrisler counting calories and eating components that are low calorie would work, I wonder though if anyone feels like they're wasting money if their food doesn't have calories. Make 1/3 of the meal be carrots and beans, and always have them swimming in a well seasoned broth that you can slurp, or having a water melon as dessert. I think a lot of people were made to be on a regular diet of soups, but we're sort of eating a lot of dry and dense foods that have no water. And then people struggle to get enough water in a day for the 2 liters a day.

  • @richardcoughlin8931

    @richardcoughlin8931

    7 ай бұрын

    @@VernCrisler I can only speak for myself. After a year of a low carb diet and loss of 30 to 35 pounds (less than 1 pound a week) my blood work taken at six month intervals showed results as good or better on cholesterol, triglycerides, glucose, and various other measures, including vitamin B12. More importantly, having taken 3 month break from the diet I’ve not regained any weight. Although I am now eating a reasonable amount of pasta, bread, and potatoes (but no added sugar) I have not returned to my previous “eat anything I want.” Would I turn down one of the semaglutides if it were offered a reasonable price? Probably not. But I would keep to a reasonably healthy diet I have become accustomed to.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    @@ayoCC That's the good thing about these drugs. You don't have to do extreme diets or restrictive diets to lose weight. For most, normal dieting and exercise should work.

  • @ArmadilloGodzilla

    @ArmadilloGodzilla

    7 ай бұрын

    ​@@VernCrislerabsolutely not true. B12 comes from meat and meat only. Its bio availability in a few veggies is close to zero and that's why over 80% of vegans are severly deficient in it. On vitamin C, carbs block the uptake of it making us need a higher dose, so decreasing carb intake decreases the amount of vitC we need.

  • @casnimot
    @casnimot7 ай бұрын

    Weird thing for me is I didn't need 'em. I was 145kg, BP 165/140, resting pulse 90. I was also drinking very heavily. I was maxing out one blood pressure med, but couldn't go on the next BP med (or statins) because of my liver counts. Now I'm 85kg, 115/75 with a resting pulse of 60. My blood work looks like a 20-something vegetarian's might. What worked for me was inflation. When they started raising prices on all that junk "food", and even started chinsing on the portions, I quit them faster than I did alcohol. I stopped buying beverages of *any* kind, prepared foods of any kind. When fast food prices started galloping, I was already losing weight and saving money. Since burger-flippers get $20/hour now, I'm 100% done with fast food of any kind. Now, I recycle twice a year, rather than once a week (there's that little left). And I have almost 6 figures in the bank I didn't used to have (alcohol and fast/prepared foods are **expensive**). No drugs + tons of money saved, just by refusing to participate.

  • @BenjaminBjornsen

    @BenjaminBjornsen

    7 ай бұрын

    I stopped eating out to, you should see the prices in Norway. Its 7.5$ (84kr) for a big-mac burger with no soda or fries and 11.2$(126kr) for a small menu. I cant believe they got customers, but its packed every time I pass it. Im conically underweight, so it sucks hard. Getting my 4500cal a day is a grind these days.

  • @casnimot

    @casnimot

    7 ай бұрын

    Lucky for me, a few almonds a day are nearly enough. If I make myself some fried rice, I'm fine. Bottom line is that the days of eating out are over for many of us. And with severe population decline coming, we'd better get used to it.

  • @BenjaminBjornsen

    @BenjaminBjornsen

    7 ай бұрын

    @@casnimot agreed

  • @zamar2158

    @zamar2158

    7 ай бұрын

    ​@@casnimotpopulation decline is a good thing. We went from 1.8bn in the 1800s to almost 8bn in a little over 150 years. Other than european origin people, the rest of the planet has been multiplying like mosquitoes. Yes human population decline is excellent.

  • @Marqan

    @Marqan

    7 ай бұрын

    Don't tell them that, they might try to ramp up inflation again to "cure" everyone!

  • @aidanclarke6106
    @aidanclarke61067 ай бұрын

    Body positivity is good... as long as it does not try to hide the fact that being fat is *not* healthy

  • @pmetham
    @pmetham7 ай бұрын

    As usual, simply brilliant - covering all aspects of the matter.

  • @markh.harris9271
    @markh.harris92717 ай бұрын

    Very good segment, Sabine. I have type II diabetes and I take Ozempic to regulate my glucose levels. The problem is that because these knot-heads in Hollywood are abusing this drug for weight loss, those of us who need the drug are having a hard time getting it; there is a shortage, and money always wins out. (Well, not always) Thanks for this message. marcus

  • @kijuanbarnes6342

    @kijuanbarnes6342

    7 ай бұрын

    No you’re right. It wins because corporations main goal is always profit. Thats what they’re in business for.

  • @albasdumbledorf5113

    @albasdumbledorf5113

    7 ай бұрын

    You can cure Tp2 diabetes by cutting out the carbs. Pharma doesn't want you cured as there's no profit in it.

  • @arthurkrumsee3995
    @arthurkrumsee39957 ай бұрын

    I found this video excellent with the exception of the facile comments about suffering, implying that people who take semagluide have been unwilling to suffer the pangs of hunger. I'm a 73 year old man who started taking semagluide a few months ago. Looking at my siblings, parents and grandparents I think I can say I came by my bodyweight issues out of an inherited proclivity and not a desire to avoid the "suffering" of weight loss. I'm no martyr but I know something of suffering (emotional and physical). Resisting a brain driven craving is a very, very different game. Really, it isn't suffering at all, it is sustaining an effort to resist an endless stream of seemingly minor choices. Semaglutide doesn't just make me feel more full faster. It somehow undercuts that craving response and not just to food. It is easy to pass on an evening cocktail as well. I find the brain endlessly fascinating and the capacity of the brain to control the choices we make equally fascinating. I'm thinking of Daniel Kahnemann's book "Thinking Fast and Slow". From that I learned that we all, even those who think of themselves as most rational (like scientists perhaps), make the vast majority of their decisions instinctively and impulsively.

  • @emersonmsd
    @emersonmsd7 ай бұрын

    As a diabetic I have been talking Ozempic since 2018. Does it work? Yes, sometimes. My blood sugar is under control, weight los... don't expect wonders. It screws with your appetite and stops you getting hungry, you can end up snacking instead.

  • @user-hm4jm1cy7m

    @user-hm4jm1cy7m

    7 ай бұрын

    if youre type 2 you could try not eating carbs and sugar to stop jacking insulin through the roof all day.

  • @fannyalbi9040

    @fannyalbi9040

    7 ай бұрын

    y sometimes?

  • @susandoerr3896

    @susandoerr3896

    7 ай бұрын

    a certain cactus leaf is a natural insulin

  • @drecksaukerl

    @drecksaukerl

    7 ай бұрын

    Same here. It controls blood sugar and slows absorption of food into the stomach, so it does help to reduce food consumption.

  • @emersonmsd

    @emersonmsd

    7 ай бұрын

    @@susandoerr3896 I don't take insulin.

  • @blas_de_lezo7375
    @blas_de_lezo73757 ай бұрын

    WOW! this was really really good, simple and on point!

  • @cesartrujillo4190
    @cesartrujillo41907 ай бұрын

    Thank you for doing this video!

  • @fabkury
    @fabkury7 ай бұрын

    One of the remedies I have been taking to lower my nonsense intake levels are Sabine's videos.

  • @Jens.Krabbe

    @Jens.Krabbe

    7 ай бұрын

    But where do you go for your daily dose of gobbledygook?

  • @fabkury

    @fabkury

    7 ай бұрын

    @@Jens.Krabbe That comes to you without you having to go for it. 😉

  • @haroldpeperkamp2030
    @haroldpeperkamp20307 ай бұрын

    Greatly appreciated Sabine! As always. My wife is on Saxenda which uses liraglutide in daily injections. Weight loss is slow but going down gradually as she gains muscle fast when exercising. Weight goes up when we go on trips where we can not keep the Saxenda cool. It scares her when that happens into thinking that all the lost weight returns and more. Fear of unknown long-term effects makes her want to decrease medication or take pauses. Cost is about €500,- a month at max dose without insurance. Insurance will cover when your doctor refers you for a life style intervention.

  • @deborahm6036
    @deborahm60367 ай бұрын

    Thank you for this video. It is the best on this subject that I have seen.

  • @chicken29843
    @chicken298437 ай бұрын

    Sucks to be all those diabetes patients that has to pay more now because the demand

  • @Thomas-gk42

    @Thomas-gk42

    7 ай бұрын

    entirely correct

  • @SNixD
    @SNixD7 ай бұрын

    My father got diabetes as a side effect of heart surgery and the Ozempic shortage has forced him to sometimes travel great distances to get it. I personally think that medication can be a great aid when getting started with weight loss but also believe that the biggest long term issues are more about how we treat food in general. I've done intermittent fasting for a few years now, only one or two meals per day with at least 16 hours of fasting, and it's done wonders. I also removed most sugar and processed foods from my diet. The result is a stable BMI of ~23, no brain fog or tiredness and I almost never feel hungry. As a bonus food is also tastier than ever, like all flavors have been enhanced.

  • @ayushsharma8804

    @ayushsharma8804

    7 ай бұрын

    Ozempic to cure obesity is probably better at curbing diabetes than directly using it with diabetics

  • @jayjay-gl4fj

    @jayjay-gl4fj

    7 ай бұрын

    Best comment here

  • @RichMitch
    @RichMitch7 ай бұрын

    I'm on ozempic injection right now and it's helped me lose 15kg and brought my blood sugar down to normal levels. They will have to pry it from my cold dead hands

  • @RichMitch

    @RichMitch

    7 ай бұрын

    I should say that I also have Ankylosing Spondylitis and exercise is extremely difficult to impossible most of the time, ozempic has (potentially) been a lifesaver

  • @nathanieljames7462

    @nathanieljames7462

    7 ай бұрын

    I have AS. I'm on adalimumab for it. You?

  • @RichMitch

    @RichMitch

    7 ай бұрын

    @@nathanieljames7462 I just changed from adalilumab to etanercept because I developed resistance to it after 2 years, I'm also on methotrexate to help stop that happening this time.

  • @hotmetalslugs

    @hotmetalslugs

    7 ай бұрын

    Sir, this comment section is for wannabe scientists to spout theories about how it doesn’t really work and will have unseen radioactive side effects in a few decades.

  • @Munchausenification

    @Munchausenification

    7 ай бұрын

    @@RichMitch oh wauw Ankylosing Spondylitis does not look fun to deal with. Yeah for a lot of people these new drugs really does save lives

  • @shmookins
    @shmookins7 ай бұрын

    On Real Time with Bill Maher latest episode, the host mentioned that these new drugs not only suppress food cravings which make you eat less and thus lose weight, but they also suppress addictions in general including food addictions but also addiction to alcohol, social media, maybe even nicotine addiction as well. A guest on the show said people on this drug drank 60% less alcohol. If this drug proves safe in the long term, it can be huge if it indeed suppresses addictions of all types.

  • @Camel_Knight
    @Camel_Knight7 ай бұрын

    This could do with a citation Ozempic is a treatment for type 2 diabetes not for type 1 diabetes. Due to type 1 being the inability of the body to produce insulin these drugs have very little to no effect on type 1 diabetics.

  • @gilgamecha

    @gilgamecha

    7 ай бұрын

    Well there are different perspectives on this and public health attitudes are changing.

  • @bartwilson2513

    @bartwilson2513

    7 ай бұрын

    Except if those Type I diabetics were obese and also suffering from Type II. The two diseases are not mutually exclusive and a reduction in weight would equal a massive reduction in insulin doses required.

  • @gilgamecha

    @gilgamecha

    7 ай бұрын

    And you are wrong about the medical effects. GLP agonists and mimetics are very interesting areas study for Type 1s.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    While these drugs were not developed for Type1 patients, they do also seem to help some Type 1 patients.

  • @gilgamecha

    @gilgamecha

    7 ай бұрын

    @@VernCrisler exactly.

  • @truth8483
    @truth84837 ай бұрын

    Most insurance companies cover wegovy but it does tend to require prior authorization. I've had good success prescribing it for my patients. The only actual requirements are a bmi > 30 and obvious no contraindications like MTC, MEN2, And personal history of pancreatitis. Obviously it causes gastroperosis, its part of how it works, so patients need to know this. It's most common side effect is nausea. It works well though. Type 2 diabetics can get on ozempic which is fantastic for a1c reduction and some weight loss.

  • @JohnHoranzy

    @JohnHoranzy

    7 ай бұрын

    Why do you not just prescribe low carb, zero sugar diet. I know lots of people throwing away diabetes meds after being on the Keto diet. The medical industry is a fraud supporting the processed food energy.

  • @kevinJmadsen

    @kevinJmadsen

    7 ай бұрын

    I think there are precious few insurance companies covering Semaglutide for weight loss, except where it is illegal to deny that coverage.

  • @markfergerson2145

    @markfergerson2145

    7 ай бұрын

    Is it gastroperosis or gastroparesis? The two terms seem to be interchangeable on google even though the former seems to be used in patient support groups, the latter by actual medical sources. Did your spielchucker force one spelling over the other? Mine doesn’t know either one. This matters to me because my wife has type 2 diabetes (I’m one of those Sabine described as not getting fat by following my body’s idea of when and what to eat) and since I do the cooking for us, I have to manage her diet while avoiding foods that induce gastric problems. I therefore have to consult with her doctors to know what to feed her, how much and how often as well as watch for and keep track of any symptoms, and try to identify the causes on the fly. During her doctor visits I report what I see in order to continuously refine my part in her health management. The point is that while I hold no degrees I have had to pick up a lot of medical terminology which makes it easier for her doctors and I to communicate effectively, and I want to get it right to avoid misunderstandings. Also, I don’t want to sound like a dummy…

  • @truth8483

    @truth8483

    7 ай бұрын

    @@markfergerson2145 Decreased gastric empyting my friend.

  • @truth8483

    @truth8483

    7 ай бұрын

    @@kevinJmadsen Correct, it's not approved for weight loss. Like Mounjaro, you need a diagnosis of DM2. Atleast in the united states which is where I practice.

  • @Master_Therion
    @Master_Therion7 ай бұрын

    My sister in law is on a waitlist to get Wegovy. So, right now she's on wait loss program.

  • @gregsotiropoulos7929

    @gregsotiropoulos7929

    6 ай бұрын

    🥁

  • @too-many-phils
    @too-many-phils7 ай бұрын

    this is a phenomenal video

  • @jlpsinde
    @jlpsinde7 ай бұрын

    Amazing video!!!!!!!!

  • @harthur2010
    @harthur20107 ай бұрын

    Ozempic was created for type 2 diabetes. I take it for that and it has been a game changer for me, but, now so many people are taking it for weight loss, I have trouble getting it.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    Have your doctor prescribe you Mounjaro. Eli Lilly has more production and supply infrastructure than Novo Nordisk.

  • @SireJoe

    @SireJoe

    7 ай бұрын

    Do you mean getting the drug, or the fact that people are taking it for weight loss? I think people want to lose weight, so I think it's pretty straightforward for why they are taking it, if that's what you meant.

  • @Athiril

    @Athiril

    7 ай бұрын

    There is a strong relationship between being overweight and diabetes

  • @rbanerjee605

    @rbanerjee605

    7 ай бұрын

    I feel ya buddy. It should be prioritised for type 2 diabetics only. Ozempic and wegovy do have different drug amounts though, might be best to talk to fam med.

  • @ohauss

    @ohauss

    7 ай бұрын

    @@Athiril Which is neither here nor there, but hey, I guess you think having an actual diagnosis is a waste of time.

  • @1953bassman
    @1953bassman7 ай бұрын

    Over the past 20 or 30 years I had slowly gained weight. I reached a point where I needed to lose 25 to 30 pounds. Compared to some other people, that may not seem to be a lot, but I didn't want to get to a point where it would be too difficult. It is said it's harder to lose weight as we get older, and I am 70. The first thing I did was looked at what I was eating and how much. I realized that even though I wasn't eating excessive amounts, what I was eating had a high sugar and carbohydrate content. So instead of a raisin bran muffin for breakfast, I switched to a higher protein meal of eggs with more vegetables. I felt less hungry for longer periods and the vegetables provided more fiber and vitamins which added to that. I also switched to Greek yogurt, which has no added sugar. I also quit having dessert after dinner. I previously had finished my evening meal with a cookie or two, or pie, or whatever. I also started logging the calories I ate using a handy app on my phone. That helped my awareness of what I was eating, too. I also quit drinking milk, since I realized I was having milk to accompany the dessert. So, over a three-month period I have lost 20 pounds, without really eating less or cutting portions. And without any drugs. I don't think I increased the amount of exercise I get, though I am somewhat active. I am a musician, and perform on weekends, which includes hauling around amplifiers, but I haven't increased how much of that I do. I am still aiming to lose another 10 pounds. I believe my success is due to taking out the sugar and carbs and adding protein. At this point, I don't miss the desserts and do not feel hungry between meals. If I do have a snack, I choose an apple instead of sweets. Maybe this might not work for everyone, but perhaps if more people took a review of their food intake they could find things they could cut out without starving themselves.

  • @austinwanner449

    @austinwanner449

    7 ай бұрын

    the reason that this drug is becoming so popular is for exactly this reason. changing your lifestyle is really hard, and a lot of people dont want to do it. this drug is a shortcut to that, so people are more inclined to take it than to change their lifestyle. i applaud you for your willpower to totally upend your diet to lost weight, but in today’s society, many people lack that willpower. an additional note however, she noted in the video (around 9 minutes in) that the people taking semiglutamide gained back a significant portion of the weight they lost, most likely you wont have that issue, so good for you!

  • @1953bassman

    @1953bassman

    7 ай бұрын

    @@austinwanner449 In my case, it didn't feel like I was changing my lifestyle or upending my diet much at all. I consider the changes to be minor in nature. The reason I commented was to demonstrate that it wasn't very difficult to make a few changes and get results. Much of the reason we find it hard to lose weight is because we think we have to turn our lives upside down. I don't feel like I had to do that.

  • @Volkbrecht

    @Volkbrecht

    7 ай бұрын

    @@1953bassman What is and is not difficult is highly dependent on personal perception. Weight loss isn't complicated, as you point out. But depending on who you are and why you overeat it can be hard to do. It requires conscious effort, which is already a strain when one has never really put much thought into their eating habits, and then of course it requires to break with habits and establish new ones. And when food intake itself is not the cause of the problem, but a symptom of one, like depression, you open a whole other can of worms. I think it's good that these drugs are becoming popular. At a moderate cost they help to stave of conditions that are generally more expensive. That's a net win for all of us.

  • @kensho123456
    @kensho1234567 ай бұрын

    Good video there's an appetite for this kind of thing.

  • @Sirm777
    @Sirm7777 ай бұрын

    Always a pleasure watching your videos. My only suggestion would be to consider placing adverts towards the end. It might help maintain the flow and focus of the content.

  • @lonnie195
    @lonnie1957 ай бұрын

    Wow! Great report Ms. Sabine. Thank you for the effort you put in your videos. I enjoy them very much and look forward to your next one. FWIW: I am a retired, overweight American truck driver with an incredible lack of dietary discipline. However, despite your positive report, I will not be chasing any weight-loss drugs. Though they will benefit many, it seems wrong for me to attack weight loss with a pill, rather than an improved diet and increased exercise. Please take care.

  • @Thomas-gk42
    @Thomas-gk427 ай бұрын

    thanks for another informative and well researched report, only knew about that as drug for diabetic deaseses. Great conclusion at the end🌳🍓

  • @UnPetitPique
    @UnPetitPique7 ай бұрын

    Thank you for covering this sensibly.

  • @salmanuel4053
    @salmanuel40537 ай бұрын

    An unusually thoughtful and well-rounded presentation, an A+!

  • @norb6492
    @norb64927 ай бұрын

    Yeah. Can't get it for my my diabetes now, which is what Ozempic was created for.

  • @sandalcandal3696
    @sandalcandal36967 ай бұрын

    Thanks for the excellent research and video as always Sabine! Some of my notes/take aways from this video: -semaglutide usage also improves cardiovascular health -injected form is much more convenient and more effective than pill form -study (potential conflict of interest present) of 2000 participants, ~12% more weight loss than placebo with same diet and exercise after 68 weeks. Placebo only lost 2.4% of their baseline weight (vs 15%) -Tirsepatide, similar drug with potentially higher weight loss (21%) higher side effects -Side effects *nausea *vomiting *diarrhoea *misc other gastro-intestinal issues -Long term side effects (further study required) *Panreatic cancer *Thyroid cancer *retina damage *self-harm *tolerance to semaglutide -Withdrawal results in weight return *back to baseline for placebo vs -6% of baseline for treated group -Blood pressure also returned to nearly pre treatment levels (control group had minimal change over full period) -High amount of muscle mass lost vs recommended ratio *other similar class drug could be better. Study with Retatrutide showed better fat to lean mass loss ratio -Expensive *cost greater than $1000 per month in the US *Some state medicare and private insurance covers the cost *US national medicare not allowed to cover weight loss drugs *Costs of obesity could outweigh costs of semaglutide and similar class drugs *Costs in other countries is much lower (~70% less than cost in US) -Success due to hunger suppression indicates weight issues are primarily due to unhealthy appetite in overweight individuals *lets people "cheat" instead of having discipline to diet and exercise -Negative impact on body positivity movement -Sabine's opinion: Overall a good development

  • @DavidCodyPeppers.

    @DavidCodyPeppers.

    7 ай бұрын

    You are a drug rep Peace! \o/

  • @sandalcandal3696

    @sandalcandal3696

    7 ай бұрын

    @@DavidCodyPeppers. wuht? 😂

  • @DavidCodyPeppers.

    @DavidCodyPeppers.

    7 ай бұрын

    @@sandalcandal3696 I will type slowly and use small words. You. Work. For. Drug. Company. Peace! \o/

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    There is no evidence that semaglutide causes cancer of any type. There was a study a long time ago that GLP-1 drugs caused thyroid cancer in rats and mice, but none of the human trials over several years involving tens of thousands of people showed any thyroid cancer. Still, because it was reported in rats and mice, it has to be listed as a black box warning. There are listed contra-indications for those with pancreatitis, but not pancreatic cancer. Side effects are usually mild and temporary for most people, and that's true for any drug. Nor is there any evidence that it damages the retina. Some people already had retinal damage because of diabetes when they took the drug. Suicidal ideation was real but around 1 percent compared to placebo, and many drugs have similar warnings about s.i., not just semaglutide. Definitely a good development, and I think Ms. Hossenfelder is actually understating just how game changing these drugs are.

  • @SabineHossenfelder

    @SabineHossenfelder

    7 ай бұрын

    Excellent summary, you pass with an A+ 😏

  • @junxiong4385
    @junxiong43857 ай бұрын

    I love your videos! Do consider making a video on Chiropractic practices :) would love to hear your thoughts and the research/theory behind it

  • @thomasgraven8067
    @thomasgraven80677 ай бұрын

    Thank you for this post. Much appreciate your perspective.

  • @matthewk9563
    @matthewk95637 ай бұрын

    I just asked my VA care manager about this yesterday. Going to do the MOVE program through VA to see if I can get Wegovy. Since my disability leaves me with little energy to burn enough calories via exercise. I am hoping that this can help my 15% weight gain post injury

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    If you can deal with the minor side effects, it should help you lose weight. It slows down digestion, so you'll feel full a lot longer and it makes it easier to stick to a diet.

  • @WelcomeToDERPLAND
    @WelcomeToDERPLAND7 ай бұрын

    Yes, but whats going to be the side effects and long term effects?

  • @SabineHossenfelder

    @SabineHossenfelder

    7 ай бұрын

    Exactly!

  • @Fiercesoulking

    @Fiercesoulking

    7 ай бұрын

    As someone who takes this stuff for diabetes type II for over 3 years. The biggest side effect is the mental effect like the video says it calms you down. As an autist I have problems of being over stimulated which won't let me focus on stuff which I choose myself . Overtime it went to a manageable level with Ozempic. For normal people this is maybe too much. Other then this for diabetes type II I doubt it because we lost(a lot) our GLP-1 production from our stomach . The whole result is the result of backtracking what part of the body "breaks first" which leads to diabetes type II.

  • @Amenti_H

    @Amenti_H

    7 ай бұрын

    Check the current lawsuit about Ozempic caused stomach paralysis.

  • @Underestimated37

    @Underestimated37

    7 ай бұрын

    @@Fiercesoulkingthat’s something I haven’t heard of before, as an autistic person with physical disabilities making it difficult to lose weight who is considering this as an option once the shortages disappear that adds an additional potential plus to the option, as I’ve been fighting that for ages unsuccessfully too.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    @@Amenti_H It doesn't cause stomach paralysis, as ambulance chasing lawyers claim. It MIMICS some of the symptoms (it was designed to do that), but chronic stomach paralysis is caused by nerve damage to the stomach, or viral infections.

  • @xlerb2286
    @xlerb22867 ай бұрын

    I had a relative that struggled with weight management for years. He ate a good diet, exercised, did NOT snack, etc. but he could not lose weight, and he wasn't just a _little bit_ overweight. I wonder if this would have helped him. Plenty of people have 100% legit weight loss issues. I also know a few folk that all they need is to put down the bag of chips and get off the couch.

  • @ohauss
    @ohauss7 ай бұрын

    As long as supplies are as limited as they are, these really should not be used off-label. Their key use is to reduce weight of those whose physical conditions simply doesn't allow them to exercise, especially when their heart is already weak, and those with diabetes whose metabolism cannot be properly dialed in by other means.

  • @ygursivad9921
    @ygursivad99217 ай бұрын

    Good morning!!!

  • @micah1337
    @micah13377 ай бұрын

    Part of me worries about widespread use of the drug in or is it just that many who suffer from symptoms of diabetes or other metabolism issues

  • @khosrofakhreddini7824
    @khosrofakhreddini78247 ай бұрын

    Ciao Sa, very good and informative clip. Thanks a lot.

  • @KeithCooper-Albuquerque
    @KeithCooper-Albuquerque7 ай бұрын

    My doctor put me on Ozempic for pre-diabetes. I lost weight, but the nausea was unbearable for me. I finally quit taking it after a month. I'm glad it works for most people. I hope the price comes down soon.

  • @herculesrockefeller8969
    @herculesrockefeller89697 ай бұрын

    Thank you, Sabine, I had only seen references to Ozempic, I never knew what it was all about, until your video.

  • @kurbads74
    @kurbads747 ай бұрын

    I just had a dream. Sabine received a Nobel prize for discovering a dot. Sabine managed to prove that the dot had its own existence outside perception. Happy Pumpkin!

  • @SabineHossenfelder

    @SabineHossenfelder

    7 ай бұрын

    I'll try to live up to that

  • @polyblank73

    @polyblank73

    7 ай бұрын

    Huh. i had a dream about her too like two days ago. I was at a lecture where she was lecturing in analog gravity models. That was it, no weird dream stuff. Just a physics lecture.

  • @CAThompson

    @CAThompson

    7 ай бұрын

    ​@@polyblank73Did she make any sense insofar as dreams tend to go? Maybe you've discovered something yourself.

  • @stacielivinthedream8510

    @stacielivinthedream8510

    7 ай бұрын

    😂😂😂

  • @polyblank73

    @polyblank73

    7 ай бұрын

    @@CAThompson I feel like she did, yeah, but 1. I'm not very educated in the field and 2. I don't really remember what she wrote. The only thing I remember is something about Bose-Einstein condensate, which would be fitting in a lecture on analog models of gravity.

  • @dux2372
    @dux23727 ай бұрын

    Most Americans do not know that there are no laws protecting them from bad overprocessed food. There are such laws in Europe.

  • @natepenn9112
    @natepenn91127 ай бұрын

    Id like to hear sabine speak to the alcohol and others addiction curing abilities of this drug.

  • @MCsCreations
    @MCsCreations7 ай бұрын

    Very, very interesting indeed! Thanks, Sabine!!! Well... I had to go through a surgery in 1992 (the option was death, so...). I had a tumor under the brain, between the 2 most important glands of the human body (which I don't remember the names in English, sorry). Either way, I started to need to take basically all hormones, as pills, injections and so on. I also lost field of view, but it's not important right now. The point is: I started to gain weight. I was 13 at the time and really thin. But in months I was big and heavy... I did everything you can think of: I changed my diet for a special one (that my mother used to buy frozen), I went to the gym everyday (except Sundays), did swimming 3x a week, even everything at the same time... And I kept gaining weight, it just didn't matter what. Fortunately, I don't have the issue anymore, because I did the stomach reduction surgery in 1999. Now that I started to cook (and I'm really good at it, a bit too much 😬) I lost even more weight. Go figure. Today I have 86kg (I am 1.85m tall), but I got to a bit over 140kg when I did the surgery. So... Yeah, there are people who could lose weight easily... But that’s not everyone, for sure. Anyway, stay safe there with your family! 🖖😊

  • @smkh2890

    @smkh2890

    7 ай бұрын

    "I didn't the stomach reduction surgery in 1999" ...did you or didn't you?

  • @MCsCreations

    @MCsCreations

    7 ай бұрын

    @@smkh2890 I did, sorry. Auto correct screwed me. 😬

  • @valerielhw
    @valerielhw7 ай бұрын

    17 years ago, I was determined to loss weight. I cut back some on food, but my main change was exercise. I walked or exercised an hour a day almost every day. Within a year, I lost 60 pounds. I kept doing it, and still walk or exercise around 45 minutes daily. I have KEPT most of the weight off. I feel that my approach is similar to how the new weight loss drugs work in that I know that the weight may come back if I ever stop this routine. But, I still think that it is a healthier option than taking weight-loss drugs. And it is certainly cheaper.

  • @HORNGEN4

    @HORNGEN4

    7 ай бұрын

    What you described is what our ancestors have done for millennia. Move a lot and eat whole foods. Don't snack. Done!

  • @ohauss

    @ohauss

    7 ай бұрын

    You're also completely missing the point of these drugs. There are many whose physical condition doesn't allow them to exercise. People suffering from heart failure who can barely walk for a few minutes. These drugs allow them to lose weight so their overall condition doesn't deteriorate further, which then, with some luck, may help them get into moderate exercise.

  • @HORNGEN4

    @HORNGEN4

    7 ай бұрын

    @@ohauss Of course, but you would never assume this based on the messaging in the relentless commercials and ads everywhere. It's clearly being pushed to those who struggle with basic healthy lifestyle decisions.

  • @valerielhw

    @valerielhw

    7 ай бұрын

    @@ohauss If you actually watched this video, that is not the group that was focused on. The host was instead discussing both ordinary people who are overweight, and celebrities.

  • @Ben-bs6qv
    @Ben-bs6qv7 ай бұрын

    Excellent explanation Sabine. I arrived knowing nothing, and left with enough knowledge to make a decision.

  • @nadiakent4082
    @nadiakent40827 ай бұрын

    Great video thank you. I’m so tired of doctors avoiding this just because they don’t like it. It is ludicrous to keep trying to keep recommending treatments that fail over 90% of the time instead of this medication.

  • @McSlobo
    @McSlobo7 ай бұрын

    Could help someone to switch to a more active lifestyle if weight is dropped first. Even a few kg can make a huge difference when using the body for what it is meant to be used.

  • @Munchausenification

    @Munchausenification

    7 ай бұрын

    that is an interest point as well. using it to further lose weight or atleast start it.

  • @abydosianchulac2

    @abydosianchulac2

    7 ай бұрын

    I could see it in the reverse, actually. I could see a program that requires 2-3 weeks of lifestyle changes first so that the body/mind doesn't associate them as strongly with the medication. That way going off the medication mightn't lead so directly to going off the full regimen.

  • @Graeme_Lastname
    @Graeme_Lastname7 ай бұрын

    In Australia and I can't get ozempic for diabetes as there have been way too many prescription give out for weight loss. I managed to loose weight, I stopped eating so much.

  • @psyringe5627
    @psyringe56277 ай бұрын

    I'm a type 1 diabetic who hardly puts on weight, but if I don't consciously control what I eat, my body gravitates toward demanding massive amounts of sweets and carbs in ever-increasing dosages. It honestly feels like an addiction, though I can't really compare, since I was never addicted to any (other) substance - I never even smoked a cigarette in my life, and I hate the taste of alcohol. Obviously, even though my weight stays at normal levels, eating mostly sweets makes my diabetes harder to control and also affects my health negatively on multiple other levels. Therefore, my physician gave me Ozempic. The drug was very efficient in removing any feeling of hunger or appetite, and it helped me to "reset" my eating habits and switch to a healthier very-low-carb diet pretty much immediately. I also lost 10kg of weight, and my HbA1c went from around 10 to less than 6 (basically that of a non-diabetic). However, I also experienced very annoying side effects: strong feelings of nausea after each weekly injection (especially at the beginning of the therapy), problems with my eyesight (constantly seeing colored "blobs" as if I had been blinded), and extreme constipation (as in, 3 weeks or more without any bowel movement). I almost never experience side effects with other drugs, so this was very unusual for me. I eventually stopped the therapy, and I now actually use the prospect of having to take Ozempic again as a motivation for not letting myself slide back into a condition where I would need to. Personally, with the side effects I was experiencing, I would never consider taking it for predominantly cosmetic reasons.

  • @Cat_Sterling
    @Cat_Sterling7 ай бұрын

    Cool idea with the quiz! I enjoyed taking it :D

  • @wisp666
    @wisp6667 ай бұрын

    Thank you for an excellent presentation, Sabine, as usual. Was thinking about trying semaglutide, but after that lean mass loss stat, I think not! 😂

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    If you exercise (weight training), it won't be a problem.

  • @SabineHossenfelder

    @SabineHossenfelder

    7 ай бұрын

    Yes indeed, that was a surprise finding. Really made me re-evaluate the whole thing.

  • @tommym1063
    @tommym10637 ай бұрын

    Oh you’ve cracked the 1mil Sabine, that’s nice! ❤️

  • @phred196
    @phred1967 ай бұрын

    I'm a fifty eight year old guy. I pay $260 a month for the pill form (Rybelsus). I've lost 48 pounds since start of spring. I'll deal with the problems of going off the drug when I'm in the healthy BMI zone. But I'd never have gotten as far as I am right now without it. For me, it WORKS. And I have a realistic chance of returning to a healthy weight I would not likely have seen otherwise. For me, it's worth it.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    Congratulations! Rybelsus doesn't work as well as the injectables but if you put in the effort, even the lower dose forms of semaglutide can work.

  • @zoulzopan

    @zoulzopan

    7 ай бұрын

    good for you, I hope the medicine has no adverse side effects and you live a healthy life.

  • @phred196

    @phred196

    7 ай бұрын

    @@VernCrisler I think it's one of those your mileage may vary situations. For me 48 lb is nothing to sneeze at.

  • @phred196

    @phred196

    7 ай бұрын

    @@zoulzopan I found it drastically reduced my Hunger. At the very beginning I had a bit of nausea until I learned that you had to take the pills exactly when and how they tell you. once I started scrupulously following the timing and dosages everything went great.

  • @CaptHollister
    @CaptHollister7 ай бұрын

    I'm diabetic and have been on 1mg Ozempic for several months. The problem with the popularity of this drug with non-diabetics is that I can no longer get the 1mg pens due to a shortage. Right now I can still get the 0.5mg which requires 2 injections. The side-effects are not great, btw. In Québec our provincial medicare covers the cost for me because I need it for therapeutic reasons and kidney failure limits the drugs I can take.

  • @k012957
    @k0129577 ай бұрын

    I've recently been prescribed Ozempic for T2 diabetes. I'm hoping that the weight loss can be maintained. Currently, my health insurance makes it roughly $17 out-of-pocket.

  • @Volkbrecht

    @Volkbrecht

    7 ай бұрын

    Weight loss generally can be maintained when you maintain your eating habits. I am struggling with my weight for quite a while now, because I'm unable to make healthy routines a permanent thing. But one thing I generally observe is that the weight never magically comes back. It usually happens because I pig out and stuff my face with things I know I should not eat or drink in these amounts. So maybe start a food and exercise diary while on the drug, then make sure that you don't allow yourself more than that when you quit it. That should do the trick.

  • @cravenmoore7778
    @cravenmoore77787 ай бұрын

    Sabine, excellent show as usual, good visual contrast. This topic is a sad commentary on today's society, once you think about it 🤔 Keep up the good work 👏 👍

  • @user-hm4jm1cy7m

    @user-hm4jm1cy7m

    7 ай бұрын

    Nothing more predatory than paid off gov officials in bed with pharmaceutical companies.

  • @NewGuyTcan

    @NewGuyTcan

    7 ай бұрын

    that's one way to look at it... there are also many positive effects of this drug for society, like lowering our carbon footprint and contributing to a greener and healthier planet.

  • @beastinshow2362

    @beastinshow2362

    7 ай бұрын

    Wholeheartedly agree, apparently the FDA:s more regulated by money than cancer risk though. The curve kinda looks like if 'rigor' and/or 'discipline' is applied to a proven method- I've lost and gained 40-50lbs through 5:2 and 'work days'- and well, unless medically appropriate this thing should just be shunned imo. Treating obesity via diabetes medicine for otherwise healthy? Nope, let's not. Take care.

  • @NunyaBidness-zr5mn
    @NunyaBidness-zr5mn5 ай бұрын

    I've taken it for about 8 months. Went from 214 lbs to 173. I feel great! Only side effect for me was a bit of constipation. I take a natural senna laxative when it's a problem.

  • @johnmckown1267
    @johnmckown12677 ай бұрын

    I use Ozempic, but for my diabetes. It is working great.

  • @JK_Vermont
    @JK_Vermont7 ай бұрын

    Me: runs to the cabinet to get a pack of Oreos to eat while I watch this video

  • @Meow_YT
    @Meow_YT7 ай бұрын

    As someone who's overweight (and has been severely overweight), and all the problems that come with it, the body-positive movement really annoys me. I don't care what others think about me, but my internal mental state does not like being overweight, and it remembers the times I struggled to get up stairs because of the weight, sat in a chair panting when doing nothing, cos I could barely breathe, stupidly high blood-pressure... so no the body "positive" creeps can just get lost. This drug has been the only thing that manages to prevent my binge-eating. I've tried will-power, I've tried group sessions, I've tried other drugs. My inability to control my eating comes from mental and neurological issues, that can't just be hand-waved away with a "try harder" attitude. On this drug, my desire to binge is almost non-existent, to the point of feeling sick if I look at food at the wrong time. So it's really helping me. Thanks for some info. on it, the issues, and possible future drugs that could be better.

  • @hotmetalslugs

    @hotmetalslugs

    7 ай бұрын

    That’s you. Others are severely affected by the senseless bullying and hate.

  • @oldcowbb

    @oldcowbb

    7 ай бұрын

    i'm sure the body positivity folks would just tell you you are being brainwashed by society

  • @mehill00

    @mehill00

    7 ай бұрын

    I love that people think body acceptance is in some way encouraging people to be fat. The world treats fat people so terribly and the health effects are so widespread, nobody who can do something about it will ever choose to be fat over being fit. Body position is about not shaming people. I don’t understand why anyone would be actually against it, unless they’re jerks who like to see people suffer needlessly.

  • @mikereid1195
    @mikereid11957 ай бұрын

    As a type2 diabetic prescribed with Trulicity (dulaglutide) I've unfortunately (?) not gotten any weight loss effects from it... I have many, MANY, *MANY* other ailments too, and it's also supposed to help somewhat for the heart issues I suffer from...but I *have* experienced my pharmacy not having my dosage in stock to do over-prescribing for off-label use...it's a pain in the rear, for sure, when those who do *not* need it, use it anyways and make it hard for those of us with an *actual* medical need.

  • @douglasheld
    @douglasheld7 ай бұрын

    13:11 I signed up with the ZOE research program, and in doing that I stopped the cycle of being hungry all the time, obsessed with food and overeating. It turns out to have been blood sugar spikes and deep crashes after most of my snacks and meals. The glucose crashes correlate with overeating for the following 2 days! So, I rearranged my diet to keep a steady blood sugar curve. The effect is I am no longer hungry, lost 5% of my body mass and feel more energetic. The only downside is I've given up a small number of my favourite foods, replacing them or sequencing them with more appropriate alternatives. I see the new approach - modifying the diet to reduce dietary inflammation - as a much more sustainable path away from metabolic syndrome than taking semaglutide for life.

  • @eljcd
    @eljcd7 ай бұрын

    Damn, this is really the dream pil... for the companies selling it

  • @a5cent

    @a5cent

    7 ай бұрын

    Yup, particularly in the US. A pack that lasts for a month will cost you $800. The same thing in Europe costs you $130.

  • @onogrirwin

    @onogrirwin

    7 ай бұрын

    @@a5cent Does it cost $130 because the government is subsidizing it? Pretty important detail.

  • @a5cent

    @a5cent

    7 ай бұрын

    @@onogrirwin No. Of course not. I'm not aware of any government program in the EU that subsidizes drugs. I'm surprised anyone still assumes US drug prices may be justified. Strange world.

  • @hermask815
    @hermask8157 ай бұрын

    If you have an ostomy and you experience diarrhoea form ozempic , stop instantly. Your water isn’t recycled in the intestines that even with high blood pressure you may end up with alarming low blood pressure from the dehydration. Happened to me and it had to go to the hospital. That stuff just isn’t for me.

  • @thebooksthelibrarian8530
    @thebooksthelibrarian85307 ай бұрын

    In Belgium there are also ristricitons on the use of Ozempic solely as an esthetic overweight remedy. For dangerous levels of obesitas it's still allowed.

  • @marc-andredesrosiers523
    @marc-andredesrosiers5237 ай бұрын

    good discussion

  • @Musix4me-Clarinet
    @Musix4me-Clarinet7 ай бұрын

    If they ever did come up with a drug to prevent _nonsense intake,_ I'd volunteer to pass it out at intersections like the homeless asking for money.

  • @shindousan
    @shindousan7 ай бұрын

    Great insights. I have struggled with weight my entire life and am considering Ozempic. Individual suffering is difficult to compare. I've seen people who have lost weight based on “willpower” alone, but for me, exercising and dieting negatively affects my performance at work (pain, fatigue and hunger cause loss of focus). There is scientific evidence that exposure of ancestors to famines increases the chance of obesity in subsequent generations through epigenetic changes. So society wrongly accuses overweight people of laziness while this is just an evolutionary adaptation (that probably worked quite well in pre-modern societies) linked to events that happened before they were born.

  • @Dead-Not-Sleeping

    @Dead-Not-Sleeping

    7 ай бұрын

    That sounds completely made up but I'm fine assuming it speaks to my utter lack of knowledge on the subject. I'll need to get back to you with either a mockingly derisive comment or an appreciative one for pointing me in an interesting direction for casual research. 😊

  • @bzuidgeest

    @bzuidgeest

    7 ай бұрын

    That is just bullshit and I'm not even talking about the epi genetic stuff. Exercise is something you need to stick with, yes it will cause muscle aches, that's normal if you didn't use them before. You need to get past that. Same for the hunger thing, with a proper diet you can eat smaller quantities all day, so you don't feel hungry ever. Change hurts and you just lack the will power. You are a prime example why this kind of drug should not be freely available. It's all an excuse to stuff more burgers. This might sound harsh to you, but drugs are not an answer for obesity. Find some proper guidance and will power, you'll be far better off than with a risky drug.

  • @lewisgann280

    @lewisgann280

    7 ай бұрын

    Pure copium. Eat less, move more. Quit making excuses and being a victim.

  • @Munchausenification

    @Munchausenification

    7 ай бұрын

    Something everyone can do and I personally do a lot is walking. Walk around at work, walk to buy groceries, cycle to work etc. I probably walk about 5-10 km a day (most of it at work) and cycle about 5-7 km. it probably ends up as effective as doing 40-50 min exercise on a daily basis. Then I just do a 2 min plank and 8 min of other exercise just to keep muscle mass in my upper body.

  • @Dead-Not-Sleeping

    @Dead-Not-Sleeping

    7 ай бұрын

    @@bzuidgeest a friend of mine is a doctor and he told me about a family that had to lock up the food up in the house due to the fact that their daughter would constantly eat, even getting up on the middle of the night and gorging herself. Going so far as to put locks on the fridge. Turns out she had a genetic condition that caused her to always feel absolutely famished. Her primary drive in life was simply food and more food. This is anecdotal obviously, but can you not imagine how it's at least possible that varying degrees of the problem could present in a portion of the population. At what point does it cease to be an issue of will power and become malady? I'm not arguing against the idea that some people simply want a quick, easy fix. I just think that absolutism is rarely going to offer any real insight and that it can easily fall short of understanding. The concept, not you personally 🙂

  • @injunsun
    @injunsun7 ай бұрын

    @SabineHossenfelder A couple other findings of note (you'd need to look up the sources): People taking Ozempic who drink alcohol or smoke cigs found themselves doing so less while taking it, so it is being explored as a possible ridding of addiction aid.

  • @onemoremisfit

    @onemoremisfit

    7 ай бұрын

    Ironically smokers since before I was born have been using the excuse "but if I quit I'll gain weight". I have also seen overweight young people, mostly women resort to smoking for weight control. My personal opinion of anti addiction drugs is it's bunk. Everybody wants a pill to fix their life. They even want a drug to make them stop taking some other drug. It's getting silly.

  • @Leon-in5qh
    @Leon-in5qh7 ай бұрын

    I am a Type II diabetic, I live in Australia. Despite the goverment regulation to limit Ozempic sales to people like myself, I have not been able to get the drug for over two months. My local pharmacist advised me that it will only be available again in late Dec 2023. This has not been the only time, I have not been able to access this treatment. A similar situation occurred in 2022, where Ozempic was unavailable for 6 months. I have now decided not to go back onto this drug even if it does become available again. I will have to try harder to regulate my blood glucose through diet and other drugs, which are more available. Very disappointing, as my blood glucose were very well controlled when I was on Ozempic.

  • @philosophy-of-science-and-law
    @philosophy-of-science-and-law7 ай бұрын

    "is it true that a person needs to be healthy to survive?" - yes

  • @deantrower7164
    @deantrower71647 ай бұрын

    It turned out in an earlier video, the other day, that antimatter falls down just like regular matter - i.e. It has normal, positive mass, and thus doesn't lend itself to cool stuff like creating anti-gravity or wormholes.. So now I'm wondering: What if we injected people with a *really-high-dose* coctail mixture of Semaglutide, Retatrutide, *and* Tirzepatide? You think there's a chance (assuming, naturally, that the effects are additive) that they might lose *more* than 100% of their body weight, attain a **negative** mass, and start exhibiting exotic anti-gravitational phenomena? 🤔

  • @itsworkinprogress
    @itsworkinprogress7 ай бұрын

    Thanks for the overview. I've been taking WeGovy since 6 weeks and have lost 13kg since. Before, although I'm living a mostly active and healthy lifestyle (okay, with phases of nerdiness and too much time at the desk), my body has always reacted to a lower intake of calories only with reduced energy levels to the point that I had problems getting out of the bed. Diets never worked, only an excessive amount of activity (3h+ per day), that does't really fit in a normal day of work. Hormonal issues (Hashimoto) have also played a role for me. With WeGovy a reduced calorie intake is - for the first time in my life - resulting in a reliable weight loss with okay-ish energy levels. I hope the side effects will not be too bad. The muscle reduction topic scares me a bit.

  • @schmetterling4477

    @schmetterling4477

    7 ай бұрын

    Your body will reduce muscle only because you don't need it any more for the same level of activity due to lower body mass. Nothing stops you from working out, though.

  • @itsworkinprogress

    @itsworkinprogress

    7 ай бұрын

    Sounds good, if this is the only reason! @@schmetterling4477

  • @BlackMambo
    @BlackMambo7 ай бұрын

    Dr. Sabine, you're a Goddess of Science. You just don't forget how awesome you are! 👍🏽👍🏽👍🏽👍🏽👍🏽👍🏽

  • @celadon2048
    @celadon20487 ай бұрын

    Good content. I wonder how it would go if someone took the drug at the same time as steroids to offset the muscle loss.

  • @Dead-Not-Sleeping

    @Dead-Not-Sleeping

    7 ай бұрын

    Since your body does decrease hormone production as a result of steroids, semi permanently (I Believe), It could lead to a permanent requirement to supplement. Again, I THINK that is the case but happy to be informed otherwise.

  • @VernCrisler

    @VernCrisler

    7 ай бұрын

    You don't need to take anabolic steroids to offset muscle loss. Simply do weight resistance training and that will stop the muscle loss. Steroids (the anabolic kind) mess up just about everything in the long run, which is why steroid abusing bodybuilders are dying before 50 years old.

  • @celadon2048

    @celadon2048

    7 ай бұрын

    @@VernCrisler Per the video, those who lifted weights still lost more muscle than they should. Also I've heard it's safe to use some steroids/PEDs with the right regimen--it's just that you pretty much need an expert to find the right regimen for yourself.

  • @zwerko
    @zwerko7 ай бұрын

    As someone who went through 'quitting excessive food intake' cold turkey and a grueling workout regime in order to bring myself bellow the obesity level - twice! - I've no ounce of jealousy for the ones taking the 'ozempic shortcut'. Just because I 'suffered' doesn't mean that others should if there is an easier way out. All power to them! The goal is to eradicate obesity-related illnesses, not to gloat just because I happen to be more strong-willed at one particular area than somebody else.

  • @Puzzlesocks

    @Puzzlesocks

    7 ай бұрын

    I would argue if taking the low-effort is actually the easier way. It doesn't seem like it does anything to tackle the root at the problem. Sure you take a drug to lose weight, but you still lack healthy musculature, probably have vitamin deficiencies, among all sorts of other side problems that stem from that. Is that better than being overweight? I'm not so sure. Research from rapid weight loss literature shows that losing the weight quickly can result in many of the same issues that being overweight cause, such as heart problems, joint problems, etc. Basically, people think being fat is the problem to be solved, when the real problem to be solved is the collective actions that led them to be fat in the first place. I think this drug should probably be a last resort.

  • @Concordeagle
    @Concordeagle7 ай бұрын

    I’m buying Novonordisk stock!

  • @Meditation409
    @Meditation4097 ай бұрын

    Sabine for President ❤💕🙏🙏

  • @Thomas-gk42

    @Thomas-gk42

    7 ай бұрын

    agrreed

  • @EliseSecond
    @EliseSecond7 ай бұрын

    My mum has diabetes 2 for over 25 years. (She was not overweight when she got it.) She was on an insulin pump for years because her blood sugar was unstable and still had problems with her blood sugar levels regularly. They started her on Ozempic a year ago and it worked miracles. It maddens me that people use it to lose some pounds. The medicine is not made for that. The shortages can damage the health of people who actually need it for what it is made for.

  • @fffUUUUUU

    @fffUUUUUU

    7 ай бұрын

    So you want everything for you and yo mama, but refuse the right for good life to the other people.

  • @fffUUUUUU

    @fffUUUUUU

    7 ай бұрын

    І hope u'ІІ гот іп неІІ

  • @EliseSecond

    @EliseSecond

    7 ай бұрын

    Lol troll

  • @DanishValkyrie

    @DanishValkyrie

    7 ай бұрын

    @@fffUUUUUU russian troll spotted

  • @marknovak6498
    @marknovak64987 ай бұрын

    It sounds like there may be more negative consequences than the loss of muscle mass. Been on this news ride before.

  • @noahway13
    @noahway137 ай бұрын

    I don't need any chemical crutches, or gimmicks to lose weight. I just buckle down and get serious with my diet. My self discipline seemed to get much stronger about two years ago, or so... maybe it was a year and a half? OK, it was 20 months ago, I remember because it happened right after my gastric-bypass surgery.

  • @judcooley1279
    @judcooley12797 ай бұрын

    Very interesting and, as always, thorough and understandable. Thank you. I have been hearing that there is a deeper implication for GLP-1 analogues in affecting many types of addiction behaviors. And I use that term loosely, I imagine that there is a spectrum of compulsivity to our behaviors. The speculation that I have heard is that this class of drugs may yield chemical therapies for behaviors such as smoking, gambling or sex addiction, alcoholism, etc. Do you believe that there is any merit to this speculation? Thank you.

  • @stefanfyhn4668
    @stefanfyhn46687 ай бұрын

    Ironically, Denmark has a severe lack of Ozempic as well. It's difficult to get enough for a standard treatment, even though our doctors love to prescribe it. I wonder how much money the doctors are paid to push these drugs to diabetes patients. Maybe you can do a video on that ;)

  • @petermcguire8565

    @petermcguire8565

    7 ай бұрын

    Kickbacks for drug prescriptions are illegal in the USA, I would be surprised if that wasn't the case in Denmark?

  • @meibing4912

    @meibing4912

    7 ай бұрын

    It is and it’s highly checked due to the strict registration when it comes to prescriptions in Denmark. @@petermcguire8565

  • @Volkbrecht

    @Volkbrecht

    7 ай бұрын

    @@petermcguire8565 Just because something is illegal that doesn't mean it doesn't happen. It just has to be shaped in an inconspicous way. I used to work for a German pharmaceutical company and got a little insight into how that works. You pay doctors to act as experts in certain functions, say, as speakers on private conferences or as consultants. All you have to do is avoid a paper trail that connects the money to the prescription numbers. But I suspect that in the case of Ozempic that isn't even necessary. The stuff works. Any doctor who sees a patient with a chronic weight problem will want to prescribe that drug from the sheer goodness of their hearts.

  • @MetalheadAndNerd
    @MetalheadAndNerd7 ай бұрын

    Wow, now I need my favorite fitness youtubers to talk about quantum physics. 😅

  • @CAThompson

    @CAThompson

    7 ай бұрын

    Some of these physicists look pretty fit, either through luck or effort.

  • @fannyalbi9040

    @fannyalbi9040

    7 ай бұрын

    ya and vice versa

  • @dashriprock592
    @dashriprock5927 ай бұрын

    I just thrown out 7 of the 12 ozempic boxes I stopped using it even though I requested that pharmacy stop sending me ozempic no one has I told my doctor I had over 15 boxes in my refrigerator and I started throwing them away. The pharmacy won't take them back. I will try again to stop receiving the prescription

  • @hiphopgeeks
    @hiphopgeeks7 ай бұрын

    I'm a type 2 diabetic and all the weight loss patients are making it hard to get. I hope it gets more widely available.

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