Nobel Prize Winners Dr. Katalin Karikó and Dr. Drew Weissman | The Story Behind mRNA Vaccines

Ғылым және технология

This is the story of how Nobel Prize winning scientists Katalin Karikó and Drew Weissman became mRNA vaccine pioneers, helped develop the first COVID vaccines, and are changing the future of medicine.
For years, Katalin Karikó, PhD and Drew Weissman, MD, PhD worked in their Penn Medicine lab, trying to figure out what made mRNA so inflammatory. They did experiment after experiment, examined the data, and refined their approach based on the results. Then in 2005, they discovered the solution they were searching for: By encapsulating the mRNA in a certain lipid, it prevented inflammation and allowed the fragile mRNA to go to work without interference.
When the COVID-19 pandemic hit, it propelled Karikó and Weissman’s mRNA technology into the mainstream, where it became the foundation for two COVID vaccines. The critical discovery and success of the COVID vaccines kicked off a flurry of mRNA vaccine research, had has led to the development of vaccines for conditions like HIV, herpes, sickle cell anemia, influenza, peanut allergies, and even cancer.
Karikó and Weissman have received the world’s most prestigious awards for their discovery, including the Lasker-DeBakey Clinical Medical Research Award, the Breakthrough Prize and the Albany Medical Center Prize in Medicine and Biomedical Research.
Learn more about mRNA vaccine history and breakthroughs at Penn: www.pennmedicine.org/mrna
#nobelprize #mRNA #mRNAVaccine #COVIDvaccine #PfizerVaccine #ModernaVaccine #pennmedicine
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Пікірлер: 151

  • @Ksaw32
    @Ksaw328 ай бұрын

    Incredible congratulations to Dr. Karikó who was demoted by Penn for not winning enough grants but persevered through their short sightedness. She is a true inspiration.

  • @vecernicek2

    @vecernicek2

    7 ай бұрын

    Grants are often a lottery

  • @cherrybeach01
    @cherrybeach017 ай бұрын

    When Dr. Kariko said, " To be a sceintist is a joy.", that brought tears in my eyes.

  • @naytewilson

    @naytewilson

    11 күн бұрын

    It sucks there are so many people who act as if they’re more intelligent than them and downplay their success.

  • 7 ай бұрын

    Thank you Dra. Katalin and Dr. Drew, in name of humanity and health care workers. Congratulations!!!

  • @kapildev4738
    @kapildev47387 ай бұрын

    Actually they deserved more than Novel Prize. Saving millions lives in a hopeless condition such a phenomenal human wellfare act. An act towards humanity services through your sacrifices, endless efforts, and dediction are greatly appreciated more and more ...God bless you both and wish you all best for your future endeavors. A big salute to both of you!

  • @untergehermuc

    @untergehermuc

    24 күн бұрын

    There not „more“ than the Nobel price.

  • @Ashishkumar-id1nn
    @Ashishkumar-id1nn7 ай бұрын

    I love this statement "To be a scientist is a joy". Wonderful work!!!

  • @zoltanczudar5886
    @zoltanczudar58867 ай бұрын

    I feel so proud of her.

  • @lucyaudrey733
    @lucyaudrey7334 ай бұрын

    the kind of people that inspire me. I am close to tears because I can imagine how difficult it was, the late nights, the fails but then when you do something you love it fuels you each time

  • @mbbsboi7248
    @mbbsboi72487 ай бұрын

    I cannot imagine the dedication and effort put in, bravo and congratulations!

  • @marymushinsky6291
    @marymushinsky62917 ай бұрын

    Penn may not have appreciated Dr. Kariko, but we do, as well as your colleague Dr. Weissman!

  • @Bullet-007
    @Bullet-0077 ай бұрын

    i want to teach my kids about science, friendship and perseverance for 27+ years. what better way to do it than with this video

  • @dr.ejazkhan7227
    @dr.ejazkhan72277 ай бұрын

    I loved the energy of Dr. kariko. 😊 Thank you to the government, universities and scientific community and last but not least, the people, that still fund us to find everyday new in science. Dr. Ejaz Khan

  • @alainaaugust1932
    @alainaaugust19327 ай бұрын

    Dr. K and Dr. W, thank you, thank you, thank you. The Nobel Prize is not nearly enough. I pray some billionaires grant millions to your institutes, to your work, to your training young scientists to extend your work for humanity. May heaven give you brilliant angels in abundance to inspire your minds. From heaven only is a reward commensurate with what you’ve done for humanity possible. Blessings.

  • @qd4051
    @qd40517 ай бұрын

    Thank you for helping humanity with your work!

  • @TubeYouTakashi
    @TubeYouTakashi7 ай бұрын

    Amazing & will respect your work. Dr. Katalin Karikó and Dr. Drew Weissman.

  • @ichinichi2009
    @ichinichi20097 ай бұрын

    Thank you for all your hard work. You're both a blessing to the world. May all your endeavors succeed as well 👏👏

  • @moonlitSapphire3691
    @moonlitSapphire36917 ай бұрын

    Thank you so much both of you❤.

  • @sreeram483
    @sreeram4837 ай бұрын

    Scope of observation from A to B in paths of deviations between sound journey vs light energy along with mechanical energy calculations is a great study Mam

  • @cosmicwarriorx1
    @cosmicwarriorx17 ай бұрын

    Congratulations 🎉 and thanks you to both.

  • @katherandefy
    @katherandefy7 ай бұрын

    This made me tear up. Thank you to both❤

  • @nasrulhoda7331
    @nasrulhoda73318 ай бұрын

    Pressure of Extramural Funding on every scientists by the institutes is indeed a “death valley” for good science and good scientists in the USA. I see it now as an alarming sign of the dark side of future good quality science in the USA.

  • @TON-vz3pe
    @TON-vz3pe7 ай бұрын

    This is the pinnacle of being a human being.

  • @angelinasouren
    @angelinasouren7 ай бұрын

    Ha! So enjoyable ! Congratulations to both of you. I think that people who believe that there's something seriously wrong with you (not said as a joke, but seriously) if you are still up at 2 or 3, working on something, need a mental health checkup. One of the most hurtful or insulting things ever said to me was about the fact that I sent someone a mail or left voicemail or whatever in the middle of the night because I was working on something. I didn't expect the other person to be up but I didn't expect people to make a major fuss out of it either. They didn't accuse me of anything but they seemed to have made a major fuss about it. That's insane. I think it had something to do with physical chemistry; it was a long time ago and I've forgotten the details but the flabbergasted feelings remain. If you don't want anyone who's driven, then don't hire someone who's clearly highly driven. End of. I wish that I had simply said in response that at the time.

  • @evamagyari6113
    @evamagyari61136 ай бұрын

    Thank you so very much to both of you! i don't think we know the hole affect of your dedication!! Thank you again!

  • @dentoncaballero9465
    @dentoncaballero94657 ай бұрын

    A MILLION THANK YOU Sir and Ma'am.

  • @peterrice365
    @peterrice3657 ай бұрын

    Just a big thank you, may your future research be successful.

  • @lenapham9377
    @lenapham93777 ай бұрын

    Admirable, truly grateful!

  • @xieluyanlouise4327
    @xieluyanlouise43277 ай бұрын

    Incredible congratulations to Dr. Kariko. I'm so proud of you

  • @richardong5501
    @richardong55016 ай бұрын

    Thank you, Dr. Katalin and Dr. Drew!!! Without your prior work in mRNA vaccines, we would not have been able to develop a vaccine for COVID-19 in a mere 2 years, and have saved a countless number of lives not just in America, but across the world! These people are incredible and the timing of when they finished their work in creating mRNA vaccines was SPOT ON. Years and years of work and clinical trials, and when COVID-19 broke out into the world, they already had the tools and ideas necessary to develop a COVID vaccine in 2 years. Incredible job, guys! You deserve this Nobel Peace Prize! 🎉

  • @SreejithSathyan-pp9cw
    @SreejithSathyan-pp9cw2 ай бұрын

    Such a big inspiration to see them talk. Thank you to them , god bless them 😊😊😊

  • @user-jm3ub4ny9i
    @user-jm3ub4ny9i7 ай бұрын

    Congratulations both of you ❤❤❤

  • @user-nx1jk3ym4l
    @user-nx1jk3ym4l7 ай бұрын

    This is incredible and truly motivating...

  • @atropine7574
    @atropine75747 ай бұрын

    Thank you doc🎉

  • @minad3643
    @minad3643Ай бұрын

    Thank you❤

  • @Mikupigeon
    @Mikupigeon7 ай бұрын

    Just bloody awesome!

  • @DP52879
    @DP528792 ай бұрын

    I forget who the Nobel Prize winner that I heard saying that often scientists do not do research with the intention of helping others in mind. They are simply driven by their curiosity. So I am amazed that our genuine curiosity serves goods for our race.

  • @loiruckgodwin2372
    @loiruckgodwin2372Ай бұрын

    Thank you for all your amazing work

  • @saifurrahman6453
    @saifurrahman64537 ай бұрын

    Thank you. We are blessed to have 'angels' amongst us, still. Their humility is amazing.

  • @AbhishekKumar-rw9iy
    @AbhishekKumar-rw9iy7 ай бұрын

    Our real superheros❤ love from India 🇮🇳❤

  • @sanaamazhar5398
    @sanaamazhar53987 ай бұрын

    My hero!!! Both of you!! You guys inspire me!!!

  • @Cgv69
    @Cgv697 ай бұрын

    Congratulations to both of you.

  • @kxwx2682
    @kxwx26827 ай бұрын

    Thank you Dr. Kariko and Dr. Weissman

  • @jorgesilva6675
    @jorgesilva66757 ай бұрын

    Katalin e Drew, muito obrigado pelo seu trabalho. Espero que vocês continuem nesta emocionantes busca pela vida. Talvez na eternidade vocês tenham a capacidade de entender a grandiosidade de sua obra, quando as vidas salvas podem ser contadas em milhões. Que toda a luz divina possa afugentar a escuridão da ignorância, que a capacidade de entendimento tenha o caráter da humildade do recomeço e aprimoramento constante. Escrevo do Brasil, meu país sofreu muito e posso garantir que se hoje eu voltei ao meu cotidiano trabalho, foi graças ao trabalho de seres humanos com vocês. Muito obrigado.

  • @specialforce8486
    @specialforce84867 ай бұрын

    Two great minds making a great change. Find your other half.✍️🧠

  • @tfla10
    @tfla107 ай бұрын

    Two incredible human beings! You not only made history but both of you became immortal! BRAVO!

  • @nattawatkantitham3791
    @nattawatkantitham37917 ай бұрын

    🤍All the best and million thanks for your endless dedication to save lives for humanity, you save the world. Utmostly, you are deserved to recognise for this medicine discovery of Nobel Prize, Congratulations.

  • @JorgeRamos-xw6dy
    @JorgeRamos-xw6dy7 ай бұрын

    Katalin and Drew, Thank you for your commitment and passion.

  • @KumarKumar-fn4sx
    @KumarKumar-fn4sx7 ай бұрын

    I now my head to your exemplary work for the well-being of the mankind. May god’s blessings keep you healthy and joyful and your life becomes a celebration

  • @Sagnikmay1
    @Sagnikmay17 ай бұрын

    Life should be like this, or nothing!

  • @katalinszabo9655
    @katalinszabo96557 ай бұрын

    Incredibly proud of Karikó Katalin, as a Hungarian, makes me so fuckin’ proud of my country

  • @zsofiahermann6525

    @zsofiahermann6525

    7 ай бұрын

  • @nathalieplum2137
    @nathalieplum21378 ай бұрын

    I've been rooting for them for the Nobel even before the pandemic. So very deserve, they've opened up a new world of prevention and treaments. Thank you Dr. Katalin Karikó and Dr. Drew Weissman 👏👏👏

  • @user-rg3eu8lk4j
    @user-rg3eu8lk4j3 ай бұрын

    One of the few scientist who inspires me to do quality science 😊 . Many people do science, publish results and they forget about it. But some scientists just stick to one thought and an idea.

  • @CarolR-uy6jc
    @CarolR-uy6jc7 ай бұрын

    Much congratulations. I love her positive spark.

  • @artivalys
    @artivalys5 ай бұрын

    Congratulations Dr Kariko and Dr Weissman and many thanks from World

  • @nancychauhan1188
    @nancychauhan11887 ай бұрын

    To see such passion! ❤

  • @xiechenyue
    @xiechenyue7 ай бұрын

    amazing work, amazing story

  • @fekadufeye1379
    @fekadufeye13797 ай бұрын

    Congratulations you made history by saving millions life from catastrophic death.

  • @zoologyngshindekjs7376
    @zoologyngshindekjs73767 ай бұрын

    Thanks Dr. Katalin & Dr. Drew for Extraordinary work for Humanity & mankind🙏🙏🙏

  • @tateyawitz9191
    @tateyawitz91917 ай бұрын

    They are international heroes!

  • @mariadelrosariovillanueva8716
    @mariadelrosariovillanueva87168 ай бұрын

    You are both amazing!! Thank you for all the sacrifices that you have both made to make these discoveries possible. Wishing you continued success in making a difference in the world. Thank you.

  • @JonathanXLindqviust
    @JonathanXLindqviust7 ай бұрын

    For anyone who is caught up in the whole "anti"-vaccine political bid, I hope you can look up what it is really about. The proteins, the way they managed to use RNA to recode (faster than usual vaccines that requires us to wait for our body to react to a foreign thing and THEN create the same recode) is fascinating. It has saved literal millions, but I am more hopeful for the future.

  • @sushilapatel2127
    @sushilapatel21277 ай бұрын

    Proud of her!!

  • @evaszeibert4888
    @evaszeibert48888 ай бұрын

    Gratulalok buszke vagyok hogy ilyen tehetseges emberek szuletnek magyarorszagon...vagy kulhonban..

  • @BadAss_691
    @BadAss_6917 ай бұрын

    Without having a cracked mind ( different mind) amd this level of passion, you don’t achieve these monumental feats

  • @lorill2631
    @lorill26318 ай бұрын

    Congratulations on your massive success ❤ you deserve kudos from the world! Literally saving millions of lives! And yes, the impact of future vaccines 🎉 because of mRNA is so powerful.

  • @esragbilir
    @esragbilir7 ай бұрын

    She is INCREDIBLE 🌌

  • @saftheartist6137
    @saftheartist61374 ай бұрын

    Utterly Incredible 😳😮

  • @Betterworldforyou.
    @Betterworldforyou.7 ай бұрын

    Thank you . Your dedication and hardworking has proven to the world that it is worth. We can enjoy now mask free world. Thank you God Bless you two.

  • @thiruGajanan
    @thiruGajanan7 ай бұрын

    Friendship goals!

  • @lindacoffin5110
    @lindacoffin51107 ай бұрын

    Joy to the world!

  • @petalsoflife
    @petalsoflife7 ай бұрын

    Congratulations👍🏼

  • @yash1071
    @yash10717 ай бұрын

    I clapped for you in my room. Thank a lot.

  • @sahinmondal8691
    @sahinmondal86917 ай бұрын

    Inspiring ❤❤

  • @KK52930
    @KK529307 ай бұрын

    Congratulations

  • @francescaaiello9427
    @francescaaiello94277 ай бұрын

    GOD BLESSED people.

  • @sreeram483
    @sreeram4837 ай бұрын

    Mam mRNA with response to sense alteration is a great study however the other effects need to be more inclined to personal level, how well can it be achieved with a gamble of cash running to take a spot either via any chance?

  • @MichaelWlliamRay
    @MichaelWlliamRay7 ай бұрын

    Awesome video!

  • @blinoldluv
    @blinoldluv7 ай бұрын

    Can't help laughing reading many sarcastic comments.

  • @Mau365PP
    @Mau365PP7 ай бұрын

    Too bad the research for the real problem is not getting the real funding and recognizion: LONG COVID

  • @TheSamonex
    @TheSamonex7 ай бұрын

    Greatest mind ever !

  • @sabrinams2325
    @sabrinams23257 ай бұрын

    😭😭😭😭😭I really wanne be a scientist like you

  • @smestartup8561
    @smestartup85617 ай бұрын

    You are a team of heroes. pan-Corona Viraus Vaccine, sickle cell anemia gene therapy, Malaria, Leptospirosis, Vaccines for peanut allergies

  • @milleniumgenesis
    @milleniumgenesis7 ай бұрын

    Felicitaciones a los Pioneros. Genios entre los genios. La humildad de la ciencia es ante todo, asumir que es divertida, muy divertida.

  • @Real_G077
    @Real_G0777 ай бұрын

    Leptospirosis, Let Goooooo. Love from Thailand.

  • @MossyMozart
    @MossyMozart7 ай бұрын

    Enthusiastic congratulations to both of these geniuses! They have already been an enormous boon to humankind. It was not trump that created the COVID-19 vaccine possible - it was these two people. To have such scientists in our midst is a joy. Big applause!

  • @chayonsaha3465
    @chayonsaha34657 ай бұрын

    Love ❤🎉 for both of them.

  • @helloworld-ow9tf
    @helloworld-ow9tf7 ай бұрын

    I like how she describes it as "an exciting crime story" at 4:13

  • @suryarp
    @suryarp8 ай бұрын

    It almost sounds like a movie. So heroic and inspiring! What an impact these relentless, dedicated, humble scientists have made to the world! May these Nobel laureates inspire generations of people take up sc ience as their careers!

  • @shankarbalakrishnan2360
    @shankarbalakrishnan236015 күн бұрын

    Working at 2 or 3 in the morning❤❤🎉🎉

  • @user-ek5ut6ib4m
    @user-ek5ut6ib4m2 ай бұрын

    Are you familiar with Acemannan?

  • @camillekissoonmohammed8664
    @camillekissoonmohammed86648 ай бұрын

    👍 She did it !!!!!!!!!!!!!!!!!!!

  • @alhaeri1

    @alhaeri1

    8 ай бұрын

    they did it

  • @camillekissoonmohammed8664

    @camillekissoonmohammed8664

    7 ай бұрын

    Oh, now that is exactly why, "she" did it !!!!!!!!!!!!!!!!!!! 👍

  • @whatsmyusername1231
    @whatsmyusername12317 ай бұрын

    I can't imagine what they feel like, coming as close to saving humanity as possible these days. Good work folks!

  • @tuando-ed9ud
    @tuando-ed9ud8 ай бұрын

    Thank you so much. Your intellectual is a gift of humanity.

  • @vihanduovin8386
    @vihanduovin83863 ай бұрын

    ❤❤🙏

  • @farmasinema
    @farmasinema8 ай бұрын

    Thank you.

  • @michaelbidu9278
    @michaelbidu92788 ай бұрын

    Great story of two great people. It's hard, hard work but in the end it has to be fun. And, being a scientist must be a JOY! Congratulations to both for 2023 The Nobel Prize for Physiology or Medicine. Well deserved!

  • @priyanktripathi7665
    @priyanktripathi76658 ай бұрын

    Congratulations both of you..and your whole team...🎉

  • @VIKASVERMA-nk8uw
    @VIKASVERMA-nk8uw7 ай бұрын

    Real God thank u very much for saving all of us

  • @notsojigglyanymore
    @notsojigglyanymore7 ай бұрын

    he kind of looks like Gru from despicable me😅

  • @vineetasinghverma7505
    @vineetasinghverma75057 ай бұрын

    Absolutely yes! Gene Therapy ! Vaccination is the first step towards gene therapy!

  • @solapowsj25
    @solapowsj257 ай бұрын

    Now and then, we pass a milestone: Dr. Edward Jenner. 😊

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