Cool video Lance. You're right, my point in my video was that not everyone needs NR/NMN. A great diet, exercise, periods of safe fasting, and ideally a way to remove senescent cells (fisetin & quercetin appear promising) in my opinion come first to look after NAD+ levels. As I get older (mid to late 30s) I'll probably need to further support my NAD+ levels, at which point I'll restart NR/NMN. So overall, my strategy is to address the reasons why NAD+ goes down in the first place, and once that's not enough, add NR/NMN to the mix

@catman4471

3 жыл бұрын

I was keen on your videos but realised that you've never been a great supporter of NMN. I'm 59 and have been taking it for around 9 months now and I can't even begin to tell you the amazing results I've experienced. I get that you've got a doctors approach but sometimes I think you need to look at the actual benfits people have been getting from this, and I think you're too young to notice any results yourself. From looking around, I find it's the older generation who sing it's praises the most.

@LanceHitchings

3 жыл бұрын

Spot on! I think 2 things are important to anyone attempting to defeat aging. Staying current on the data and adjusting your strategy; and listening to your own individual body rather than doing exactly the same thing that everyone else is doing. Everyone's different and responds differently to various intervention. Great channel, keep up the good work!

@deansusec8745

3 жыл бұрын

@@catman4471 HE's 29. Do you remember that age? I would say it is near perfection, physically, so you cant increase your youthfullness. BTW, I watch his videos, and by no means to I question his intellect or knowledge. He just isnt a good subject for study.

@catman4471

3 жыл бұрын

@@deansusec8745 Yes I remember 29...I unsubscribed after his NMN and other anti videos mainly because he started to come over as if he had an alterior motive to them. I prefer to take anti aging advice from those who are old enough to want to anti-age! BTW in 9 months NMN has restored about 50% of my grey hair. I take isosrbide mononitrate due to angina, which is a Nitric Oxide donor, so I've been wondering if the combinaion might be the reason for the restored colour?

@catman4471

3 жыл бұрын

@@TheRealTommyR For the first three months I was taking a low dose of around 100mg NMN per day, and noticed increased energy levels by the second day, and my hair had turned from white to yellowy/hazel about six to 8 weeks later. I take 60 mg isosorbide mononitrate per day but do not know how much NO this provides. I have taken as much as 3g per day of NMN but have settled for 500mg's now and have added Citruline, 1500mg as it also provides NO. My hair is a really good combination of dark and grey now and seems to be getting more uniformly dark as the days go by. Also noticeable is my face stubble which used to be all white, but is now also a combination of dark and white.

you look great for 71... I would say whatever you're doing is working....

@LanceHitchings

3 жыл бұрын

I appreciate that

@izzerstennisscorekeeper3971

3 жыл бұрын

Oh yeah, he should have that on the screen at all times "I'm 71". Would cut thru the youtube clutter.

@mikeyaureliush9017

3 жыл бұрын

I don't think he looks "great" for 71, he looks 71 (though I will say that he does seem to be relatively energetic). I agree that the strategy of continuing to exercise regularly, for at least 150 mins a week, is the only way we know of that reliably holds back senescence

@larrytate1657

3 жыл бұрын

Looks early 60s. I’d think he was about 61.

@izzerstennisscorekeeper3971

3 жыл бұрын

@@mikeyaureliush9017 I guess "71" depends on your area. Sibling comparisons would probably be helpful... one twin does longevity for a few months, the other goes on a cruise.

I stand corrected! One of the companies that I'm an affiliate for, DoNotAge, just notified me that they launched a NAD Test KIt for $195, a couple of weeks ago. If you're interested in finding out what your NAD levels are, here's the link: donotage.org/products/nad-test-kit/ Use my discount code to save some money: LANCE Also, as Housend's Homestead pointed out, there's a typo in the title of my second recommendation. Instead of "raise CD-38 levels", I meant "raise NAMPT levels."

Lance I don’t what do you do for living but the way you approach each topic, the way you explaining it is amazing! Truly appreciate your videos. I will recommend it to all my friends interested in that topics! Thank you 🙏🏻

I'm shocked there is no way you could be 71...this is amazing... what you do clearly works. thanks for educating and inspiration ❤

@jorgeluisrodrigues1322

2 жыл бұрын

I'm 60.Some people say that I look younger cuz I have no kids.

@leelunk8235

2 жыл бұрын

@@jorgeluisrodrigues1322 I'M 47..NO KIDS..I LOOK 33..NO LIE, I STILL HAVE BICEPS LIKE MY THUMBNAIL...KEY IS TO TAKE YOUR VITAMIN SUPPLEMENTS, WORKOUT AND SWEAT, I DO SAUNA 5 TIMES A WEEK ALSO, KEEP STRESS LOW BY NOT GIVING A FUXX SO MUCH ABOUT STUFF LOL

Hey Lance. Great video. I too saw the Brad Stanfield video and immediately stopped taking NMN. I'm 61 years old. Just like you I have decided to focus on keeping CD38 levels down for now by increasing exercise particularly weight training. I already run a lot and also have been taking apigenin and quercetin for a while. I also stopped taking resveratrol and since stopping that and NMN my energy levels have really improved a lot. Thanks for affirming my decision with this video and keep up the good work. By the way I thought that you were around my age not 10 years older! You're obviously doing something right!

@LanceHitchings

3 жыл бұрын

You're obviously on the right track, keep up the good work!

@Spartan21blue

2 жыл бұрын

Likewise I’m 68 and exercise via resistance training etci the supplements I take are zinc rutin bit b3 and ascorbic acid I have noticed that my white hair is staring to turn black in patches . Best of health to you ☺️

@lexosney6432

2 жыл бұрын

Would love to know the dosage amounts you are taking.

@omrit2

Жыл бұрын

Your energy levels improved because you increased exercise and weight training, not because you stopped resveratrol or nmn.

@gaston.

Жыл бұрын

@@Spartan21blue what is bit? thanks.. otherwise I take the same as you.

At 70 years of age I have become lethargic. I have been taking NMN for only a week now and have noticed a HUGE increase in energy and motivation. The doctor mentioned Is only 29, so stopping NMN might be advisable. At 70, not so much.

@sethseth9059

3 жыл бұрын

Dave Sinclair said NMN should only be taken when in your forties at the earliest.

@catman4471

3 жыл бұрын

Spot on. I'm 59 and have been taking it for 9 months, the results are amazing. If you get days where you feel worn out, stop the NMN for a week or so, your body will tell you when you've overdone it, and take TMG with the NMN and Resveratrol intermittently, maybe on your NMN days off. ps: make sure you exercise when on NMN, if only by walking, you'll get the best results.

@LanceHitchings

3 жыл бұрын

I couldn't agree more. My whole point, though, is to stop the drain on your NAD+ pool first, then top it off with NMN or NR.

@george6252

3 жыл бұрын

Up date. Told last week I've had COVID and coming out of it. Didn't know I had it. NMN ?

@catman4471

3 жыл бұрын

@@george6252 It could well be, George. If you're taking other supplements as well, such as Vitamins C and D then you might just find you're able to tackle anything.

Thanks, that was useful information. I, too, was struck by Dr. Brad's discontinuance of NMN supplementation. Consequently, I stopped taking it also. However, considering I'm 65, I'm going to rethink that decision, in light of the information you presented. Btw, you look great for 71!

Wow! Miss a couple weeks of your videos and look what happens! I'm so glad to see you and this channel get a tiny bit of the attention you so richly deserve.

@LanceHitchings

3 жыл бұрын

Me too! Thanks Jason.

I am 73 and been taking MNM for 2 months and definitely see the difference in my skin and brown spots vanishing. Skin was very dry and rough but not now. Also my glasses seem to be out of focus ,,,my eyesight seems to be improving..much more energy now

@claudius_drusus_

Жыл бұрын

Nmn is a form of vitamin b3. Nmn is most likely broken down into niacin within the body.

@HH-gv8mx

Жыл бұрын

Which NMN supplement do you use?

@michaelk7194

Жыл бұрын

​@@HH-gv8mx renue by science

You may not be a doctor, but you make a stronger impression on me. I like your logical thinking. Thanks for the vid!

@LanceHitchings

3 жыл бұрын

Wow, thanks!

Thanks for the great content. Was conflicted about starting nmn for myself and parents, due to the contradictions between Dr Sinclair and Dr Brad... Thanks for the clarification. You look amazing 🌷

Hey man, you put this in a more understandable way, less complicated. I am grateful for you sharing your thoughts. Now I only got into this by accident, years ago I was in a wheelchair for two years and used a walker for the following three years. I was told in 2004, I would never Bipedal walk again but in 2006 a group of unknown people sent a pizza guy to my home with pizza and bag of medical cannabis from another state say they would provide if it help if I use it 3 times a day for 8 weeks using 1 to 3 puffs 3 times day(less than 1% CBD and 20% THC), after 8 weeks I began to be able to clean up the room, then the house, then yard work, then riding a bicycle, it made me active and excusing. I now walk and work part time and pain medication rarely require(terrible dependent drugs that made the pain worse, the more they prescribed the worse it got to a deathly point of not willing to stay alive any longer which is where the pizza guy comes in. I now do part time construction cleanup, that activity seemed to make it better. Now I have been taking supplements that seem to mimic the effort, NAD, NMN, Quercetin and a few more, stop this or the cannabis and I end up back in the walker in great pain, something relates here sir. I had been saying for years I the cannabis help by causing me to exercise and I am beginning to understand, just beginning though. I can spend $250 a month on supplements or $500+ on cannabis. It appears to be the exercise now with maybe some effect on inflammation. Not CBD alone put me in tears as it made me to restful I guess. I am 59 years old and still trying to understand what to do. Now I be given a drug for a awake seizer called Phenytoin and is safer than the previous but makes me tried and make cannabis ineffective to help causing a decline in my ability to exercise and increase in pain as now take 14, mg of methadone instead of 180 mg to which I would not to stay alive if it was required again at high doses. Someone please help.....

@LanceHitchings

2 жыл бұрын

Sounds like you're on the right track. Experiment, try different things and see what works for you. Everyone's different and everyone reacts to different drugs in different ways. Only you can decide what works for you and what doesn't. Good luck, man.

bro, i thought you were like 50-60. you’re killing it my man! keep it up! my goal is to be like you at 71+!

@LanceHitchings

3 жыл бұрын

Thanks, I feel like I'm in my 20's or 30's.

Either you are a teacher or naturally talented to pass information on. Maybe both:) Thank you for this excellent super explanatory presentation. Grateful

I really love the way you take complex interactions and make it understandable. Love Dr Brad too, watch both of you every day.

@LanceHitchings

2 жыл бұрын

Thanks, I appreciate it. That's my goal.

Resistance exercise is a must. I supplement with NAD+ and Fisetin after a fast. I’ve had to quarantine while travelling so have used that time to do a week fast. Autophagy induced through fasting is a great way to clear senescent cells

@HH-gv8mx

Жыл бұрын

Which NAD supplement do you use?

@megret1808

Жыл бұрын

@@HH-gv8mx Life Extension NAD+

Really great video, Lance. I am glad you mentioned that NAD+ test as well as I just recently discovered it. I am tempted to take it or one of their other tests. I really like your logical and well researched approach.

@LanceHitchings

3 жыл бұрын

Hi Holly. Glad you liked the video. I'm going to be doing a video on epigenetic test kits, I've contacted several companies that offer them and will be doing a head-to-head comparison of about 4 or 5. It should post in a couple of months.

@LifeDIY

3 жыл бұрын

@@LanceHitchings Lance, thanks for sharing that. That is going to be so awesome. I cannot wait to see it!

@kristinvc349

2 жыл бұрын

Donotage has a NAD test

@LifeDIY

2 жыл бұрын

@@kristinvc349 yes Alive By Science does all well. I have done their NAD tests numerous times now.

Very well done. I would suggest that the arrow in the diagram of the action of NAD+ on pro inflammatory factors should probably point to the senescent cell, since NAD+ is probably increasing pro inflammatory factors by increasing energy metabolism in the senescent cells and thereby enabling greater production of pro inflammatory factors. Eliminating senescent cells eliminates the inflammation, and thereby probably also eliminates the increased cancer risk seen in some studies. It is well documented that suppressing pro inflammatory cytokines with low dose aspirin reduces some kinds of cancer risk. The take away I get is to not try to boost NAD+ without first using some kind of senolytic protocol to clear senescent cells. Unfortunately this is also an area where more data is needed. For example how does Quercetin, Fisetin and Theoflavins compare with Dasitinab and Quercetin for efficacy in removing senescent cells from the body? Can we measure pro inflammatory markers as an indirect measure of efficacy rather than having to do a histological evaluation of a tissue biopsy to count senescent cells under a microscope? Medical doctors tend to be very risk averse, but older people are dying of risk aversion. Choosing to do nothing to intervene in the aging process is also an action, and one with a very predictable and well documented negative outcome.

@LanceHitchings

3 жыл бұрын

You're probably right. Another way to test for senescent cells might be to get a NAD+ test. I would think that a low count probably means a lot of cellular senescent causing inflammation and secreting CD-38.

Well done. Just finished watching Rhonda Patrick basically discuss the same thing, but not in as much detail as you. Appreciate it!

Excellent video, as usual. Stanfield also stopped taking Resveratrol, claiming that it does not activate sirt1, causes cellular stress, increases cholesterol, and has an adverse effect on exercise.

@LanceHitchings

2 жыл бұрын

Thanks.

I know you're not a doctor but what a smart guy you are. I'm in agreement with you and Dr Brad.

Dear Lance I am 68 years old and I started to take NMN a 1 year ago. and Now I have to consider dr. Stanfield opinion . It is very new to everybody . You are doing a god Work to us. thanks.

@LanceHitchings

3 жыл бұрын

At our age, the first thing I'd do is try to clear out senescent cells with a senolytic. But I think that a NAD+ precursor is called for at our age.

Really great video. Thank you. I’m 58 and I recently started taking NMN pro 500. I take many supplements and have successfully improved my heath over the last several years. BUT- I think I’m going to stop the NMN, NAC, NAD+ experiment. I have an autoimmune disease that just flared up this week . I have arthritis, tendinitis and circular ring like rashes on or around my joints. This has happened before but I had it under control for years until this flare up. The timing is consistent with my NMN experiment. Im worried this caused the severe flare up of inflammation - it makes total sense. Your video is very clear and I learned a lot. Thank you!! I’ll go back to my Qucertin with red light therapy and increase my exercise level until I learn more. Still, the NMN chemistry is very exciting for the future if anti aging.

@LanceHitchings

Жыл бұрын

Thanks, Pamela. This is all really new science and we're learning more everyday. Stay tuned!

8:05 the point when my jaw dropped the way you figured out the whole thing and explained. Very well 👏🏻

@LanceHitchings

3 жыл бұрын

First time one of videos has been described as "jaw-dropping." Glad you liked it.

Great explanation of how NAD works under a variety of circumstances. I learned a lot from this video. Thx! 🌱

@LanceHitchings

3 жыл бұрын

Glad you enjoyed it.

@ibperson7765

2 жыл бұрын

@@LanceHitchings Yeah that was excellent. Thanks. I looked at your channel and didnt immediately see: can you point me to a good video about clearing out senescent cells by you or another?

Great video, thank you for the breakdown. Also you look great for 71, keep it up!

I have been listening to Dr. Sinclair recently and just saw Dr. Stanfield's post also. It is like most things we should look at the benefit vs risk. I think I will research a little more and try it myself. You are looking good. Thanks for the information.

Many thanks - Having read Sinclair's book and looked at the research and then stumbled on Stanfield's video, I was struggling with the apparent contradiction - you've put the pieces in place - brilliant explanation and use of graphics!

@LanceHitchings

3 жыл бұрын

You're very welcome! Glad you liked it.

Here's my dirt cheap hack: Niacinamide, $3-4. Sirtuin foods: green tea, strawberries, kale, onions, good olive oil, parsley, 85% dark chocolate, walnuts, red wine. Sirtuin activating foods also include turmeric, capers, olives, black currants and dates. Parsley is high in apegenin and also boosts NAD, along with red onions and dill. I plan to add quite a bit of parsley to my salads now! Onions, kale and capers are also high in quercitin, along with red grapes, apples, raspberries, citrus fruits, blueberries and green leafy veggies. Oregano's also in there someplace....vey beneficial.

@frankduffy7471

3 жыл бұрын

I AM WITH YOU ! I knew you were the real deal when you wrote "good" olive oil . Most consumers buy fake olive oil at exorbitant prices and do not properly research what they eat. 85 % dark chocolate, turmeric and parsley is a daily essential for good health. Don't forget red CABBAGE -(can be sauteed in red wine) is extremely good and a weight loss agent as well.

@ruudboek

3 жыл бұрын

It's actually dried parsley that has a meaningful amount of apegenin. Fresh parsley not so much.

@staceykersting705

3 жыл бұрын

@@ruudboek Looks as if my next project may be drying parsley! Wd you please provide a source for this info? Also, do u know if avocado oil is particularly sirtuin rich?

@ruudboek

3 жыл бұрын

@@staceykersting705 Check the comparison table in this video in this timestamp: kzread.info/dash/bejne/f3qT25OzYLTfYbQ.html

@ruudboek

3 жыл бұрын

@@staceykersting705 All oleid acids are good for stimulating the sirtuins, if i understand correctly.

Just found you. Thanks so much for the awesome content - comprehensive and you explain in detail without being pedantic & lofty (like some others).

@LanceHitchings

2 жыл бұрын

So happy to welcome you to the community. Welcome aboard.

Excellent video + channel. 1st time here and I’m subscribed! Given that Inflammation is such a large precursor to so many ailments and diseases could I suggest you make a video on how to supplement to reduce it? Coming from you I’d be very interested in hearing your take on it. Thx and cheers

@LanceHitchings

2 жыл бұрын

Thanks. I think I'm going to do a video on inflammation as a potential 10th Hallmark of Aging, along with vascular stiffening and a declining gut microbiome.

Your production quality is so top-notch yet so simple, you are truly underrated lol. I'm 18 and i'm dealing with the stress of school and sleeplessness caused by it, but I'm currently taking 500 MG NMN in the morning and Berberine at the night to kinda compensate for it and once i move out for college next year, i'll devote myself to exercise and intermittent fasting and probably add D + Q in my 20's to maximize my chances of benefiting from true age-reversing therapies (That Aubrey de Grey predicts we would have the first gen of them in 15 years with a %50 chance and reach Longevity Escape Velocity) that are hopefully on the way for me to enjoy eternal life, youth, and pleasure! And also i geniunly thought you were in your early 60's, whatever you're doing is working quite well for today's standarts xD

@LanceHitchings

3 жыл бұрын

If I may offer up an opinion, if I were your age, I don't think I'd be taking NMN. Instead, I'd be taking apigenin and exercising consistently. I think you'll get more bang for you buck. But thanks for commenting and for watching the vid. I agree, the next several years hold a lot of hope.

@jefflittle8913

3 жыл бұрын

@@LanceHitchings Brad mentioned that one way to add apigenin to your routine would be to add parsley to your diet. Something to think about...

@willcook403

3 жыл бұрын

Whoah I thought he was early 50’s!

@Violetswirl

3 жыл бұрын

Bro, at 18 you absolutely do NOT need to be taking NMN, no way no how. Save your money and learn to eat healthy, keep at a good weight, and get exercise.

@jensenachilles2766

2 жыл бұрын

nmn at 18 is a waste. even under 35.

I'm 32 and I've been active for a good 10years +. I just started nmn and quercetin 2 months ago and it's made such a big difference in my life. It literally feels like my cells are just sucking up more oxygen. I feel refreshed as if I am taking a proper vitamin B complex that gives natural energy. Edit: I'm reading what I wrote a few months later, ok "cells sucking up oxygen" sounds funny, but what I meant was I feel like I'm breathing easier and I feel much lighter on my feet. Ok? :)

@LanceHitchings

3 жыл бұрын

👍

@britty2hottie842

2 жыл бұрын

I'm 35 and have felt like shit for a while now. Thinking of going on NMN and see if it makes a difference.

@viamem6933

2 жыл бұрын

😂

@Man-u-flex

2 жыл бұрын

Yea ok

@fitfrek

2 жыл бұрын

@@Man-u-flex ok. We still on for lunch tomorrow?

Nice summary 👌. So glad to have found your channel.

@LanceHitchings

3 жыл бұрын

Thanks, Welcome aboard!

You nailed this topic and made it very straightforward. Thank you for the clear and in-depth explanation!

@LanceHitchings

Жыл бұрын

Glad you liked it.

Wow. I have a master's degree in biotech and this guy is far more knowledgeable than I am. He said he is not a scientist. What is his background? He really does his research. And yes, he does NOT look 71. He looks like he isn't a day over 60. I subscribed!

@jpsh75

Жыл бұрын

Yeah but Brad is a legend

Damn dude, you're looking great for 71! My dad's the same age. He was on a similar trajectory to looking like you until a minor stroke a couple of years ago. He's a retired doctor, and I think I'm going to send him some papers on NMN to read.

@blowfish8203

2 жыл бұрын

This dude is 71? If true then that's amazing

@supercal333

2 жыл бұрын

Was your dad monitoring his CV health by doing scans like calcium score and others looking for potential blockages/infarctions?

You just blew my mind. 71? I am watching the video and thinking that you are in your early 50s. Wow. whatever you are doing, it is working :) Thank you for the great video

Excellent! Clear, balanced, respectful. I like ur graphics.

@LanceHitchings

3 жыл бұрын

thanks

Omg you are 71!!!!! You're strategy is clearly working, I'm floored!! 😮😮😮 Fantastic explanation and detail, best I've seen.

@LanceHitchings

3 жыл бұрын

Wow, thank you!

Thank you for the well-researched video! May I ask: What strategies do you use for decreasing senescent cells? Do you use any senolytics like Dasatinib, quercetin, fisetin, apigenin or theaflavins? What other strategies work for decreasing senescent cells?

@LanceHitchings

3 жыл бұрын

I use a 3-pronged approach. First, I take a senolytic to get rid to senescent cells and the accompanying SASPs. I take apigenin to block CD-38 and I take NR to boost the supple of NAD+.

@EricJosephLewis

2 жыл бұрын

@@LanceHitchings what is your favorite senolytic?

@karenk3339

2 жыл бұрын

Don't know about longevity aspect, but at 70 I feel more energy on NMN, a small amount of 100mg ea day. Have some apigenin, so will try that soon.

From SE ASIA We sincerely admire & respect world famous Dr Sinclair & we admire & respect you. Your a brilliant man & gifted with excellent communication skills. God First 🙏🙏🙏

That's a very smart strategy. At 71 I would throw most of my caution to the wind too since at that point you have way less to lose and certainly know that you can benefit from any and all anti-aging strategies. I'm currently 29 and probably will just stick to sauna, fasting, and exercise.

Great explanation, thank you. Would you have any thoughts on coremed sciences’ liposomal NAD+ supplement? It’s actual NAD+ not a precursor. Would you group taking straight NAD+ in with the same caution as the precursors?

@LanceHitchings

3 жыл бұрын

Yep, same cautions.

Hi! Really enjoying your videos and thoughts. Have you seen that Dr. Brad Stanfield also very recently made a video about stopping Resveratrol (and Pterostilbene). Looking forward to seeing a video with your thoughts on that one!

@LanceHitchings

3 жыл бұрын

Yeah, I watched Dr. Stanfield's video when it came out. My thoughts? Pretty much in agreement with him, really not sure what I could add. I'll have to do some more research.

@dikeledimogobe5117

2 жыл бұрын

I am confused and have decided to stop Resveratrol for a while because I don’t know who to believe. When Stanfield mentioned that Resveratrol may raise the level of cholesterol, I was shocked because on the 16 Feb, I did full blood count and to my surprise, my cholesterol, sugar and triglycerides levels had gone high. I startt Resveratrol in 2020

Brilliant video. You outlined a great strategy and it makes great sense to this physician.

@LanceHitchings

3 жыл бұрын

Thanks, so much. Coming from a physician, that means a lot.

I like your video very much because you have explain the concept much better and in a simpler way

Lance, that was excellent! I shall certainly he linking this video to answer questions asked of me. So clear and concise.

@catman4471

3 жыл бұрын

Hi, just to say I'm still doing well on the NMN. White hair turned yellowy/hazel and has now turned into nice shades of dark brown and grey. I have samples showing the difference which i will save for future upload.

@madben9981

3 жыл бұрын

Cat Man - I don't believe you. Have tried NMN for close to two years and not one grey hair has changed. Have also tried various potions with logical explanations behind them and have seen no results. In fact, I've never known Anyone's hair to go from grey to its original color.

@catman4471

3 жыл бұрын

@@madben9981 a) My hair has not returned to it's normal colour all over, it's changed from white to grey with more and more sections becoming it's original colour, I have samples to prove it which I am willing to have lab tested. b.) Grecian 2000 will restore normal hair colour in most cases, tried it, done it. Takes months and months. c.) Google search 'NMN and Grey hair', there are no definite conclusions but some have suggested it might one day be connected with hair colour restoration.

@catman4471

3 жыл бұрын

@@madben9981 I should also point out that I take isosorbide mononitrate for angina, which is a Nitric Oxide donor, but had not affected my hair colour prior to starting NMN and I have been trying to discover if the combination might be the cause.

@LanceHitchings

3 жыл бұрын

Thanks, Vince, I really appreciate it. Gotta say, I worked my ass off on this video, glad it's doing so well. I feel like I'm finally getting the hang of this.

Hey Lance, great explanations. I'm really curious on how you were able to have an extensive understanding on the topic of longevity despite not having a scholastic background on it. Could you share some tips on how to start learning about longevity? Like where to start, how to progress, and what topics to read on?

@LanceHitchings

3 жыл бұрын

Great questions. Personally, I read a lot. But it's a problem, educating yourself about longevity, especially when there are so many different strategies. I'm in the process of creating a couple of online-courses to help people learn about longevity and how to biohack their own systems to get better results. Stay tuned to this channel for more info as they come online.

@vinnrui5913

3 жыл бұрын

@@LanceHitchings Thanks for replying man. I look to forward to your upcoming content.

@abdulelahkhunji6871

2 жыл бұрын

Great question indeed 👍🏻

@lightbeingpontifex

2 жыл бұрын

um how about studying the truth and not institutionalised hogwash,,,, ex most medical doctors are highly studied but have no idea how to help a patient be healthy with no disease,,,

@marysmith4811

Жыл бұрын

Books are all around us.

Hey Lance, there are NADH supplements available. Do you think taking them could allow you to balance the NAD+/NADH levels in your body?

@teddybearroosevelt1847

Жыл бұрын

He says he’s not a doctor or a researcher so you might as well go ask a random person in the street.

Good to have smart people around. With age we learn sometimes in a hard way that balance is needed in everything.

I love Dr. Stanfield’s videos and his approach. You talked about the NAD+ process from a different angle and you really enhanced my understanding! Thanks for the great explanation.

@LanceHitchings

3 жыл бұрын

Awesome, thank you!

@Dystopoid

3 жыл бұрын

@@LanceHitchings hi, I’m 41 and was diagnosed with rheumatoid arthritis ten years ago and I’m currently taking NMN. I’ve been taking it for the past 2-3 months. Now I’m getting nervous about it with all the videos coming out. What would be your opinion about me taking NMN at my age and current health issues. Thanks

Great info, might want to check your #2 title. It says "Start exercising to raise cd-38 levels" a little typo I'm sure.

@LanceHitchings

3 жыл бұрын

Good call! I meant to say "raise NAMPT levels". If only KZread allowed me to edit videos that have already posted.

@zacknow

3 жыл бұрын

@@LanceHitchings I've just started watching your videos, great content 👌

@pkk.9107

2 жыл бұрын

@@LanceHitchings Great job on this video, subscribed. The pathway graphics were helpful.

I thought your age was 60-65 looking at you and your mental acuity, but you're 71! Good on you man. Seems like your research and commitment has paid off!

@Taty14002

Жыл бұрын

Nah he looks younger it’s the gray hair and balding that makes him l lo look older but his face gives early 50s.

Excellent video thanks ❤. Very well structured and clear.

Glad you posted this. I've gone off Dr Brad because I don't think he can be trusted. In one video he say's he's chosen NR over NMN, then suddenly he's stopped using NMN??? I'm 59 and have been taking NMN for around 9 months now, the results are and continue to be amazing. I trust how I feel and how I look and how much my life has improved due to NMN.

@LanceHitchings

3 жыл бұрын

Thanks, I appreciate it. I've watched Dr. Stanfield since he first put up his channel, and I think he's got a lot of great info. But I can see his point-of-view. There is SO MUCH medical data out there to read, I can totally see how he might take one stance, then read something that changes his mind. Because longevity science is so new, it's still imperfect. I'm sure we'll all have completely different strategies in 10 or 15 years.

@jemhuckabee4222

2 жыл бұрын

I'm with you on that. Something not right. Love this viewpoint from older generation. I am 61 and just beginning my journey. I took resveratrol 1g and it removed my chronic backpain! I'm sold on that product. I've learned a lot, even seeing replies here. Long life to all!

@catman4471

2 жыл бұрын

@@jemhuckabee4222 Thanks for the comment. I recently saw a video where they interpreted Sinclair's view and mentioned that much longevity research is still in it's infancy and those who take nmn, resveratrol etc are all part of the experiment. I have wanted a forum where users could log their results and may start one myself. Also, when I started nmn I had unstable angina. I had a stress mri 2 weeks ago and angina is stable. My skin feels phenomenonal too.

@jemhuckabee4222

2 жыл бұрын

@@catman4471 that's wonderful news that you're getting results! I have not started my nmn as of yet but will soon. I've also purchased Fisetin and TMG to go along with nmn. Yes that's a great idea to gather reports from others.

@catman4471

2 жыл бұрын

@@jemhuckabee4222 I'm sure you're going to like it. I also take tmg and fisetin, i don't know what benefits i can definitely attribute to fisetin as yet. Berberine is my second favourite after nmn. Good luck with the nmn, i got results from day 2 and continue to do so.

I unfortunately got heart palpitations from taking NMN, every minute or so my heart skipped twice. I kept taking NMN because most sites state there are no known side effects, but for some people this might not be the case. So as soon as I stopped taking it, the palpitations became less and less. Now after 72 hours after I stopped, the palpitations are as good as gone.

@PopCulturzTV

Жыл бұрын

How much were you taking, a gram a day or less..

@itsmagnator

Жыл бұрын

Maybe high dosage? Maybe you combined with something else that created this effects? Are you taking any other types of meds?

@j.a.h.vandelaak3477

Жыл бұрын

I took one capsule a day, not in combination with medicines.

@itsmagnator

Жыл бұрын

@@j.a.h.vandelaak3477 It's a rare event. How much mg? I take several supplements, I also take NMN 150mg, NR 150mg, planning to add TMG 500 mg once a week, I'm still doing more research about TMG. Side effects can be related to gene expressions just like drinking milk so if you don't feel good maybe it's better to stop, on the other hand some side effects may subdue after some time just like taking niacin, after some time flushing disappears.

@tiawells290

10 ай бұрын

I took nmn and it made me feel slow and out of it and tired. I'm now scared to try it again. Because I don't want that. Twice it's happen to me. I've seen one person on KZread who seem to have had the same effect like I did. That person decided to try another brand and now they feel alot better.

Thank You for Your good presentation! I have been taking nmn and resveratrol both 1mg twice a day for 1 year now. At first I felt great, but recently more tired. I am almost as old as You and considering lowering my doses and excercising more. I eat some vegetables but not enough. I have had inflammation on my knee which varies. I am at a point where Your formula is beneficial for me to apply. Thank You! But I am not considering stopping to take nmn as it has made me feel much better than before I started taking it. I believe ones body tells You what is good for You, and what is not, I trust that.

@LanceHitchings

3 жыл бұрын

Yeah, I think that at our age and without testing for NAD+ levels, supplementing with NMN is probably a good thing.

@jefflittle8913

2 жыл бұрын

One thing you can try is to switch Resveratrol from a daily thing to a 3 days a month thing. Also for the inflammation, add beans and legumes, flax, and fruits and vegetables to your diet. Spices that help with inflammation include rosemary, ginger, turmeric, and cloves. If you are under metabolic stress, then another possible thing to research is NAC.

@malin1635

2 жыл бұрын

@@jefflittle8913 Thank You for Your extenxsive suggestions on how to reduce inflammation.

I subscribed to your channel thanks to this fantastic video. Thank you for clearing things up.

@LanceHitchings

3 жыл бұрын

Thanks for the sub! Glad you liked the video.

I took NMN for two years straight, I decided to have a break to see how I felt, slept , performed without taking it. My blood pressure shot up, I'd like to say gradually but I had to go to the GP because of terrible ringing in my ears that seemed to get worse week after week and a bit of tight chest. My BP was 200 / 100. The GP freaked out. I was not taking anything else except TMG with the NMN. No drugs, high fat med protein and low cards about 50g a day which I was used to. I refused to be medicated and purchased my own BP monitor and since it has settled but it has taken 3 months for it come back to 140 / 90. I still got a ways to go. I got a feeling cold turkey on this stuff can leave your body wanting and I'm not sure I would ever take it again.

@popstarbootycamp4304

Жыл бұрын

I guess you stopped cold turkey instead of winding down?

@jennifermcrayde3294

Жыл бұрын

Wow. I’m currently going through the same thing…so I’ve been taking NMN for almost 4 years! I just stopped and started taking Nuchido Time (form of Niacin) for only 2 months. I am all of a sudden feeling shortness of breathe, chest tightness and electrolyte imbalance. My blood protein levels are flagged low and my WBC count is also very low. I’m scared and not sure what to do. Thinking of adding it back in at only 250mg every other day and then every 3rd day and 4th day, etc. Thoughts??!

@jennifermcrayde3294

Жыл бұрын

Also, when did you notice your symptoms start after stopping NMN? I’m currently experiencing very low protein in blood, chest tightness, and very low neutrophils. It sucks and taking NMN is the only thing right now that helps, but I want to just stop taking it. Please, does anyone have any recommendations on how to safely weed off of NMN after 4 years?

@DArnow

10 ай бұрын

I would assume if you have very low protein in blood but and are consuming protein via diet...then you are not absorbing and lack of minerals are causing a deficiency in stomach acids. Lack of stomach acids cause you to have food sensitivities and other issues because your body is not able to unfold and absorb peptides that food ultimately breaks down to.@@jennifermcrayde3294

Nice video Lance!

@LanceHitchings

3 жыл бұрын

Glad you enjoyed it

Hi Lance, may I know what's your strategy in clearing out senescent cells? Thanks!

Great video Lance! Super informative!

I am in my mid 40s and have recently started taking 300 mg of Nicotinamide Riboside. I am feeling pretty good and more focused. Dr Brad said he is young so he doesn't need to take NMN. He will start taking it as he gets older.

You could pass for 49 easily.. I've been taking nmn for a year. This video has helped me realize the inconvenient truth involved with these supplements

@LanceHitchings

3 жыл бұрын

Thanks, man! Glad you enjoyed it and found it helpful.

Wait, what is the enzyme which converts NAD+ to SASP? Could we inhibit it? And then try to increase the enzyme which converts NAD+ into activating Sirtuins and PARPS??

It is an outstading presentation, clear with full reference documents, super. Thank you very much for your sharing.

@LanceHitchings

2 жыл бұрын

You are most welcome

I watch Dr. Brad's videos regularly and I think the real reason behind him saying that he is stopping NMN consumption is that the company DoNotAge cut his sponsorship. Dr Brad has promoted their products several times in past, and though he says that he doesn't have any financial backing behind it, it's pretty clear that it isn't the case. I mean it's laughable that he promotes their products for free. So now Dr. Brad is advocating NR, the NMN rival which Donotage doesn't make. What solidifies my assertion further is that all the research papers he used to draw his conclusion were available even 2-3 years back. So why did he not see them before, given that he keeps a very close tab on the latest research papers? A lot of KZreadrs out their are there for just money and will cash in on any sponsorship they get - and that's fine if they are transparent about it, but I don't think Dr. Brad is transparent in that regard. I have watched few of your videos and I didn't find any brand promotion in them, plus I think you are really genuine about exploring the world of anti-aging and sharing it with us. Keep up the good work!

@catman4471

3 жыл бұрын

Yes, I've gone off Dr Brad. I take NMN, aged 59 and I look and feel amazing. At one point Dr B was saying why he's chosen NR over NMN, then suddenly he's stopped taking NMN? I've taken both and both bring results but NMN brings far more benefits than NR.

@LanceHitchings

3 жыл бұрын

I'm an affiliate for a few products that I believe in, like DoNotAge, Alive by Science, Life Extension and PerfectAmino. I've been approached by several companies wanting to sponsor me, but I've found that they want to control what I say and what my videos are about. So I've chosen not to be sponsored by anyone...for now. I want to be able to say what I want without stepping on any toes. Glad to hear that's appreciated.

@DK-ox7ze

3 жыл бұрын

@@LanceHitchings Nice to hear that Lance. It's important that we receive unbiased news regarding the anti-aging products, as these are really expensive and also because their efficacy hasn't been proven yet. I look forward to hearing more genuine and great content from you. Stay healthy!

Professor always said to us. when in doubt - don't! Again and again it seems exercise is the magic bullet. overall not bad for a non doctor, nonscientists, or non researcher!

@LanceHitchings

3 жыл бұрын

Yeah, that's what I keep coming back to. Working out and a good diet do more than any other intervention.

hey lance I have one question, doesn't the inflammation help our body target the senescent cells to eradicate them?

@LanceHitchings

2 жыл бұрын

In small amounts, yes. But when the load of senescent cells get too large, it's one of the big drivers of chronic inflammation.

MashaAllah... You are a wonderful person... May Allah give you longer and heathy life.

Right choice is Metformin (+Berberine) + NAM (+Nic Acid) + Quercetin. Also, senolytics. Don't pay too much. I have a recent video on it. .

@LanceHitchings

3 жыл бұрын

Thanks, I'll have to check out your video.

It's easy: Keto + IF + resistance training + good sleep + low stress. Eat your parsley and take long walks.

@LanceHitchings

3 жыл бұрын

I'd include doing HIIT.

@abdullahalajmi1313

3 жыл бұрын

I'd include clod showers, hot sauna, red light therapy, and kangen water.

@spoudaois4535

3 жыл бұрын

Keto on animal products increase mortality.

@TriAxis-KB

3 жыл бұрын

@@LanceHitchings HIIT is bad for mitohondrial health. Good book about this is The quick and the dead by Pavel Tsatsouline.., he recommended antiglycolytic type of training (AA)

Thank you Lance, great information! I had started taking both NSM and resveratrol at 1g/day, resveratrol with 1tb olive oil after seeing Dr Sinclair on KZread and reading his book. I am stopping both today thanks to Dr Brad's info. Maybe I will restart in the future if human studies show efficacy. I have also stopped taking ALA thanks to his video on that (which was recommended to me by Inside Tracker). I appreciate you taking the time to share this.

As sugguested by Dr. Brad Stanfield, NMN and NR both may be converted to NAM, which acts differently in vivo from in vitro, so why not just take NAM, which is economical, instead of NMN and NR? and further more, under-dosage NA can be combined with under-dosage NAM to create a better formulation as to prevent side effects of these two.

In that same video, Dr Stanfield made it clear he will resume NMN when he's older. Don't forget, he's not even 30 yet and is considering things from his point of view.

@deansusec8745

3 жыл бұрын

I commented about a year ago that he wouldnt even see any results of taking NMN since hes not even 30! I'm 50 and I think if I can can feel 50 when Im 70 that will be progress!

@LanceHitchings

3 жыл бұрын

Yeah, I'm pretty much in agreement with Dr. Stanfield.

@scottherf

3 жыл бұрын

I totally agree that senolitics is the first priority, and that’s what I did. Although I’ve certainly cycled a heap of nmn in the last 18 months, it’s without any doubt helped me go from 25% body fat to under 15% fairly quickly.

@deansusec8745

3 жыл бұрын

I don't think he is. I think he found an interesting hot topic which gets alot of views. There is no way a 20 something can notice any effects from anti aging supplements. Mike drop

@deansusec8745

3 жыл бұрын

When I was in my 20's I think I could quite literally fly if I wanted to.

Sleeping well, exercising, eating a well balanced diet twice a day is enough for me to feel great. No Need take any supplements. I am 75.

@LanceHitchings

3 жыл бұрын

👍

@williamtomkiel8215

3 жыл бұрын

@Carlos Laurel popular supplements . . . iirc, Egyptians used crocodile excrement as a birth control agent an opinion vs an educated opinion at 73, the above advice is the smart start

Great nuanced taje on this! Appreciate it a lot!

@LanceHitchings

2 жыл бұрын

Glad it was helpful!

Have you tried the DoNotAge NAD test? I assume its new since you did not mention it

Some have also asked me why a 29 year old would be taking NMN. I can't answer, I don't think he has hinted to a reason either?

@Libertas_P77

3 жыл бұрын

There is no good reason or need.

@HyperionMP

3 жыл бұрын

Agreed. That never made sense to me either.

@DrBradStanfield

3 жыл бұрын

With all the strategies I currently use (great diet, HIIT exercise, periods of safe fasting, etc) there likely won't be a benefit for me to take NMN/NR as a 29 year old. I previously thought there may have been a benefit for starting NR/NMN early, but looking at the data we have available I no longer think that is the case

@catman4471

3 жыл бұрын

I've been following Dr B for around 9 months now but he's always had a negative stance towrds NMN. I've been taking it for 9 months, aged 59, and I can tell you the results are amazing. At 29 you can't tell if NMN is good for you or not, and the only way you'll know is if you get results. I'm sticking with it!

@Libertas_P77

3 жыл бұрын

@@catman4471 I similarly felt incredible results from the moment I first took it in my 40's. Anybody his age likely would notice no difference as their NAD levels are so much higher anyway. He's more "scientifically cautious" than negative I would say. It's a very good and helpful approach. His first video wasn't well communicated but his follow up clarifying made a lot more sense (context is everything). He runs a great channel.

Most of what you were saying was as they say, "Greek to me." But one key word caught my attention, inflammation. I am considering starting to take NMN. I have severe arthritis in both shoulders which so far I've been able to control OK with cortisone and diclofenac. Do you have any thoughts on how taking NMN might affect my arthritis?

@ozzie444

Жыл бұрын

FYI I am 72 and very active. I'm still working overseas on rotation and go to the gym every day when I'm not working. I do 4-5 hours high intensity cardio every week. On my last treadmill test a couple of years ago the doctor's report said I have a high capacity for exercise.

Hi Lance my Father's consuming 20 mg NAD+ not the precursors for the last couple of months and he is feeling really good, has helped with his BP levels, lethargy is gone, feels energetic, the tingling sensation he used to have is gone, so I couldn't get why there's not much talk about using this form of NAD, everyone says it's a bigger molecule and it won't enter the cells, but it's actually working fine

@LanceHitchings

3 жыл бұрын

I've heard the same. Not sure why it's working, but if it is...great!

Can you please tell me if Methylene Blue does the same thing as NMN? I'm also 70 years old and I do believe resistance training should be a big part of staying healthy. Thanks for the video.

BRILLIANT at all levels! Just subscribed!

@LanceHitchings

2 жыл бұрын

Welcome aboard.

Would you take both QUERCETIN and APIGENIN or one or the other?

Thanks for the video Lance. If NAD is always trying to stay in balance with NADH would there be a benefit in taking a NAD precursor and also taking a NADH tablet which I note are also available?

@LanceHitchings

3 жыл бұрын

Great question, I'm not sure. I'll need to do more research and get back to you.

How do you raise CD-38 w exercise & Simultaneously block CD-38 with apigenin. What are you left with? Isn't it contradicting?

I am new to this longevity research and supplementation but I am a climber and calesthenics addict and though 38, my biological age according to my scale is 22. Since I am sure this scale isn't estimating NAD+ levels is this scale a decent proxy for defining the biological age talked about in this video or is there a better/alt test?

@LanceHitchings

3 жыл бұрын

Right now, the gold standard for biological age testing is an epigenetic test, which tests for methylation of the epigenome. There are several out there, and I'm currently testing 4 or 5 of them and will be doing a video about my results in a month or so.

All new to this. Mostly interested on behalf of my dad - late 60’s. How much do we know about the safety of these supplements?

Wow, you look amazing for 71, good for you! I am 65, and it shocks most people when they find out. Our family enjoys longevity (knock on wood), so I often wonder how genetics plays into this. We have centurions going back in our family for almost 200 years. I would be so curious about what genetically predisposes longer life in people.

@LanceHitchings

Жыл бұрын

I've heard that genetics only accounts for a low percentage, somewhere around 10% or 15%. Lifestyle plays a much bigger role. On the other hand, my mom is still alive, she's 98.

This is a good take. Very good. Another check on the plus column for autophagy.

You kind of spoke my mind on this. I am curious what is your view on Resveratrol.

I'm sorry, you're 71?!?!?!? You honestly don't look a day over 52. Thank you for taking a highly complex concept and making it understandable. Whatever you're doing is working, wow!!!!

At 10:20 the caption is: "(2) Start exercising to raise CD-38 levels". Is that correct? Seems like the opposite of what your trying to achieve.

From SE ASIA Between Dr Brad & Dr Sinclair we always choose Dr Sinclair. God Bless All Viewers Worldwide Jian ❤️❤️❤️

You made an excellent video. What is your prescription for terminating senescent cells? Autophagy through intermittent fasting? This is the first of your video’s that was recommended to me, and I see it was made a year ago. I’ll look for updates you may have made since then.

@LanceHitchings

Жыл бұрын

No, autophagy doesn't do much for senescent cells. Autophagy is a process that is internal to cells, where they recycle cellular components that are damaged or non-functional. Senescent cells are eliminated through apoptosis, also know as programmed cell death, and are then cleared out by the immune system. I use senolytics to clear senescent cells, as they promote apoptosis. Here's a video I did on the subject: kzread.info/dash/bejne/dYaIxqOppbyoYJc.html

Do you know or can hypothesize the effects of taking NMN in cycles. For example, some athlethes are using a protocol of 250mg per day for 12 days and the 13 day finish with a dosis of 750mg. Then they get off NMN for a month and do it again, doing the math they are taking NMN daily 30% of days during the year. What do you think happens if you take NMN one day yes one day no, would it negate its effects?

@LanceHitchings

2 жыл бұрын

Interesting. I hadn't heard of this protocol and have no idea about it's affect on longevity. I would like to point out that athletes are using it to enhance performance, not for longevity.

thoroughly enjoyed this video, clear and straightforward, now all I have to do next is exercise regularly and eat more onions, correct ?

@LanceHitchings

2 жыл бұрын

glad you liked it.

Thank you for posting your video and explanation!

@LanceHitchings

3 жыл бұрын

Glad it was helpful!