I listen to Dr. Prasad, because it reestablishes my respect for scientists. Thank you, you did it again!

Dr. Prasad is looking and sounding more and more like a grumpy homeless man with each video and I like it.

@JCResDoc94

Жыл бұрын

*actually he lives behind the 3rd orange dumpster, on the left, you know the south east side of golden gate park? yep, w his whole family. & it's STILL $4050/M!* also, rather than addressing the problem: we say 'unhoused' now -_-. bigot. -_-.

Prasad with Zeb got me through the pandemic.

The CDC and FDA could use reviewers like Dr Prasad. We would all benefit.

I've called on medical oncologists for 20 years and very few think as deeply about clinical trials as Dr V.

This is what needs to be heard. Thanks

Dr Prasad I subb to only a few MDs on YT and refer to in comments or in person for current health issues: you, Dr Mobeen, Dr Suneel Dhand, York Cardiology and as I’m Canadian Merogenomics. All unbiased politically + evidence based trying to educate and be on side of good. We can only imagine how draining and hard it is but you are all appreciated incl those not on YT. ✌️🌎

@mballer

Жыл бұрын

Everyone has a bias and Vinay is not an exception.

@transkryption

Жыл бұрын

@@mballer how would you describe it? You're right, as my English teachet said generally avoid using the word "bias" as it has connotations. Partisan? But I feel like the polarisation of people into camps over not-innately political issues is a recent thing. At least for thia generation.

@surgerystudio7654

Жыл бұрын

Add Dr John Campbell to your list 😊

@johnsheehy4192

Жыл бұрын

@@mballer Yes, although he requires quality data to accept any new notions in general, he seems to start out with the assumption that the j4bs actually have a net positive for some groups, but it seems to me that this might only seem to be based on semantic tricks of definitions and timing, and the assumption that any C fatality is an excess one well before its expected time. If you look at any trend of cumulative C fatalities for the world or smaller areas, there is no downward deflection whatsoever upon rollout, and the whole curve is simply explained by building natural immunity to C fatality. If you look at all-cause fatality, it only gets worse after massive intervention. The hard outcomes seem to be saying that nothing positive actually happened.

@johnsheehy4192

Жыл бұрын

@@transkryption Yes, politics has broken out of its container and is polluting the entire landscape.

I heard Dr Keating from MDACC call Chlorambucil a toxic placebo which makes it a perfect control arm if your goal is regulatory approval.

Can definitely see the justified frustration you have with the trial designs. Very informative. Thank you!

I made it this far!! All the way to the end! So there, be shocked Dr. Prasad! I hope that one day you take a sabbatical and are appointed to be the FDA director.

I just watched this to soak my brain in good thinking outside my field. I don’t know most of those drugs or acronyms, but the main thing is good thinking and understanding and mitigating corruption. Just a comp sci dropout living with his parents, honestly. I think when bad studies are taken out of the veil of technical jargon they fall apart by themselves. Computer scientists face similar problems when they write tests and manage bug reports. How can we prove our code isn’t buggy?

Thank you for all you do.

Would love if you would have tracey beth hoeg do some of these for observational studies

Outstanding!

Excellent video. I probably will need to study more to take full advantage but the video's availability sure helps.

Thank you for sharing !

Yall.... I think I've just had the wrong doctors ... There's a few select that really can relay and make it understood. Finally.

I like the rebel look Vinyay

I would definitely take the course!!

*13:34** oh thats good,* rule out, dont always aim to rule in. how good would it have to be to matr: power for that. bc it can not matr otherwise anyway. that is a nice thing to have in a clear statement. not for publication or career, but for science. so, most scientists arent doing science. arguably. _JC

Please talk about how big data can enhance observational studies.

Dr. Prasad, you grow a great beard!

19:00 non-inferiority is inferior wo justification. _JC

Dr. Prasad, I've read that all cause mortality isn't a realistic endpoint for most studies. That it would need way too many participants to have the needed statistical power. Is this true? What are the ramifications of this? Could you address this in a future video. Thanks.

@mballer

Жыл бұрын

It's all BS. If something helped ten percent of people but harmed ninety percent of the people a randomized trial would show it to be a failure. Our bodies are not random. Categorizing those ten percent would show who could be helped. Vinay has an educational bias.

@edkeller8078

Жыл бұрын

Great comment / request

Aw ! Rooting for Canada!

@JCResDoc94

Жыл бұрын

some1 has to. _JC

Tremendous!

It could possibly occur more so there are during times of heavy allocated stress

Might you provide more details on crossover? I managed to understand the first example (where it wasn't desired), but everything after that fell into Chemo acronym soup and I failed to understand why you might want it. Otherwise, a great series!

@danno94

Жыл бұрын

Also got lost in the soup a little, my takeaway: the second example is where crossover could be used, if you have control group (standard of care, get treatment X and then Y if they progress), and you want to test a new treatment giving X and Y at the same time before progression, you can crossover some of the control patients at a specific time to see what performs better, even if they havent progressed yet. If the new intervention is superior, one result may be that patients crossing over from control to treatment have slower progression.

@HeyYall398

Жыл бұрын

​@@danno94Thank you. I appreciate the explanation.

So marginal or non superiority would be ethical if the drug being tested is cheaper and available to everyone. Wouldn't that be a wonderful world!

The Roots Canada hoodie he is wearing is confusing me.. why?

Please review the new meta analysis by Tom Jefferson et al re: physical interventions to interrupt or reduce the spread of respiratory viruses.

@lesjchristianson

Жыл бұрын

He’s already done that.

@JCResDoc94

Жыл бұрын

are you srs rn? _JC

@JCResDoc94

Жыл бұрын

type masks into the yt search on his main pg, youll find a lot, including that.

21:21 ima post you some duct tape. bet that mic stand is expensive too. they got you good. _JC

fasting for a min of 4 days removes vii rushes

Flu vaccine and c19 vac. How many people got that combination

Don’t you understand they’re just trying to get stuff approved and make money? It’s not about actually doing science or actually improving lives. It’s business.

For as fussy as your mic stand is, I'd be putting black electrical tape over the logo 🤣

Cortisol =fight or flight adrenaline. Should have a score for anxiety and see what chemicals cause the anxiety damage .. cortisol affects the hairs in the ears... this tinnitus stuff can make you crazy on weak days. . I like the videos like this because it gives you the background why we say safe and what that means .. and why it likely should not have been presented like that to people. Like you said .. We have to hold them accountable this goes all the way up everything is just lacking in accountability and I mean there are oathes. And you know the fail thing I mean more importantly maybe now at this point is if you did fail be willing to admit it you know be willing to say OK at the beginning I thought one way and then figure it out something else later be willing to admit that that way we can get on to the point where We might start to recognize if it's causing actual problems because they're being told that it isn't and just believing in that Once again blindly the same way that they took the shot And then instantly had a false sense of security even on who was the good guy who was the bad guy and who's the guy that's gonna get sick and who's gonna make everyone else sick and whose fault is it and all this other craziness that was madness we never need to go through that again so I feel like these types of things where you're telling us all this background like that is the most beneficial thing for some of us right now honestly . Like it's better medicine than anything honestly. I learned that when having to learn a lot about parasites you have to be careful without when you can really get the OCD going but the more you learn about it the more it finally starts to make sense and then you start to see how you become a magnet for something that's gonna feed off of you because you have all this excess the body is the house

Why play fair when its cheaper to just cheat your resolut?

Hi Casey Neistat's Indian cousin

Why has Vinay stopped dressing smart for podcasts? And stopped shaving? Hope he’s ok…

@lesjchristianson

Жыл бұрын

Please

@JCResDoc94

Жыл бұрын

*actually he joined the nation of islam, & i think thats gr8! . . . &, unrelated, lives behind the 3rd orange dumpster, on the left, you know the south east side of golden gate park? yep, w his whole family. & it's STILL $4050/M!* a ive already used half this jk. but i like that it is a cmts topic. _JC

Unrandomized trials are better than randomized trials. Vinay has been brainwashed.

@pancakelizard00

Жыл бұрын

Huh?

@laveraparato258

Жыл бұрын

Did you watch the entire video. He talks about what a good randomized trial versus a shoddy one, but observational studies have way too many problems.

@mballer

Жыл бұрын

@@laveraparato258 I've watched many of his videos and many of other doctors who have all had the same biased medical education. Randomized trials are crap compared to categorizing people, and not by relatively worthless categories of age. He lives in a bubble of doctors. He's inside the forest.

@mballer

Жыл бұрын

@@laveraparato258 One thing he talked about was taking blood pressure readings and being biased, that is blinding, not randomization. Two totally different things, why did he conflate them?

@ricottalaw

Жыл бұрын

@@mballer Lack of blinding introduces more bias into a study.