Cytokine Release Syndrome covers the definition, pathophysiology, and grading criteria of cytokine release syndrome (CRS), a potentially severe and life-threatening inflammatory syndrome associated with CAR T cell therapy.
Key messages:
Early identification and monitoring are crucial. Close monitoring of vital signs and anticipating the need for quick escalation of care are required to effectively manage this potentially severe inflammatory syndrome.
Comprehensive management strategies ensure appropriate care. Supportive care and management strategies include administration of antipyretics, antimicrobial prophylaxis, blood product support, fluid resuscitation, and oxygen therapy.
Learning objectives:
1. Recognize patients at higher risk for CRS and understand the specific time periods during which patients are most susceptible to developing CRS after CAR T therapy.
2. Reference and apply the CRS grading system and utilize biomarkers to define CRS risk and severity in patients undergoing CAR T therapy.
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