Metabolism | Fatty Acid Oxidation: Part 1

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
In this lecture Professor Zach Murphy will present on part 1 of this two part series on fatty acid oxidation. During this lecture we discuss the transport of fatty acids within the bloodstream, as well as the activation of fatty acids. We also talk about the translocation of fatty acids from the cytoplasm into the mitochondria via CPT-1, and CPT-2. We hope you enjoy this lecture and be sure to support us below!
We also have a discussion on the 4 stages of beta oxidation:
1. Oxidation
2. Hydration
3. Oxidation
4. Thiolase activity
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#ninjanerd #FattyAcidOxidation #Metabolism

Пікірлер: 577

  • @Mani-hs8dd
    @Mani-hs8dd5 жыл бұрын

    I attend a fu**ing 4 hour lecture about this exact same content and I don't understand a word , but I understand it all in less than 30 minutes vid with this guy, dude this is unfair

  • @juancorrea8591

    @juancorrea8591

    4 жыл бұрын

    Monyal Knowing that these videos are free, and that I’m gonna be paying tens of thousands of dollars in loans for inferior lectures makes me angry lol

  • @wallmethod

    @wallmethod

    4 жыл бұрын

    Thats bec you attended! Each lecture is a “build up” to the next level :)

  • @meghanac6128

    @meghanac6128

    4 жыл бұрын

    Same here

  • @hhykk

    @hhykk

    4 жыл бұрын

    same lol i Spent three days

  • @ayushthakar691

    @ayushthakar691

    4 жыл бұрын

    Might be you r dumb

  • @kevo1295
    @kevo12956 жыл бұрын

    Dude, you're a genius. Metabolism actually makes sense now. Thanks.

  • @NinjaNerdOfficial

    @NinjaNerdOfficial

    6 жыл бұрын

    +kevo1295 That’s awesome! Glad to help!

  • @jamyangbhutia9936

    @jamyangbhutia9936

    6 жыл бұрын

    You are amazing man! I wish there would be professors like you in our college. Keep it up man. Waiting for new vids👍

  • @mahawafofanah631

    @mahawafofanah631

    5 жыл бұрын

    Thanks ninja

  • @muhammadazanafzalbutt1004

    @muhammadazanafzalbutt1004

    4 жыл бұрын

    Yay man!!!!

  • @muhammadazanafzalbutt1004

    @muhammadazanafzalbutt1004

    4 жыл бұрын

    You r awesome

  • @zeebalz7038
    @zeebalz70383 жыл бұрын

    Greetings from Nigeria 🇳🇬 You’re appreciated ❤️

  • @RUYINAETENGsMEDICDIARY

    @RUYINAETENGsMEDICDIARY

    2 жыл бұрын

    Nice to meet u❤️

  • @clintonodinaka6737

    @clintonodinaka6737

    2 жыл бұрын

    🇳🇬 9ja

  • @nickygm3429
    @nickygm34292 жыл бұрын

    Thank a lot! saving me form med school. Btw I want to comment that in 20:21 the enzyme used is B-hydroxyacyl CoA dehydrogenase in order to move to B-ketoacyl CoA. Thanks a lot.

  • @chitrakarcosmo

    @chitrakarcosmo

    Ай бұрын

    Yes

  • @questioneverymatter5851

    @questioneverymatter5851

    26 күн бұрын

    ​@@chitrakarcosmoI was like why acyl CoA dehydrogenase responsible for convertion to Enoyl acy CoA. So B-hydroxyacyl CoA dehydrogenase responsible for the conversion to B-ketoacyl CoA. Looks like the reversed process of Fatty acid CoA synthesis.

  • @nidaiqbal7216
    @nidaiqbal72163 жыл бұрын

    I literally don't know why I get excited when I listen to you .... I just start walking with the excitement that I have got the core concept that I couldn't get when I listened 100 other videos. I think you are the most underrated man on utube , u deserve atleast 10M or more.... I can't appreciate you with Thankyou only .... U deserve award for all your efforts. I wish you never stop making videos please My Favrt processor in All of my life 🖤🖤🖤 Countless blessings ❤️

  • @naseelmoursy
    @naseelmoursy2 жыл бұрын

    Man you are a life saver for real!!! I would've never understood Biochemistry without your videos😭! THANK YOUUU😍

  • @alfiemed1317
    @alfiemed13174 жыл бұрын

    Well done, but there’s a small mistake at the beginning of the lecture. You mentioned that atp is converted to adp in fact it’s converted to amp and the 2 inorganic phosphates and the phosphoanhydride bond is broken by inorganic pyrophosphatase otherwise perfect video

  • @nancyezike7952

    @nancyezike7952

    3 жыл бұрын

    Awesome!! Thank you so much!!

  • @sciencenerd7639

    @sciencenerd7639

    3 жыл бұрын

    thank you for adding this clarification

  • @teomatsa6836

    @teomatsa6836

    2 жыл бұрын

    dude speak English

  • @basharathussain7212

    @basharathussain7212

    Жыл бұрын

    What is atp and ADP bro?

  • @roqeebatbolarinwa670

    @roqeebatbolarinwa670

    Жыл бұрын

    @@basharathussain7212 ATP is Adenosine tri-phosphate. ADP is Adenosine di-phosphate.

  • @nizamulhaq6886
    @nizamulhaq68862 жыл бұрын

    no word of appreciation can entirely explain your personality SIR U ARE SUCH A GENIUS PERSONALITY ALOT OF LOVE AND RESPECT FOR YOU.U ARE JUST AMAZING SIR.

  • @Hugo-no1si
    @Hugo-no1si6 жыл бұрын

    In one word: LIFESAVER. Thank you so much!

  • @NinjaNerdOfficial

    @NinjaNerdOfficial

    6 жыл бұрын

    You are so welcome Hugo!

  • @patiencejohnson4837

    @patiencejohnson4837

    5 ай бұрын

    Literally ❤

  • @bhavanakathuria3697
    @bhavanakathuria36975 жыл бұрын

    You deserve more views. You easily explained something my "highly accredited" professor couldn't in 53min, while you did in less than 30. THANK YOU!!!

  • @elianjoensen2756

    @elianjoensen2756

    2 жыл бұрын

    this is a scripted video. some would call that an advantage

  • @MarieKametani

    @MarieKametani

    2 жыл бұрын

    @@elianjoensen2756 yea but he did it in one take pretty much

  • @elianjoensen2756

    @elianjoensen2756

    2 жыл бұрын

    @@MarieKametani teachers do that too. it’s called real life, and they don’t have a script

  • @MarieKametani

    @MarieKametani

    2 жыл бұрын

    @@elianjoensen2756 ohh my classes are recorded rn bc of covid lol

  • @momo-mn7wn
    @momo-mn7wn3 жыл бұрын

    You're a genius man!! I spent my whole day to understand this and i got it in 40mins..hats off to you

  • @Aleyofication
    @Aleyofication6 жыл бұрын

    Isn't it a Hydroxyacetyl CoA D.H and not the Ketoacyl CoA D.H in the third reaction?

  • @NinjaNerdOfficial

    @NinjaNerdOfficial

    6 жыл бұрын

    +Op Nutrition You are absolutely correct! I am sorry for that mistake!!

  • @Aleyofication

    @Aleyofication

    6 жыл бұрын

    Np mate...great vids. btw!

  • @ZainabMostafa-gk5jc

    @ZainabMostafa-gk5jc

    6 жыл бұрын

    why did not u change it or added a comment till now ??

  • @baraaka5376

    @baraaka5376

    6 жыл бұрын

    Op Nutrition Why??? There is keton group😅

  • @nischayjairaj

    @nischayjairaj

    5 жыл бұрын

    baraa ka because the dehydrogenase is acting on the b-hydroxyacyl-coa to form your b-ketoacyl-coa

  • @amynainan1157
    @amynainan11573 жыл бұрын

    You are a legend thank you so much for helping me through med school... You manage to do more in half an hour than hours of professors or the textbook😁

  • @ahmetziyaaktas9179
    @ahmetziyaaktas91797 ай бұрын

    I adore your knowledge of Biochemistry and enthusiasm. How clean and pleasant an explanation this is! 💕

  • @moonchildc3894
    @moonchildc3894Ай бұрын

    I know I'm late but honestly saying you're a LIFESAVER !!!! I understood so beautifully 💜

  • @AjaySensei
    @AjaySensei3 жыл бұрын

    This is the absolute best video on fatty acid oxidation i've ever seen! I feel like I just had an epiphany.

  • @learnwithareesha458
    @learnwithareesha4582 жыл бұрын

    Ninja nerd is a blessing. This channel has helped me so much that a small thank you just won't do justice. I'm so grateful 💫💫

  • @sohaibalaa8228
    @sohaibalaa82284 жыл бұрын

    Brother I’m really owe u, u summarized about 2 three-hours lectures in about 30 minutes! u r incredible!!

  • @darshinimalukar3246
    @darshinimalukar32462 жыл бұрын

    All the praise here multiplied by 100, and that still wouldn't suffice what an amazing lecture this is.

  • @Dr_Harsh07
    @Dr_Harsh073 жыл бұрын

    Reading my book after 30 mins of ur lecture is smooth ... Thanks a lot u are a life saviour

  • @parvathitiruviluamala9870
    @parvathitiruviluamala98702 жыл бұрын

    I never paid attention to this while in Medial School. What an AWESOME teacher !! God bless you !!

  • @kusocm
    @kusocm5 жыл бұрын

    Nice and concise, I really appreciate what you're doing, particularly for people that cant afford education...but bear in mind, palmitoleic acid is a monounsaturated acid, necessitating more reactions that you drew, but for palmitic acid it is perfectly correct, and the thiol group is what connects the CoA to the acyl group.

  • @tchdkstar3944
    @tchdkstar39445 ай бұрын

    I know I am watching this 6 years later, but I just want to say you are a genius. I used to hate biochem, but by watching your videos, I am now omw to become a biochem guru. Thx

  • @fayyoosh7870
    @fayyoosh78703 жыл бұрын

    I like how we all in comments are amazed and thankful for ur great explanation .. thx ! ❤️

  • @jackjyoung
    @jackjyoung3 жыл бұрын

    You explain things so well I watched it twice and probably will watch it again.

  • @asserm.8047
    @asserm.80475 жыл бұрын

    Great video!!!!! If only my professors were as good at teaching as u are 😂😂

  • @ahmednaser7770
    @ahmednaser77704 жыл бұрын

    thank you for making everything we much easier and enjoyable.. you are putting a lot of effort ..I appreciate.

  • @afrozayaz7871
    @afrozayaz78714 жыл бұрын

    I can't even imagine looking at my book for metabolism buhh you're awesome. The legend ninja.

  • @sarahgutierrez5628
    @sarahgutierrez56287 ай бұрын

    This was the best teaching video I've ever seen, you're a great teacher ! Thank you so much!!

  • @shanicem3929
    @shanicem39295 жыл бұрын

    So excited when we finally got to the acetyl CoA. Yaaay. Finally

  • @zainab-dr9sy
    @zainab-dr9sy Жыл бұрын

    My exam is in 2 weeks thankssssss you just saved meee and ur lecture notes are rlly so legit!! Keep uppp ur saving billions of medical students

  • @markmuravec8624
    @markmuravec8624 Жыл бұрын

    Amazing explanation! Thank you ninja master. I think you flipped the CoA-SH in the opposite direct. I believe it should be Acetyl-S-CoA, so that CoA is bound to acetyl with thioester bond:)

  • @pavkata97
    @pavkata974 жыл бұрын

    You are a very talented teacher. Love your videos!

  • @golgiskarimi927
    @golgiskarimi9274 жыл бұрын

    It was amazing, thanks for the smooth and understandable explanation

  • @osedunmeevans7051
    @osedunmeevans7051 Жыл бұрын

    With your videos I don’t have to necessarily memorize but rather, to understand. Thank you so much!

  • @user-vw4yh6ld7n
    @user-vw4yh6ld7n5 жыл бұрын

    You’re saving my life with your videos

  • @tejasvidalla2982
    @tejasvidalla29826 жыл бұрын

    Nice video sir.. but a small correction .... in the first step.... ATP is converted to AMP + PPi... which is converted to Pi by an enzyme inorganic pyrophosphatase ... this makes the first step irreversible!!!

  • @GoodKnight5252

    @GoodKnight5252

    5 жыл бұрын

    first thing i was going to say! they should fix it....

  • @guffronagung8316

    @guffronagung8316

    4 жыл бұрын

    i think tejasvi is right

  • @GoodKnight5252

    @GoodKnight5252

    4 жыл бұрын

    @@guffronagung8316 i saw it in lehninger but I'm not at home right now to confirm..

  • @umarjalal397

    @umarjalal397

    3 жыл бұрын

    H

  • @nidaiqbal7216

    @nidaiqbal7216

    3 жыл бұрын

    In which step? Please mention the step

  • @jokodubga6535
    @jokodubga6535 Жыл бұрын

    Thank God, I finally understand the topic. Thank you Ninja Nerd, God bless you!

  • @igj3224
    @igj32245 жыл бұрын

    Guys, amazing job! Just amazing!

  • @vinayakkapatral4246
    @vinayakkapatral42463 жыл бұрын

    Genius for sure... wonder how many hours of reading Zach has put in and his team getting this type of lecture.. Congratulations to Zach and his team!!! Best! Obama should see this and endorse it.

  • @anthonypeltier4039

    @anthonypeltier4039

    2 жыл бұрын

    What

  • @reyazeram
    @reyazeram4 жыл бұрын

    i cant stress how much your videos have helped me . thank u so much :)

  • @vincentarthur8699
    @vincentarthur8699 Жыл бұрын

    Thank you very much Prof,you make Biochemistry more comprehensible,greetings from Ghana🇬🇭

  • @AhmadAhmad-rv6ms
    @AhmadAhmad-rv6ms5 жыл бұрын

    i just wish that in the other videos like glycolysis if you explain the chemical structure like here :( i had to search about it back then :( thank you for your effort :D you are really amazing

  • @MaylinGinestra
    @MaylinGinestra5 жыл бұрын

    I am in love with your videos !!! Thanks so much

  • @sophias4280
    @sophias42803 ай бұрын

    You're such a gem, thank you SO much for making all these videos

  • @parthajitdevpurkayastha2515
    @parthajitdevpurkayastha25156 жыл бұрын

    It's Just too good....U Are really doing a great job ..Thanks a lot for your priceless efforts..

  • @MohsinAli-bu2os
    @MohsinAli-bu2os2 жыл бұрын

    I have no words to praise ur hardword , such an excelent work , mindblowing. U r a hero bro .

  • @marysia5525
    @marysia5525 Жыл бұрын

    You are helping me get that exemption from biochem exam and I could not be more thankful!!!

  • @serena3135
    @serena31353 жыл бұрын

    Is it weird to say I love you? No? Okay. because This video just saved my life

  • @uroojmustafamalik9249
    @uroojmustafamalik92495 жыл бұрын

    superb...💕💕MAY ALLAH BLESS YOU SIR💛💛

  • @user-hc2yx9tp2n
    @user-hc2yx9tp2n2 жыл бұрын

    you help us alot I'm so thankful to what you do 💙💙💙 عاششش يا كبير

  • @kattran3798
    @kattran37983 жыл бұрын

    This helps me sooo much with the MCAT, thank you!

  • @DaRa-lw6rw
    @DaRa-lw6rw3 жыл бұрын

    Bravo man! I'm and grateful and full of inspiration to get more and more! thanks!

  • @chisomongalande8745
    @chisomongalande8745 Жыл бұрын

    can't figure the actual words to use to thank this guy😁.. he's absolutely the best of the best😍, thank you@ Ninja Nerd

  • @beautifyingnaturewithcreat2498
    @beautifyingnaturewithcreat24982 жыл бұрын

    Just amazing man...urs lecture just cleared my all concept related to oxidation of fatty acid...m very thankful for it

  • @gihanimanodara4264
    @gihanimanodara42642 жыл бұрын

    Thank you for your determination and the excitement in explaining the processes so well! Love from Sydney Australia

  • @roshan6253
    @roshan6253 Жыл бұрын

    Normally i wouldnt even like subscribe and pay for this knowledge but you my friend explain it soooooo easy im sold.

  • @vetsathi9154
    @vetsathi91545 жыл бұрын

    love you sir. your lectures are excellent and detailed.

  • @Amanda-bk9lu
    @Amanda-bk9lu3 жыл бұрын

    Better than my metabolism prof. I have a metabolism midterm tomorrow and you are SAVING me

  • @user-vu9st6fd7v
    @user-vu9st6fd7v2 жыл бұрын

    This is beyond description ... Thank you so much!!!

  • @mhmde7260
    @mhmde72602 жыл бұрын

    You deserve major respect Thanks alot for your videos

  • @sploallthyme
    @sploallthyme3 жыл бұрын

    Thank you! This has helped me tremendously.

  • @laceymauritz8053
    @laceymauritz80534 жыл бұрын

    you're like the guardian angel of grad school. thanks for teaching me science!

  • @hakonskog480
    @hakonskog4806 жыл бұрын

    Thanks again, Ninja! Now I can face my exam head on!

  • @sapphiregem12
    @sapphiregem123 жыл бұрын

    This really help! Thank you for making this video

  • @imeneamina2342
    @imeneamina23426 жыл бұрын

    can't find a better video sooo simple thaaank youu from north africa

  • @awetyeman5315
    @awetyeman5315Ай бұрын

    Great job Nija nurd.I was struggling my head to get around this.Thank you as always

  • @amirrezag
    @amirrezag9 ай бұрын

    You are a lifesaver for real!!!! Thank youuuu.

  • @VG__
    @VG__2 ай бұрын

    Greetings from India. You're appreciated 🙏🏻

  • @ahmedallam1457
    @ahmedallam14575 жыл бұрын

    Yeah.. Thanks alot.. Keep going u r the best for me ♥️🙆‍♂️

  • @raghadalomari4058
    @raghadalomari40586 жыл бұрын

    why would 4 people dislike this phenomenal video??? Thank you tons!

  • @vinayakkapatral4246
    @vinayakkapatral42464 жыл бұрын

    Zach... You are amazing I am hooked to your lectures,

  • @gayathrid753
    @gayathrid753 Жыл бұрын

    Iam doing my ug.... And u r the most helpful part of my life for physiology and biochemistry✨ thanks a ton✨

  • @sinombulelozamani7361
    @sinombulelozamani73614 жыл бұрын

    wow your videos are the BEST!! Thank you soo much they are so awesome, God bless you

  • @hayllatte
    @hayllatte4 жыл бұрын

    thank you so much. you helped me for my final ❤️

  • @camilleseguin2316
    @camilleseguin2316 Жыл бұрын

    Thank you for your videos, they are so helpful!!

  • @aniketbrar4759
    @aniketbrar47594 жыл бұрын

    God bless yall at ninja nerd. Ily. ❤️

  • @n.c.pharmap.3436
    @n.c.pharmap.34366 жыл бұрын

    nice presentation Zack, clear explaining but in the 3rd step of beta oxidation the enzyme is called 3 hydroxyacyl coa dehydrogenase

  • @NinjaNerdOfficial

    @NinjaNerdOfficial

    6 жыл бұрын

    +N.C.pharma p.3 yes I did sorry about that!!

  • @joannahpaulinecruz9830
    @joannahpaulinecruz98304 жыл бұрын

    Hi, thanks a lot for these videos! but I just have a little correction. I think the enzyme involved in step 3 is beta hydroxyacyl coA DH

  • @user-jl3wc8ws6k

    @user-jl3wc8ws6k

    Жыл бұрын

    true, you are right

  • @maryb3380

    @maryb3380

    6 ай бұрын

    yes this is accurate

  • @masoodahmed6276
    @masoodahmed627627 күн бұрын

    Brilliant. What a pleasant and rewarding experience for learning biochemistry with clarity.

  • @stavhen7753
    @stavhen77532 жыл бұрын

    You're amazing. I had no idea how simple this could be, thank you so much for your efforts!

  • @husseinderdoom1923
    @husseinderdoom19235 жыл бұрын

    thanks so much, you are highly great teacher for us..

  • @karolinaverbanova3165
    @karolinaverbanova31655 жыл бұрын

    I spent 15 minutes watching this and I already know some badass stuff to shut everyone's mouth tomorrow Haha. You're making me the best student in the class!

  • @emtiazsproduction9455
    @emtiazsproduction9455 Жыл бұрын

    Great i understood beta oxidation fully with your video sir, while i couldn't understand anything from my BIOC professors.. Thanks a ton.

  • @maryamnisar3874
    @maryamnisar38742 жыл бұрын

    You are life saver Zach 🙌

  • @artinagta1533
    @artinagta15333 жыл бұрын

    Thank you so much man you made this topic so easy.. Realllyy. Thank you. 🙏🙏🙏

  • @aarfakhan4473
    @aarfakhan44733 жыл бұрын

    Your all lectures are amazing,,, I press the like button before watching your videos🤗

  • @KingSpark-bc1zd
    @KingSpark-bc1zd25 күн бұрын

    I really enjoyed your lessons and have recommended to all my friends

  • @أبواب-الجنة-8
    @أبواب-الجنة-813 күн бұрын

    Thank you so much, you have made the concept easier.

  • @hibazahid190
    @hibazahid1904 жыл бұрын

    Thanks sir.You cleared all my concepts.A Clap of appreciation from PAKISTAN 👌👋👋👋

  • @Didsomebodysayslay
    @Didsomebodysayslay2 жыл бұрын

    i attended the lecture at uni but didn't get a word and here i am completely understanding the whole thing thanks to u

  • @maxdb550
    @maxdb5502 жыл бұрын

    All my classmates study with your videos :) They are amazing

  • @shreyasineogi256
    @shreyasineogi2565 жыл бұрын

    Hey, I just wanted to ask if there are separate carnitine acetyl transferases for different types of fatty acids? Also, when the body breaks down the fat deposits due to the absence of glucose, it is producing a lot of energy. So will the person still feel lethargic and tired due to the absence of food?

  • @user-wi6ri4fz9k
    @user-wi6ri4fz9k3 жыл бұрын

    You are just a real biochemistry savior, god bless you

  • @satinderjit4
    @satinderjit44 жыл бұрын

    Hell yeah, that you very much for this.

  • @ppl7263
    @ppl72635 жыл бұрын

  • @anuachu2146
    @anuachu21466 жыл бұрын

    Sir,now i started to love my subject.sir you are really great😃😃😃😃

  • @franckynjantou8124
    @franckynjantou81243 жыл бұрын

    I don't even need to watch your videos lesson before liking...I like it with blink eyes.......I love your Teaching Professor...you are just amazing. I wish to be like you someday...really you overmotivate me. Thanks a lot/ Be blessed

  • @ohonbaosazuwaemmanuel1265
    @ohonbaosazuwaemmanuel12652 жыл бұрын

    I love what you do....no one does it better....please recommend a biochemistry textbook similar to urs

  • @mosesshior6317
    @mosesshior63172 жыл бұрын

    God Bless for all you do prof🙌🙌