My brain eats itself. Sounds about right.

@hasanmuhammad6651

3 жыл бұрын

yum

@aniksamiurrahman6365

3 жыл бұрын

Actually this happens all over our body. Take the more popular cousin of Microglia - the Macrophase. It's their job to eat frail or dead cells, but also rebellious (tumorous) and virus infected cells. Macrophase do this many times each day. So here you have it. You eat yourself, all of you.

@SaschaUncia

3 жыл бұрын

Your brain is... eating itself... That is terrifying...

@JohnSmith-ft2tw

3 жыл бұрын

Well, bite me has a new slant. 🙄

@aniksamiurrahman6365

2 жыл бұрын

@Iggy the Mad More like careful remodeling.

The mitochondria is the powerhouse of the cell The microglia is the janitor of the brain

@Fists91

3 жыл бұрын

The kind of janitor that would be played by Liam Neeson or Jean Claude van Damme in a movie adaptation

@alexnalli422

3 жыл бұрын

@@Fists91 Or Hannibal Lecter (alias Anthony Hopkins) to be more precise.

Not all heroes wear capes. Some wear protruding, spidery arms.

@dorabrooks76

3 жыл бұрын

Sounds like they're the Judge Dredd of brain cells. Strange super hero for sure!

@RunItsTheCat

3 жыл бұрын

Imagine wearing your arms

@danisonice.

3 жыл бұрын

Some way eat the people they rescue

@UGNAvalon

3 жыл бұрын

Doc Oc?

@Carewolf

3 жыл бұрын

and eat brains...

I laughed way too hard at the image of a nurse noticing a problem with a patient, and therefore proceeding to eat them 😂😂

@brodriguez11000

3 жыл бұрын

Give 'em gas.

I work in a glial biology lab and we consistently refer to neurons as useless haha. Without glia, they just die. Ive dropped flasks of glia and they did not care one bit. If I did that with neurons? Instant death

@Fitten06

3 жыл бұрын

😂 I appreciate this

@MaskedNozza

3 жыл бұрын

That's super interesting to hear about

@aneeshmohan5696

3 жыл бұрын

Where do you studyyyy dude. Can I apply to your laboratory

@aneeshmohan5696

3 жыл бұрын

@whesley hynes okay! Please offer yourselves for the cause. Would love to dissect your brain and study microglia, run electrophysiology tests on your neurons😍

@Megan-nt7dm

3 жыл бұрын

@whesley hynes Could you stop copy pasting the same poorly worded comment on all these videos? Once again, my lab uses zero (0) animals, we use all induced pluripotent stem cells from human patients (that consented to sample donation) mind you. But stop railing against people who are trying to do good in the world by using animals to cure horrible diseases. I hope you never get one of the diseases we now have treatments for due to these animal studies, since you probably won't accept this 'immoral' treatment, right? Millions of lives have been saved. And every institute that uses animals has extensive animal care protocols in place to minimize pain, and all animals are taken care of very well.

I too like eating my problems away, so I can relate

@hasanmuhammad6651

3 жыл бұрын

homework?

@healthya7975

3 жыл бұрын

Childcare?

@mayabartolabac

2 жыл бұрын

ahhh good to know that i'm not the only guy who cannibalized their ex-girlfriend

It hurt my heart to hear that these important heroes can be permanently altered by trauma

@MaskedNozza

3 жыл бұрын

We have first-hand experience in that field. I imagine our microglia are malfunctioning quite badly

@tranayajordan8508

3 жыл бұрын

@@MaskedNozza just up there eating anything 😂

@Noukz37

3 жыл бұрын

Be careful, if your heartache persists, it could lead to depression which in turn could permanently damage your microglia. :-P

@mv8908

2 жыл бұрын

@@Noukz37 how do you fix them? I have brain on fire!

@Noukz37

2 жыл бұрын

@@mv8908 I'd say, start with acceptance, then move on to forgiveness and finally gratefulness. Meditate daily 🙂

Thank you all patrons for allowing the rest of us to enjoy these fantastic videos

Janitors: "Time to pull out the broom." Microglia: "OM NOM NOM!"

Such a cool episode and you're so good at making the science fun and easy to follow!

@lurking_silhouette5802

3 жыл бұрын

Agreed. Brit is one of my favourite science presenter. This video doesn't feel like 10 minutes at all.

If microglia eat unneeded synapses, underactivity in depression may be why you're prone to obsessing over negative thoughts

@lilylopnco

3 жыл бұрын

Yeah, that's my theory. Underactive microglia means lots of dead and harmful connections that don't get removed. Thus depression, anxiety, ADHD, etc.

@vegetossgss1114

Жыл бұрын

@@lilylopnco for anxiety it is more complex please have a look on an article that was released yesterday on this topic cheers from morocco!

I definitely would appreciate some updated news on this in the future on here.

@vegetossgss1114

Жыл бұрын

Yes! Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?

@vegetossgss1114

Жыл бұрын

I've just seen one paper that was published yesterday on anxiety and OCD related to microglia. Cheers and good luck, from morocco! Please let me know if you find new papers!

4:00 - That's the reason that babies do that weird jittery shaky movement (which Beck Bennett parodied in the SNL sketch about a CEO with the body of a baby). They have too many synapses so they can't control their bodies and are essentially having constant seizures until their brains prune the synapses to give them better control over their movements.

@freeofavia

3 жыл бұрын

Whoa

I think this is among the most exciting science developments that have happened in a good while

@thisisahumanlol8255

3 жыл бұрын

AMONG?2???2?!!1!!1!1 SUS 😳😳😳😳🤣🤣🤣🤣

@vegetossgss1114

Жыл бұрын

Yes! Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?

Singing in my head: "Brain neurons and microglia, glia, ia, eh eh oh" 😅

That t-shirt is amazing :D Also wow, this is fascinating! I have learned a lot on this episode

@MaskedNozza

3 жыл бұрын

I was so focused on the video that I didn't even notice the shirt

@lauraelaineallen21

3 жыл бұрын

I came to the comments to see if anyone had mentioned where the shirt is from.

" gives MS a nasty look.... Gives Microglia a shifty worried look "

@Gretchen1978

3 жыл бұрын

my thoughts exactly

Love this woman and how she talks :)

@jennymisteqq5399

3 жыл бұрын

The gestures that go along with the script are ridiculous and downright embarrassing. Somehow she manages to pull them off! She’s a rare sort of person who’s able to act out what the script calls for in a normal, fluid manner. I think most people would look goofy or downright stupid. I don’t think I’m describing what I mean right, but it’s hard to describe.

@The_stone_Philosopher

3 жыл бұрын

Besides Hank she's the best complexly host imo, then I would say Michael Aranda

As a chronic pain patient I can FEEL how strong glial cells are. The signal of pain gets stuck in the glial cells (the chemicals) and these cells keep producing them giving me an endless sense of pain

@dinodude7290

Жыл бұрын

uhh

Incredible! This makes me want to learn so much more about microglia and glia in general!

I like this one a lot. Thank you, SciShow.

@grrttr

3 жыл бұрын

I like her too

I'm wondering right now how glial cells would look like in Cells At Work.

@Twistedcrescendo

3 жыл бұрын

Judge Dredd?

@iwanabana

3 жыл бұрын

Like a desi nurse, checking to see if youre alright and devours you aggressively if youre not.

@humanistreason

3 жыл бұрын

Glia: hm think I'll just in case. You look like someone who will cause problems

Microglia, the zombie nurses of the cell world.

@SatumainenOlento

2 жыл бұрын

Perfect!!!

Wait, no, that doesn't make sense. The synapse is the small gap between one neuron's axon and another neuron's dendrite. It's not a cell in itself. How can the microglia eat a synpase?? Did you mean it eats the involved neurons? That's a bit overkill for just one malfunctioning synapse, isn't it? Or does it severe the neurons' axon and dendrite and eat those? What's going on????

@icejustice6122

3 жыл бұрын

I think the synapse may be the junction made up of the axon, dendrite, and synaptic cleft (which is the gap itself).

@JoseRojas-hl7sn

3 жыл бұрын

@@icejustice6122 This

Thank you. Eggs have the kind of cholesterol that feeds the brain.

What a genuinely fascinating topic and very well covered

@vegetossgss1114

Жыл бұрын

Yes! Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?

With all these microorganisms at work in and around you, can you really still feel in control

There are shapeshifting cells in my brain that EAT my neurons?? What if those neurons had some good thoughts in them

@adnan7698

3 жыл бұрын

You forget stuff in exams 😂

@roneliadelgrange8315

3 жыл бұрын

Nice username. Did you get it from Lemony Snicket’s Austere Academy?

@DoodleDan

3 жыл бұрын

@@roneliadelgrange8315 more like Unus Annus

@w01dnick

3 жыл бұрын

@@roneliadelgrange8315 that's a well known latin phrase... why connect it to some random unknown book?

While watching this, I wondered how microglia would be portrayed in the anime Cells At Work.

I feel like this is going to be a huge complex branch of brain health we are going to learn about.

@vegetossgss1114

Жыл бұрын

I've just seen one paper that was published yesterday on anxiety and OCD related to microglia. Please let me know if you find new papers! Cheers and good luck to all of us, from morocco!

I remember a movie about this kid who doesn't have enough microglia

@SuperbusQuartus159

3 жыл бұрын

Source???? :D

@mv8908

2 жыл бұрын

Link?

This explains so much. I've had severe allergies and chronic sinusitis for my whole life, and my brain has never worked right. I've tried everything for anti-depressants. Welbutrin worked the best, which is in line with this video, but due to side effects I can't take it. ECT didn't work, which would be expected with overactive microglia due to inflammation. OCD, bipolar, anxiety, memory issues, autism, ADD, I've got it all. It's amazing to think neuroscience might give me a couple good decades before age brings these problems back. That's far better than anything I expected.

These channels are my adulthood bill nye the science guy show 😆

My microglia are working on repairing my brain from a recent concussion then

Amazing, thank you very much! Very informative ❤️

Long story short: microglias can cause some pretty nasty stuff :p

@vegetossgss1114

Жыл бұрын

implication to treat anxiety?

What an excellent episode. Great breakdown of information and cautioning of information

So.... microglia.... are basically the cell equivalent of a zombie... eating brains...?

@Carewolf

3 жыл бұрын

Zombies would be macroglia.

Thank you so much. I adore your style of presentation.

Love her delivery style. Very clear and engaging. 🙂

It's weird seeing captain marvel talks about microglia

I definitely need to hear more about these!!!

Thank you for talking about this!

6:44 low microglia activity means not enough janitors to clean neurons, means junk will accumulate and damage neurons, leading to the same end result, damaged neurons

Awesome video, such good information

This is the coolest episode ever omfg

Phenomenal video, thank you

Sounds like neurons evolved to avoid being eaten by microglia.

thank you for all the sources! looking forward to doing some reading up on this topic

Great explanation!!love it..👏👏

I appreciate how you use scientific naming along with metaphors to facilitate understanding. I'm in the midst of a discussion on the benefits to this technique for teaching.

An episode about current information about advances in ASD research would be helpful for those of us in the spectrum.

@MaximilianBerkmann

3 жыл бұрын

This.

@PRDreams

3 жыл бұрын

@whesley hynes thanks for taking the time to comment. Have a lovely evening!

Very good episode!

Oh wow 😮 This was very enlightening. We have multiple personalities as well as a wide range of comorbidities. The current disorders our psychiatrist is looking at are generalised anxiety disorder, social anxiety, panic disorder, OCD, agoraphobia, autism, ADHD, major depressive disorder, bipolar II, PTSD, OSDD / DID, and others that I don't recall. It sounds like microglia could potentially be part of the issues for those with multiple identities like us, especially since there are typically a wide range of comorbidities related to increased stress and anxiety. It would be interesting to be included in study or research into this. I'll ask our psychiatrist and see if there's anything happening in Australia, but are there any current studies in Australia that you came across while researching for this video? - Ian

@MaximilianBerkmann

3 жыл бұрын

Yeah, and I've seen only one Psychology expert connecting the dots between that and Neurology. I wonder if there are current areas of research in that.

@MaskedNozza

3 жыл бұрын

@@MaximilianBerkmann We will try to find out

@chiaroscuroamore

3 жыл бұрын

I was thinking of DID and how this new information could be useful

@vegetossgss1114

Жыл бұрын

Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?

@vegetossgss1114

Жыл бұрын

@@MaximilianBerkmann I've just seen one paper that was published yesterday on anxiety and OCD related to microglia. Cheers and good luck, from morocco! Please let me know if you find new papers!

Do microglia ever get full and have to call another one in to eat for them?

Brains are sooooo complicated!! who new i had so much going on upstairs.

@vegetossgss1114

Жыл бұрын

yes but very important!

Awesome video Brit, as per usual, informative and interesting. I love that shirt!! All I can hear in my mind now is James Woods saying “need a bigger boat” 😂🤣

Really excellent video! The presentation was a bit fun, too.

Interesting enough, now I am completing "anatomy and physiology" playlist :p , one video per day :p And just started learning about them . (From the "crash course" channel )

Wow... this is crazy interesting!!! Another reminder of how little we know.

"Eat the problem" sounds like I was doing things right all this time already!

Awesome stuff

Neat to know about them!

Amazing!

Really good video 👍👍👍

"shape-shifting housekeepers"(and assassins too probly), gosh, debut of this long lost member of the immune cell family is gonna be glorious in Cells at Work

Great presenter and interesting video!

So cool and interesting!

Thanks!

This is the best.

amazing video

Thank you for this really interesting video! I would love to hear more about the brain, in future videos perhaps? Astrocyst cells(sorry I don't know if that's the correct English term) would be interesting and also the different areas of the brain.

You guys should do an episode on astrocytes; there have been recent studies that suggest astrocyte size and diversity is responsible for human intelligence!

Amazing S2

This might help explain why and how Long COVID often produces neurological problems ! 1. Long COVID usually means ongoing cytokine storms or overactivity. 2. Cytokines get into the brain, thanks to microglia, as indicated in the middle of this video. 3. Maybe they do neurological damage there.

yes please!

Funky macrophages. There's similar in mammalian ovarian tissue. Microglia activity in different areas of the CNS, would have different affects and different symptoms

If depression is associated with both overactive and underactive microglia, does that not suggest that there might be different forms of depression that are similar in their superficial presentation, but are extremely different in how they function on a neurological level, and might require very different treatment?

The childhood stress causing issues with glia, could that be part of my wife’s chronic migraines ?

That is one cool t-shirt 😄

In this episode I noticed less trimming of micro-pauses. The information was thus less time-dense and the pauses almost left me with the time to think and digest the information. Good work. Pass the info to the others.

There was a study many years ago that found that blocking PKR, an important immune signaling molecule, caused mice to exhibit what appeared to be perfect recall. This was also associated with apparently asymptomatic microseizures. Sounds like maybe the lack of PKR interfered with the microglia pruning new memories 🤔

5:36 annnnd one more reason to suspect my brain is more than fucked up

Your shirt is really cool

Aside from John Green, Brit Garner and Reid Reimers are my favourite hosts from SciShows, CrashCourses and PBS channels. Seems like they're actually talking to me when they're speaking, which I guess is the ultimate compliment for a host. :-)

@natureleague

3 жыл бұрын

It is indeed! Many thanks 😊 -Brit

@Noukz37

3 жыл бұрын

@@natureleague Aww

awesome

Microglia are the aliens who, when you discover them, tell you about the positive vibes you sent to the universe. They ATE them!

ML libraries developers should notice and add neuron eating layers as a new way to traind DNNs.

Amazing! How this can lead to new drugs to treat severe anxiety and OCD, without the side effects (excess sleepiness for instance) of SSRIs and SNRIs?

I have an urge to go back and find a vhs copy of the blob for reference

@sophierobinson2738

3 жыл бұрын

Beware the Blob!

I like her attitude dwl lolololo and she is still factua

Judge, jury, and executionner and NOT ONE reference to Dredd ?! I'm beyond disappointed.

Soooo... Nurse zombies? "Are you all right, dear? No? OK, then... BRAINS!"

Goodd!! Can we keep her?!

That Megalodon shirt is cool

Am i the only one that wants a scishow cell biology???

Spidery Blobby Things is going to be the name of my Celtic-Hot Jazz band.

So they’re basically the ninja maids of the cell world! :D

nice shirt for this video XD

Microglia: the zombies of the brain