Келесі
- 13:42
- 54 М.
- 15:18
- 65 М.
- 00:32
- 8 МЛН
- 23 күн бұрын
- 00:28
- 27 МЛН
- 16 күн бұрын
- 00:59
- 36 МЛН
- 9 күн бұрын
- 00:16
- 37 МЛН
- 23 күн бұрын
- 10:33
- 78 М.
- 13:33
- 43 М.
- 28:33
- 206 М.
- 30:52
- 167 М.
- 14:49
- 20 М.
- 10:21
- 69 М.
- 0:30
- 2 МЛН
- 0:58
- 1,4 МЛН
- 0:58
- 376 М.
Пікірлер: 110
Babe wake up. A new reducing agent just dropped.
@Spencergolde
3 ай бұрын
Biggest news since carrot reducing agents dropped
@B_u_L_i
3 ай бұрын
@@Spencergolde omg yass, that paper slayed so hard
@Spencergolde
3 ай бұрын
@@B_u_L_i Right? And their setup was so far from being optimized. Carrots or other root vegetables could be such a gamechanger in a world where decent reducing agents are so strictly controlled
@07Roux
3 ай бұрын
Literally as soon as he woke up. “O….k.? What’s that?”
@GoikOShea
3 ай бұрын
OIL RIG
This video has everything! Dean Stark, multiple diy reagents, mercury, crazy looking molecules, amalgamation, vacuum distillation, impurity, reducing an oxide layer, nitrogen balloon, and even a sweet cameo by sick boilover itself! on a scale of 1 to 10 this one's a 25 bruh! Can we just appreciate the effort he puts into keeping us on the edge of our seats for 11 minutes with ethoxides? This one's a banger!
@nunyabisnass1141
3 ай бұрын
Dont. forget a broken graduated cylinder. You're not a chemist if you don't have one of those.
@rustymustard7798
3 ай бұрын
@@nunyabisnass1141 That and a lot more, there's too much to list!
@andrewjuby6339
3 ай бұрын
You had me at Dean-Stark.
@baha17222
3 ай бұрын
Lil ball of iodine
@again5t.your53lf6
2 ай бұрын
But has it Tar?
Sodium cyanoborohydride has been pretty quiet since this reductant dropped
@Spencergolde
3 ай бұрын
It was reduced to silence
@user-yb5cn3np5q
3 ай бұрын
@@Spencergolde You mean, silanes?
@andym.s.5231
3 ай бұрын
@@user-yb5cn3np5q lolololol
@ShortFuseMan
3 ай бұрын
Si _❕️_ *❲* yes in spanish, also happens to be silicon ▪︎‿▪︎ *❳*
Loved the in depth discussion for the last mechanism on this one. The mark of a true organic chemist.
it amazes me every time how much time and effort is spent on every chemiolis video...
very based move of linking the procedures via scihub in the description
Fun fact, reciprocating steam engines use a device like that Dean-Stark trap, but to cause accumulated water to lift a controlled quantity of lube oil into each cylinder.
Always nice to see new and safer reagents come along, looking foward to seeing how it compares to NaBH3CN!
@Bob-lv1xs
3 ай бұрын
Yes it's "safer" if you ignore how it's made. If you don't it's not safer or greener
@mduckernz
3 ай бұрын
@@Bob-lv1xsIn a proper industrial manufacturing setup I actually think this could be made rather cheaply and safely, with minimal wastage
@andym.s.5231
3 ай бұрын
@@mduckernz I have yet to see anything on its EHS or LCA so even if it could be manufactured safely and with minimal waste that still says nothing about the waste itself or what happens once it's actually used, and unless it's perfectly catalytc (see AlCl3 which might as well have to be added stoichiometrically) the waste/product mass ratio is meh
It is nice to see pentacoordinate Silicon compounds get more attention. They are pretty neat
Boratrane can be made by just heating boric acid and triethanolamine neat at 200C for a few hours until the mix solidifies
I am so insanely jealous of your glassware, your beautifully stocked lab, and your knowledge. So very fucking jealous.
This video was incredibly cool. Group 13/14 elements are very powerful and understudied as catalysts
this is awesome I just today had my organic chem lecture about reductive amination. I feel supremely nerdy for this but i dont remember another time i've been this hype for an upcoming yt video
Cool vid mate! Well done!
Cyanoborohydride is a pain because you need to do purification afterward. Is this easily removable?
This is amazing!
Since you're heating it anyway and just trying to amalgamate the aluminum to increase surface area, can you just substitute the mercury with gallium so you don't have to risk using a toxic metal?
Using mercury to react the aluminum seems like the spiciest way to do this reaction, although probably also the easiest.
Holy shit this took so much effort this is so good
Why mercury instead or iodine to remove the passivation oxide layer>?
Amazing video. Thnx buddy🎉🎉🎉🎉❤
Could you try making the alkyl variant of this substrate to see if it can do hiyama couplings?
@pharmdiesel
3 ай бұрын
How 'bout you get going on this if he can't and let us know.
Can this reduce pseudoephedrine? Asking for a friend
@kjpmi
3 ай бұрын
😗
@kaboom4679
3 ай бұрын
No , you have to use germanium instead , since it is better for doping ...
@t0lek511
3 ай бұрын
HI/H3PO4 friend that is the way or I2/Red P
Yeah bro very cool i will see this Vid now!
Hey Chemi! I'm just waiting for you to tell me how does a very chill (Menthol 20x) chemical will do with a very spicy one! Nice video btw! Love your work!
@Chemiolis
3 ай бұрын
You can eat mint and spicy food, and report back your results. You will likely feel both, they are different receptors.
@AManChoosesASlaveObeys
3 ай бұрын
@@Chemiolis I just wanted to see the results of your top organic ones, since you are the GOAT in making things very extreme and the one who probably can take it like a champ! I tried one time. Mentol in almost freezing water and eating a Habanero. It was very weird and the problem wasn't even in my tongue, it was in my stomach for some reason. Yeah, I could feel both and it was WEIRD! Maybe doing it, mixing in some slurry, adding some carbonation or something that feels like it makes you tongue "tingle" like an electric shock is my end goal if my stomach can take that.
@otterconnor942
3 ай бұрын
Sounds like you want to put chemiolis through hell
@ShortFuseMan
3 ай бұрын
True, and he definitely goes throughenoughof that as is, lol‥…@@otterconnor942
How does the iodine destroy the al2o3 layer ??
Inorganic chemistry - who knows!?
@andym.s.5231
3 ай бұрын
_cries in point group symmetry and ligand field theory_
does this also reduce aldehydes? the favorable advantage of cyanoborohydride in these reactions is that it doesnt fight against the aldhyde like nabh4 does.
Ooooh nice and fluffy silicon oxides at the end! Just don't breath it in.
I get the purpose of iodine but I don’t understand why is it important to use mercury chloride to the solution to create an amalgam. As long as Aluminum is exposed out of the oxide layer, the reaction should follow suit or did miss something?
0:33 that alone makes it worth replacing LAH in lab settings at least, if it weren't for cost, same going to the borohydride and such
Nice synthesis and structure. Reminds me of pyrrolizidine alkaloids of my PhD. Is this dark background the inside of a hood? I hope it is!😉👍❤
@Girvo747
3 ай бұрын
He’s mentioned he works in a hood yeah :)
STAB is super useful though, I always make mine in situ from acetic acid and NaBH4
I came across an interesting molecule you should try synthesizing! It’s called Iceane, and is an obscure carbon structure that has the same base structure of a mineral found only in meteorites called lonsdaleite which is (theoretically) stronger than typical diamond.
Dude cool Love your videos Have you thought of using a huber ministat and a jacketed flask for the temperature sensitive stuff? (Lot of coin but can be done semi-cheap if you get creative)
@Chemiolis
3 ай бұрын
I plan to use something like that for cooling very exothermic reactions like nitration, but coolers are a bit pricey to justify atm
Damn those three dimensional reagents are fancy
I don't understand chemistry but I love learning things I don't know.
You can also find boric acid in the feminine hygiene section.
As an inorganic chemist, I also have no idea how that reaction works.
This channel is becoming more and more of a "How to speedrun Pihkal"
Uuuu, sounds good from the getgo
pretty sure triacetoxyborohydride would be easier to synthesize from sodium borohydride
7:18 Couldn't we just used _sodium ethoxide_ would had made sodium chloride instead of HCl. If i most say, some inorganic compounds are special in organic chemistry, opens up more possibility that can take shortcuts to building molecule.
hydrostannatrane is an even stronger hydrogen donor
@adrianhenle
3 ай бұрын
Yes, and also a *much* stronger poison.
I hate it when my silanes turn yellow. I can't stop them from doing it.
@Litepaw
3 ай бұрын
Yellow chemistry 🥹💛✨
Very interesting procedure here. The 1st reduction reaction I learned of that reduces aldehydes and ketones into amines was the Lukehart reduction. Pretty cool to see other avenues like this that work in what seems to be a fairly easy manner. Keep educating Chemiolis! 🙏🏼🫡
Ketones and esters, Oh my! Ketones and esters, Oh my! Ketones and esters, Oh my! Signed: Dorothy and gang.
JESSE WE HAVE TO COOK
Woah I subbed and a new video dropped?!
@kaboom4679
3 ай бұрын
Quick , do it again .
Reductive amination? Don’t mind if I do…
Neat, but realistically, I don't see this replacing traditional reducing agents. Borohydrides are just so cheap, versatile and easy to tune. Instead of buying cyanoborohydride, I'd just add 1 equiv of NaCN to my reaction and it works just as well.
Hm maybe I could make this one: “First add toluene” - good I got that “Then boric acid” - cool I have a kilo of that, so far so good “Then triethanolamine” - shit…
b but the reaction mechanism 😢
Spoiler (from that future video): LiAlH4 is still better
This is Tybut Tubytu/ naddrganian burzanu / darbyt darbyton
please don`t say Aluminum! it`s ALUMINIUM! ... the Americans are too lazy to say it correctly ... you are European, stay professional :D ... always striggers me when I see bottles of chemicals at work, that are produced in the US and the label says "aluminum" :/
@davidshelly9142
3 ай бұрын
Both are acceptable by the scientific community, but Aluminium isn't a European thing, its really just a commonwealth thing
@kpunkt98
3 ай бұрын
In German it's also Aluminium.
@Faro1909
3 ай бұрын
@@davidshelly9142 "Aluminium (aluminum in North American English) is a chemical element" ... from Wiki only Americans say Aluminum ... A Scottish once told me that the people in America are too lazy to say that extra syllable :D
@Correct_Opinion
3 ай бұрын
language prescriptivists gtfo
@6alecapristrudel
3 ай бұрын
Aluminimum
Silly me, always seeing you as a fellow Dutchy... Only to hear you butcher the pronunciation of aluminium to aluminum. 😢
Enough bullshit! We want syntheses of L-SD !
Loving it. Keep up the good work!