Lymphoma Explained Clearly - Hodgkins & Non-Hodgkin's Pathophysiology

Understand Non-Hodgkin's Lymphoma with this clear explanation from Dr. Seheult of www.medcram.com/?Y...
This is video 1 of 2 on lymphoma.
Speaker: Roger Seheult, MD
Clinical and Exam Preparation Instructor
Board Certified in Internal Medicine, Pulmonary Disease, Critical Care, and Sleep Medicine.
Co-founder of www.medcram.com/?Y...
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Пікірлер: 101

  • @meong1992
    @meong19923 жыл бұрын

    I was diagnosed with Hodgin Lymphoma since last month, now im getting chemotherapy. Pray for me, i hope luck is in my side so I can be Cured

  • @Maryjcorder

    @Maryjcorder

    3 жыл бұрын

    dwi dyyra 🙏

  • @kathleenmcculley6177

    @kathleenmcculley6177

    3 жыл бұрын

    Praying for God to lay his hand upon you and restore u to perfect health. God loves you

  • @gary50shotz31

    @gary50shotz31

    3 жыл бұрын

    You’ll get through this most high has your back🙏🏾

  • @racheltumey3594
    @racheltumey35945 жыл бұрын

    I'm not studying to be a doctor/nurse or anything. but my daughter was just diagnosed with lymphoma and this is the most informative video I have seen. Thank you!

  • @alisonmorgan6600
    @alisonmorgan6600 Жыл бұрын

    Diagnosed in May of 2021 with diffuse lg B Cell non Hodgkin's lymphoma. Started aggressive chemo immediately, May -dec of 2021. Shrunk the tumor, but my body has not been the same. I lost 110 pounds, constant fatigue, have had COVID 4 times, spent Jan of 2022 in the hospital fighting COVID and pneumonia, while just coming off chemo, my face has aged at least 10 year's. If I get a recurrent diagnosis, I'll think twice about chemo.

  • @roselucht4583
    @roselucht458319 күн бұрын

    I’ve been diagnosed with Invasive lobular breast cancer and through the CAT scan and a biopsy they found I have B cell Non Hodgkin’s Lymphoma. I had a bone marrow biopsy and I’m awaiting results in 5 days,when I see my Oncologist. The net day I will be having my bilateral mastectomy. All this waiting (6 months of all this ) is really hard

  • @user-qn1rb5cu8w
    @user-qn1rb5cu8w5 жыл бұрын

    Good day thanks for coming back to me to hear you. Such a wonderful voice and way to make me understand everything even english is not my mother language. Bless you.

  • @tonnikask
    @tonnikask10 жыл бұрын

    i have seen many lectures meant for medical students but they are not as full of information as this one...this is really great :) this lecture was worth spending time...moving on to next lecture with high hopes

  • @ned9819
    @ned98199 жыл бұрын

    Dude i love your channel.Every time im stuck in first aid I always wind up at your videos.

  • @tgtina.g2613
    @tgtina.g26132 жыл бұрын

    Last night I noticed my right side under my arm to the front is swollen,were the lymph nodes are. Just one side very visibly. I don't feel a lump underneath but I didn't palpate to much because it makes me feel uncomfortable. I made a doctor appointment and it's in 8 days.. my biological sister has had breast cancer twice and 3 of my paternal aunts have had breast cancer. My mother who is in her 70s never had cancer but her along with my sister and paternal aunts test positive for braket. I never got tested because my insurance would not cover. The spit sample they took on me was sent for testing but I recieved a letter saying they couldn't test. But anyways.. I have a doc appointment soon and I'm hoping I don't have cancer .I would hope whoever is reading this can say a prayer for me. I'm 46 years old and my name is Tina.

  • @bfoster2335
    @bfoster23356 жыл бұрын

    All I know is I had diffused large B cell non Hoskins lymphoma. I finished my chemo Jan18, 2018. Feel great. It was found when I got my mammogram. Lady's get your mammogram every year.

  • @MoamerKday
    @MoamerKday6 жыл бұрын

    first time to understand lymphoma , Thanks Dr

  • @azinrostami1721
    @azinrostami172110 жыл бұрын

    Hello, that was great, please more lectures about chemotherapy and cancer

  • @lalalaladify
    @lalalaladify11 жыл бұрын

    This is very helpful. Thank you so much!

  • @vmjable
    @vmjable11 жыл бұрын

    thanks for the video :). one thing i wanted to mention... i assumed that the translocation(14:18) of the bcl2 gene to the Ig heavy chain locus caused overexpression of bcl2 which stabalized the mitochondria and prevented apoptosis...rendering the cell immortal...

  • @ancabostinariu6550
    @ancabostinariu6550 Жыл бұрын

    Excellent as usual.

  • @marygraceabellera3237
    @marygraceabellera32378 жыл бұрын

    thank you so much it really helps me a lot

  • @amandalal4854
    @amandalal48546 жыл бұрын

    Just add that, bcl2 is antiapoptotic gene that gets overexpressed when translocated next to IgH gene (on Chr 14), so cells skip apoptosis, hence lymphoma.

  • @amandalal4854
    @amandalal48546 жыл бұрын

    Thank you . It was of Great help

  • @Medcram
    @Medcram7 жыл бұрын

    See the whole series at www.medcram.com along with other top quality videos including reviews in pulmonary, cardiology, infectious disease, and hematology!

  • @harch972
    @harch9729 жыл бұрын

    I was taught that Bcl-2 allowed the cell to avoid apoptosis, and the translocation junctions the Bcl-2 gene to the gene encoding the heavy chain of immunoglobulins. B cells transcribe the immunoglobulin genes a lot, so every time the heavy chain gene was being transcribed, the Bcl-2 gene would be transcribed too, giving the cell more Bcl-2 and therefore more evasion of apoptosis...and I just realised someone else has already explained this further down but oh well :p nice video though! thanks!

  • @ashishpanthi1

    @ashishpanthi1

    7 жыл бұрын

    i thought the same bcl-2 and bcl-x antiapoptosis ???

  • @caylynmopp1062

    @caylynmopp1062

    6 жыл бұрын

    It inhibits and induces cell death.

  • @jimkhatib7158
    @jimkhatib71585 жыл бұрын

    In January I was diagnosed with T cell anaplastic large cell lymphoma, ALK positive. Truly fascinating stuff I’ve learned throughout this.

  • @rocky-mh5xg

    @rocky-mh5xg

    4 жыл бұрын

    I was diagnose with t cell non Hodgkin's as well back in 2016, still fighting this . I m learning a lot about this type of cancer. Its a hard war in your body. Somehow I keep getting another chance, ja Thx

  • @alimiri4949
    @alimiri49493 жыл бұрын

    This was very useful.thank you sir

  • @medschoolradio
    @medschoolradio9 жыл бұрын

    Great! Thanks!

  • @aslandaghighi3736
    @aslandaghighi37365 жыл бұрын

    Thank you!

  • @fatimaumar5566
    @fatimaumar55666 жыл бұрын

    Great!

  • @ISANDRA2008
    @ISANDRA200811 жыл бұрын

    great!! can you please do one on Diabetes??? thank you

  • @DrDoniak
    @DrDoniak10 жыл бұрын

    Thanks alot :)!

  • @drmohammadazzam
    @drmohammadazzam10 жыл бұрын

    Thanks alot .

  • @tatry3015
    @tatry30154 жыл бұрын

    Excellent presentation. Thanks.

  • @Hamigal
    @Hamigal Жыл бұрын

    I just got a NHL diagnosis 2 days ago. I see the Oncologist/Hematologist Aug 10.

  • @user-qn1rb5cu8w
    @user-qn1rb5cu8w5 жыл бұрын

    Thank you so much.

  • @ISinisterI
    @ISinisterI11 жыл бұрын

    You made a mistake while explaining follicular lymphoma t(14;18). bcl-2 is an ANTI-apoptotic gene that codes for stabilization of the mitochondrial membrane preventing cytochrome c loss from the inner mitochondrial space (and downstream caspase cascade). The translocation to the heavy chain locus on chromosome 14 results in overexpression of bcl-2 making the cells unresponsive to apoptosis.

  • @imagonzalez7632
    @imagonzalez7632 Жыл бұрын

    I’ve been treating for non-Hodgkins lymphoma and before my last treatment I was diagnosed with classic Hodgkin lymphoma I my lung. How could this happen.?

  • @soumyasachdeva
    @soumyasachdeva11 жыл бұрын

    very nice!!!:):)

  • @Monster-he4if
    @Monster-he4if8 жыл бұрын

    Amazing doctor .. Thank you very much!!

  • @H.Doc11

    @H.Doc11

    8 жыл бұрын

    لا شكر علي واجب

  • @arrancockroft2834

    @arrancockroft2834

    7 жыл бұрын

    +crazy doc clearly😎

  • @tetamemy3277
    @tetamemy327710 жыл бұрын

    Thanks alot .... go ahead

  • @kathymarquis9
    @kathymarquis910 жыл бұрын

    Cesium is found in natural nonradioactive form. . Thiosufate. . In fresh unpolluted water helps. .the lymph glands clear. . Redhills bakin powder without alluminum is a great buffer. .

  • @Chandan_UMICH
    @Chandan_UMICH7 жыл бұрын

    Very nice, useful video! Just noted one mistake at ~16:32. c-MYC is not a tyrosine kinase. Its a DNA binding transcription factor.

  • @Medcram

    @Medcram

    7 жыл бұрын

    Yes, thank you for this clarification. c-MYC is part of a cascade that is part of a tyrosine kinase pathway, but is not a tyrosine kinase gene as I suggested.

  • @mahmoudmetwally719
    @mahmoudmetwally71911 жыл бұрын

    very good but i ask the difference between leukemia &lymphoma blastic

  • @jasonwiley798
    @jasonwiley798 Жыл бұрын

    So what. Which ones are more serious and when should you think about treatment?

  • @iqrabutt105
    @iqrabutt1053 жыл бұрын

    Good approach... But you should update this according to current WHO terms otherwise it will cause confusion

  • @rellikniap1
    @rellikniap110 жыл бұрын

    cMyc is NOT a tyrosine kinase gene. It is a transcription factor

  • @AA-vn2nq
    @AA-vn2nq7 жыл бұрын

    When you give plasma, do they take your white blood cells and give you back your red blood cells? I ask this because I have read that NHL increases when people give their plasma overtime.

  • @ImaLoneWolfintheWoods
    @ImaLoneWolfintheWoods9 жыл бұрын

    I'm so lost and confused :( I had melanoma and surgery removed it, but a year later it's back in my neck in lymph nodes, is this lymphoma? Because I have all lymphoma symptoms but my oncologist has not said anything about lymphoma. I have serious bone pain I lower body and night sweats quite often as well as my body gets so itchy mostly at night and has often kept me awake all night. My doctor has not diagnosed anything except he says it could be anxiety, I had a PET scan and it apparently shows just one spot on my neck which I'm getting surgically removed a second time, parotidoctomy and neck dissection to remove all nodes in the area. Does anyone have any input on this? I need to talk to someone

  • @kitt7082

    @kitt7082

    9 жыл бұрын

    Chris, bone pain and night sweats are signs of leukemia. You should talk to The Leukemia and Lymphoma Society to see what information and help they can give you. Take care of yourself, mythical beast.

  • @Bekind79
    @Bekind796 жыл бұрын

    Not a comment, I'm just putting this here for reference as I read this video. I got tired of pausing and going into my iBooks to see lab work. Remove if you want. Thank you. Large B cell lymphoma. Large atypical cells positive for cd20, pax5, significant patchy staining for bcl-6. The large cells are negative for ae1/ae3 cd3,c5,cd10, and cyclin d1. Small background lymphocytes show populations that are both cd20 and pax5 positive as well as a population that is cd3 cd5positive. Positive staining for bcl6 may indicate lymphoma of center cell origin.

  • @Medcram

    @Medcram

    6 жыл бұрын

    +Michelle Denise awesome! Your comments also help others. It's the beauty of this platform. Thank you!

  • @ClaraJC99
    @ClaraJC99 Жыл бұрын

    Can people with lymphoma maybe non hodgkins or hodgkins... When they have swollen lymph node for more than 1 -2 years and then the lymph node decrease in size in a few months and then maybe spread to other lymph nodes causing them to be slightly swollen? If that makes sense I'm sorry if it doesn't

  • @tyzer32
    @tyzer3210 жыл бұрын

    No mention of diffuse large B cell lymphoma?

  • @racheltumey3594

    @racheltumey3594

    5 жыл бұрын

    RIGHT?! That's what my daughter was just diagnosed with. I was hoping to see something about it, but didn't. I still learned a lot though.

  • @swifter6976

    @swifter6976

    5 жыл бұрын

    What he referred to as the first intermediate lymphoma under ‘follicular’ is most likely diffuse large B cell lymphoma. He mentioned that it was a progression of follicular lymphoma to a “large cell lymphoma”. He just didn’t use all of its title

  • @rf8754
    @rf87545 жыл бұрын

    I have a solid, swollen lymph node on my neck that cant be moved, it's been there for 3 weeks now and no other symptons, I have an appointment today, I'm so concerned.

  • @futureflow8645

    @futureflow8645

    3 жыл бұрын

    Any update?

  • @TheWhitemoon11
    @TheWhitemoon1111 жыл бұрын

    hi! may you please do a video about BMT and PBSCT...thanks!

  • @raymraym6914
    @raymraym69143 жыл бұрын

    Health Anxiety 😔😥

  • @sophiemckenzie7527
    @sophiemckenzie75273 жыл бұрын

    I have it in my lungs not fun in pain but cant have chemo had radation ..theres gotta be a cure my nephew died from it alot do ..whys that?

  • @Carrington2024
    @Carrington2024 Жыл бұрын

    I have been having health issues for last three years including recurrent cervical lymph node swelling but on the right cervical node should I ask my pc to look for lymphoma as it’s been three years almost of same lymph node swelling and a normal body temp of 99 degrees since pre covid era also I am a legionaires survivor idk if I can ask for guidance or not but opinions r welcome

  • @SuperNinger
    @SuperNinger5 жыл бұрын

    Dose all lymphoma show in blood tests?

  • @gravityrain4683

    @gravityrain4683

    4 жыл бұрын

    SuperNinger no, I’ve heard of tons of patients that had a blood test that came back normal but they later got diagnosed by a biopsy. The only way to diagnose lymphoma is a biopsy.

  • @Bichonfrise369
    @Bichonfrise3693 ай бұрын

    I have RA i take chemotherapy. So I guess I’m like one of those Tcell Bcell that don’t want to die. 😂 sometimes best medicine 💊 is a good lol. Good luck 🤞🏼

  • @leckemi
    @leckemi5 жыл бұрын

    Can Hodgkin's Lymphoma - C81 be cured?

  • @toxicbee990
    @toxicbee9904 жыл бұрын

    Can lymphoma be diagnosed through a blood test ? I hate biopsies....

  • @artisticwhistleblower1756

    @artisticwhistleblower1756

    4 жыл бұрын

    no

  • @richardcastle75
    @richardcastle757 жыл бұрын

    So how are you supposed to work out the actual cell deformities (cleaved, chronic or acute, follicles or diffuse) from the actual names of the cancer? E.g- Small Lymphositic Lymphoma. *(As far as I can tell, its small=so acute cells, (but apparently it looks like CLL, a large matured cell-why?). And they are B-cells, but the name only mentions that its in the Lymphoid lineage so how can you tell they are B???) E.g- Lymphoblastic Lymphoma (I get they are blast cells (immature, acute)..where does the name indicate a Tcell??) Am I to understand that the names hardly give you an incite to the cell deformities ?

  • @nystagmus
    @nystagmus4 жыл бұрын

    I get it :)

  • @just1lifexx11
    @just1lifexx11 Жыл бұрын

    Lymphoma vs herndisk?

  • @markgarrod8326
    @markgarrod83265 жыл бұрын

    I need a smart doctor like yourself... I am so sick.. I know this crap is in my bones, my nurse practitioner thinks i'm crazy.. my family misses the real me.. I actually hate how you warn on what's on tests, cuz my weird sickness (I have had dr.s Talk about lymphoma for 9mons now) I guess I will die, and my pretend doctors will lose their jobs... that is a horrible and sad statement..

  • @artisticwhistleblower1756

    @artisticwhistleblower1756

    4 жыл бұрын

    Trust your instincts, never the "professionals"! I almost died bc of quacks.

  • @gary50shotz31

    @gary50shotz31

    3 жыл бұрын

    How are you now?

  • @MichaelsUgly
    @MichaelsUgly7 жыл бұрын

    Follicular lymphoma- TX: low dose chemo or rituximab-anti-cd20 ab

  • @user-wg5xl9vo8u
    @user-wg5xl9vo8uАй бұрын

    Clear as mud

  • @IIlIIlIIlII
    @IIlIIlIIlII8 жыл бұрын

    I hope Gavi is okay

  • @assassinonroad
    @assassinonroad10 жыл бұрын

    but where is the multiple myeloma and plasmacytoma?

  • @rustyfo1

    @rustyfo1

    8 жыл бұрын

    +Berhiv DURSUN Technically they are Lymphomas, you're right. However they are usually discussed separately as "Plasma Cell Disorders", along with Waldenstroms Macroglobulinemia.

  • @darkestnbl

    @darkestnbl

    6 жыл бұрын

    dumb nut

  • @stepside2839
    @stepside2839 Жыл бұрын

    🤔nothing about CD20, MCL, 11 &.14 translocation..?..🤷🏻‍♂

  • @bangsmatter4394
    @bangsmatter43947 жыл бұрын

    when you cut 80% in to two, it should be 50% still. I was waiting for the other 20%, expecting there was another variant of B Non-Hodgkins, yet still, very informative and helpful.

  • @noahwic1
    @noahwic13 жыл бұрын

    A *pop* toe sis

  • @lorinwelch9543
    @lorinwelch95435 жыл бұрын

    This explains nothing

  • @grenebulax
    @grenebulax4 жыл бұрын

    CD19... covid-19?

  • @DieterSoegemeier
    @DieterSoegemeier11 жыл бұрын

    Eat more alkaline foods and never need to worry about being sick ever.

  • @bankjobworldofwarcraft5853

    @bankjobworldofwarcraft5853

    4 жыл бұрын

    Dieter Soegemeier what are those?

  • @kathymarquis9
    @kathymarquis910 жыл бұрын

    Now take the tras out of the water. . .your least common denominator