The following is an interview with Luca Cavalli-Sforza, Professor of Genetics Emeritus, at Stanford University, California The interview was conducted by his friend and colleague, Marcus Feldman, Wohlford Professor of Biological Sciences, and Director of the Morrison Institute for Population and Resource Studies at Stanford University, California. The interview was recorded at the home of Luca Cavalli-Sforza in Stanford, California on November 8, 2006.