The following is an interview with Charles Yanofsky, Morris Herzstein Professor of Biology, Emeritus at Stanford University, California. The interview was conducted by his friend and colleague, David Botstein, Anthony B. Evnin Professor of Genomics and Director, Lewis-Sigler Institute at Princeton University, New Jersey. The interview was recorded at the Herrin Laboratories on the campus of Stanford University in Stanford, California on November 7th, 2002.