I love videos like this. I'm always greatful when you interview scientists and experts who aren't plant based but also follow the science.

I have been a armchair nutrition student for many years after the death of my mother, now more than 20 years ago, I have found Gil´s videos and take on so many important topics to be one of the best resources on You Tube. I hope he keeps up this important work as so much that is presented in other places are simply confusing, poorly done, opinion driven and often, plain off the mark. Real food forms the basis of all things healthy. Hope you re well Gil...

I love these conversations with specialists who closely follow the data and just care about what the facts are. Keep em comin!

What a great discussion! Very good, clear questions and good, clear answers. Thank you both for your time and effort, much appreciated!

These type of videos are greatly appreciated, thank you. They bring clarity to really complex topics that could be difficult to understand, the explanations are just so accessible and clear. And so many of the points are pertinent given all of the noise that surrounds topics like LDL-C and cardiovascular risk. Please keep doing them, it's really helpful.

I'm very much looking forward to the next video. I'm on a low carb diet now for two months and any guidance on best practices to keep ApoB under control is very, very welcome.

These videos are terrific. Thank you so much. There's so much conflicting and confusing information out there, a lot of camps and a lot of agendas. Its refreshing and extremely helpful to listen to you cover the science without bias. Again, thanks so much!

looking forward to part 2. Great video.

This is a good foundation for part 2. I eat a little meat, a steak a week , a little chicken too.Grass fed. The rest is a range of all that is seen as healthy.I stopped added sugar totally..I stopped breads and cakes.I have rice sometimes.An egg every cupla days.I like an apple a day, blueberries etc. I love pulses and vegetable dishes.Salmon and other oily fish is a must. My weight is lowering. I eat only when hungry and I approximate the intake akin to a 16/8 ...but vary it , sometimes I push it more towards 18-20 hours. I don't beat myself up if I eat too many nuts here and there. I am losing a steady amount.About 6 pounds every 5 weeks but I don't obsess.I just feel more nimble. Walk about 2-3 miles a day. This channel is the best I have found because it doesn't feel like a cult. Not yet, anyway ! 😂 Thank you.

@MeMe-dw1sm

10 ай бұрын

Exactly the way I eat, feel great

@xnoreq

4 ай бұрын

​@@MeMe-dw1smBut feeling great is not an indicator of a healthy diet.

@astcal

Ай бұрын

if you run at least 6 miles a day 5 days plus intense 2 day resistance training per week, would you eat the same type of food ?

Thank you, both! This is very helpful. Can’t wait for next video.

I have a Friend who has high triglycerides and very low HDL , he eats mostly refined carbs , I have low triglycerides and optimal HDL , I was eating a ketogenic diet at the time of the blood work, the only marker that he had that was better than me was LDL , I m not saying LDL isn’t important especially if APOB is high , but it interesting how someone that unhealthy ( he’s overweight and doesn’t exercise, still has totally normal LDL. I don’t know his APOB because his doctor only ran the standard lipid panel.

Just want to say thank you for the thorough reference list, and for flagging them during the video. Much appreciated Gil

Found you on my feed. Just subscribed. Yes looking forward to part 2...great content & info I am interested in.

This is really helpful and fascinating. Many thanks!

We need to re-define “carbs”. I think of fruits and vegetables when carbs are mentioned while others are thinking donuts and pancakes.

@timsahkelebek5901

Жыл бұрын

YES. Carbophobia went so insane that people are even scared of whole fruits.

@Radjehuty

Жыл бұрын

This is indeed annoying. In fact, it's gotten so bad that people will even claim fruits are bad for you because they're "full of sugar" as if equating apples to donuts. Unfortunately, we just don't have great differentiating terms.

@seller559

Жыл бұрын

@@Radjehuty Agreed

@joe1071

Жыл бұрын

Yeah, I think the research on fructose ruined the definition, lumping all fructose together and assuming fruit was the same as candy or sugar soda. Then the research showed fruit has positive health effects and isolated fructose did not. They are not the same

@seller559

Жыл бұрын

@@joe1071 Exactly

Great guest, keeping it real, having an open mind, and pointing out things that are currently unknown!

I'm glad to have come across your video. This was very interesting and helpful. Thanks. Will look for Part 2.

Excellent video and very helpful. Thanks so much!

This is really useful! Please continue to produce more content like this

That was a great conversation. I am doing well on a low carb diet. I am looking forward to learning more about saturated fat in part 2. Thank you.

@doherpa

Жыл бұрын

As am I. Don’t buy into the vilification of saturated fats.

I did Atkins for 5 years then went Keto and back to Low Carb. Last year I developed Hyperinsulinemia 316 pmol/L. I have switched to mostly Plant-based eating Fish once or twice a week and perhaps chicken once or twice a month. I am now at 107 pmol/L. Nutrition is not a one size fits all. Find what works for you ignore the rest.

@Fearzero

5 ай бұрын

Animal products shorten lifespan for the majority of people.

@xnoreq

4 ай бұрын

You are not at all alone in that. The liver primarily accumulates fat from dietary fat, which ultimately impairs suppression of glucose production in the liver. So now you have high blood glucose. You know what happens next. The pancreas compensates by producing more insulin. Hyperinsulinemia. If you kept supplying fat then both the liver and pancreas would keep accumulating fat, aided by the extra insulin, which results in a downward health spiral. This is how type 2 diabetes develops, because at some point the pancreas will burn out. At this point insulin production will go down and blood sugar will go up uncontrollably. It's sad there there are so many "health influencers" and people paid by the industry that spread so much misinformation and promote these sort of diets, so it often takes people several years to figure out that these diets are not healthy at all - at their own health's cost. But all the basic nutritional science has been known for many decades.

@erastvandoren

3 ай бұрын

​@@xnoreq lol, where do you get this? He never said anything about high blood glucose

@erastvandoren

3 ай бұрын

Actually, plant-based is the base diet for everyone

@FacundoMontoya

2 ай бұрын

For Monkeys

Thank you, great conversation.

Very clear and informative. Onward to part II!

Great job as always. Keep it up!

First of all thank you for this video. I'm 75 no meds no pain, eat low Carb, no sugar, and exercise regularly. My LDL however, is always a bit higher than it should be. I recently had an ApoB test done, and seeing my doctor soon to discuss. I am one of the fortunate people with a doctor who is a collaborator in my health-care. This video helps me to discuss my ApoB with some degree of understanding. ALSO thanks for your thoughtfulness in having an esthetically pleasing background for your viewers. So many ignore that they don't have to look at the "mess" but we do.

@robertusga

Жыл бұрын

Nothing wrong with going low carb and adding low dose statin and ezetimibe to keep LDL-C and ApoB in healthy range.

@elizabethk3238

Жыл бұрын

@@robertusga yes, a lot wrong when the lowest dose makes you very sick! Speak to your level of experience, not just what you're FED!

@michealfriedman7084

Жыл бұрын

You can have high LDL. If you have large particle LDL you are OK. It's the tiny LDL particles that are the issue.

@robertusga

Жыл бұрын

@@michealfriedman7084 particle sizes are irrelevant in the context of ApoB. If you know your ApoB, you know your CVD risk.

@Pokerface8899

9 ай бұрын

Do you consume fruits are fruits bad for you

Great topic and information! Please continue.

Thank you for this interview, it brings well needed context to the conversation of a low carb diet which I just started as a 72 year old male with heart disease.

These videos absolutely help. An actual breakdown of foods to eat, how much and how often is even more helpful and I look forward to part 2 although a comprehensive list that we can take away is more practical.

@clavenbeth123

Жыл бұрын

Everyone is different though.

@NimpanZ

Жыл бұрын

@@clavenbeth123 you can say that again. I'm one of those people that has to drink their veg.

@AlwaysSeekingTruth13

Жыл бұрын

@@andrewclark3236, what is your ApoB count?

@andrewclark3236

Жыл бұрын

@@AlwaysSeekingTruth13 I don't know. Haven't been to the doctors for years. Are you able to give me a reference to a randomized control trial that links eating high amounts of protein is significantly associated with ApoB levels?

@scottcunningham79

Жыл бұрын

Do you have any idea when part 2 will be released? I’m new to this channel and am not sure how often he post new videos. I really want to listen to the follow up.

Very interesting! Thank you!

Looking forward to the next episode.

Looking forward to next week.

One of the most useful videos on this controversial topics I have ever seen. Looking forward to the practical implications in part 2!

Very interesting! I can’t wait til next week 👍

Interesting. Good conversation. Thanks.

Learnt lots, thanks

Great conversation! Just what we need, an informed discussion vs absolutes that are all over the internet.

Eye opening conversation on the calcium score, thanks I did not know the nuances of how it worked

Good video. Appreciate it.

Excellent video.

Another great, great video, Gil. No bs or quasi-science. I argue with the keto crowd until I'm blue in the face and tell everyone I know and love to get their ApoB measured. Please continue this series. It's solid, very useful, and practical. Thank you to you and Dr. Weiss. A+ work. 🙏

Great video, thank you. I am on a low-ish carb diet, mainly because it helps me maintaining the intermittent fasting regimen (less cravings). I use MCT in the salad instead of or in addition to olive oil, for the ketones. What is your guest's opinion on MCT oil? Also, what is his opinion on the trygliceride/HDL ratio as a marker?

@astonuk9403

Жыл бұрын

C8 C10 and maybe C12 are not considered the atherogenic fatty acids and don't damage the gut microbiome.

Very valuable info. 🙏

Nice haircut Gil. I liked the video and the guest speaker. Looking forward to part 2

My ApoB shot up to >180 while on a strict keto diet. I was in good shape and good BP, but I've got two teenage kids I need to see through university. At least! I can't just die on them. So I switched to a low carbish diet by adding two cans of beans (protein + fiber) per day while swapping out SFAs and reducing dietary cholesterol generally. No more eggs or red meat, just chicken breast and fish. Now my ApoB is 83.

@presence5426

Жыл бұрын

Nice. That's the way problems should be approached. Different strokes for different folks.

@hikedayley9309

Жыл бұрын

Andrew, I applaud your individual approach. "Strict" Keto doesn't work for me. I include some beans too. Eliminating refined sugar is more important than eating some complex carbs the beans provide.

@aquamarine99911

Жыл бұрын

@@hikedayley9309 To me, the main benefit of legumes is the fiber. Contrary to what low-carb "experts" say, I've come to believe the body needs lots of fiber, and legumes are the most efficient way of getting it. They are truly a wonder food. Their high protein content also helps to lower the amount of animal protein (and SFA's) you have to eat. .The net carbs they provide are their least important nutrient.

@presence5426

Жыл бұрын

@@hikedayley9309 Beans can be a part of strict keto. As long as you're not going over 30g of carbs a day. But, like you say, strict keto is tough for many people. Just keeping a lid on carbs, especially refined, is probably better.

@cartmansuperstar

6 ай бұрын

@aquamarine99911: so the two cans of beans and vegetables are your only carbohydrate-source ? And apart from that you consume mainly unsaturated fats and your apoB is still only 83? That sounds great. Please confirm. Thanks.

What if their other risk factors-obesity, hypertension, blood pressure, inflammation, energy and mental health improve significantly on low-carb high fat-does LDL/ApoB become a less significant concern?

THIS absolutely helps! There is so much "info" out there and most of it is huey.

Great content. ❤

Yes, very helpful conversation, Gil and Ethan. Thanks! What is "ideal" ApoB level? What is "reasonably good" ApoB level?

@rubix01

9 ай бұрын

Ideal:

@PauloSousaPinto

8 ай бұрын

kzread.info/dash/bejne/aZWcsbGnf7vZZMY.html

Great discussion! Have a couple video ideas for you! Would love a video on long term water fasting (3-7 days or more). Second, maybe something on how meditation can impact body composition or diets (dont know if there are studies for this). Thanks for your content as always

This interview will probably confuse the hell out of most people, even those with a moderate science background. The cardiologist is constantly changing frames between him, his patients, and "evidence". However, the ultimate goal for any respectable healthcare professional towards their patients is a way of eating that: 1. lasts for a lifetime 2. is sustainable 3. doesn't exclude from the social sphere 4. doesn't introduce major health risks. These criteria may exclude most "diet clubs", but some do score better than others, and probably by a wide margin. All in all, I was not convinced. His patients should probably ask for a second opinion before gamefying their ketones and getting a high score on their LDL.

Super helpful. Very hot topic. Please more like this conversation:)

These were great questions! It's interesting that CAC is not a good indicator especially with people below 40. I wonder what could be said about inflammation markers and their link to CVD, and what specific markers would be meaningful in that context. Thanks!

Great video, incredibly useful and informative, my wife was prescribed a keto diet and I was doing my research but there is so much bunk it is sometimes hard to navigate this field.

So good! Thank you and, yes, more please :)

A couple of nutrition geeks in full flight. Great to see you talking to someone on your same level. High carb vegan here trying to keep an open mind on low carb.

Glad to see you doing more interviews. Any plans to have high carb low fat/low-no oil advocates on?

@mrbigsdaddy

Жыл бұрын

High carb life is a real drag. You will never understand the power of steady blood glucose until you test.

What an interesting dicussion!

Love your videos.

regarding the issue of high LDL-C and ASCVD risk, I am sure you have seen the hazard ratios of various conditions published in JAMA. At the top is diabetes, smoking, the various metabolic syndromes (such as obesity) on down to TGD and low HDL. At the bottom is LDL-C in terms of risk factors. So if you reverse the items with the highest risk, namely diabetes, ( and pre-diabetes assuming there is risk from that), obesity, hypertension but were stuck with higher LDL-C, wouldn't that be a good trade?

@NutritionMadeSimple

Жыл бұрын

there are many technical issues with using these data to directly compare risk factors (e.g. contrast of exposure and adjustment models). also, bear in mind LDL-C is just a surrogate of ApoB, which associates more strongly with risk. all that aside, the key realization is that most people can control ALL their risk factors at the same time. glucose AND body weight AND cholesterol metabolism. a healthy lifestyle does all of that. choosing between risk factors is not needed in most cases. this video and next week´s continue to explore these questions

@robertusga

Жыл бұрын

Why would that be a good trade if the only essential condition for CVD is high ApoB. Reduce that and the others are irrelevant. Not saying you should not try and keep all of them in a healthy range, but trying to ignore ApoB is just an excuse to binge on saturated fats while playing Russian roulette with heart disease and stroke.

@AZ89231

Жыл бұрын

@@NutritionMadeSimple FYI, the paper is Association of Lipid, Inflammatory, and Metabolic Biomarkers With Age at Onset for Incident Coronary Heart Disease in Women and the HR for apoB was 1.26 to 1.89 whereas diabetes was 3.47 to 10.92 and LPIR was 1.15 to 6.4

@AZ89231

Жыл бұрын

@@robertusga because it’s almost certainly not the only essential condition. I would argue it’s necessary but not sufficient (you also need inflammation and endothelial dysfunction generally) - see comment above - apoB as an independent risk factor is generally squashed by other markers of metabolic health and not very informative without interpretation in context. For example, when you use the AHA/ACC risk calculator, a higher LDL-c is trumped by TC/HDL-c ratio, I have patients whose LDL-c increased by 20% but their HDL-c incr by 25% and their total cholesterol stays the same and comparatively their baseline risks of ASCVD drops by 25%. LDL-c is a poor man’s apoB (sometimes). Beating up ApoB is VERY important for secondary prevention or VERY high risk individuals bc you’re taking the oxygen away from the fire of atherosclerosis, but to lower apoB into a “healthy range”…whatever that is…is perhaps a mistake IMO unless it’s absolutely necessary and it’s hardly playing Russian roulette. That is gross hyperbole.

@robertusga

Жыл бұрын

@@AZ89231 except it is proven essential. Check the Mendelian randomization. Low ApoB, 0 heart disease.

Question: Peter Attia said the ceiling for optimal ApoB is ~60mg/dl. What's your view on that? Any science behind this number??

Yes, please, more videos like these. Although, I'm not sure I understand it all.....

This is great info. Yes I do want to see a vid on CVD Low carb diet. I would love to talk to you about my CVD experience. How about a CVD patient viewpoint video?

When you explained oxidized LDL you cited pharma drug development data. It is murky business to rely on pharmaceutical drug development data to determine practice.

I do hope that Gil synthesizes and explains in layman terms what the low carb Cardiologist is talking about come the end of his interviews with him. If you put a gun to my head, I could not tell you anything definitive about this conversation

this was great

Can you summarise the take home points of this discussion please?

Thank you for asking about calcium score. One thing I'm curious about is do we know what causes a persons calcium score to get high over time? Is it different than what causes high LDL and ApoB?

This video answered a question I posted on another of your videos about whether there was a distinction between what happens on a high fat/high carb diet and a high fat/low carb diet. And the answer to that appears to be: look at ApoB levels.

What is a healthy range for ApoB? I could have missed it, I have not heard any numbers. Thank you.

I must confess, as soon as you mentioned you were interviewing a low carb cardiologist, I was slightly apprehensive. But that is a lesson learned for me, as Dr Ethan was completely reasonable - and interesting! Really appreciate you sharing this conversation and I look forward to seeing the next part.

@creativesource3514

Жыл бұрын

Why would you get apprehensive?

Great Video THANK You. Question: One Additional way CVD risk is assessed is by the Apo-B / Apo A1 RATIO... Can You please help us understand this in one of your future videos...? Thanks Again

@NutritionMadeSimple

Жыл бұрын

definitely. FAQ! :)

@jarichards99utube

Жыл бұрын

@@NutritionMadeSimple Awesome...! 😊👍

Well I found a lot of what he said confusing - not clear. if you’re going to sum it up for us that’s great. and I am looking forward to next week show so thanks.

Thank you very much for the content, very insightful. I found that the link is no longer valid for reference 11 - it woudl be great if you could update that.

@NutritionMadeSimple

9 ай бұрын

thanks!! fixed it. definitely let us know if you find other glitches

Thanks for the video. Is Lp(a) part of VLDL cholesterol? And is VLDL part of apoB?

Great2 video. The guy being low carb still gave a very unbiased opinion.

Hopefully this doctor can put together a study showing that you can reverse heart disease on a low carb diet, I will be patiently holding my breath.

Interesting to hear his point of view on oxydated LDL.

I had a recent blood profile. Though I didn't include an Apo-b test my triglycerides was in the possibly too low category, LDL 40 and VLDL 7. Would this indicate my Apo-b is probably fine?

Interested in learning his diet. From what I recall, he follows a kind of low-carb Mediterranean approach

I agree with the first two people who left comments or should I say the last two people. Great video and thank you but this guy speaking was so choppy and all over the place. It was very hard for me to take away what he was trying to relay on most of the topics so some clarity and clarification would be very beneficial and helpful. Thank you and keep up the amazing job you do.

What about cacao butter, is that a good source of saturated fat?

Very helpful, thanks! Wondering if someone can provide some insight? I'm 52, not overweight, don't smoke, and have low blood pressure. My previous total cholesterol was 300! This last lab work, I had my doctor test APoB (she had no idea what it was!) and my number is high. Current results: Cholesterol, Total 244 mg/dL Triglycerides 76 mg/dL HDL Cholesterol 84 mg/dL VLDL Cholesterol Calculation 13 mg/dL LDL Cholesterol Calculation (NIH) 147 mg/dL APoB 116 mg/dL I was able to lower total cholesterol by 56 points - but this is still bad, right? Can I get APoB in a low enough range without drugs? What should I aim for?

I did Low carb + time-restricted eating and got myself to a pre-diabetic state on my glucose levels. Got the Nutrisense tracker and saw my spikes go UP for every "breakfast." I started adding in healthy carbs and breakfast and my A1C went back to below 5.2. I'm working now toward whole food plant-based, as my LDLs have always been high and I haven't really paid attention to saturated fats in my diet.

How does the risk associated with ApoB compare to high fasting insulin?

thanks, appreciate the discussions about LDL/ApoB, oxidation/glycation risk > vs its only bad if its so, otherwise its ok

Absolutely great video. Yes more. We don't have to agree on every detail, we just have to take a moment to listen and learn a new perspective. 1000% agree, the keto carnivore world has not provided long term RCT'S. The rest everything one "but our ancestors ate meat". I still eat keto / carnivore but than again Im not here for a long time, just here to enjoy a short time then move on to the next life. My personal belief is that carnivore makes us strong, vegan helps us to live longer. Excess anything is bad. People have to choose and roll the dice. Driving a car or inner city living is a major risk. All part of life.

Good conversation, Gil and Ethan. These types of clear agenda-free, evidence-based conversations are a huge boon to the community (or at least those who are open to facts). Thank you!

@uncoiledfish2561

Жыл бұрын

But their personal ‘facts’ disagree 😂

@jarichards99utube

Жыл бұрын

Yes very true. Not all carbs spike glucose & insulin. I think of carbs as basically FIBER vs Non-Fiber (Sugar generating) carbs... Stay Well : )

Very interesting

A video explaining calcium score would be interesting

Can Dr Weiss address having low Lp(a) and high apoB at the same time? IE, Lp(a) is sticky. So if that is low and apoB is high, are you any better off, relatively?

Dr Carvallo, would you say that the frequent and sudden increase in ldl we see in people losing weight on a lower carb diet is due to transcient hypercholesterolemia? If not, what is your take and what happens to the ldl liver receptors under such a diet?

Another great video! What about ketogenic diets and alzheimers disease? Dose our brain perform better on ketons compared to carbs? Can a keto diet reduce the risk of getting alzheimers?

This was awesome!! Low Carb diet is the only that works after you develop certain degree of insulin resistance (alternatively, GLP1-RA drugs or surgery) --- well at least that's my experience. So it's really important to learn CVD risk while eating low carb. Clear & straightforward advice in this video! References are super helpful too! TY!!

@spiral-m

Жыл бұрын

"Low Carb diet is the only that works after you develop certain degree of insulin resistance ". Incorrect. Based upon successful peer-reviewed trials: "The Natural Food Interaction Diet (NFI diet) will allow you to eat what you want and as a much as you want each day, providing it is written on the plan. It is a personally tailored plan designed to give any person a sufficient and well balanced diet containing all the nutrient and minerals that you require and does not have any yo-yo effect whilst on the diet due to its specific tailoring to an individual." There is no calorie restriction at all.

@doddsalfa

Жыл бұрын

Low carb makes you insulin resistance

@keriwilliams8980

Жыл бұрын

@@doddsalfa ???

@doddsalfa

Жыл бұрын

@@keriwilliams8980 overconsumption of animal fat is the cause of diabetes 2

@ginadaley5414

Жыл бұрын

I'm sorry, but was very confused by "heart doctor"

The obvious un-asked question in the interview was why Dr Weis would continue a low carb ketogenic diet while acknowledging that it confers increased risk via Apob. Otherwise, quite interesting and I look forward to part 2. Thank you!

@butterf1sh

11 ай бұрын

Completely

@Madamegato

6 ай бұрын

While keto is low carb, there is a difference when saying you eat low carb (under 150g of carbs) and keto (under 50g and often under 20g). From what I gathered, this doc isn't keto anymore but went up to low carb.

@jeffreywp

5 ай бұрын

He doesn’t do keto anymore. He’s only low carb.

It's interesting to hear from someone who clearly has considered the risks and benefits to their dietary choices. Most of the loudest voices don't have this background knowledge orbjave rose tinted glasses. This lifestyle is not for me but maybe it is for someone. Great work Gill on this one

Yes, very interesting.

a brief summary at the end of the video would be nice

What's the difference between an NMR lipids panel and an ApoB test?

If someone has an ApoB within the "normal" range (e.g., ~100), but would like to drive it closer to optimal (e.g.,

Some of what he said went over my head. Your questions and comments helped make sense of it. The references are useful too. It's not just someone saying something because of the mood he/she is in or what people want to hear. Thanks. I appreciate the topic. Would appreciate more such interviews as you help create a bridge between scientists and lay people like me.