Lambert-Eaton Myasthenic Syndrome - pathophysiology, signs and symptoms and treatment

"Lambert- Eaton Myasthenic Syndrome (LEMS) is a neuromuscular junction disorder that was described by Lambert, Eaton and Rooke in the 1950s.
It is a disorder of calcium voltage gated channels in the preysynaptic motor neurons. The motor neurons supply the skeletal muscles. The voltage gated calcium channel do not allow calcium influx causing reduced Acetylcholine release into the synaptic cleft and thus reduced muscle contraction. LEMS causes muscle weakness which interestingly improves with activity unlike the other neuromuscular junction disorder myasthenia gravis which manifests as muscle fatigability.
Lambert Eaton syndrome is a paraneoplastic syndrome because of its close association with small cell lung cancer. Paraneoplastic syndromes are symptoms that occur at sites distant from a tumour or its metastasis."
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Пікірлер: 25

  • @ptrlxc
    @ptrlxc2 жыл бұрын

    I have a cousin who has had to deal with this for over 20 years. She really struggles when her medication comes late. Would be nice if they could degenerate the Ca gated antibodies that target this area. But LEMS is very, very rare and funding (it’s always about the funding) for research is very limited. Thank you for doing this video. It’s helped me understand more her Syndrome. Of course I’m dealing with ME/CFS myself, which has a promising direction it never had before with tryptophan metabolism issues.

  • @lenushpopa
    @lenushpopa8 ай бұрын

    Thank you for this comprehensive video!

  • @humanicgenes8825
    @humanicgenes88252 жыл бұрын

    Thank you so much...tomorrow am having a test on this topic and I was looking for such video

  • @jasurbekparpiyev2265
    @jasurbekparpiyev2265 Жыл бұрын

    Thank you brother for all

  • @mishamalghani7955
    @mishamalghani79552 жыл бұрын

    Loveee your videos!!! Much love ❤

  • @nadirabbas8114
    @nadirabbas81142 жыл бұрын

    Another great presentation sir

  • @driffat100
    @driffat1005 ай бұрын

    Thanks for such masterpiece 💖 really helpful for exam preparation. God bless you 👍 🎉

  • @Dr_feelgood_zw
    @Dr_feelgood_zw Жыл бұрын

    Thank you so much ❤❤ mbchb 5 exam preps👏

  • @tabp8448
    @tabp84482 жыл бұрын

    Thank you!

  • @musastuart10
    @musastuart107 ай бұрын

    Good summary for my exam period

  • @estherhemming2314
    @estherhemming2314 Жыл бұрын

    Thank you, now I know why I have the need to move all day.

  • @dr.nahidaftab1042
    @dr.nahidaftab10422 жыл бұрын

    Thanks a lot

  • @veravero5715
    @veravero57152 жыл бұрын

    Great info It is any special center or clinic who is treating LEMS?

  • @saidmo1797
    @saidmo17972 жыл бұрын

    Genius Armando.

  • @3li487
    @3li4872 жыл бұрын

    مشكور حجي ارماندو

  • @theartisticautist3123
    @theartisticautist31232 жыл бұрын

    That poor rooke Thank you for the great explanation!!

  • @christinesalami7712
    @christinesalami7712 Жыл бұрын

    Lovely

  • @Abdelrahimwalid
    @Abdelrahimwalid2 жыл бұрын

    Great 😃

  • @kartikaymohan1
    @kartikaymohan12 жыл бұрын

    Liked it better when you used to draw it on paper.

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    @abrahamthomas4680

    2 жыл бұрын

    I have suffered Melanoma Cancer critically for 2 years , all promises for cure are lies. I finally got cured with herbal medicine I purchased from Dr.OSAKA ON KZread channel and now I’m completely cured.

  • @mrrishiraj88
    @mrrishiraj882 жыл бұрын

    👍

  • @micfin109
    @micfin1092 жыл бұрын

    Say the title 3 times fast