This one truly left me SHOOK. Big brain moment right here

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Thank u very much 😍 this literary saves tons of time!!!! It's amazing how you cover THIS huge topic just in 20 mins!!

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Literally the best explanation on this topic I've ever come across! You are the best. I'm sitting here in awe at how much clarity I've gained from this one video :o Thank you so much DM!

5:02 Ketones Synthesis Summary 6:04. Starvation 9:44 Diabetic Ketoacidosis (DKA) 13:22 Alcoholism 17:29 Ketone Synthesis Chart (Use & Pathophysiology) 18:09 HMG CoA Synthase mneumonic 19:17 Other high yields

You have clarified the content and point out some very important parts for me. Big thump up !!,

Incredibly helpful. Thank you so much!!!

You are awesomely has the science, the general vision and the detailed one..beside the marvilous mnemonics. Go on plz

sir I don’t know what this world has done to deserve you , you are amazing teacher. you are doing a great job ,keep going and stay blessed. i almost watched your each and every video and every single video is amazing thank you so much sir !

NAD-y Light. Genius. I wish I could've partied with Dirty back in his undergrad 😂

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Your biochem series is amazing! Great job. 😄

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You hammered it down with repetition, WAY TOO MUCH, so that it can be engraved in my brain.😍 I love it because it's just what I need!

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Great job .... You have made the topic so simple ...

it 's really help me for my final examination . GOOD EXPLANATION !!!!

God Bless you for the great work....

you ATE with this one. Thank you so so much

Awesome 😎! Seriously, thank you! .

You’re amazing. Seriously you’re GOD to me, I was severely depressed about biochem but I see hope for myself now 🙏🏻

@laynesameerstaleymagari3176

3 жыл бұрын

yeah, this teacher is amazing

@addistimez8760

3 жыл бұрын

@Oscar Rodriguez Agreed!

Thank you very much for this, it has been very useful

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@dr.poornaprajna

11 ай бұрын

Did it help for solving Uworld and passing step 1?

@drme2399

8 ай бұрын

hi did it help in usmle step 1 exam?

THANKS for this!

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Impeccable 💝

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Another informative enlightening video! Could you please make a video on cholesterol synthesis?

amazing good job!

me - 'fasting' brain - *gimme them ketones*

Amazinng

Thank you very much ❤

The BHB tests will measure only the BHB that has NOT been used by the body.

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thank you

A 4th way you can form ketone bodies is by following the KETO Diet! haha. But I suppose this can go under starvation because the idea is to deprive your body from Carbs so insulin stays low.

Increased NADH to NAD ration in alcholics and pyruvate - lactate pathway

You are the best 😭♥️♥️♥️♥️♥️♥️♥️♥️♥️

everytime u ask me how the hell we gonna do that?? I smile. thanks

Help me understand the process of alcoholism and TCA cycle shuts down? What happens when that person eats sugar? Where does the sugar go? Stored in the liver and not the cells? Or the sugar doesn’t produce atp energy for the alcoholic? Is seems like the solution would be to take mct oil and exogenous ketones? This is good stuff?? This video has me really curious as to the pathway?

I will pass Philippine Licensure Examination because of you.

Legend

I wonder if his other topics are as good as his biochem series?

You are simply HIM, dirty medicine, HIM I say!!! GOD BLESS YOU FROM A STRUGGLING M1

Please explain how ketone synthesis occurs when someone eats low curb high fat diet.

My savior ❤️😍😍😍😍

I'm late to the video but just in case you're still active and replying, I have a question. Is acetylacetyl CoA the same as acetoacetyl CoA? That's what I'm seeing in my textbook

To clarify, the body's primary preference is to eliminate glucose as soon as possible. Before the advent of highly processed foods and the introduction of sugar, mankind relied on burning ketones for energy. It is important to remember that the body will make every effort to get rid of glucose due to its potential harm.

I would be very interested in references on this. It seems not quite right in that 1. OAA scan be supplied from Asp via transamination. 2. Acetyl-CoA is an activator of pyruvate carboxylase which will increase OAA when needed for TCA cycle. No? Also, liver is active in gluconeogenesis but liver doesn’t use ketone bodies. Not a challenge but what about these points?

Can Someone Please Clear This Doubt For ME.. Why does buildup of acetyl CoA from failure of TCA cycle shunt towards Ketones and not gluconeogenesis? Acetyl CoA stimulates pyruvate carboxylase right

So Keto-Diet is ?.. good/bad?

GOAT!!!!

If alcoholic have increase NADH why dont they directly go to ETC?????

@whitelion124

4 жыл бұрын

Probably because we're in the liver, at least that's my best guess.

@ianferneepr5648

3 жыл бұрын

@@whitelion124 I would also think that ETC Complex 2 is an enzyme on TCA Cycle (Succinyl DH). So inhibiting TCA cycle directly inhibits ETC. So they can't use it even though there's a high amount of NADH

❤️

Ketones get converted back to acetyl-coA when they reach their destination. How are ketones then helping to produce energy if the TCA cycle can't continue because of the lack of oxaloacetat? Why form ketones because of oxaloacetate depletion if you need oxaloacetate to gain energy from ketones?

Very well-done 🥰🤩

Da bestest

Great video for students but why does the body make 3 ketones? Surely one is enough?

Please make a video on harmful effects of ketone bodies.

Did you mean starvation was equal to very low carbohydrate diet?

How is this free :'D Thank you sir!

Can someone please explain how it is possible to use Ketones as an energy source? If it is actually formed due to oxaloacetate depletion or a NAD/NADH disbalance and if it's degradation would form acetyl CoA as a final product, how would it produce energy without undergoing TCA cycle?

@sunvavachi

4 жыл бұрын

He states when things are depleted and no oxaloacetate, our body will produce ketones as a result of a loss of ATP. The TCA cycle will not commence. Ketones will be the new source of energy.

@chadaitken5476

4 жыл бұрын

That TCA cycle takes energy to go thru the whole process? Thus more energy short cut with ketones? Ketones also release less free radicals, so less Glutathione needed?

i love you

Wait a sec, statins are called hmg-Coa inhibitors. So basically statins will prevent you from building ketones.

@sgill4833

4 ай бұрын

Does that mean, byproduct of ketones synthesis is cholesterol? I'm not in medical school. Just learning for personal health.

ok I love you

i gonna give the IFOM exam ...i hope this video helpful for me😍😍

@hamzashahid5543

4 жыл бұрын

Umakant Shinde Yes , extremely useful for IFOM , I recommend you all the videos for review Good Luck

acetoacetyl-CoA* but same thing.

If you're NOT DIABETIC ketosis is the preferred fuel of the body. BHB is what you want.

You got a magic ocean potion advertisement on your video. Really pushing the agenda they are.

You are not starving, you are fasting.