I think replacement will play a major role in life extension, that being said it feels like a very crude and invasive approach. With regards to the intercellular matrix, I wonder if it could be repaired via epigenetic reprogramming if we intentionally cause damage to the tissue so that the now young stem cells replace and rebuild it, I believe Vittorio Sebastiano demonstrated this in mice when his lab reprogrammed the cells and then intentionally chemically dissolved part of the muscles.

Questions to Jean Hebert & his Team: 1.What is your view on PTB Inhibition (Ptbp1) triggering glial cells (specifically astrocytes) to convert to neurons in the brain and general "Astrocyte to Neuron conversion" approach via drugs/chemical induction? I know there has been conflicting evidence of its effectiveness...your opinion? Its been researched for Parkinsons but wouldnt this method also apply for general brain rejuvenation or at least reverse alzheimer? 2. In your outline using grafts to replace brain tissue you hint for applying local jamming of parts of the brain to further facilitate network connectivity of newly grafted neuronal cell lines. Is jamming really necessary...wouldnt it be sufficient to engage in cognitive training and/or tailoring it with stimulation techniques (like TMS)? 3. Do you ve plans to apply for DeSci? Thank you and your team so much for working on one of if not the most important research area there is.

I'm a bit confused by the claim that whole body replacement would require little new technological advancements. Isn't the brain required for development (making it hard to grow a brainless body)? For example, the pituitary is necessary for adrenarcheal development in teens. And doesn't the body require movement/exercise to develop to adulthood properly? Is the suggestion to place an adult head on the equivalent of a child's body? Wouldn't a child's heart not be able to pump enough blood to an adult's head? Maybe these questions have been answered in the preclinical studies mentioned and I'm simply unaware, but these seem like really massive hurdles, especially compared to organ replacement from non-human animals.

@Moonlightfire88

Ай бұрын

All good questions, but ultimately they don’t compare to the scope of identifying and reversing all types of damage in our bodies

Vid at least a year old or older since he leave out recent procedures that are quite relevant to his talk

Would the entire head be replaced except for the brain?

no timestamp so I click 4 times in video and I am out.

Timestamp would help ❤

Sorry but the solution to age reversal should not revolve around multiple surgeries. All surgery comes with complications. Ridiculously over complicated and too many risks.

its yada yada, nothing helpful for the users