please make more videos about the lives of cells. this is incredible

Amazing work. Although I am an immunologist, the helminth clearance, just surpasses me. Congratulations, your endeavor simply is the strongest motive for any young scientist. Wish I had KZread during my bachelor studies.

@basiliqbal5218

Жыл бұрын

How are you ?

If you think about it, this is happening right now in our bodies

And this is why i love science!!!! Microscopic responses are always going on in and outside of our bodies! and untill you study medical science won't really understand it all but once you do trust me you will feel like a damn super hero with all that amazing knowledge btw im a Paramedical Esthetician and even though its a specialty in skin care i did understand what this video was talking about, The body is simply amazing!

Stunning illustration. Extremely clear and concise. Thank you!

Now that is quality beyond anything you can imagine possible

This is the most amazing thing I've ever seen. Do other people drool over molecular biology like I do?

this is such a beautifully made video, thank you for the clear explanation!

Superlatives are well-deserved here. Amazing work!!! Pleeeeeease more!!!!

so i have been binge watching on cellular interpretation and am now in awe of the complexity of our immune response system. i can not believe that we have evolved into this magnificent entity and we have no idea who we are under the skin. i know that doctors and scientist already think this is boring stuff but holy shit!... i had no idea. mind blown!!!!!!!

@view1st

Жыл бұрын

And to think it only took 3½ billon years to get to this stage of cellular complexity.

Going for quality explanations like this is the way, the way to get better doctors and scientists which are less confused about their knowledge and so can make easier the next steps in the medical science.

this makes me so happy for some reason

RIP to us medical students with an medical immunology exam in a few days.

@miruvae

4 жыл бұрын

Mine's in 10 days don't call me out like this

@arlenismendez1611

3 жыл бұрын

I have an undergrad immunology exam tonight!

@akiteruapologist2820

3 ай бұрын

how did yall do?

Incredibly well done

Estou encantada com as animações espetaculares presente nesse canal. PARABÉNS!!!

Full transcription Our body is in constant contact with environmental factors. Epithelial barriers like the skin or gut mucosa represent the first line of defense in the gut mucosa specialized immune cells actively reinforce the barrier and induce tolerance against food or commensal bacteria. Among those immune cells a recently discovered type of lymphocytes called innate lymphoid cells (ILCs) orchestrate immune responses and maintain tissue homeostasis. Unlike the T and B lymphocytes, ILCs do not express adaptive antigen recognition receptors. As such, their activation and expansion is not driven by antigen but rather by cytokine signals from the tissue. ILCs come in three types: ILC 1 / 2 / 3. ILC 3 interact with dendritic cells to maintain the epithelial barrier. Dendritic cells which are specialized in the presentation of antigen, acquire antigen from the gut microbiota and secrete IL-23. IL-23 stimulates the ILC3s to make IL-22 which then activates the epithelium to secrete antimicrobial peptides or AMPs that kill bacteria directly. IL-22 also enhances IL-23 production in dendritic cells. This dialogue between dendritic cells and ILC 3s maintains the barrier against pathogenic or commensal bacteria. ILC3s also interact with macrophages to establish tolerance towards the commensal microbiota. Antigen from gut bacteria induces the inflammatory cytokine IL-1β in macrophages which in turn triggers the secretion of GM-CSF in ILC3s. GM_CSF signals back to macrophages to induce retinoic-acid which promotes the differentiation of regulatory T-cells. Regulatory T-cells are essential in maintaining tolerance towards the commensal microbiota. ILC2s contributes to responses against helminths. These parasitic worms release enzymes that digest the mucus barrier and cause massive cell death. Epithelial cells sense the danger signals released by the dying cells and produce alarmins (IL-25,IL-33, TSLP). In response to the alarmin IL-25, ILC2s make mediators that induce mucus production from goblet cells, send activated dendritic cells to the lymph node (by IL-13 secretion) where they can prime T-cell effectors, recruit eosinophils and mast, and induce muscle contraction. These actions results in the expulsion of worms from the gut. In response to IL-33, ILC2s also make Amphiregulin, which induces tissue repair following worm clearance. However, ILCs also contribute to tissue pathology. ILC 1s which make the inflammatory mediator IFN-gamma and ILC3s which can acquire the ability to make INF-gamma during chronic inflammation are found in inflammatory bowel diseases such as colitis and Crohn's disease and contribute to gut pathology. As such, ILCs participate in various aspects of immunity from maintenance of the epithelial barrier and tolerance against commensals to immune responses against parasites and pathology associated with chronic inflammation.

@julianschachter2262

11 ай бұрын

did you trancribe it by hand or with an app?

@ornitnahman4914

11 ай бұрын

@@julianschachter2262 By hand

What an Amazing video... #after read so many writings and in a deep of lack of knowledge this video makes it brief clear!

thanks nature, you did it again

absolutely fascinating

Fascinating!!! Thanks for posting :)

Marvelous animation, great narrative. Serious problems with the closed captioning, though.

Excellent! Many Thanks.

Perfect!

Beautiful!

Obscure but crazy beautiful

wonderful , thank you

This is beautiful. I study the immune system / tolerance and exhaustion /and always open to collaborations. Best,

I'm amazed by the fact that there is a class of molecules that are called alarmin

@TheBZStudios

4 жыл бұрын

Alarmins are actually just normal cell peptides that are not normally found extracellularly. Because they're only meant to be found inside cells, when they're sensed in the tissue by immune cells its clear that cells have been killed.

@fara.r.8181

3 жыл бұрын

Alarmin as of when these molecules out of the cells as a "danger signal" to others.

@mrniceguy4277

3 жыл бұрын

Yes, I know. Still cool to call these alarmin :)

@fara.r.8181

3 жыл бұрын

@@mrniceguy4277 Yes. You can search out DAMP and PAMP for further reading.

@mrniceguy4277

3 жыл бұрын

@@fara.r.8181 I'm a PhD student with a M.Sc. in Immunology, mate :) Still a good tip in case some random person reads this xD

increidible explanation i appreciate

amazing so complex system going on in our bodies 😊

Astounding!

Great video ❤ please keep making videos like this ❤

This is amazing....thank you so much🥰

Insane animation.

Fantastic !

It is very amazing thank you

Simply great channel. I subscribed.

Super explanation and animation ❤️💙💛

thank you very much

cool animated videos plz dont stop making videos like this

This was so intense😰I loved it

this is great!!!! thanks

I love this work, it feels like you are watching a movie 🎬

Excellent video. 👏👏👏

Had this been available 40 years ago I would have likely not switched from pre-med to poli sci...Never too late to learn.

thanks ad

Good video

awesome videos

Amazing!!!!! 👏🏼👏🏼👏🏼

Beautiful 😯👍🏽

Superb !

Amazing❤❤❤

These videos and the narration are so helpful. Spell-binding.

I want to become a scientist now

I love this work and appreciate your efforts to make this | ❀ ☆✿♡

AWESOME 👏🏽

Amazing what we don’t know.

Informative

Maravilloso

3:10 What about peyer's patches instead of a LN?

Good video👍😉

please make the video on MHC pathways

Please explain the work of the enzyme 5 alpha reductase in changing the male hormone, and where it is produced. Thank you.

I could watch videos like this on every single subject inside of biological creatures. This is like a version of the magic school bus haha

So good I "almost" get it !!

@StephenMortimer

8 жыл бұрын

***** Nooo.. that was helpful ... the problem is that I am 71

@g63music95

5 жыл бұрын

Lol 😆

Is it a similar situation in the lung?

Helminthic worms also evolve to counteract the gut's defences. Thus, how effective is the current stage of human gut evolution vis-a-vis helminthic worm evolution; are we ahead or just equal?

so many interleukins,,,,,, cries

spacy animation :D

hi everyone hope all are keeping fine .reactive population of lymphoid cells pls help us how to overcome with lymphoid cells what is best treatments ? thank you very much in advance ,

A replica of the universe

Strange to see when a cell fires signal molecules directly in direction to an another cell. It is wrong visualization

Anyone else sent here by Jenny/A Kelly?

It's magic

في بعض المصطلحات ما فهمتها

Immunology Out Of The Gut Mucosa 2

our bodies are kinda badass

This is kind of complex

👍👍👍👍👍👍👍👍👍👍👍

Those Parasite Worms

اخخخ😟لو يترجم الى عربي ب يكون أحسن للفهم

Hummugos

Boja

Lol lol 😂

"evolution" ... ha ha!

Everything is proving one end Allah (God) is great