Immunology | T- Cell Development

Official Ninja Nerd Website: ninjanerd.org
Ninja Nerds!
Join Professor Zach Murphy for our lecture about the thymus gland and T-cell development. We go into detail on positive and negative selection, and the movement to secondary lymphatic organs. We hope you enjoy this lecture and be sure to support us below!
References:
● Steve Ford. 2020. [Digital photo] The lymphatic system 2: structure and function of the lymphoid organs www.nursingtimes.net/clinical...
● Vector Shock Lymph node structure medical educational vector image. [Digital photo ] www.vectorstock.com/royalty-f...
● Indiana University. Histology of Spleen [Digital image] vmicro.iusm.iu.edu/hs_vm/docs...
● Teach Me Anatomy. Tonsils [Digital Image] teachmeanatomy.info/neck/misc...
● Varsity Tutors. MCAT Biology [Quiz] www.varsitytutors.com/mcat_bi...
● Le T, Bhushan V, Sochat M, Chavda Y, Zureick A. First Aid for the USMLE Step 1 2018. New York, NY: McGraw-Hill Medical; 2017
● Marieb EN, Hoehn K. Anatomy & Physiology. Hoboken, NJ: Pearson; 2020.
● Boron WF, Boulpaep EL. Medical Physiology.; 2017.
● Urry LA, Cain ML, Wasserman SA, Minorsky PV, Orr RB, Campbell NA. Campbell Biology. New York, NY: Pearson; 2020.
● Jameson JL, Fauci AS, Kasper DL, Hauser SL, Longo DL, Loscalzo J. Harrison's Principles of Internal Medicine. New York etc.: McGraw-Hill Education; 2018.
● lberts B, Johnson A, Lewis J, Raff M, Roberts K, Walter P . Molecular Biology of the Cell. New York, NY: Garland Science; 2002
● Murphy K, Weaver C. Janeway's Immunobiology. Garland Science; 2016
● Doan T, Melvold R, Viselli S, Waltenbaugh C. Immunology. Lippincott Williams & Wilkins; 2012
● Levinson W. Review of Medical Microbiology and Immunology. Lange; 2012
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#ninjanerd #TcellDevelopment #Immunology

Пікірлер: 541

  • @ahmedelhenawy1998
    @ahmedelhenawy19985 жыл бұрын

    This was more informative than a 2 hour university lecture from a phd that has written his own textbook on immunology.

  • @AestheticMEDICO

    @AestheticMEDICO

    4 жыл бұрын

    Lmao yessss

  • @namitachanda2124

    @namitachanda2124

    3 жыл бұрын

    Exactly

  • @nbme-answers

    @nbme-answers

    3 жыл бұрын

    Good research and good teaching are two separate, highly specialized and unrelated skills. Don't let anyone tell ya different!

  • @Jabreup.

    @Jabreup.

    3 жыл бұрын

    💯!!! This guy is the best!!

  • @gulanzafar7636

    @gulanzafar7636

    3 жыл бұрын

    Yup indeed!

  • @katerbrig
    @katerbrig2 жыл бұрын

    There's a big difference between an expert and an expert who can teach. Thank you for being the latter.

  • @Almog6k
    @Almog6k5 жыл бұрын

    This is how education should look like. Thank you!

  • @sayalidukare135
    @sayalidukare135 Жыл бұрын

    Plz make a whole series of an immunology leacture, it's very beneficial to us

  • @DrZoonotics

    @DrZoonotics

    4 ай бұрын

    Actually, I have counted 8 Ninja Nerd videos concerning inflammation.

  • @carolinerivera108
    @carolinerivera1083 жыл бұрын

    I have been teaching this stuff for close to 20 years and yours is the best explanation I have ever seen!

  • @princessjazz5767

    @princessjazz5767

    10 ай бұрын

    I really hope u r a good Professor because... most of the Professors just assume we know all of this. What ZACK did is TEACHING, what Professors in Uni's do is not TEACHING at all, i dnt care what anyone says.

  • @abdoulazizdabo9064

    @abdoulazizdabo9064

    10 ай бұрын

    I like your humbleness and honestly, I wouldn’t surprise if yours also is the best.

  • @elenasultan3627
    @elenasultan36272 жыл бұрын

    Good teacher. Shame that we can only see and learn from KZread nowadays when the course has been paid thousands of pounds and no one there to teach, so I end up listening this guy here.

  • @xSEALs2007x
    @xSEALs2007x8 ай бұрын

    Teaching cannot get any better than this. This is the best I’ve seen by far.

  • @TheFarahzz
    @TheFarahzz3 жыл бұрын

    I know that you guys hear this a lot, but I am truly thankful for these videos. It has been 3 days now in which I haven't been able to grasp this concept when my teacher has explained it and you guys were able to do it in just 20 min. Much appreciated and keep them videos coming

  • @amdgarcia17
    @amdgarcia172 жыл бұрын

    Please please make more on the immune system 🙏🏽 your videos are very detailed and explained well for someone with no medical backgrounds. Mom has had auto immune disorder/RBCAPLASIA (acquired). And when we found out we were so lost and confused because her doctors would explain it in medical terms, we didn’t understand anything until we started searching and watching videos like yours. Truly appreciate you, I feel like I better understand her situation and feel confident explaining it to others as well

  • @DrZoonotics

    @DrZoonotics

    4 ай бұрын

    Actually, there are 8 Ninja Nerd videos concerning inflammation.

  • @amdgarcia17

    @amdgarcia17

    3 ай бұрын

    @@DrZoonotics Actually when I posted my original comment which was a year ago, there weren’t all the videos that are up now. Of course now there’s been more uploads since then.

  • @hamzenouh4911
    @hamzenouh49112 жыл бұрын

    you guys are helping humanity. you deserve the highest award possible for education

  • @lilchiliflake
    @lilchiliflake3 жыл бұрын

    Thank you so much for this Immunology playlist as well as the videos on COPD and asthma pathophysiology! You helped a desperate biology master student to dive into therapy research on chronic lung diseases and to pass her oral exam with flying colors :D The Janeway was giving me a hard time to get myself oriented! You are my hero

  • @zuluzero4659
    @zuluzero46595 жыл бұрын

    Simpily amazing! My university lectures explain this in such a difficult way with 100s of slides and i almost gave up but watching your video motivated me that I CAN DO THIS!!!

  • @leeannstorms3239
    @leeannstorms32392 жыл бұрын

    I am a retired high school biology teacher and I enjoy watching your videos so much. You truly have a gift.

  • @Welshwildthing
    @Welshwildthing3 жыл бұрын

    So thankful for your videos! I struggle with my reading sometimes but you explain things so well, I wouldn’t get through some of it without you!

  • @yuqingcai3447
    @yuqingcai3447 Жыл бұрын

    I had been struggling with this part for many hours, and now everything is clear. Thank you so much, sir!

  • @uqunerds1180
    @uqunerds11805 жыл бұрын

    I love the way that you explain , oh god thank you sooo much for every things you saved my medical life❤❤☹

  • @SpoonieSensei
    @SpoonieSensei3 жыл бұрын

    i have always been a little shaky on my t-cell development and this is honestly the most straightforward and comprehensive information i have ever come across. thank you!

  • @MK-ih6wp

    @MK-ih6wp

    3 жыл бұрын

    Same. I have decent memory of what we learned back in school but never felt very confident about t-cells, until now!

  • @paromitasarker151
    @paromitasarker1514 жыл бұрын

    It is exactly what i was looking for. It synchronizes perfectly with the main text book. Thanks a lot. You saved me

  • @chandlereyre8792
    @chandlereyre87922 жыл бұрын

    Thank you for the video! I did want to add/ask one thing, however. Current medical student, and we were taught that the downregulation of CD4 or CD8 on the thymocyte is due to the interaction between TCRs and the MHC 1/2. If the TCR (by chance) interacts with MHC1, then the corresponding CD8 will also interact alongside it, and CD4 is downregulated. If the TCR on a thymocyte interacts with MHC2, then CD4 will persist, and CD8 is downregulated. I guess this differs from your explanation in that you imply the CD's are what determines this varability and choice. But I believe the chance originates from RAG recombiation to the TCR earlier on. Thank you for such a helpful video!

  • @princessjazz5767
    @princessjazz576710 ай бұрын

    GOD BLESS U MAN.... I dont know why we go to universities at this point when we learn more from KZread than our Professors.

  • @MK-ih6wp
    @MK-ih6wp3 жыл бұрын

    I know we are all marveling at this guy's incredible teaching skills... but do you guys ever get blown away by the complexity of the human body? I just can't get over how intelligently our bodies are designed.

  • @sashaschtein2690
    @sashaschtein26903 жыл бұрын

    I can't express how thankful I am for this.

  • @user-gg2ne4mm8c
    @user-gg2ne4mm8c Жыл бұрын

    I just wanted to come back to these videos and thank you so much for single handedly helping me achieve my goals in my immunology course! I just finished my first year as a pharmacy student and your videos really helped me, thank you!

  • @stellawu1768
    @stellawu17684 жыл бұрын

    Bro, that was awesome. I can't understand jack in my immunology lecture and you just made it so clear and simple (well, it's never simple), but definitely manageable especially during these times where my exams are online I can't understand any of my e-learning lectures!

  • @nightlythoughts4701
    @nightlythoughts47012 жыл бұрын

    I've been staring at my pathophysiology book trying to understand this for hours. thank you!!

  • @abdullahibrahim531
    @abdullahibrahim5316 жыл бұрын

    no one in thizs world can b better than this guy.....thanks alot

  • @patponggullayanon3075

    @patponggullayanon3075

    2 жыл бұрын

  • @joanapires8883

    @joanapires8883

    2 жыл бұрын

    A minha vida

  • @xclvrfip
    @xclvrfip4 ай бұрын

    Thank you! I couldn't get this topic for the past hour trying to skim and read my textbook over and over again. I'm glad I found this video. Thank you a thousand times!

  • @sannahshah1115
    @sannahshah11154 жыл бұрын

    honestly, you are an angel sent down to us depressed and tiredlookingforanswers students. may God bless you :)

  • @lilygyu6080
    @lilygyu60804 жыл бұрын

    You guys are life saviors thank you so much for every course you upload❤

  • @humanitytribe1111
    @humanitytribe11114 ай бұрын

    Thank youuuuu! I spent hours trying to understand this in my text and you literally helped me completely understand it in a short period with zero confusion.

  • @ftyuiokmn
    @ftyuiokmn4 жыл бұрын

    Been looking for a proper explanation of the T-cell development for quite some time now and I'm glad I came across this video! Goodluck to me analysing and memorizing all this to report in front of the whole class and our teacher. 😬 Aiming for that high score for the evaluation!

  • @AGrant-eb5mr
    @AGrant-eb5mr2 жыл бұрын

    Thank you so much -- you cleared up my confusions! Your teaching is the absolute BEST!

  • @TheAmmarKeylani
    @TheAmmarKeylani5 жыл бұрын

    perfectly explained. The only missing info you missed is the fact that it is NOT RANDOM where the stage of T cells become either T helper cells or T cytotoxic cells but according to a regulatory hormone from the liver reflecting the status of the body at the time of formation of T cells and its demands to which kind of cells it needs such as in yellow fever or Malaria or Dengue etc .. Thank you for an extremely simple and elaborate lecture! :)

  • @elenemchedlishvili303

    @elenemchedlishvili303

    Жыл бұрын

    Could you please provide reference? I have been searching for paper that describes the process.

  • @SilenceInTheBliss
    @SilenceInTheBliss4 жыл бұрын

    Oh my goodness I want to cry this is so good. Thank you!

  • @sliderulelover
    @sliderulelover2 жыл бұрын

    Excellent description of how T cells differentiate via the thymous and various chemical signals.

  • @KG-pt2sr
    @KG-pt2sr4 жыл бұрын

    Dude! You are a flat out BEAST/BOSS!!!! I'm an engineer and can't help but appreciate your mastery of what you're talking about. You're a natural!! Keep up the GREAT work!! Love this site - best site out there.

  • @tranll1
    @tranll12 жыл бұрын

    Love it!!! This is the best demonstration for T Cell development so far!! Thank you 😊

  • @ameliajohson4329
    @ameliajohson43295 жыл бұрын

    You've explained it so well, I was really confused.

  • @sunghoonsbiceps2287
    @sunghoonsbiceps22873 жыл бұрын

    I swear bro you were meant to be a teacher. Thank you so much! ❤️

  • @pvsraju7092

    @pvsraju7092

    3 жыл бұрын

    May God bless you, at 76yrs I am learning. Ths Pvsraju

  • @user-yh4ky1cb9o
    @user-yh4ky1cb9o4 жыл бұрын

    OMG, I'm speechless. Thank you.

  • @lucyforeman9950
    @lucyforeman99504 жыл бұрын

    Thank you, thank you, thank you!! This was incredibly helpful!

  • @dev-ir7ox
    @dev-ir7ox7 ай бұрын

    This downright has to be the best way of teaching anatomy and physiology there is

  • @madhavdhakal1715
    @madhavdhakal17154 жыл бұрын

    Wow you are expressing so nicely. I am doing PhD Biotechnology and I learned so many things from this video. Thank you for this video

  • @raynehentges5414
    @raynehentges5414 Жыл бұрын

    I have been working on learning this information for a while and watching this video, everything finally clicked. Thank you so much!

  • @latonaakaworkaholic_rn3502
    @latonaakaworkaholic_rn35023 жыл бұрын

    Dang I needed this lecture more than words can say. Thank you!! For real - THANK YOU! 💜🙏🏼

  • @CarnivoreAnesthetist
    @CarnivoreAnesthetist3 жыл бұрын

    Who are the 48 people didn’t like this video? Probably immunologist somewhere thinking this physician assistant knows more about this stuff than I do ha ha. Nicely done great video. I practice clinical anesthesia. but, I have been addicted to the immune system the last 6-7months. Most of what I washed on other videos I have learned nothing from. Probably very basic for the casual watcher. I learned a bunch watching this video. Very good job do you have a true gift

  • @marinara2596
    @marinara25966 жыл бұрын

    I could watch you for hours

  • @oscarortega1136
    @oscarortega11365 жыл бұрын

    This was seriously well made. Thank you

  • @shahiramohammadi7284
    @shahiramohammadi72842 жыл бұрын

    Because of professor Zach immunology playlist I got 100 marks in immunology 😁Thanks to Zach and his wonderful team🥰

  • @jacquim5134
    @jacquim51344 жыл бұрын

    I'm a first year med student and I just finished watching your series of videos on immunology. Wow, you explained it all so well! As someone with myasthenia gravis I'd be interested to see your explanation of MG's effect on the thymus, t cells and what implications thymectomy to remove a thymus with hyperplasia would have on an adult.

  • @bionium6976

    @bionium6976

    2 жыл бұрын

    Mg is so painful i beleive

  • @walebelayneh2892
    @walebelayneh28922 жыл бұрын

    how you can keep all these things in your mind? is so amazing you deserve so much respect

  • @maram5102
    @maram51025 жыл бұрын

    Masterpiece! Perfect explanation!

  • @yaklub
    @yaklub Жыл бұрын

    Dude, you keep amazing me. This r cell development video is outstanding. Humbled by both you, Ninja Nerd, and evolution.

  • @elfreixo
    @elfreixo5 жыл бұрын

    Thank you so much mate! great videos and explanations!!! Keep up the good work!

  • @mouhamedcherfi8202
    @mouhamedcherfi8202 Жыл бұрын

    The video already relisted before 5 years ago but this is the best explanation I have seen thank you teacher you are amazing 💯💯💯

  • @aimyclapano1933
    @aimyclapano19335 жыл бұрын

    wow! Ninja Nerd Science..this is my favorite. thank you!

  • @zacharygomes1843
    @zacharygomes18434 ай бұрын

    The marker capping and uncapping is soothing to my brain

  • @saeedsahebdel855
    @saeedsahebdel8553 жыл бұрын

    I really wished you were our teacher each semester and each course! Keep going!

  • @hossamsaeed7088
    @hossamsaeed70884 жыл бұрын

    this is a pretty good and satisfying explanation ❤ thank you so much ❤

  • @mohitk325
    @mohitk3256 жыл бұрын

    Thanks for the videos. Hope to see more. Keep up the good work. Thanks once again

  • @aloquoraespada3580
    @aloquoraespada35806 жыл бұрын

    Ninja Nerd forever 😍💜

  • @NinjaNerdOfficial

    @NinjaNerdOfficial

    6 жыл бұрын

    +Fatima Alaa that's awesome!

  • @aditijoshi4959
    @aditijoshi49593 жыл бұрын

    Finallyy !! I got the concept !! Thanks a lot for this video :)

  • @sirinesaleh5398
    @sirinesaleh53983 жыл бұрын

    Hello ninja nerd, first thank you so much for your videos they saved my life. Can you make more immunology videos, because a vast subject, and i think many people, other than me need them ( cytokines and chemokines, Dendritic cells, MHC, B-cells development, immunological synapse). Thank you deserve so much more recognition.

  • @TrupthiJanet

    @TrupthiJanet

    2 жыл бұрын

    you can check out Shomu's Biology too!!

  • @mateuslacerda284
    @mateuslacerda2844 жыл бұрын

    This was very helpful. Thank you, Sire.

  • @AbdulWahab-eh3sq
    @AbdulWahab-eh3sq5 жыл бұрын

    Fav KZread teacher ❤️❤️ you're faaaaaaaaar better than all of my physiology teachers

  • @mokukim7205
    @mokukim72053 жыл бұрын

    Omg thank you so much for making this video, you helped me understand this concept much better!

  • @amnamustafa2942
    @amnamustafa29422 жыл бұрын

    "I hope that helped" there has literally not been one ninja nerd vid that did not help, they're all amazing

  • @mariammusri5640
    @mariammusri56403 жыл бұрын

    You are amazing! This was literally the best thing ever. Thank you so so much!

  • @darshinimalukar3246
    @darshinimalukar32462 жыл бұрын

    Perfection in teaching's every aspect. Thankyou sir. awesome video

  • @aib7592
    @aib75925 жыл бұрын

    You are the best seriously, you deserve much more.Thank you a lot. -Love from Turkey

  • @ivanhdz503
    @ivanhdz5032 жыл бұрын

    love the passion and love for medicine! great Job explaining this!

  • @digitiminimi5730
    @digitiminimi57302 жыл бұрын

    it's almost 2022 and i love you man, you made my life wayyy easier

  • @mitochondria7554
    @mitochondria75544 жыл бұрын

    You're a great teacher After Dr Najeeb I follow your lectures..💓

  • @vence84
    @vence84Ай бұрын

    The whole thing is, there is no hard lesson there is bad teaching. Thank you soooo much, actually this issue was very simple i know that now because of you❤

  • @josephdahdouh2725
    @josephdahdouh27254 жыл бұрын

    I'm learning some immunology in Highschool, and this is helpful. I rewrote my own lecture on my C.B. to revise this material later.

  • @josephdahdouh2725

    @josephdahdouh2725

    3 ай бұрын

    Well. Here I am again, in premed senior year watching this because I was forced to skip the class that concerns T cell development. Lol. I knew I watched this a couple years back, but that was so long ago ahahhaha. Hopefully, 4 years later, I don't return to this again omg.

  • @user-dx1jr9es3m
    @user-dx1jr9es3m2 жыл бұрын

    Great thanks for you Mr. Ninja we hope to complete immunology course with autoimmune diseases, hypersensitivity, tolerance and other important topics which related with immunity. Thank you again 👊🏻❤

  • @michellebaudelaire1131
    @michellebaudelaire11315 жыл бұрын

    Thank you ! You just saved my life !!!

  • @hawraawhite
    @hawraawhite3 жыл бұрын

    I have a final coming and this video definitely saved me. THANK YOU.

  • @dr.ayolizer8778
    @dr.ayolizer87783 жыл бұрын

    Thank you so much ❤️ It's short and direct to the point To more of this💪

  • @user-qc3uv8bu8b
    @user-qc3uv8bu8b3 жыл бұрын

    thank u, sending much love from Egypt

  • @dra.acosta7397
    @dra.acosta73972 жыл бұрын

    I'm so amazed in the scrumptious way he explaine everything. Thank u sooooo much 😍😍😍😍

  • @layalitamesh2125
    @layalitamesh21253 ай бұрын

    It’s the last night before my immunology exam. You simply explained me 90 slides ❤

  • @sabrinademello2036
    @sabrinademello20367 ай бұрын

    Just perfect! Thanks, guys!

  • @system3008
    @system30082 жыл бұрын

    This is insane. Wow so much respect understanding all this.

  • @architasaha8917
    @architasaha89174 жыл бұрын

    Extremely talented teacher.

  • @rageturkey
    @rageturkey5 жыл бұрын

    can you please become a professor?

  • @morsz6829
    @morsz68294 жыл бұрын

    Omg love your videos so much, thank you and it’s so far the best one

  • @suzanneanderson3193
    @suzanneanderson31932 жыл бұрын

    You have helped me so much in A and P 1&2! Thanks for making these videos! Sadhu!

  • @aqsa968
    @aqsa9682 жыл бұрын

    very wonderfully explained THANKS ALOT

  • @shaguftamalik649
    @shaguftamalik6494 жыл бұрын

    your way of teaching is amazing.

  • @Mar-ue9cr
    @Mar-ue9cr8 ай бұрын

    I mean what should we do without your lectures

  • @priscilamarcondes7635
    @priscilamarcondes76354 жыл бұрын

    Thank you!!! You are reeeally good explaining!!! congrats for the talent!!

  • @joudizawet7573
    @joudizawet75733 жыл бұрын

    Very helpful ❤❤❤ thanks a million.. I know that I'm watching this video after 3 years after uploading it but it really helped me a lot.. much love 🔥❤

  • @emmazblewski7837
    @emmazblewski78372 жыл бұрын

    Thank you so much!! This was so helpful for me as a medical student :)

  • @just_a_nerd01
    @just_a_nerd012 жыл бұрын

    I am a high school student and I understand T cell lesson very well from you ... I am more concerned with immunology now !

  • @itsmeaddie
    @itsmeaddie Жыл бұрын

    Thank youuuuu! Was able to understand this in preparation for my board exams!!

  • @wolfie5470
    @wolfie54704 жыл бұрын

    I dont know what I would do without your lectures! You are so great, guys! Thank you a lot!

  • @danniibucci
    @danniibucci Жыл бұрын

    This is awesome! Thank you; all the way from Australia!

  • @bilalsafi1090
    @bilalsafi10904 жыл бұрын

    Really helpful and easy to understand video, thanks a lot.

  • @sbtsbt4224
    @sbtsbt42243 жыл бұрын

    Ohhh...thank u so much sir Zach.... U are just perfect....! I really enjoying learning by you and never get tired or bore... Thank u 🤗 Love from Pakistan...