How Your Digestive System Fights Pathogens

Ғылым және технология

Our digestive system does a lot more than just break down food for us. It actually has a role in our immunity. In this episode, Patrick explores how immune system checkpoints within the digestive tract protect us from pathogens.
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There’s a long and winding canal that goes from our mouths to our anuses called the alimentary canal or sometimes the gastrointestinal tract. This tube starts and ends outside of your body, and it’s how you process and extract nutrients and materials from the food you eat. But it’s also a spot for potential pathogens to sneak in.
Our digestive system interfaces with all kinds of nasty germs, and as a result, it’s armed with multiple immune system resources to protect our insides from the outside.
Digestion itself is a long process and involves everything from mechanically grinding down food in our mouths to treating food with enzymes so that we can absorb the nutrients better. Therefore, there isn’t just one immune system checkpoint - there are safeguards along the entire system.
#digestivesystem #human #physiology #seeker #humanseries
Read More:
Introduction to the Digestive System
training.seer.cancer.gov/anat...
“The digestive system includes the digestive tract and its accessory organs, which process food into molecules that can be absorbed and utilized by the cells of the body. Food is broken down, bit by bit, until the molecules are small enough to be absorbed and the waste products are eliminated.”
Physiology - Digestion
www.ncbi.nlm.nih.gov/books/NB...
“Digestion is the process of mechanically and enzymatically breaking down food into substances for absorption into the bloodstream. The food contains three macronutrients that require digestion before they can be absorbed: fats, carbohydrates, and proteins. Through the process of digestion, these macronutrients are broken down into molecules that can traverse the intestinal epithelium and enter the bloodstream for use in the body.”
Immunity in the Gut
www.immunology.org/public-inf...
“The large intestine (colon) has a large resident population of microbiota, consisting of at least 1012 organisms per gram of luminal contents. These organisms, together with the antigenic load provided by the diet and the constant threat of potential pathogens, means the intestinal immune system encounters more antigen than any other part of the body.”
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Пікірлер: 139

  • @Corporis
    @Corporis3 жыл бұрын

    Host and writer here. Did any of y’all see that episode of the Magic Schoolbus where they shrink down and go through that kid’s digestive system?

  • @kholozondi9904

    @kholozondi9904

    3 жыл бұрын

    Nope. Didn't air in my country but very similar once off episodes of different cartoons did.

  • @renebelmontez489

    @renebelmontez489

    3 жыл бұрын

    Arnold… yeah I remember. Poor kid, he always had the worst experiences.

  • @aarondelgado3421

    @aarondelgado3421

    3 жыл бұрын

    You should be ashamed of yourself for believing in Evolution!

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    @@aarondelgado3421 Why? 🤨

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Yeah about 30 years ago. Was a cool episode! 😅 Also, one of my favorite movies growing up was 'Innerspace'. Also a really cool movie with a silly plot. 😏

  • @Master_Therion
    @Master_Therion3 жыл бұрын

    How do you know when your digestive system has failed to protect you from pathogens? You just have a gut feeling.

  • @Khemani_RL

    @Khemani_RL

    3 жыл бұрын

    Nice one 😂

  • @muteebbhat1024

    @muteebbhat1024

    3 жыл бұрын

    You must have at least 3000 iq

  • @carnsoaks1

    @carnsoaks1

    3 жыл бұрын

    @@muteebbhat1024 Genius, you could outsmart a donald.

  • @Gold63Beast
    @Gold63Beast3 жыл бұрын

    I see someone saw Vsauce’s video on holes lmao. We are donuts lol.

  • @shivamshandilya573

    @shivamshandilya573

    3 жыл бұрын

    Or are we?

  • @luissemedo3597

    @luissemedo3597

    3 жыл бұрын

    A 7 holed donut

  • @adityasonawane686

    @adityasonawane686

    3 жыл бұрын

    @@luissemedo3597 the ears and other etc arent actually holes Watch the v sauce video of holes

  • @luissemedo3597

    @luissemedo3597

    3 жыл бұрын

    @@adityasonawane686 ... I did, maybe you should watch it again

  • @adityasonawane686

    @adityasonawane686

    3 жыл бұрын

    @@luissemedo3597 hmmm oookkkkk sure

  • @farirai.natalie
    @farirai.natalie3 жыл бұрын

    The video I didn’t know I needed

  • @gracioussaxena8318
    @gracioussaxena83183 жыл бұрын

    Didn't think I'd hear "our anuses" in my life.

  • @saulgoodman2018

    @saulgoodman2018

    3 жыл бұрын

    How about uranus?

  • @adityasonawane686

    @adityasonawane686

    3 жыл бұрын

    @@saulgoodman2018 😂I thought that

  • @QueenElsaVeganfromEurope

    @QueenElsaVeganfromEurope

    3 жыл бұрын

    @@adityasonawane686 へーーお

  • @adityasonawane686

    @adityasonawane686

    3 жыл бұрын

    @@QueenElsaVeganfromEurope what??!!??

  • @SymphonyTaylor
    @SymphonyTaylor3 жыл бұрын

    *I’ve been having gut issues lately and this honestly helped me understand my gut more.* 💯

  • @SymphonyTaylor

    @SymphonyTaylor

    3 жыл бұрын

    @@cosmic_love_5 I might have SIBO so I don’t know

  • @headhonchotheone9041

    @headhonchotheone9041

    3 жыл бұрын

    You eat a lot of nonsense that's why .

  • @headhonchotheone9041

    @headhonchotheone9041

    3 жыл бұрын

    You must go vegan .

  • @frankotradez

    @frankotradez

    3 жыл бұрын

    @@headhonchotheone9041 lol u don’t even know what she eats

  • @kspradeep8397

    @kspradeep8397

    3 жыл бұрын

    Gut can be revitalized by using only organic foods, complete no to processed foods, organic fruits, drinking red wine in certain doses, yoghurt, sprouts, vegetable salads

  • @jonbilgutay2
    @jonbilgutay23 жыл бұрын

    No wonder stomach viruses are so short lived; with all these immune systems, as well as vomiting and diarriah, we get the germs out fast.

  • @queenofdramatech
    @queenofdramatech3 жыл бұрын

    Can you talk about what happens when your immune system goes awry in your gut AKA discuss Chon's and Ulcerative Colitis.

  • @casbot71
    @casbot713 жыл бұрын

    So having my appendix removed has had long term effects… Great, not only did I have the problem that it was imploded instead of the regular exploded. And it was removed with just a few hours to go before 💥, so they removed some of the surrounding tissue as well. All in all this is a design flaw…

  • @01DOGG01
    @01DOGG013 жыл бұрын

    When I was a youngin in school, they asked the class where food went after it went into your stomach. I answered 'blood'. And they agreed. Now I understand that they were looking for another, a lot more smelly answer lol. They didn't expect my response.

  • @nikolas8741

    @nikolas8741

    3 жыл бұрын

    Eat your self

  • @teehanming
    @teehanming3 жыл бұрын

    Again, please make the sound volume louder please. You the only channel that I need to up my volume

  • @Melissa0774
    @Melissa07743 жыл бұрын

    How close are they to knowing what causes ulceritive colitis? After seeing this video, I would think they would know the cause by now, but I don't think they really do yet.

  • @wilsonbeltran4245
    @wilsonbeltran42453 жыл бұрын

    Hi, you have a wonderful way to explain and make understand how things work in our body. I am wondering if I can you make a video explaining how the digestive system is damaged for gastroparesis due to diabetes and it would be possible to reverse?

  • @jamesgrifaord7608
    @jamesgrifaord76082 жыл бұрын

    Amazing and well explained thank you

  • @Dudleymiddleton
    @Dudleymiddleton3 жыл бұрын

    Tell Homer Simpson he's a long donut - then he'll eat himself lol !

  • @naveenraj2008eee
    @naveenraj2008eee3 жыл бұрын

    Great video.. Nice to learn. Thanks seeker..🙏👍

  • @rajendrakhanvilkar9362
    @rajendrakhanvilkar93623 жыл бұрын

    Great video

  • @thinkdifferent4021
    @thinkdifferent40213 жыл бұрын

    This channel and its content is super cool and super infomative, but idk why these types of super hardworking channels are not getting enough views and subscribers!!? Great work.👍

  • @electronresonator8882
    @electronresonator88823 жыл бұрын

    Researchers : "appendix is not useless remnant of evolution" Charles Darwin : "impossible !!"

  • @aaronwilson9763
    @aaronwilson97633 жыл бұрын

    QUESTION: how does "food poisoning" fit into this dialog? ...what is chemically happening?

  • @AwesomeMusicLady

    @AwesomeMusicLady

    3 жыл бұрын

    That video would be interesting

  • @alparslankorkmaz2964
    @alparslankorkmaz29643 жыл бұрын

    Nice video.

  • @MadhavanSureshRobos
    @MadhavanSureshRobos3 жыл бұрын

    This is great. It'll be even better if it's made simpler for a common with little technical knowledge as there seems to be a lot of words thrown at me and I retain lesser. Great effort though thanks.

  • @Lunarplex
    @Lunarplex3 жыл бұрын

    And I’m watching this with a stomach bug 😞 there are some things our wonderful alimentary canal can’t fight.

  • @dogarualexandru-stefan
    @dogarualexandru-stefan3 жыл бұрын

    This needs a more in depth detail video, or better yet a hole series, in wich, each portion has its own episode.

  • @xsforreal
    @xsforreal3 жыл бұрын

    I don't like the thought of being referred to as a long donut lol

  • @mrdeath9132

    @mrdeath9132

    3 жыл бұрын

    😂

  • @jimbox31
    @jimbox313 жыл бұрын

    “Awkward Work Bingo”!!!! I’m winning!!!

  • @rockers6963
    @rockers69632 жыл бұрын

    plz make vedio on apendix

  • @muhammadosama350
    @muhammadosama3503 жыл бұрын

    my appendix blast in my stomach? so my immune system is weaker? can you please make video about appendix its use and its danger?

  • @meghabisht7456
    @meghabisht74563 жыл бұрын

    Gut microbiome and appendix play role in innate immunity.. interesting🤩🤩 want to know more....

  • @azhari7968
    @azhari79683 жыл бұрын

    I'm relieved that you showed someone's mouth without any tonsils in it

  • @saulgoodman2018
    @saulgoodman20183 жыл бұрын

    2:25 looks like pieces of corn. Which looks the same coming out, as going in.

  • @sweithshetty9463
    @sweithshetty94633 жыл бұрын

    Honestly, I expected a lot more when I read the title..even someone going to school will know all these things

  • @PuneetMehra
    @PuneetMehra3 жыл бұрын

    So, If we get our appendix removed, will we not lower our immunity?

  • @sash2590
    @sash25903 жыл бұрын

    Accurate

  • @Bassotronics
    @Bassotronics3 жыл бұрын

    I’m a Krispy Kreme walking donut.

  • @jasonloke274
    @jasonloke2743 жыл бұрын

    Wow

  • @hypergraphic
    @hypergraphic3 жыл бұрын

    Fun fact, I get frequent cold sores and no joke, French kissing my wife helps them heal faster. She hardly ever gets them, so I think there is some definite immune system boosting going on 😉

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Could be just the saliva, which your own mouth could probably provide, but would be less fun. Also, doing that during an outbreak may be more likely to cause an outbreak on her. 😅

  • @Universalbeing0
    @Universalbeing03 жыл бұрын

    Isn't it awesome being human?

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Sometimes. 😅

  • @Universalbeing0

    @Universalbeing0

    3 жыл бұрын

    @@megamanx466 I should've said most of the time at the end 😅

  • @pvtpain66k
    @pvtpain66k3 жыл бұрын

    Peyers patch. I just watched Cells at Work. >_>

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Interesting anime. If you ever get the time and inclination, I'd suggest the 80's movie 'Innerspace'. 😅

  • @thebongringtone8952
    @thebongringtone89523 жыл бұрын

    You know that everyone can imagine everything 🔥🤟❣️❣️❣️❣️❣️

  • @Pseudo___

    @Pseudo___

    3 жыл бұрын

    Imagine a googleplex of balls

  • @emilianom6975
    @emilianom69753 жыл бұрын

    We are apparently a 7 hole donut according to Vsauce

  • @MichaelProds99
    @MichaelProds993 жыл бұрын

    I was gonna write 'I was gonna write 'First' but I remembered I had a life' but I remembered I had a life

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Lol... needs an small edit bud. 😅

  • @davidsweeney111
    @davidsweeney1113 жыл бұрын

    the gut is the reason why we need to sleep, do a video on that please

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Hmm...why with the gut and not the brain? 🤔

  • @karanarora1468
    @karanarora1468 Жыл бұрын

    👍

  • @211teitake
    @211teitake3 жыл бұрын

    So how does tonsils work as a checkpoint?

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Probably the gag reflex. 😅

  • @AdityaBolt
    @AdityaBolt3 жыл бұрын

    Host looks like Matt from yes theory!

  • @justsomepersononyoutube9271
    @justsomepersononyoutube92713 жыл бұрын

    The future is the best

  • @philsophkenny
    @philsophkenny3 жыл бұрын

    😀

  • @HernanPastenes
    @HernanPastenes3 жыл бұрын

    That ain't no Patrick star 🌟

  • @visheshsharma93
    @visheshsharma933 жыл бұрын

    just like many other seeker videos, this video is too quiet

  • @dudeguy3391
    @dudeguy33913 жыл бұрын

    he just had to say it didnt he.

  • @davidwilkie9551
    @davidwilkie95512 жыл бұрын

    The whole message, holography, in the big picture, is restricted to understanding aspects of real-time Infinity, and some aspects are Scientific Categorization of Superspin Modulation positioning function cause-effect in Actuality-Singularity Perspective, in e-Pi-i Principle, so it's stratified focal matricies of Quantum Chemistry atomistic arrangements of pure-math ideal gas of time-timing sync-duration recirculation, and according to Documentaries on UCTV, our biological integration of Predator-prey balance included in bodily defences is an unexpectedly fine balance of pathogens and general ecology of life somewhat similar in concept to the Anthropic Principle Imagery projection-drawing composed of Holographic AM-FM Communication In-form-ation alignments. It is not what I expected to think of about what, how and why things happen as they do in continuous creation cause-effect connection. E=mC² logarithmic condensation wave-packaging formation is Quantum Chemistry, and fundamental to Be Here Now holography dimensionality coordination shaping. One should not be surprised, but also the wonder of Sciencing Re-search is surprising that there is no actual limit on things to learn.

  • @alstonmiller212
    @alstonmiller2123 жыл бұрын

    What I'm a🍩 all I knew was a lie!

  • @chomes8048
    @chomes80483 жыл бұрын

    People with tonsils and appendix removed: *Concerned*

  • @irzeeshan___
    @irzeeshan___3 жыл бұрын

    We are safe...

  • @gamereditor59ner22
    @gamereditor59ner223 жыл бұрын

    "The power is yours!" - Captain Planet ....Even though it is not environmental information.

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    "Knowing is half the battle." -G.I.Joe 😅

  • @buymefrommaxico8894
    @buymefrommaxico88942 жыл бұрын

    Wait isn’t we opposite back of lobster?

  • @jcstang8952
    @jcstang89523 жыл бұрын

    Wait. I thought the human immune system didn't exists, according to W.H.O.

  • @swarnarekha
    @swarnarekha3 жыл бұрын

    GALT MALT

  • @TELEVISIBLE
    @TELEVISIBLE3 жыл бұрын

    hi 😉

  • @carnsoaks1
    @carnsoaks13 жыл бұрын

    Honestly, rather than long donuts, better to say "A Worm wrapped in Bacon." I mean, like really now, a freaking donut? Stoopid.

  • @pinemaple5115
    @pinemaple51153 жыл бұрын

    wondering how much he took to learn this 🙄

  • @dulynoted2427
    @dulynoted24272 жыл бұрын

    I'm a cannoli

  • @DrVishalT
    @DrVishalT3 жыл бұрын

    The comment is section is like nerd comicon

  • @richardcheng7622
    @richardcheng76223 жыл бұрын

    Sometimes it’s up to the guts.

  • @BeanOnTheFlipside
    @BeanOnTheFlipside3 жыл бұрын

    Someone on the internet just called me a donut

  • @mrdeath9132

    @mrdeath9132

    3 жыл бұрын

    😂

  • @SteveVi0lence
    @SteveVi0lence3 жыл бұрын

    You stole that opening from vsauce

  • @mohammedshaik9647
    @mohammedshaik96473 жыл бұрын

    I'm not first, I'm not last, But most importantly, *nobody asked*

  • @mrdeath9132

    @mrdeath9132

    3 жыл бұрын

    👍

  • @nickyohare2839
    @nickyohare28393 жыл бұрын

    So spit on wounds got you.

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    As long as you have a clean mouth, then you should be fine. Saliva also has blood coagulants to help start the sealing/healing process. I've heard in a country in South America, they have a believe that you should have a pregnant woman spit on it, which scientifically has been shown to have a higher concentration of coagulants and antibacterial properties. 😅

  • @brunodosreis
    @brunodosreis3 жыл бұрын

    Topology 101 😂

  • @axem.8338
    @axem.83383 жыл бұрын

    'Taking a tour from the elementary canal' I dont like where this is going

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Lol. Alimentary Canal? 😅

  • @rickjames5998
    @rickjames59983 жыл бұрын

    who is this joker

  • @NyanCatzzz

    @NyanCatzzz

    3 жыл бұрын

    Rick.

  • @Corporis

    @Corporis

    3 жыл бұрын

    No, this is Patrick

  • @vaibhavjaiswal6416
    @vaibhavjaiswal64163 жыл бұрын

    First

  • @NyanCatzzz

    @NyanCatzzz

    3 жыл бұрын

    Shudup

  • @charliemaybe
    @charliemaybe3 жыл бұрын

    What is this, third party rob dahm

  • @shiroi1000
    @shiroi10003 жыл бұрын

    WTF WHERE IS EVAN ANTON !!!!

  • @tadeuszreytan8654
    @tadeuszreytan86543 жыл бұрын

    BORING

  • @ibadullahtahir7541
    @ibadullahtahir75413 жыл бұрын

    SHAME ON THIS VIDEO AND THIS CHANNELS

  • @megamanx466

    @megamanx466

    3 жыл бұрын

    Why?

  • @3divy
    @3divy3 жыл бұрын

    First

  • @NyanCatzzz

    @NyanCatzzz

    3 жыл бұрын

    Shudup

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