Fantastic, what a brilliant synthesis. The BHT serendipity was great. Thanks !

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

This video makes me realise I need to go over my year 1 undergrad chemistry notes again

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

When this channel uploads, I have a good day

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

based molecules

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

@petevenuti7355

Жыл бұрын

Are you on the "that chemist" discord or something?

@petevenuti7355

Жыл бұрын

@@richardlyman2961 that will do it... anything drug related could get you in trouble too...

Great video! One note--the molecule at 5:13 was developed by BMS, not Pfizer. I know because I was on the team that made hundreds of kg of it. My first project in industry and a fun project as well.

@totalsynthesis

2 жыл бұрын

Thanks for clarifying. Of course you’re right, the original inhibitor was BMS and just the BCP analog was Pfizer.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

@petitkus4408

Жыл бұрын

🤯

So stunning. I'm not organic folk, though. yet it's really interesting to watch. Keep your great work. Thanks!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

I'm an undergraduate chemistry student at a university in Taiwan, and KZread has finally recommended to me the video I really want to watch, instead of random/clickbaiting videos. 12:00 Is where I start to have 0% understanding lol.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

@Torteufel

2 жыл бұрын

maybe you should consult the paper. it is greatly written and perfectly understandable with a little knowledge of organic chemistry

Very well done! Congrats on putting together a really great video on this complex target!

@totalsynthesis

2 жыл бұрын

Thank you! Great work on your videos as well, I featured you on my channel page if that helps in any way :-)

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

a beautiful synthesis. Pericylic mechanisms are so powerful in the construction of these stereogenic centres. Appreciate the detail and care in presentation.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

My PhD is on this complex molecule,Taxol.. Nice to be a part of its synthetic studies...

@totalsynthesis

Жыл бұрын

Nice, good luck!!

Great synthesis and great video. Amazing!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

this videos are awesome !! keep doing this fantastic job!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

crazy synthesis 💯

Great to know what was the initial thought process of total synthesis of these complex molecules..Thank u so much for providing this informative content.. Lots of Love From INDIA 🤩🤩

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

I have just read this original literature in July. Very impressvie for this total synthesis. When I was reading, I followed this literature and drew every steps in this synthesis. Art of total synthesis

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Your videos are brilliant, I really hope you will post more often in the future

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

It came different!!! Awesome update to ur request on Taxol, excellent surprise!!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

A very nice video indeed, thank you for making them!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Very nice video, glad you highlighted this one as I was not aware of this science publication of her

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Just fantastic!

I love your channel. You are a master.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

I vote for video with explaining of carborane acid synthesis ^_^

you uploaded this in the middle of an LSD trip this is NOT a coincidence what WHAT

@_iakvb771

2 жыл бұрын

nightmare nightmare nightmare

@lucidchem

2 жыл бұрын

good travels! here's a video if you need to CALM down (click on the link): kzread.info/dash/bejne/enqVxdNtpq6zp5s.html

@knivesnico8775

2 жыл бұрын

oh and btw it was an excelent video and very beautiful experience believe it or not, for some reason his voice has this smile inducing undertone, very charming the reactions were fascinating as well, very good experience overall

@knivesnico8775

2 жыл бұрын

@@lucidchem thankfully i didnt need your video, but thank you!

@lucidchem

2 жыл бұрын

@@knivesnico8775 No worries, I'm glad to hear that!

Need more videos like that.

Total Synthesis: -Covers decades of org Chem history, about a group of Molecules only known by people who actually studied/ worked in chem and total nerds. -Introduces the audience to a absolute Raid Boss of a molecule (in terms of complexity) -Covers the development, retrosynthetic considerations and most of the 26 step total synthesis. And he did all of that with in a little over 20 minutes and with a calming voice. Beyond Based. PS: I was really surprised how how stable that Peroxide was. That Synthesis was a wild ride.

@totalsynthesis

2 жыл бұрын

Love you!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Danke für das interessante video! In der Tonaufnahme ist viel Hall, vllt kann man das günstig mit Isolation an der Wand verbessern (Schaumstoff, Eierkarton; klingt wie ein kleiner Raum bzw. direkt vor einer Wand aufgenommen)

Another great video

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

love the vids man

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

Hi! I'm graduating my B. Sc in chemistry, and i'm currently doing a chemistry methods course. We learn how to synthesise polyfunctionnal complex molecules. We had to explain the uses of all the protecting groups in litterature. Your videos really helped me to understand why using MOM chloride in certain cases instead of Boc. Your videos help (probably) lots of people, and we are super greatful of having your help! Keep it up :)

@totalsynthesis

2 жыл бұрын

Very happy to hear this! Wishing you all the best for your courses :)

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Great video once again! Keep up the good work :)

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

I love your unique topics and approach to organic sinthesys, you might not be able to upload often but quality never drops,keep it up!!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Why this Chanel not putting videos anymore, very interesting stuff

Fantastic!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

Great video

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

Thank you so much for your work! You are awesome.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

@crabcrab2024

2 жыл бұрын

@@ChemNews With great pleasure! Thank you.

@ChemNews

2 жыл бұрын

@@crabcrab2024 Thanks!

Thank you for sharing! Just searched for Taxol Synthesis as I got news today that I'm gonna do my bachelor in the AG of Prof. Gaich. Really exciting.

@totalsynthesis

2 жыл бұрын

Amazing. All the best!

@Mr.Cucumba

Жыл бұрын

@@totalsynthesis I've got some questions concerning the use of the building blocks (dienophiele and diene). Would it be possible to get some more insight into the mechanism of the [2+2] cycloaddition as well as the reasons for choosing these two substrates? Sure, regio- and diastereoselektivity are key to achieving the endo-diels alder adduct, but i would like to know some more detail. Since you put all this effort into this video, maybe you want to pass some of your findings to me? regards

nice video

Awesome👏

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

Actually got to watch Tanja Gaich give a talk on this. My mouth was in the floor for 30 straight minutes

@totalsynthesis

2 жыл бұрын

Cool!

I can't follow you longer than some seconds because I have no clue of the topic but I like to listen to your beautifully calming voice ❤️

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Brilliant.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

Could you some day talk about the total synthesis of gingerol (chemical present in ginger)?

@00bean00

Жыл бұрын

yes, gingerol is immensely important

thanks

really nice vid!!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

@NightLightnight

2 жыл бұрын

@@ChemNews lol okay I'll check that out in a bit

@NightLightnight

2 жыл бұрын

@@ChemNews also I suggest I not comment on everyone's comment or KZread might think u r spamming

@ChemNews

2 жыл бұрын

@@NightLightnight If you change the text a little bit - youtube does not mind :) Unfortunately, there are not too many ways to get new subscribers in the initial stages of the channel...

whats the thing at the beginning that says not this maybe later?

Fantastic video!!!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

wow, the dearomatization cycloaddition is really nice!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Niduterpenoid A seems very complicated molecule as well, do you think we will see soon it’s total synthesis? Congratulations for your Chanel, this kind of contents are not so common in youtube

@totalsynthesis

2 жыл бұрын

Definitely looks interesting! Thank you!!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

Absolut madlads

Please make video about ONC (octanitrocubane) synthesis

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

If I had a penny for each word I didn't understand, I'd be able to open copper foundry.

@totalsynthesis

Жыл бұрын

Here's a penny for watching the video regardless 🪙

@doit9854

Жыл бұрын

@@totalsynthesis what class. & anyone who says "melting pennies is illegal" is just volunteering to be your lab assistant/slaves.

How do you explain the regioselectivity reduction of the ester in presence of a ketone using LAH ? In my understanding LAH should reduce a ketone very easily 17:50 min

@totalsynthesis

2 жыл бұрын

I think it’s just sterics - even though “the bottom” face looks open, the attack trajectory of nucleophiles would be quite shielded by the bulky acetal group. So the ester gets reduced first. The authors didn’t comment on this - but I wouldn’t be surprised if they saw some reduction, especially at more forcing conditions

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Based synthesis

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

8:45 would this not be 1,3-butadiene?

@totalsynthesis

Жыл бұрын

Yep, misspoke

So did it cure cancer? I think this would be pertinent info.

@totalsynthesis

7 ай бұрын

No but it looks cute

Hello! Very interesting video. Tell me, you can meet a trotofan bromination reaction or tripartamine bromom in a 5th position. And then in the Russian-speaking literature such a technique to find a gentle. I really know English very badly and I find it difficult to search for such a technique.

@totalsynthesis

2 жыл бұрын

Do you have access to reaxys? This database shows different ways to prepare chemicals Are you talking about direct 5-bromination of tryptophan? Not sure if that is possible, you probably need multiple reactions via the 5 bromoindole or others

@modeidraorossman5273

2 жыл бұрын

@@totalsynthesis I'm from Ukraine. I am a little difficult to speak English. I do not have access to REAXYS. Give a reference to Reaxys. For me, very interesting foreign works of chemists. Maybe I find something for myself.

Thanks for that, very clear. However, I expect it will be more complicated on a second viewing!

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) kzread.infovideos

Am I a bad viewer for using your video to cope with my insomnia? 😂😂😂

@totalsynthesis

Жыл бұрын

No, glad I can help ☺️

more videos plz

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

@jesusbauer4074

2 жыл бұрын

@@ChemNews thank u so much for you work, i apreciate it .

This is why I did bad in orgo. Just seeing synthesis after synthesis frustrated me because I need to understand why each step behaves the way it does and they all have some crazy explanation I'm always either skeptical of or don't understand. And then on the tests all my synthesis proposals are wrong. Each step could take hours to days, and your yield is going to be tiny. 26 steps must have taken months.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

by Gaich Group.

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html

I can make a pitcher of kool aid all by myself.

@totalsynthesis

Жыл бұрын

Teach me your ways

here's a comment for the algo

@totalsynthesis

Жыл бұрын

💪

Penguinone

@ChemNews

2 жыл бұрын

Hi, perhaps you will like my channel about recent chemistry publications. Just released a video about the recent work of Benjamin List (the guy with the 2021 Nobel prize) hkzread.info/dash/bejne/d4CtldeLaaXZnZc.html