Maybe you can now make an episode about the side effects of antidepressants. It would be really useful.

@dv_vid

10 ай бұрын

Yes like when your sex drive goes to zero and may not come back for the rest of your life. The psychiatrist don't want to hear about this!

@RobespierreThePoof

13 күн бұрын

Not very useful. That kind of information should come directly from a doctor for individual patients

LOL antidepressants were a "happy accident."

@jadethegingergoblin718

6 жыл бұрын

Master Therion, entertaining as always! 😂

@andyplaysgundam

6 жыл бұрын

SAVED

@luhfangs3611

4 жыл бұрын

Master Therion what is that symbol on your profile pic called looks fascinating

@tempusnostrumest

3 жыл бұрын

Antidepressants can do very little to make you "happy" (they just shut down your emotions and thought process a little so you can be more conformist with your life, the same happens with antipsychotics but in surprisingly strong way aka reversible chemical lobotomy (it is reversible but will surely damage your brain (body too) in long run i.e 1+~ years) recreational drugs are far superior if you want to feel happier.

@LIITEMIES

3 жыл бұрын

@@tempusnostrumest amfetamine much? well depends what you call recreational. if you want to feel ''well'' it better be considered ''addictive''. you hawe much to do in your daily life... like stubbornes of a child when it comes to food. alcohol aint that greate after and the ''meds'' seem far worse than uneducated.

It really does surprise me (as well as slightly scare me) just how much the things we use to help improve our lives, were found entirely by accident.

when you convince military hospital people to test psychoactive substances on their patients..... that gives me a shiver

@ljhendrickson2960

4 жыл бұрын

Yes!! My husband was one of their victims...He is significantly changed, and NOT for the better. Criminal in my eyes...

@allisond.46

4 жыл бұрын

@@ljhendrickson2960 Is he okay?

@ljhendrickson2960

4 жыл бұрын

AllisonD, Thank you so very much for asking! No, actually, he's getting worse. The VA's 'solution' is more meds...God Bless, Allison

More Psychopharmacology, please! Thanks for covering a favorite subject of mine. It is worth note that the reason that increased Serotonin "elevates mood" is not because "Serotonin makes you feel good" (That would be Enkephalin), but because Serotonin is a major transmitter for sensory regulation, processing, and general inter-brain communication, so a lot of serotonin system activation has secondary effects in other areas of the brain, which tend to elevate mood. It's a persistent myth that "Serotonin/Dopamine" are "feel-good neurotransmitters", which is why I figured it would be worth amending.

@neonsilver1936

3 жыл бұрын

@Brodie Francis wow, blast from the past! 3 years later and I get a reply on this, wow, time flies.... great job on that reply, BTW, great job 👏 Super productive 👌 Edit: Also, you were watching the same video, f*ck off dude

@neonsilver1936

3 жыл бұрын

@Brodie Francis consider my jimmies rustled lol

@neonsilver1936

3 жыл бұрын

@Brodie Francis you too

These drugs are still too little understood. When I was young I was given, following a major trauma, one dose of one of the earlier "tranquilizers". I experienced something worse than the worst LSD trip ever described, the side effects never quit and I have suffered from, apparently neurological, damage for decades. I have worked all of my adult life to be in a position to fund medical research to find causes and cures for diseases of the brain and neurosystem. I am in a position to proceed with this dream and intend to do so. Nobody should EVER have been left to suffer as I have.

@extragoogleaccount6061

4 жыл бұрын

Obviously that is quite unfortunate that you had to go through something like that, but your desire to learn more and put yourself in a position to help others and advance the science in little understood areas is absolutely more than commendable! I presume you've heard about/looked into HPPD and whether that syndrome played a role in the effects you experienced?

@annalisette5897

4 жыл бұрын

@@extragoogleaccount6061 Thank you. Yes...HPPD was not recognized as such when my problem began. Looks like I have a peculiarity in my heart and the original experience sent my blood pressure and heart rate too high. Then doctors said I was "too young" to have a heart problem. Where I lived there were no cardiologists or specialists. In addition to a permanently fast heart rate, the main 'symptom' was a feeling of terror, thus 'panic disorder'--which was not recognized yet back then. Thus plain "mental illness" but psychiatric drugs made it worse. There is a good, biochemical reason for that. Anyway, 8 years ago the rapid heart rate nearly killed me and a tiny beta blocker was like a miracle.

@k.taylor3526

3 жыл бұрын

Wow, so sorry that you had these experiences. And what eye-opening commentary. Thank you for your dedication to funding research.

@annalisette5897

3 жыл бұрын

@@k.taylor3526 Thank you!

@ChristopherGray00

2 жыл бұрын

This is completely unrelated to SSRI's which are pretty well documented and understood, which do not carry these risks, i would say it is quite irresponsible to fear monger because it only makes people more hestitent to get medication for a severe disorder they may have, i was originally hesitant with SSRI's when my anxiety was very bad, but when i started taking lexapro it had helped me greatly.

So good to see an episode on treatments for mental illnesses! Being on sertraline has absolutely changed my life - I used to lock myself away in my room because I was afraid to the leave the house and cross the street, or talk to anyone outside my immediate family. Now I've moved out and have had several jobs - even in customer service, for years! It's been amazing and I can't speak highly enough of how grateful I am for it.

@alanb7469

6 жыл бұрын

SeoulTeamworkGaming That is such a beautiful comment, I don't know how it can get much better than that. We adapt to the things we're taking on a regular basis.

@lupoallupato3305

5 жыл бұрын

Sorry, can you Say how antidepressant helped you i dont understand how they can be helpful, they make you forget about your problem or they helped fixing you problems, or stabilizing your mood, can you explain exactly how they helped ,Sorry for the band english

@andycokeski7744

5 жыл бұрын

@@lupoallupato3305 Hey, I can see Marth hasn't responded in a month so maybe I can help you out. I've been on an SNRI program for roughly two months now and have seen dramatic improvement in my mood stability, and far less of the panic I had previously suffered as a result of a lifelong panic disorder. A major thing SSRIs and SNRIs do is limit the panic (or anxiety if you like) response, meaning you'll have less trouble emotionally dealing with things that might have made you anxious previously. If you're looking for answers more on the mood improving size, I find that I have more "positive energy," that I can keep a happy mood longer, which helps me remember some things better, and seeing these improvements make me feel good, like a cycle of positivity for yourself. Obviously its impossible to know how you'll react until you try it yourself, but if you are looking for a depression treatment for yourself, it's definitely worth a shot! Good luck

@fivesix3868

4 жыл бұрын

Anti-depressants work by making your brain not use chemicals that usually increase things like fear, sadness, etc.. Without these chemicals, negative thoughts also occur less. This is a very vague explanation. They (maybe) also increase your brain using chemicals that increase relaxation, pleasure, etc.. So they are very helpful for people whose brains are using the chemicals causing negative emotions too much. They help those whose brains have sadness far beyond the normal, healthy amount.

@basedcat2349

2 жыл бұрын

I hated setraline. Gave me no mental clarity and didn’t help with any depression. Now I’m on an anti psychotic (vraylar) and I hate it even more. Worse mental clarity and unbearable restlessness, anxiety, tremors, excessive sweating. I hate medication. It’s poison.

I always wondered how all of these psychiatric drugs were discovered when they were mentioned in previous videos..... Thank you for explaining it..... :)

Surprised he didn't mention Lithium. Its mood stabilization effects were discovered totally by accident by an Australian doctor in the 40's.

@karimaogden3875

2 жыл бұрын

His name was John Cade.

Correction: Higher serotonin levels haven't been causally connected to a decrease in depressive symptoms yet. (4:19)

@ChristopherGray00

2 жыл бұрын

While higher serotonin levels do not necessarily equate to lower depression, there is extremely substantial evidence to show that serotonin's role is a modulator for almost all of the neurotransmitters within the brain that are directly responsible for mood, cognition, stress response, and reward/pleasure,when patients have a deficiency of serotonin that is severe enough, whether it be from genetics, mental/physical trauma, chronic stress, etc, they have signs of depression/anxiety and that is where SSRI's have a very high efficacy. This basically explains why SSRI's can be extremely effective for people like me, but not effective for others, serotonin is a big part of depression but not the entire picture, most commonly depressed patients have low serotonin function, but that is not all of the time, they could have normal serotonin levels for example, but low dopamine release for whatever reason, there are also psychological/lifestyle causes, rather than clinical such as an inherent chemical imbalance. TLDR, it's not black and white, there is no magical pill that will solve everything, but it is substantiated that SSRI's do infact help depression and anxiety with those who have a clinical cause.

@ChristopherGray00

Жыл бұрын

@Guy Whose opinions will offend you Because SSRI's have been heavily studied in the last 20 years for their efficacy, and with double blind it still shows a very significant improvement over placebo. It is absolutely testable and has been tested for as long as even first generation antidepressants have existed, i'm not sure where you're getting the impression that it "can't be tested".

I love scishow!! Great episode today.

You missed SNRI And like someone else already posted, I really appreciate this episode. You should do an episode on Gabapentin. I had a badly pinched nerve and I was literally running out of will to endure the pain and then my Dr prescribed me the Brand name version of gabapentin and it was like God reached down to me from heaven and removed my pain, that stuff is a miracle drug for sure.

@nathanielmathews2617

6 жыл бұрын

Hard to say if it is a psychiatric drug, hell, we hardly know how the vast majority of painkillers work.

@wholeNwon

6 жыл бұрын

When I had a pinched nerve, it was completely ineffective for me.

@GuadalupeMendoza6119

6 жыл бұрын

Gabapentin worked really well for my neuropathic pain, which was almost driving me crazy. Gabapentin was first used for seizures but accidentally was discovered was also good to treat neurological pain and also hot flashes which also help me with my hot flashes a lot.

@nobbie01

6 жыл бұрын

I have insomnia and use gabapentin to help me go to sleep.

@theveganflower5135

5 жыл бұрын

Gabapentun did help my pain but did have horrible side effects

Yes yes yes. Remove the stigma on taking medication for mental illness with education and empathy.

@manbeerpigs16

4 жыл бұрын

He forgot to add the neurotoxicity of antidepressant drugs or any drug that affects seratonin

@JohnRambo1947-July-6th

4 жыл бұрын

@@manbeerpigs16 these drugs are dangerous. They destroyed my life.

@cosmicallis7936

3 жыл бұрын

I don't judge people who take medication, however, I highly disagree with it and nothing will ever change my mind about that!!! I have learned first hand just how harmful and damaging these drugs can b, especially in the long term..😵😵😫😫😫 there r WAY more effective and much, much healthier ways of treating someone with a mental illness(s) that the system does not promote, encourage or even suggest because the patients r cash cows to them and nothing more..smfh WE DESERVE BETTER!!!!!

I really appreciate this episode.

That’s crazy Thank you for all the enlightening information Hank

Fantastic episode, thanks so very much SciShow Psych! You guys are on a roll lately! :)

Still we know very little about mental-health problems. It can, for example, be a lengthy process of trial and error to find the right drug and dosage against depression, even within drugs that use much the same mechanism. The results of two SSRI may vary wildly to completely opposite effects on one person while showing identical effects and strength on another, even if both persons have a comparable history, diagnosis and show virtually the same symptoms. That is hardly the hallmark of well understood mechanisms, but more of rough guesswork. Nevertheless, meds can do good and save lifes. Talk to a professional before changing anything about them. Be safe and not alone.

@kulanchandrasekaran4462

4 жыл бұрын

Yarra Phénix Well said. Very insightful. And very true.

@lrrrruleroftheplanetomicro6881

4 жыл бұрын

I'd argue that we know a lot about mental health problems. specifically about personality structures that lead to mental health problems. Drugs should only be a stop-gap measure. Concerning what medications work for whom, there's genetic tests that can determine that in advance.

@matthewatwood8641

2 жыл бұрын

They destroy lives, not save them. Anyone who would give someone a drug that induces suicidal ideation to treat them for depression should be locked up.

While we can mostly treat so-called positive symptoms of schizophrenia (hallucinations, delusions, etc.) we are less good at treating so-called negative symptoms (apathy, absent or blunted emotions, etc.). These are often almost as debilitating as positive symptoms. We need better drug and we need to realize that psychotherapy and medicines should not be seen as exclusive alternatives - they work better together.

@gregorymalchuk272

4 жыл бұрын

Are there any medications for treating the negative symptoms?

@rodofiron1583

3 жыл бұрын

Negative symptoms are often exacerbated by neuroleptic drugs

@Valdagast

3 жыл бұрын

@@rodofiron1583 I've heard that for classical antipsychotics, but atypical antipsychotics actually do have some effect on them. The only problem is that they shut down your bone marrow, but you don't really need an immune system, do you?

Can you do a video on why this class of drugs have so dramatic side effects?

oh hell yeah psychopharmacology! Antidepressants and antipsychotics (in low doses) have had an immensely beneficial impact on my mental health and have helped me recover from severe depression as well as helped me manage my sleep and anxiety

@adembilgic8900

3 жыл бұрын

antipsychotics are pure toxics for the body they destroy you

@blairsterling6141

Жыл бұрын

@@adembilgic8900 ..truth !!!

Abilify is truly a horrible drug. It's a hardcore anti-psychotic that is very frequently given to people with simply mild depression and is advertised as if it's just an ssri (which are horrible too - look up Tardive Dysphoria). Frankly I have no idea how they were allowed to advertise this drug on tv given that it's *illegal* to advertise anti-psychotics on tv.

@ChristopherGray00

2 жыл бұрын

Tardive dysphoria is from taking too high of a dose for the initial period of getting on the drug, it is not inherent to proper dosing of the drug. Please don't fear monger and make people hesitant from getting medication because i have been in a very bad situation with anxiety and was worried about all of the misinformation people were spreading about it, but it has helped me greatly and gotten me back on my feet.

@martalaatsch8358

Ай бұрын

My psychiatrist wanted me on Abilify but I couldn't figure out why (I have moderate depression and ADHD) so I'm on Lexapro now

How about an episode on antidepressants withdrawals and how they ruin your body ;)

This is easily one of the best SciShow Psych episodes... great work! Would love to learn more about ECT that is mentioned.

Happy accidents like these gave birth to Viagra from a heart medicine trial

The moment when you try to count how many of the drugs mentioned you already have taken.

I love scishow! I’m entering my Mental Health Rotation in Nursing school and this was very helpful and informative! Keep up the good work!

Can you guys talk about ADHD medication?

@luciferangelica

6 жыл бұрын

DPCisAWESOME someone had a better scam than walter white or even gus fring, you see, they shoved some meth in a prescription bottle and started feeding it to children that don't get to play outside enough... if their parents don't snort it first

@Matthew-cx9gj

5 жыл бұрын

@@luciferangelica They rarely even use methamphetamine to treat ADHD, as it is a potent neurotoxin. Methylphenidate and amphetamine actually help those with ADHD, and because of the fact they are controlled substances, they require a proper medical diagnosis, meaning misdiagnosis rates are actually quite low.

I take Zoloft and since they doubled my dose two weeks ago I've had way less fatigue. I can actually walk my dog now! Edit: I have fibromyalgia and POTS which causes exercise intolerance, so fatigue is a very big thing with me. I still can't do as much as a normal person, but I can do more. It's nice! I like going on walks with my dog now, it's not as painful and tiring.

Thank you so much! My final in drugs like these is on Wednesday and this is a great kind of refresher! As usual, SciShow's timing is impeccable!

@luciferangelica

6 жыл бұрын

expressoface then watch something on tardiv disconesia while you're at it

@agoogleuser3918

3 жыл бұрын

@iMushmellow Neuroleptics ruined my life. I now have Drug induced movement disorders. Tardive dyskinesia, dystonia, in addition to my original dx of epilepsy, and now AKATHISIA, all stemming from TRAUMA , DOMESTIC ABUSE, and childhood bullying , that was not addressed, just medicated and poly drugged. I had been seizure free for many years, and too many drugs were prescribed. In 2016, I had a near fatal Serotonin Syndrome. All the tremors, partial seizures, dystonia, TD, I had to get off my meds, and I was NEVER told there were any withdrawals, and NEVER told that benzodiazepines should not be taken for longer than 2 to 4 weeks because of risk of physiological dependence. Now, my Epilepsy has returned, and I am now on AED'S again. Permanent memory loss. Permanent damage to my nervous system( Tardive syndromes) . I suffer DAILY. I have PTSD now. Not only because of the original TRAUMA, but now it is related to anything MEDICAL.

GOOD WORK MAN. I APPRECIATE YOUR NEAT PRESENTATION SKILLS.

These drugs destroyed my life.

@bhatkat

4 жыл бұрын

Could be worse, know a few folks who never had lives to be destroyed.

@martalaatsch8358

Ай бұрын

Antipsychotics or antidepressants?

@martalaatsch8358

Ай бұрын

The antipsychotics? I'm asking because my doctors wanted me on Abilify but I refused and now I'm on Lexapro

@JohnRambo1947-July-6th

Ай бұрын

@martalaatsch8358 mostly effexor, risperdal, and benzos. But effexor and benzos were the worst. I'm still not fully healed, and I don't know if my brain ever will be. My story is long and horrid. I'd suggest staying away from any psychiatric medicine if possible....... Good luck.......

@martalaatsch8358

Ай бұрын

@@JohnRambo1947-July-6th I'm so sorry that happened to you. I don't get why they prescribe benzos so much. Bad enough they tried to push antipsychotics. I'm doing all my own research... I hope SSRIs or ADHD medication (I believe I'm adhd but they say they can't tell because of the autism and depression) works otherwise I'll just... abandon hope in psychiatry like so many others before me

I just saw Hank's aura! Right at 2:33 when he's talking about the focus of study being on the brain's electrical activity, his yellow aura becomes visible! I'm not crazy after all!

So anti-depressive drugs Lower MonoAmine Oxidase levels. LMAO. (Okay, I'll see myself out)

@greensteve9307

6 жыл бұрын

Nice!

@symmetrygames8142

4 жыл бұрын

Me: Wut *10 seconds later* Me: Ohh I get it.

@drbreeden4093

4 жыл бұрын

Makes sense if you never think about it! And that’s why there’s warnings of tuberculosis in most every prescription medication today! Listen to any Pharmaceutical commercial on TV and you’ll understand.

Thanks to valproate, lamictal and fluoxetine my bipolar is well under control.

@FrancesBaconandEggs

5 жыл бұрын

I take lamictal for cyclothymia! Good stuff.

@vibe6750

5 жыл бұрын

Glad to hear that

Best episode I've seen in a while. I love that it's more detailed and specific. Let's see some more like this! Can we get episodes on (other) antipsychotics, lithium, and anticonvulsants? Oh and bupropion! ...I'm sitting here next to my bottles of quetiapine and bupropion, lol

Antidepressants work just fine, they make the shareholders of the companies that sell them very happy.

Do a presentation on damaging side effects of both Antipsychotics, and antidepressants. Mention ailments like: akathisia, Tardive Dyskinesia, Parkinson's, neuroleptic malignant syndrome, death, weight gain, diabetes, uncontrolled muscle movements, sexual disfunction, skin disorders, acne, stiff muscles and rigidity, ataxia, memory loss. These are just a few. There are many many more horrendous side effects from psychiatric drugs. So, do society a favor and present the truth about all these so called miracle drugs... please present the truth. Thank you.

TCAs still get prescribed, especially to people like me who don't respond to SSRIs and SNRIs. I'm on Doxepin, to treat my insomnia but also the underlying anxiety and depression that causes it.

@kulanchandrasekaran4462

4 жыл бұрын

Solomon Boukai True,TCAs still have a niche role in a select group of individuals who respond to them and can tolerate their side effects. Thanks for sharing.

I am extremely grateful for what psychotropic medications have done for me. As others has already said, these medication saved my life. Without them my anxiety and depression are unbearable to the point of suicidal thoughts and with them I can live a fulfilling life. With that being said, people need to realize that it's not an exact science. You may have to try multiple drugs from multiple categories at varying doses before you find the right mix and even then the effects might not work forever. I guess what I am trying to say is it takes time to find what works for you. It is an ongoing process of monitoring yourself and not settling for meds that aren't working and doctors who won't listen.

Psychopharmacology is really weird but interesting! Loved the episode.

I think I'll hold off dancing in the halls until I find out if holes in my lungs are a prerequisite, thank you.

A lot of tricyclics antidepressants also have efficacy on blocking the reuptake of noradrenaline as well! Increasing noradrenaline as well as serotonin tends to help more people

and failed psychiatric drugs became epilepsy medication

@KAFaye-nk5tl

6 жыл бұрын

serge00storms lmao at this heh

@1MarkKeller

6 жыл бұрын

Rave candy too.

@amyk6869

6 жыл бұрын

Also preventative migraine medication.

I like the part at 2:33

SSRI and benzo taker here 🙋🏻 I'm so in love with psychiatry, and so thankful for the new world that just opened up for me. It's like I'm lost at high sea on treacherous gusts, but all of a sudden, amap floated into my hands from the sky above. Yes it's still harsh, choppy, stormy weather.... but now I know where I'm going and how to navigate! 💪🏼

@lrrrruleroftheplanetomicro6881

4 жыл бұрын

I hope the benzos are only occasional. Europe frowns on the idea of taking them longer than four weeks.

@martalaatsch8358

Ай бұрын

I'm on Europe and a lot of people get antipsychotics or even benzos just to fall asleep in mental hospitals.

These drugs were first known as neuroleptics (to seize the nervous system) and major tranquilizers. They were designed to make patients complient and easier for the doctors to deal with, much like the frontal lobotomy... they basically cause what is known as a chemical lobotomy. They're neurotoxic and come with severe and potentially life-altering and permanent "side-effects" and can cause severe protracted withdrawal, if not tapered properly they can cause neurological damage. I've been on many of these drugs, they nearly killed me. Do your research before talking any of these drugs, doctors will not tell clients of the side-effects and never give informed consent.

@martalaatsch8358

Ай бұрын

My doctor tried to tell me Abilify treats depression and "hyperactivity" (I had asked for adhd medication and/or antidepressants). I refused and am on Lexapro

I don't think I've ever heard SSRIs being described as having less side effects, those older drugs must have been terrifying.

@michaelmeissner7545

6 жыл бұрын

Well, some are pretty good on the side effects front. I was on Lexapro, and except for slight nausea for a week and sexual dysfunction (heckin' long refractory period), I was fine. Of course, it also did nothing for my symptoms, but it was the first drug I trialed. The withdrawal symptoms on it, though... not fun at all.

@thebadfairyprincess

5 жыл бұрын

I can't take SSRIs cause they give me horrific side effects - no balance, slight slurring, not sure if awake or asleep.. ghastly. But amitriptyline, a tricyclic (TCA) works wonders and the only real side effects are a bit of dry mouth every now and again and 5kg weight gain, which is locked at 5kg. As far as I'm aware TCAs are just more likely to result in death with overdose, and that's why SSRIs are preferred.

@martalaatsch8358

Ай бұрын

​@@michaelmeissner7545can you tell me more about your experience coming off Lexapro? I just started it and am having depersonalization and tinnitus (and an increase in suicidal thoughts, probably due to the other side effects)

Wow great video!

I feel that the inclusion of Abilify is erroneous due to legal charges brought against it by way of it causing nerve damage and other serious ailments with long term use. but i might have bias from my hellish experience with it, taking the information more to heart.

@martalaatsch8358

Ай бұрын

Any idea why I was recommended Abilify for depression and ADHD?

i was on imipramine for many years for my depression...it really helped a lot.

04:14 There are two classes of MAOI - A and B. A will affect serotonin, but B will affect Dopamine.

People don't use triciclic antidepressants anymore, really? They have many many indications both on and off label, they can be used on pain, enuresis, even on treating rashes. Imipramine is such a good antidepressant that it is the golden standard on research, all new medication must be compared to it. They certainly still have much to contribute to people's health.

@tizianodematteis7071

5 жыл бұрын

They don't usually use them as treatment for depression, but they still have a lot of other uses.

Nice T-shirt Hank.

Abilify saved my life

@kit4910

6 жыл бұрын

SirChocula Wellbutrin is saving mine :')

@christine1902

6 жыл бұрын

My doc wants to put me on abilify, but I'm scared. I've been on the same meds for 3.5 years now...

@phoenixfritzinger9185

4 жыл бұрын

I’m a seroquel gal myself

@cynthiaennis3107

4 жыл бұрын

SirChocula if you stay on it long enough...you may think otherwise! See Peter Breggin MD channel! He’s a psychiatrist speaking out & has been called in to court to testify against the drug companies for wrongful death & the perverted psych studies that went on in McLain Hospital in Boston!

@martalaatsch8358

Ай бұрын

May I ask what you had? My doctor suggested Abilify for depression and ADHD but I refused, I'm starting Lexapro now

Don't forget lamotrigine which was marketed as an anticonvulsant for epilepsy but scientists realized it also worked as a mood stabilizer for bipolar disorder

Bupropion has the lovely side effect that you tend to just.. stop smoking.

@michaelmeissner7545

6 жыл бұрын

It's also used off label to treat ADHD, so it's just like when I was misdiagnosed and put on Ritalin, but it also actually treats depression!

This story is nuts.

I once considered the idea of using Advil as an antidepressant(not on myself) before realizing that that idea was pure lunacy.

When I was first diagnosed with GAD with comorbid MDD, I was prescribed fluoxetine (Prozac). I was on it for about a month or two; I had the common sexual side effects, which my then-psychiatrist dismissed as "usually happens in women, so just try more foreplay and you'll be fine" (instead of prescribing Wellbutrin to lower my Prozac dose like most competent doctors would...) Then I moved back home and switched therapists, and my new therapist weaned me right off the meds because he didn't believe in medication. He ended up not being the right therapist for me, so I switched to yet another one, who wasn't so much against medicine... but by that time, my insurance had changed, and I can't afford meds anymore. Did it help? No idea. I was going through a *lot* at the time, and two months isn't really enough time to notice any effects anyway. Maybe it would have helped if I'd stuck with it, but I literally, financially can't afford to try again. Go figure.

@lrrrruleroftheplanetomicro6881

4 жыл бұрын

"my insurance had changed, and I can't afford meds anymore" The US are a shithole country in some regards. I recommend you vote Bernie in the primaries.

Having practiced pharmacy for 50 years, I was hoping they would name a drug serendipity. I think that would hilarious.

Don’t think for a second that these don’t have horrible side effects, consult with your psychiatrist only. Note it may take years to get off then once on.

@capresti3537

9 ай бұрын

NEVER consult with a psychiatrist to come off these drugs. They never take people off and if they do do it very fast to cause injury and suffering so their patients will stay on them. Only a competent medical doctor can do this.

As much as modern psych drugs often suck, it's kinda crazy to think how far we've come since thorazine

I take Zoloft and Seroquel and they work wonders! I can’t say the same for all people but for me it is a life saver.

What about the holes in their lungs? Very interesting episode!!!!

SEROTONINWIEDERAUFNAHMEHEMMER You gotta love german

@martalaatsch8358

Ай бұрын

Man kann auch ganz einfach SSRI sagen

I’m on amnitriptyline and Lexipro. It’s a good combo for me that we found on accident pretty much.

Amaizing

I don't get how the calming effects of Chlorpromazine led the scientist to the conclusion, that it could help with psychosis. My first conclusion would have been that it could help with aggression, anxiety, etc. I suppose you couldn't list all details of the effects and the conclusions in a short video. Still very informative and interesting video on this :)

@kulanchandrasekaran4462

4 жыл бұрын

Lost in Translation It’s not just the calming effect or the help with reducing aggression and anxiety. Chlorpromazine specifically reduces, or in many cases, completely ELIMINATES the auditory hallucinations and disordered thought patterns in schizophrenia. That’s how it is recognized as an anti psychotic. Not just as a calming or aggression reducing agent.

Discovery of lithium was an interesting accident as well.

Suddenly everyone’s a pharmacologist

I've taken aripiprazole/abilify before and it just made me extremely uncomfortable. I couldn't sit down, or go to bed. instead I felt like I had a tonne of energy I had to get out but nothing to put that energy into. so instead I would walk around not able to feel comfortable. I couldn't focus on tasks because it would just feel uncomfortable to stay doing them. I found it a terrible drug to take.

@nickjohn2051

6 жыл бұрын

SadamFlu Abilify is mild dopamine booster. So what you are experiencing is the same as someone that have excessive dopamine like behavior. Any insomnia lately? I think you should refer back to Dr for dosage or check other alternative drug. I dont know what your diagnosis is, so I cannot say more than recommend that you refer to your Dr.

@SadamFlu

6 жыл бұрын

Nick John yeah I suffer from insomnia, so I take Zopiclone for that. yeah I was told that Aripiprozole would boost dopamine levels. I'm not keen on continuing even small doses of it. I suffer from depression and anxiety and occasionally but very rarely I have psychotic episodes where I'm completely detached from reality. basically every 2-5 years I'll go without sleep and stress out then my thinking goes warped. I have tried a few drugs from psychiatrists but find that they turn me into a zombie. a zombie that still thinks the same way and feels depressed and anxious lol! at the moment I'm not taking any drugs other than the sleep medication Zopiclone.

@raraavis7782

6 жыл бұрын

SadamFlu If you like sciency stuff (well, I guess you must do, watching this channel), check out this podcast episode by Dr. Rhonda Patrick: www.foundmyfitness.com/episodes/charles-raison I‘m kinda researching the topic for a family member with treatment resistant depression and Dr. Patrick strikes me as someone who is deep into the science of the topics she discusses with her guests...and she isn’t trying to sell anything... Maybe there’s something in there worth following up on for you as well.

@spoonyquine1584

6 жыл бұрын

I had even worse effects, not able to control anything I did or said, rocking back and forth endlessly, which kept me awake. It even caused psychotic delusions until I stopped taking it.

@jankamir5423

6 жыл бұрын

I can relate. I have been treated with adjustement disorder (altho that is a way how psychiatrist in CZ "mark" depressive patients under 18 usually) and went from quetiapine up to venflafaxine. Klonopin and Diazepamine used for related hyposomnia and sometimes absolute insomnia. Abilify was... I have mixed feelings about it. I've got much larger introduction dose I should've get (I was 14 at the time and got 7.5mg - upped after a week to 15mg) and considering I struggle with obesity I was terrified, shocked and pleased at the same time. I drank 300-400mls of liquid a day at max (I usually do 4-5 liters of pure water - yes I am that thirsty, it is not a "loose weight" strategy), didn't ate at all. All calories I consumed were maybe some leftovers of microbes in the water if anything and lost 10 kilos in the first week of taking it. I was taking one at morning. Made me walking zombie, teachers thought I started doing illicit drugs,I didn't focus, I didn't showed any emotions whatsoever etc. Worst thing was that when combined with coffee at morning to battle the "sleeppy don't care" mood I became extremely anxious and paranoid. I nearly ran away from school because of fear. So I was told to take it in the night. And what happened was exact opposite. I had absolute insomnia during that. So altho I was happy with the anorectic properties I had to withdraw it. My only worse experience was sertraline (25mg introduction - 50mg normal - then upped 75mg) and oh boy I never was so depressive for two months (so long enough to see at least some improvement) but rather my mental state was getting worse and worse to the point I was so depressed that I weren't even able to kill myself. I was just lying down waiting for it to end because even if I wanted to (and I wanted a lot) I was unable toget out of the bed and look for something that could kill me and I had a lot of things to do that at home. What worked for me was Venflafaxine. Only side effect I experience was hyperhidrosis but outside of the faux-pa it sometimes caused it was fine. I had to withdraw it too because my psychiatrist (only around) refused to treat me anymore.

buspirone and escitalopram...represent! 💊✨

Hey SciShow folks! This is an awesome episode, but is missing your sources! It just has the header, but it would be great to see it updated if you can track them down, because this is super interesting and not discussed a ton.

Shout out to that awesome star cadet graphic tee!

im on a trycylic antidepressant cause it's the only thing my health centre were willing to give me and it makes able to sleep.... what r those bade side effects scishow talks about cause i hace not expereienced many?

Awesome episode. I only have a single major problem with the pharmapsychological research (or what ever that word was. Can't remember). And that is the frantic research effort in finding a drug that eases the problems a person with Autism faces. They might as well try turning lead to gold via cat hairs and pee, cause I honestly dont think that to be possible. Sure, some people with autism or severe autism can struggle a lot with a lot of different things. But that's usually because those people are quite vulnerable, so when they're exposed to large quantities of things they cant handle, then they get super stressed and are at risk for developping other mental disorders. But then it's those that should be treated. Not the Autism. I have Aspergers and I would hate such a piece of medicine. I fear that with the current trends of wanting to make the perfect world, aspergers like me, who aren't really affected by our problems, may be forced into taking a new kind of medicine which hasn't been tested for long term side effects yet and thus risk to damage ourselves by taking it or lose the help we need if we refuse to take it. Thats what I fear from the research into such a pill.

@martalaatsch8358

Ай бұрын

Yeah, also autistic here and an actual "antiautistic" would be terrifying... there's studies trying to put autistic children on SSRIs to see if that treats it, which is also terrifying to me, having to start an SSRI after refusing Abilify and not being allowed medication for the ADHD I know I also have. I would literally rather die than become neurotypical, but psychiatry doesn't seem to understand that. Not to mention *side effects* (I currently have tinnitus and depersonalization from starting Lexapro last week)

Make a video on winks and where and how they originated and got the meaning they have today please!

Oh wait, why am I giving a like? I didn't watch the whole video yet! Nah, i kid. I love SciShow as well c:

Most developments in understanding the way in which consciousness and mind operate, whether behavioral or pharmaceutical in nature, are somewhat whimsical in that the original research was aimed elsewhere. Scientific research is almost always directed toward a specific goal but any and all data obtained in such research are worthy of analysis. The pattern seeking nature of the human mind can make inferences and connections across huge gaps of information. I don't believe any computer has had an "idea". Ideas drive humans to find out! Our brains are slow but massively parallel computers. Recently, tools have become available to see brains in action. Machine learning and neural networks are beginning to expose the probable operating system(s) of the mind. The brain has it's own very considerable pharmacy. We have only tinkered with it so far but results are encouraging. Eventually, pharmacological therapies will be precisely tailored to individual needs in a more knowledgeable society.

Is iproniazid legal for recreational use?

I have seen commercials for a medication that treated one condition then a year or so later it would be advertised for another condition. I always thought that was strange, but if it works...

@karimaogden3875

2 жыл бұрын

That's called " Off-label" use.

I take Imipramine for Irritable Bowel Syndrome and it really helps

Could you do an episode on bipolar disorder and how it often can look like other illnesses? After 11 years being told I had ADHD and depression, it turns out I may have just been experiencing under-treated cyclothymia. Unbeknownst to me, almost every ADHD medication and many anti-depressants can trigger hypomanic episodes. Which explains part of why I ended up having to drop out of school and was terrible at keeping friends. Anyway I had no idea bipolar could be misdiagnosed and I’d love to see a video on that.

Video on Psychiatric drugs has a t-shirt seemingly inspired by psychotropic hallucinogens.

that t-shirt :D 10/10

Never understood why people didn't look up the Springer link on chemical Imbalances. It's quite interesting on the cause and relation theory but why after it was found out no one changed the label? Idk just curious.

For me the worst side effect drug has been Seroquel or Quetipine

There are no Side Effects. There are desired and undesired effects. Which category they fall under depends on the reason for taking the drug.

I attended a lecture about electronics engineering and at Q&A time I asked, was the discovery of the transistor serendipidous? Hardly. The physics to explain how it works is very satisfying. I don't trust my psychiatrist when he says "we don't know how they work, but they work." The chemical imbalance theory is just a marketing myth to keep companies like Lundbeck in business.

psychologists are flies in a world of ants.

I found SSRIs to be the absolute most useless medication ever created. I know they work for some people, but all I got were side effects and months of withdrawals.

What? No love for good old benadryl (diphenhydramine) as a precursor to SSRI's?

MAO Inhibors (MAOI) will boost the duration of your favorite hallucinogen - LSD, Peyote, Mushrooms, particularly DMT.

Azidoazide Azide fixes everything with enthusiasm.

No mention of Viagra that was supposed to be beneficial for the heart and blood to avoid clots at high altitude, but later turned into a different use? Maybe better categorized in another "accidental medicine" video.

@normansmith4166

6 жыл бұрын

Sizukun1 Good idea. Would watch.

@latelaughlove

6 жыл бұрын

Well this video is specifically about psychiatric medications and this is a psychology channel, so that would probably be a topic for regular SciShow.

@jkm7983

6 жыл бұрын

Sizukun1 accidentally science would be a cool channel. Important scientific inventions or ideas created or found my accident. For ex matches for fires, antibiotics, super glue, etc

@ehjaybee85

6 жыл бұрын

I think the difference is off brand Viagra is still used for the general vascular systom

@married222mayhem2

6 жыл бұрын

They have a video on that

Dancing on the ceiling with Fred.

That’s when nightmares happen

Well this ended up being a depressing video, given my mental health issues and the utter failure of SSRIs, an NSRI, an anti-psychotic and even an anti-convulsant to cause any discernible improvement. I also have beef specifically with Sertraline after it took 6 months to come off it cleanly without nasty withdrawal symptoms.

@kit4910

6 жыл бұрын

SeoulTeamworkGaming Maybe TMS (transcranial magnetic stimulation) would be a good alternative, since it has less side effects and is more targeted. It's pretty new, but it's pretty darn effective and super cool! It's also for people who haven't had success with other treatments!

@nickjohn2051

6 жыл бұрын

Mitsy This. I recommend TMS. Non invasive unlike ECT.

@raraavis7782

6 жыл бұрын

Ath Athanasius SadamFlu If you like sciency stuff (well, I guess you must do, watching this channel), check out this podcast episode by Dr. Rhonda Patrick: www.foundmyfitness.com/episodes/charles-raison I‘m kinda researching the topic for a family member with treatment resistant depression and Dr. Patrick strikes me as someone who is deep into the science of the topics she discusses with her guests...and she isn’t trying to sell anything... Maybe there’s something in there worth following up on for you as well.

Literally the only thing that keeps my mother stable is thorazine. It took us too many years for the doctor's to think of trying it.

Hank unconsciously activating super saiyan at 2:32

@konona8982

3 жыл бұрын

More like further beyond state of ultra instinct