I just want you to know that your videos are literally the only things that have helped me get through organic chemistry. So thank you!

@PunmasterSTP

2 жыл бұрын

How did the rest of your ochem classes go?

I'm pissed. My professor didn't say anything about making the carbon groups nucleophilic. Suddenly this makes so much more sense.

@shanemichael9404

5 жыл бұрын

They often don't. They know chemistry like the back of their hand and they sometimes teach as if you should already know this stuff. I hate it !

@akhilgajjala4922

3 жыл бұрын

@@shanemichael9404 Ikr

@PunmasterSTP

2 жыл бұрын

I know it's been awhile, but I was just curious; how did the rest of your class go?

@ClicClikBang

2 жыл бұрын

@@PunmasterSTP awful but I passed with a B, and I’m in medical school now. I never have to look at another dumb ochem reaction again. All’s well that ends well.

@PunmasterSTP

2 жыл бұрын

@@ClicClikBang I'm glad you passed, and I wish you the best with medical school! Also, yeah, I don't think ochem is going to come up in there...

The handsomeness makes it difficult to focus sir

@lavishagera1302

8 жыл бұрын

If i had a professor this hot i'd never be missing classes. NEVER.

@subikksha4941

4 жыл бұрын

Guys! He's our teacher! It's not fine to speak like this!

@duleetharajapaksha6493

3 жыл бұрын

dafaqs wrong with you

@besimeaslan9589

3 жыл бұрын

😂😂

@soniafragoso5376

3 жыл бұрын

but for real tho!

1.5 minutes in i had my first "OHHH" moment. bless u kind sir

Best video on grignard regent I have ever seen. Thank you professor ❤

the opening jingle is stuck in my head forever.

Thank you so much for this video Professor Dave! This is by far the most engaging video on youtube about Grignard reactions and it is always helpful to see the person teaching being interactive in the video! Have subscribed and will recommend to friends!

Studying for the MCAT this January, absolutely amazing I stumbled across this video. Thank you for the blessing

thnk's sir a lot teachers like u make student confident that we can solve problems and are not stupids

this was so helpful. thank you for actually explaining what it is. I was trying to watch the o chem tutor and he was just doin problems like I already had all of this background knowledge about what happens and why. thank you!

This is the best video that I have watched so far about this topic. THANK YOU SOOOO MUUUUCHHH!!!!!!!

Wow, man! Your lessons are really amazing. I love that there's always subtitles. Congrats! ;)

Sweet, everything I needed in 8 minutes!

@rizzarizzo

7 жыл бұрын

True

Hi Professor I just want to say thank you very very much for your videos, I finally finished my organic chem with acing my final exam because of your awesome videos. I owe you a lot and I wish you the best again, thank you very much. Sincerely, Hamed.

@ProfessorDaveExplains

7 жыл бұрын

congrats! thanks for watching!

I like it. The videos are short and straight to the point.

Haha, love how the chemists decided to use my nickname to name this reaction😂

This video was uploaded in 2015, Just saw a comment given 2 days back and he had replied to it!!! Awesome

a very clear and helpful video. thank you very much!

Amazing video... thank you for your time

Thank you for your help, you have no idea how much this this video taught me.

simple, easy and concrete. Thanks man =)

I was looking for a video like this 😌 In Spanish I couldn't find it, but KZread recommended me this video 🤣❤

the fact that in Greece we're learning these in high-school is something out of your minds. I'm going to cry alone😭

@NEETAspirant-li3tu

2 жыл бұрын

Lol In india we have to learn 100x more than this, in high school lmao

@andy0695

2 жыл бұрын

@@NEETAspirant-li3tu Fact buddy,,,, + maths & phy tooo

@NEETAspirant-li3tu

2 жыл бұрын

@@andy0695 yup, pretty much XD what a pain in the ass

I cannot thank you enough for these videos! Not only did you get me through Gen Chem 2 but now you make Orgo 2 simple.

@PunmasterSTP

2 жыл бұрын

How'd the rest of Orgo 2 go?

Thank you, professor Dave, for this videos, specially during the corona virus, I'm going to take an exam of Organic chemistry II, you helped a lot !

@PunmasterSTP

2 жыл бұрын

How did your exam go?

Thank you professor grohl

I love it! Well explained and easy to take in. Thanks

Professor Dave you are amazingly amazing, thank you so much ✨🌈

thx alot for your video profefesor dave!

man I love your channel

This has been really helpful thank you

Very nice Video! Easy to understand! thank you : )

Your explainations are super.thank u professor

These videos are really nice.

Dave, your youtube channel has been incredibly helpful for me in understanding organic chemistry. Thanks for all of the great and informative content!

@PunmasterSTP

2 жыл бұрын

Are you still taking ochem or did you finish that up? And if so, how did the rest of it go?

Sir I am from India and Iwant to tell you that your teaching style is so beautiful!!!!!!

This well explained, clearly understood 🎉🎉

Thanks Professor Dave.

Thank you so much! you answered one question that I had of one retrosynthesis, now I know why we used grignard reaction, c:

When you think about it it's pretty remarkable how as a species we have been able to develop such chemical reactions.

Now it makes sense! Thank you, just reading it is so confusing. I really appreciate!!

THAAANK you, now I can pass tomorrow's paper!!! yaaaaay

very helpful, thx so much

Thank you for the excellent explanations as always, Professor Dave!!

Just found this and I'm a biology student from Germany and I just have so much problems with OC and I think you just saved my life.

Thank You Sir

Thanks for not having a 2hr long video

Thank you so much

You are really helping people learn, thank you so much for this free and wonderful content! I wish you were my professor

Thank you Professor. Idk how in eight minutes you can do what in 50 my professor cannot

@PunmasterSTP

2 жыл бұрын

How'd the rest of ochem go?

Thank you so much!!

This is the best explanation ever. I finally understand Grignard reactions. Thank you so much professor!!!!

thanks sir.....your videos make a difference indeed......:))) helped a lot....thanks

Your videos are easy to digest and very helpful. My exam is tomorrow and you've helped so much! Thanks for all the hard work!

@ProfessorDaveExplains

8 жыл бұрын

+Hunter Goodreau my great pleasure! tell your classmates!

@PunmasterSTP

2 жыл бұрын

I know it's been awhile, but how did your exam go?

Thank you very much sir ❤️

Nice video!

Grignard reaction? More like "Gee, this video gives me knowledge satisfaction!" Thanks again so much for making so many educational and entertaining videos.

Thank you :)

Great video thanks!

I would not be a junior without this guy

I always recomend you to my friends 💓

shook by how easy you made something that seemed impossible to conquer! infinite thank-yous!!!!

Thank you.

You're a life saver

thank you for this video! im from germany so its sometimes a little bit hard for me understand the... chemical term but your videos are much better than the german ones! thanks a lot!

thank you sir

Thank You for answering my questions today :)

Thx very much professor Dave!!!! u clear all my doubt about grignard reagent since i was on secondary school..XD

ty omg savior we love u man

Thank you so much!!!!!!!!!

Thank uuuuu soooooooo muchhhh God bless you😍😍

Thankyou sir

thanks!

Should we technically be drawing arrows originating from a carbon atom? Which electrons are specifically forming the new bonds here?

hello prof dave! i have a question, why does the O- reform the double bond and why does this kick out the OCH3? thank you!

I love your explanations. straightforward. thanks!!!

Thank you so much. I was really struggling with understanding this.

!!! Thank you so much! Your video was extremely helpful for my organic chemistry final!!

@PunmasterSTP

2 жыл бұрын

I know it's been awhile, but how did your final go?

Excellent! Wish you had been making videos during my degree!!

@PunmasterSTP

2 жыл бұрын

I know it's been awhile but I was just curious; what did you get your degree in?

thanks sir

Thanks for sharing. Anyways, where do water and proton come from?

I don't understand why carbocilyt acid. But that compund has carbonyl in it/.

This is amazing.. you da bestest

omg u are a hero!

This is so easy example for grignard reaction.

Actually, why wouldn't the Grignard reagents react with carboxylic acid? Why isn't that going to work ( 6:23 )?

THANK YOU so much for this video! Our labs do not mesh with our lecture material. We are chapters behind, and the explanation to the background of the reaction was non-existent. Thank you so much so I can write a more precise lab report!

@ProfessorDaveExplains

8 жыл бұрын

+Kelly Burns my pleasure! spread the good word!

briliant Bro

nice one

fantastic

why does -OCH3 gets eliminated and O again forms double bond in the last problem?What would be the result if acedic build up was done just after the first grignard? What would happen if we hadn't had grignard in excess?

@breetaylor5249

7 жыл бұрын

This might be a useful link: chem.libretexts.org/Core/Organic_Chemistry/Esters/Reactivity_of_Esters/Grignard_Reagents_Convert_Esters_into_Tertiary_Alcohols The lone pair on the oxygen forms a double bond because the formal charge requires higher energy to remain that way, so it is more stable if some mechanism exists to allow it to form a C=O bond instead. In this case, if a leaving group on the carbon does exist, then a C=O bond can form. Here we see the -OCH3 act as a leaving group. It seems that since the MgBr+ placed itself near the RCO- before the lone pair came down to form a double-bond, the -OCH3 leaving group is stabilized by the MgBr+, and an ionic bond forms as it leaves the organic chain. Usually, -OR is a poor leaving group since it's a strong base, so the MgBr+ seems like the only good explanation as to how it leaves. Since the grignard reagent reacting with the substrate isn't really something you can tell it to stop halfway through, I don't think you can simply apply acidic workup after just the first grignard process, because it's all kind of happening in real-time. So, if you have excess grignard present, it is going to be used up until both processes have finished and all substrate has reacted. If you simply tried to add the grignard reagent and then quickly add acid somewhere you think about-halfway-through-the-reaction is, I think you'd just get a weird concoction of poor yield and side-reacted species. Now, you can definitely control how much grignard-to-substrate you use, i.e. control whether or not you actually use an excess amount. Since you need two parts of grignard for each one part of ester, you could hypothetically try using an equimolar solution of grignard reagent with your ester, to try to obtain only ketone products (the result of only one grignard reaction to the ester). However, I don't know if it would work this perfectly either, since your grignard probably isn't discriminating between reacting with fresh substrate and newly-formed ketone, so as your reaction proceeds, you'd start to see a mixture of ketone, tertiary alcohols (after doing acidic workup), and unreacted esters (for each alcohol formed, an ester was deprived it's one grignard molecule, assuming equimolar conditions). If you used more substrate than grignard reagent, you could probably yield only ketones in your product with virtually no alcohols, but you'd have a ton of wasted ester reagent, since the ester would need to be in excess. This is probably a very inefficient way of getting ketones, though.

@ProfessorDaveExplains

7 жыл бұрын

yep, mostly what this guy said. chemical reactions happen in picoseconds, so there's no way to prevent an ester from going all the way to the alcohol. even without excess grignard reagent, you're just going to get a mixture of alcohol, ketone, and unreacted substrate.

Thank you, Professor Dave!

I got into a fist fight with my wife about this the other day. She won, but I was right.

Very nice videos! Thank you very much!

These videos are a godsend, theres a special place in heaven for you!!

Metal-halogen exchange is awesome. Great video! :)

Cramming for my exam tomorrow, and I legit thought the title of the video said "Cramming Reactions"

You say that it a Grignard connection shall not interact with a water molecule, but before getting the 5-Carbon alcohol, there is water...?

@ProfessorDaveExplains

6 жыл бұрын

that's aqueous workup! the oxyanion has formed so the grignard reaction is complete, then you just toss in some aqueous ammonium chloride or some other weak acid to protonate and get the alcohol product.

Great explanations. Well done. Better than the professor at our college.

I didn't think methoxy was a good leaving group unless it was protnated first, but you can't use a gringnard reagent in acidic conditions. Am I mistaken by this?

@ProfessorDaveExplains

6 жыл бұрын

in this situation it's no problem! but yes, no acidic conditions for grignards.