Gq Pathway Of G-Protein-Coupled Receptors Explained | Clip
Welcome to Science With Tal!
In this video, we will cover the Gq pathway of the G-protein-coupled receptors (GPCRs). The Gq pathway is very important to understand, as it mediates many intracellular cascades in neurons and other types of cells. Through this discussion, we will discuss protein kinase C (PKC) and calcium-calmodulin dependent kinase (CaMK), which are 2 very important kinases in the body.
This conversation on neurons in the CNS derives from important concepts that are described in two previous full discussions:
1- To watch the first part (Signal propagation in the Neuron), make sure to go to: • Signal Propagation In ...
2- To watch the second (The Neuromuscular Junction as the model of the chemical synapse) make sure to go to: • Neuromuscular Junction...
To improve the quality of my content, I highly value the feedback from the viewer so do not hesitate to give any feedback in the comment section.
TIMESTAMPS
0:00 Introduction
0:15 Gq pathway (PLC, PIP2, PKC, CaMK)
4:16 Word on CaMK2
5:04 Summary of Gq pathway
6:08 Conclusion
RESOURCES
Here is a list of the resources that I’ve used to produce this video. (Author(s): title resource)
- Dale Purves: Neuroscience (6th edition)
- Eric Kandel: Principles of neural science (6th edition)
- Lodish: Molecular Cell Biology (9th edition)
- Niswender, Colleen M, and P Jeffrey Conn: Metabotropic glutamate Receptors: physiology, pharmacology, and disease
- Bünemann, M et al: Activation and deactivation kinetics of alpha 2A- and alpha 2C-adrenergic receptor-activated G protein-activated inwardly rectifying K+ channel currents
- Howlett, Allyn C et al: CB(1) cannabinoid receptors and their associated proteins
- Morris, R G: D.O. Hebb: The Organization of Behavior, Wiley: New York; 1949
- Stent, G S: A physiological mechanism fo Hebb’s postulate of learning
To have more information on these resources, you can refer to the conclusion section where a more formal citation is provided.
CREDITS
Writing: Tal Klimenko
Voice: Tal Klimenko
Animations: Tal Klimenko
Drawings: Tal Klimenko
Editing: Tal Klimenko
Introductory jingle: Thierry Du Sablond
Conclusion music: lukrembo - sunflower ( • lukrembo - sunflower (... )
Пікірлер: 14
Thank you so much, this is so much easier to understand than trying to read papers to figure out what this pathway is and what it does. I really appreciate the work that went into this!
@sciencewithtal
3 ай бұрын
Thanks a lot! Glad you found the video useful!
Your videos are my favourite for learning these concepts! Not only is the explanation super clear, but the visual graphics really help integrate it all after class. Keep doing what you're doing :)
@sciencewithtal
8 ай бұрын
Thank you so much!
awesome
@sciencewithtal
2 ай бұрын
Thank you!!
THANK YOUUUUUUUUUUUU
@sciencewithtal
Ай бұрын
My pleasure, thanks!
Excellent work done💖
@sciencewithtal
2 ай бұрын
Thanks!! Glad I could help!
What does the q in Gq protein stands for?? In Gi “i” is inhibiting and in Gs “s” is stimulating. I can’t find information anywhere…
@sciencewithtal
3 ай бұрын
To be honest, I don't know either. I guess it's one of those scientific conventions where you have to go with it and not think too deeply about it. Let me know if you ever figure out the meaning!
Your channel deserves more subscribers, your work is really great keep it up 🤍
@sciencewithtal
3 ай бұрын
Thank you very much!!