One of my favorite AK lecture quotes "And what that means is...." Everything is always explain so thoroughly. Una de las citas que me gusta más es cuando él dice " Y lo que eso significa es.." Todo se explica con tanto claridad, lectores tan buenos.

@AKLECTURES

9 жыл бұрын

Miles Holmes Thanks Miles, thanks for watching all the lectures and being such a good subscriber! :)

@jubilantsundar1

7 жыл бұрын

my fav is "we will see in jusssssst a moment"

@samirgeorges2686

7 жыл бұрын

mine is "which I will explain in a future lecture..."

This man is amazing! So grateful that he takes his time to teach people!

you are a masterpiece man!!!! My favourite line is, " ........as we shall see in just a moment." Continue simplifying life during my studies. Thanx a lot, that was really helpful

Andrey u are amazing human u relief of so many confusion pains thank u

You have made me like cell biology I’m doing my masters in molecular biology 🎉

awesome video! gotta love the city sounds at 10:07, I thought someone was outside of my house lol

@AKLECTURES

8 жыл бұрын

+ForzuhBaby lol! :-)

complex topic explained so well! Props to you. proper teaching is a talent.

Danke, das war fantastisch. Du bist perfekt!!

Hey, I find your notes super helpful. I wish there was a way I could look back at them without watching the video again. Is there a way you can upload your notes on the board somehow?

Should that last bullet point be switched around? GDP for GTP instead of GTP for GDP?

@thatbossguy123

4 жыл бұрын

ya I believe so

i think u also have to mention that the alpha and gamma are bound to the inner membrane great great videos! i watcsh all ur videos for my exams:!!!

So helpful, thank you.

Thankyou sir....... Msc biotechnology...

Great explanation.. cute diagrams👍🏻

Now I understand Multiplication effect on first phase. Maybe mentioned in books but I do not think so.

you are excellent at teaching. can you do a pulmonology series.

thank you so much ^_^!

v. nice

i love that horn sound

I can't tell if the notes are a some kind of screen or a white board.

Love your videos! I took molecular biology in college and I did not understand this particular pathway but it is becoming clearer now. just one thing though, GDP becomes GTP when epinephrine binds to 7tm, where does the phosphorus come from to bind to GDP? Is it just randomly "wandering" out in the cytoplasm and just happens to bind to the GDP making it GTP?

@AKLECTURES

9 жыл бұрын

Isaac Murphy Awesome :) Yes, the GTP is randomly moving about the cytoplasm. Upon binding to the receptor, the epinephrine causes a conformational change that constricts the space that GDP is in and that squeezes it out. At the same time, it creates a space that can fit in the GTP, so as the GTP randomly collides with it, it feels a strong enough electromagnetic force that brings it in. So we exchange one guanyl nucleotide for another (We don't simply add a phosphoryl group).

@violinist86

9 жыл бұрын

Thank you! I guess that concept of randomly floating around applies to the ADP and ATP as well.

@AKLECTURES

9 жыл бұрын

Isaac Murphy Absolutely! Amino acids, monosaccharides and nucleoside di/triphosphates are all floating around the cytoplasm.

It’s true that upon binding with GATP the alpha unit of G associated protein binds with Adenylate cyclase but the books state that the movement starts with displacement of adenylate cyclase but I get the impression that the alpha unit initiates the movement. Kindly clarify..

Hey! How does cross talk afect to the secondary messenger?

A single epinephrine can cause many G proteins to exchange GTP for GDP. This is not simultaneously is it? I imagine the signal molecule can unbind and go on to do the same thing on other receptors. Is this right?

Are the seven transmembrane helix receptors analogous to the G-protein coupled receptors?

@lawyerdoctor

5 жыл бұрын

Yes, they are the same thing. He could have said GPCR instead

Horn sound at 10:06