Regarding the relationship between low blood glucose and glucagon release... it looks confusing. But I guess the explanation by Ninja Nerd is the best at present moment. The link between low concentrations of glucose and depolarization of the cell membrane is still under debate. According to one of the hypotheses, they think ATP-dependent K+ channels (KATP) plays important roles as in beta cells but the downstream link seems to be not clear yet. At moderate inhibition of KATP (low glucose concentration), membrane is moderately depolarized to open Na+ channels, resulting in the opening of voltage-dependent calcium channels. At high glucose concentration, KATP is strongly inhibited and the membrane potential is strong enough to inactivate Na+ channels, and calcium channels cannot be activated. This is just one of the current hypothesis, and it is not still clear why this does not apply in the regulation of insulin secretion in beta cells.

@vidhivora3578

3 жыл бұрын

this part was bugging in whole video... thanks you so much

@saurabhranakoti7621

3 жыл бұрын

@@vidhivora3578 even I came to comment section just to clear that part

@Easypeasy007

2 жыл бұрын

@@saurabhranakoti7621 can u plz explain m not able to understand

@Easypeasy007

2 жыл бұрын

@@vidhivora3578 can u explain

@vidhivora3578

2 жыл бұрын

@@Easypeasy007 there's video on insulin just before watch that first and then this ..you will know why I got confused and the above explaination ..then I guess you might get answer to your doubt ..if not then I'll explain you ..

For anyone perplexed about the Ca Channels, I think the answer is : Voltage-activated calcium channels can be divided into two subgroups based on their activation threshold, low-voltage-activated (LVA) and high-voltage-activated (HVA).

@damlakacmaz8743

3 жыл бұрын

Oh now it makes sense! Alpha cells, ones secrete glucagon has LVA Ca channels and beta cells has HVA Ca channels.

@unkown-uz4lp

Жыл бұрын

Exectly

@fretelianadedeus7951

Жыл бұрын

Thank you! I was so confused in the beginning

@questioneverymatter5851

11 ай бұрын

Now I got it right. For Alpha cell the membrane is embedded by LVA calcium channel and for Beta cell it's HVA calcium channel. It's just a matter of cell type.

@-BhadoriyaMohitSinghN

Ай бұрын

You all people....Thank you so much for being involved and to initiate this kind of discussion on calcium channel...❤ Its really really very helpful...

He is a gifted teacher!

You are a god's gift to medical students. Thank you so much for sharing your knowledge with us. Really very grateful!

You get all the concepts together and make them understandable in a very easy manner. Great work and thank u so much for all these videos

Comprehensive information provided here. You make life really easy in just 25 minutes. And after this, reading through text book becomes a breeze. Keep up the work and would love to see more topics covered.

I love how you added glucagons effect on the myocardium... useful in beta blocker and CCB overdose. Great review!

I appreciate the way you're enthusiastic about the things you explain - it makes the difference!! :D

This helped me so much in connecting the important key points and describing an overall picture of the process. So helpful .🙏🏻

Pancreas- Hetrocrine Accini Islets of langerhans. Alpha cells glucagon hypoglycemia Beta cells insulin hyperglycemia. In alpha cells GLUT1.less ATP. Less membrane depolarization. Ca++ chhanel. NE CCK SECRETIN. GLUCAGON. IN blood. Liver fasting state- Glyogenolysis. Glucogenesis. Adipocytes- Hormone sensitive lipase. LIPOLYSIS. Heart- Ca++ uptake. Thank you sir

Hey ! I am studying Biotechnology and have some exams in a few weeks. I just wanted to tell you that your videos are incredibly well explained. I could just watch them for fun. Congratulations for all the work and effort and thank you very much :)

I hope you reach 10 million subscribers Very well explained, You are amazing teacher ! Lucky to have you Ninja nerd ❤️

I am now a fan. You are becoming my favorite KZread channel. I am so glad you exist as a person and you do what you do. Keep making these videos and I'll keep watching them. Look for a patreon donation coming your way.

yes !! i did enjoy the video !! and thank you for keeping these for free us students to learn and always come back to!! Much appreciation from a fellow med student.

AMAZING EXPLANATION! Wow, CLEAR explanation to the details! I'm a visual learner so your video really provides a complete picture for my understanding. Thank you very much! SUBSCRIBED!

hello Dr. WE need more videos of yours. start a new series of videos on any system. please keep em coming. we really love and appreciate your work.

My favorite teaching on this subject. I am definitely subscribing. I am a visual learner. Thank you so much.

You're an angel. I'll marathon your videos as prep for my licensure exam!!

surprisingly during my bodybuilding prep, your content has massively helped keep me productive & focused. I've learnt so much information from your videos which will significantly help me deliver a better service to my clients as a online nutritionist coach. Thank you

One thing for you is, you are my Super hero for biology, You gave me inspiration, and yeah man I am getting addicted to it. Thanks a lot for these lectures, and I gonna meet you one day Mr biologist

Thanks a lot for your great way of teaching.. I never thought I'd understand Biochemistry the way I start to understand it now..

thank you for sticking through the whole process of making this video

My exams are all oral and your videos are precious for explaining and connecting dotes

i had my endocrine exam today and it went absoleutuly great, actually i aced it, thank u sooo much for all of these videos. this whole endocrine palylist was soo detailed yet so easy to understand.

the best teacher... i wish i could pay my med school tuition to this king

Thank you! This summer I aim to review all my physiology following your videos!! Thank you!!

I'm so addicted to all your vidss/ Love t them, start making shorts they actually help me even more

This man👨‍💼 is so firm, confident and understandable in the era where people opt for confusion related data. 🙌 Just so in love❤ with you, your teaching skills and your management skills 🙌✌🌟 Kindly keep doing what you do 😍💕🌠

this is awesome... its helped me to more understand about glucagon.. thank you

Thank you man . Amazing as usual . Keep going my friend .

Saved me. Amazing work. Love Ninja Science nerd.

Dude best class on glucagon on have seen so far.

You are one of the best teacher in the world 👍

the best teacher on youtube.THank you for the effort

Fantastic.... man I am running out of words to comment. Still feel like having notes or prints! Zachcellent!

at the end can you leave a picture of the board so it can be printed off?

@odysseyoddworld572

6 жыл бұрын

Yes please, that would be very helpful. Thank you ninja nerd science.

@danielachavez8346

5 жыл бұрын

Pleaseee

@frayedendsofsanity1733

5 жыл бұрын

Omg yesssss

@Pieguts123

4 жыл бұрын

@@frayedendsofsanity1733 I go over the video, bit at a time, draw the diagrams and make notes of the explanations. I use coloured, erasable pens and this allows me to correct mistakes. Doing this means that I am re-listening to the lecture plus writing it down and then reviewing it whenever I want. This means a lot of revision of the topic: re-listening, note-taking, drawing, re-reading. I think this might help to truly learn rather than looking at a print-out?? I don't know; we all learn differently.

@drholiday4147

4 жыл бұрын

Pieguts123 same here ; )

Awesome thank you very much. You're the gift to community and our blessing.

Beautifully explained. Awesome teacher

Absolutely amazing thank you so much professor i have never understood more, such an amazing explanation really simple and clear bravo ✅❤️

According to Costanzo CCK is a factor that stimulates glucagon secretion, so you were originally correct.

incredible lecture. Well done!!!

Packed with information and the drawings really help for someone like me that is a visual learner. Im actually a IT guy thus well done cruizin through the medical sections

Every single time I feel like I had an epiphany watching your videos :D

Professor Zach! You are awesome! Thank you so much!!!

Who are the 20 people that didn’t like this video? Good job! Loved the refresher!

Love you sir,,sault to your effort,,you make very easy every topic for us,,a bundle of thanks sir...keep it up,,I am only depending on your sweet lecture...

U are a Hero without a cape! Greets from Germany.

Thank you for making learning so enjoyable 💓💓💓

Ur videos are really helpful...uh did a great job...thanx for making these very informative videos 🌺✨

Excellent talk!

I love your videos , you have a teaching gift .

you make biochemistry so simple to understand

Secretin inhibits Glucagon secretion , while CCK stimulates it. So you were partly correct originally. Love your work, Zach just can’t thank you enough for your amazing videos ❤️

Laymen here. Interesting and mind challenging. Thank you

In a short time presenting a lot of things ! If the time of lectures in this video would be one hour it would be so good to present all the information more simply & easily what you wanted to present that goes to be more understandable ! Lastly thanks a lot to present all these mechanisms deeply !!

Thank you so so much for this gold as always

You are a heaven sent... Thank you soo much!!!!!! now I am feeling kinda Nerdy :D Great videos! very clear ! love it all, I don't even notice the time whenever I binge watch your videos..... Hope for some printed materials to guide medical students like me as well, practice quizzes and what not :)

well defined and great lecture

Hey man I got a question, in the video on Insulin you actually said that those Calcium channels open, to stimulate the insulin release to the blood, now you say when there is too much depolarization they close, I'm quiet confused with what you mean, if you could help me get this right, thank you in advance!

@laithenani671

6 жыл бұрын

second that, please elaborate. Thank you

@LHost-sx2kk

6 жыл бұрын

6:00 , but maybe it has do do with the different threshold levels for that Calcium channels in alpha and beta cell's? I understood what he said but not why it doesn't happen in the beta cell as well

@teekay5166

6 жыл бұрын

Yes same. Confused at this point

@NouziMora

6 жыл бұрын

Same! If ATP channels close and K+ accumulates, there should be a membrane depolarization which causes Ca++ channels open. Don't understand why would positive charge close the channels?

@LHost-sx2kk

6 жыл бұрын

Okay,clearification for you guys since this guy refuses either to admit he is wrong about this topic or he either too cool to answer to us, forget what he said, when B cells release insulin caused by hyperglycemia it also secretes glutamate, that will have effect on alfa cells Cl- receptor channels, increasing uptake of cloride by cell and hyperpolarizing it. When the stimulus is low glucose levels this action of Cl- channels is inhubited because less glutamate is comming form b-cells and the alfa cell will depolarize, giving the threshold for Ca++ release into the cell

Amazing work 👍👍. Thankyou so much🤗♥️♥️

THANK YOU FOR THIS VIDEOS YOUR AMAZING FOR DOING THIS

Sir, you are great teacher, I am your big fan from India ❤️

Just amazing, good job man!

brilliant explanation

Thank you so much, this is awesome! You're absolutely mind blowing in your teaching skills.

@NinjaNerdOfficial

6 жыл бұрын

+Elizabeth Charles wow thank You so much for your kind comment!! I am so glad we were able to help!

Great job, thank you!

god give u health and wealth professor ur incredible from algeria

Can you do a video on fasting, glucagon and lipolysis? Key to fat loss?

Good doctor ever

amazing explanation

Awesome explaination 👍

Thank you my brother for the great info.😁🙏🏾🌈

Thank you so much for your great videos...love them💕 Can you please make a video on oversecretion and undersecretion of adrenal hormones......pathologies.

Lovel 💕💕💕💕 your lessons you are great explaining.

Cool presentation

Great concepts bro😘😘stay blessed

love your videos,can you please give me biosynthesis of glucagon with structure...I found nothing good in internet,

Good explanation amazing sir

Thank you 😊

Excellent!

what an amazing explain

Zachcellent!

Hello I hope you are doing well. Your video are really informative and enjoyable ❤ I actually have a confusion regarding the calcium channel. In this video you are saying that when there is increased glucose level, there is production of ATP which binds to the potassium channels causing their closure, in response to accumulation of K+, the calcium channel closes (6:35). while in the other video on insulin function, you mention it as that there is opening of calcium channels for its influx and release of insulin(11:15). It is creating a little confusing.😟

very brilliant, just thinking can one do lipolysis under the normal blood sugar levels? or this person needs to fast and undergo hypoglycemia?

Hi there, I've been reading up on the adrenal cortex and medulla and how cortisol, adrenaline and noradrenaline can stimulate alpha cells and I was wondering if there are hormones that stimulate beta cells as well

Sir I have one question Actually a confusion....in previous lec. You talked directly about increase k+ ions and it stimulates opening of ca2+ channels and here you said that increased positive polarization inhibits the opening of ca+ ion channels..... please can you help me in clearing this confusion?!! Thank you !

@LuchiaNan165

2 жыл бұрын

Hi, Voltage-activated Ca channels can be divided into 2 subgroups based on their activation threshold: Low voltage activated LVA (Alpha) cells And High voltage activated HVA (Beta) cells.. Hope that makes sense!!

The α-cells and β-cells have opposite Ca+ signaling patterns in response to glucose. At low glucose concentration, the cytosolic ATP/ADP ratio is low; KATP channels demonstrate a moderate activity, which situates the α-cells to a membrane potential that allows the opening of voltage-dependent T- and N-type Ca2 + channels. The resulting increased intracellular calcium concentrations, in turn, stimulate exocytosis and glucagon secretion. On the contrary, high glucose blocks KATP channels, which depolarizes the α-cells to a membrane potential range that suppresses the voltage-dependent Ca2 + channels. Consequently, Ca2 + signaling and glucagon release are blocked. (Adapted from Anatomy, Histology, and Function of the Pancreas. C. Shi, E. Liu, in Pathobiology of Human Disease, 2014)

Eyvallah Ninja kardeş! 🙏🏽❤️

I am not a bio student but I can understand, thanks for ur video

thank you so much

Adipose tissue contain both insulin and glucagon receptor which produces protein kinase A that stimulates different functions. How does the protein kinase A know which function to perform.

Thank you 🙏 ☺️ 😊

Thank you so much ☺️👏🏻👏🏻👏🏻

Great sir . Thank Uh 💙💙

I wish I could talk about this as you do!

Thnkk uu sir uu teach really really well

thank you

thank you sir

Hi, some concept is wrong in this video. The opening of voltage-dependent N and T type -Ca channel and Na-channel is because of Katp channel. (opens with a low ATP/ADP level). when K flows out the membrane, locally, the membrane will depolarize and opens the Ca and Na channels. your video is still awesome for learning.

Thanks!