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In this lecture EKG is going to cover drug-receptor interactions.
We’ll explore important concepts like drug binding, affinity, efficacy, potency, and concentration response curves. We’ll also break down the role of agonist drugs and dive into the different types of antagonism.
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Lecture Overview:
0:00 Intro
0:22 Concept of Drug-Receptor Interaction
3:50 Affinity, Law of Mass Action & Equilibrium Dissociation Constant (KD)
11:55 Efficacy & Receptor States
16:50 Concentration-Response Curves (CRCs)
21:02 Emax & EC50
23:37 Potency
29:48 Subdivisions within Agonists: Full & Partial
31:22 Types of Antagonism - Competitive (Reversible & Surmountable) & Non-competitive (Irreversible & Insurmountable)
✏️ All diagrams were made by EKG.
For educational purposes only; NOT medical or other advice.
Lecture Source:
Ritter, J., Flower, R.J., Henderson, G., Yoon Kong Loke and Rang, H.P. (2018). Rang and Dale’s Pharmacology. 9th ed. Endinburgh: Elsevier.
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