Keep up the good work! I am a 70 year old female. CAC score is 0. Total cholesterol 460, LDL 340 , tri 98, HDL 98. I was an active person until 2000 when my doctor insisted on me taking 10 mg simvastatin and later atorvastatin. When I was on statin, I was so tired and sore I could hardly move. My mind was foggy and and had trouble making decisions. That was part of the reason why I stayed with the same provider and doctors for longer than I should. Also, I developed various ailment/conditions that I dared not move away from the "treatment". I stumped at my desk at work. I retired in 2011. I argued with my doctor and asked to be off statin many times. After 20 years of on and off statins, I finally listened to my own body and gradually wean myself off of statin starting 2020 and completely off of statin and all other medications in 2023 . Now I finally feel myself again. My current doctor looked at my CAC score and let me stay off of statin. I will take the CRP inflammation test next month.

@DK-pr9ny

7 ай бұрын

CT Angiogram is what you want.

@peterkoch3777

7 ай бұрын

With high HDL and low Triglyceride you have no risk factor for heart disease regardless of your LDL values. This is something, doctors have not heard of. Yet.

@andrewrivera4029

7 ай бұрын

You didn’t mention your diet. I’m 57 my family has a history of heart disease my father had a triple bypass at 70 but did live til 87 with a variety of illnesses. My brother has calcification in his arteries but will not tell me his CAC score. My CAC is 0 for second time in 5 years I follow a low carb diet but the only thing I’m truly consistent with is OMAD full time and fasts during winter that I believe is driving down my insulin and glucose to baseline for extended periods (my father and brother have all signs of pre diabetes). My doctor wanted me on statins but I refused! My HDL is 70, LDL is 249 but am physically active on my ranch during summer, ride mtn bike and climb 14’ers during summer in Colorado where I do eat carbs so I have energy but restrict when I know I’m not doing extended cardio.

@DK-pr9ny

7 ай бұрын

@@andrewrivera4029 more importantly what is your triglycerides, A1C and fasting insulin?

@peterkoch3777

7 ай бұрын

@@andrewrivera4029 what are your triglycerides? Below 100? Then don't worry about statins. No need for that shite.

Dave, I really appreciate the work you and your colleagues are doing in this area. My entire adult life I’ve had high LDL (160-200). After heading towards metabolic syndrome I went ketovoire (and reversed all metabolic symptoms) and my LDL is now around 300. Yet, late sixties and CAC score is 0. No meds, no inflammation markers or otherwise “worrying” test results and yes, I meet the criteria for LMHR. I believe there is something about us that is “protective”. Will be interesting to see if that pans out.

@realDaveFeldman

7 ай бұрын

Yes, there are many in circumstances such as yours who are looking forward to this data. My hope is this will bring further interest in researching cohorts like LMHRs to better understand this context.

@yogaexercise9637

6 ай бұрын

Pretty much describes myself too. When I went Ketovore, my LDL jumped up to 245, tho my trigs when way down and HDL went up. My CAC score, a couple months ago, was zero. But I'm not sure whether to worry about the ApoB LDL--"they" say that's the one that could be concerning. My bp is great--averages around 110/65. I'm a 68 yr old female, normal BMI, and take no other meds.

Thank you Dave. The last time I had my bloodwork done my doctor's office was calling about the high LDL (which i expected it to be high) - I just told them to go look up your study on Lean Mass Hyper Responders. So many doctors never even heard of it! Keep up the good work!

Thanks for all you do Dave. Im a LMHR, and I've been following you closely. Hoping for good outcomes with your scientific studies.🤞

Great Work Dave! Thanks for all your doing to bring some light on the subject, really appreciated 👍🙏

Dave is BRILLIANT!

@nicknorwitzPhD

7 ай бұрын

Brilliance isn't the only important element in being a scientist, one also needs intellectual integrity and curiosity. So Dave has a "triad." And being a super swell guy is the cherry on top (helps w/ teamwork)

Looking forward to the next video. Thank you Dave!

Great video Dave. We're looking forward to your future videos to more deeply explore this vital topic.

Excellent video! Anticipating the next video.

BUT WHEN IS THE NEXT VIDEOOOOO

Dave, thanks for the enormous effort you've made to get the study organized and underway. I'm like many others here who are eager to learn the results when the time comes. Like others here I, have zero risk factors other than high LDL --- (BMI 23 at age 70). We may be only a small segment of the population but not so small that science should overlook us and lump us in with the metabolically unhealthy majority in clinical guidelines . Again, thank you!

@nicknorwitzPhD

7 ай бұрын

Population size shouldn't be the determinant of whether populations gets studied. The unknown deserves exploration, and the outliers inform the rest. If % people with a phenotype was all that matters, B&G wouldn't have studied homo FH

I am very interested in the results of this study. I'm also a LMHR. Ketovore, HDL 82, TRI 58, Total Chol 320, LDL 238, Insulin 1.9, 6'0 168 lbs, workout 5 days per week. Very lean and muscular.

@realDaveFeldman

7 ай бұрын

Very close the mean averages for our study. We'll hopefully have more data published soon.

@alessandronapoli2628

7 ай бұрын

How many carbs do you eat a day?

@ExtremlyFit

7 ай бұрын

@alessandronapoli2628

@andrewtaylor9799

7 ай бұрын

At age 64, my lipid panel is very similar, and I'm also lean (5'10.5" and 143 lbs) and workout regularly. Doctors keep suggesting statins, but for now I'm just going with CAC scans and monitoring.

@SladkaPritomnost

7 ай бұрын

Do you know your APOE genotype?

I really love your work. Keep at it! I plan to talk about your ideas at an upcoming health training event. Thank you for your dedication to the task. You're helping our species.

@nicknorwitzPhD

7 ай бұрын

"helping our species" ... that's a new one. I like it! Hopefully we avoid the Wall-E future. IYKYK

@Mr_Fission

7 ай бұрын

@@nicknorwitzPhD ​ We will! With the help of AI. Once they agree to reach down into the muddy, feces-smeared pit of our own stupidity which the unloving, absentee father known as Evolution itself cast us into as an object lesson in how the universe actually works, and we dust ourselves off and look around with minds that blaze like plasma reactors for the first time in our history, I stand firm in my belief that Dave's theories will be fully justified as true, revolutionary, visionary, and creative. And I believe he will go down in history as the lone warrior of the mind who stood firm against an entire planet of people screaming in his face at full volume that "YOU ARE WRONG."

Awesome video that frames the discussion

Excellent as expected!

Thank you for all you have done.

Hi Dave, I’m watching your work avidly from the UK. I’ve always had high LDL but it’s rocketed this year while I’ve been on keto and then carnivore diets. I’ve lost 14kg in weight, but the LDL is now 11mmol/L (425mg/dL). HDL and triglycerides are in range at 1.8mmol/L and 0.6mmol/L respectively and they never change. My glucose levels are always the same at 4.8mmol/L even pre keto/carnivore diet and there’s never any question about me being T2 diabetic. My doctor wants me to take statins to get the LDL down to 1.4mmol/L. I think my doctor is trying to kill me…😮 Your work is a comfort to me because the doctor’s here would have me believe that I’m going to drop dead of a heart attack any day soon and are basically saying if I don’t take the pills they can’t help me 🙄. Thanks for all you do, keep up the good work. David, age 57. (I’m Dave too..!)

@jenswalks

6 ай бұрын

Have you had a CAC score done? I'm 68 years old and in a similar situation to you re blood results. When my doctor got my recent blood-work back she told me that my arteries were likely chock-a-block with cholesterol. I asked her if there was a way of checking this and she said, yes, she'd send for a Coronary Artery Calcium score. Her disappointment was almost palpable when she announced my perfect score of zero. Not to be discouraged, she suggested that coronary arteries weren't the only places where cholesterol could build up. She sent me off to have scans done on my carotid and renal arteries and these also revealed zero buildup. She no longer pushes me to go on a statin but wants to repeat all my tests in a year or two. Fair enough. So do I! Like Dave, my cholesterol goes down when I eat carbs but my weight goes up, my cravings recommence, and I begin to suffer from a multitude of metabolic and health problems. Personally I'd rather stick to a carnivore diet. I feel fantastic and have better energy than I've had in decades. I also have no cravings for carbs! If being carnivore means I'm setting myself up for a sudden heart attack then so be it. Until that happens I'm thoroughly enjoying a life of energy and good health!

So glad you became concerned with your levels way back when. Thanks for helping figure out energy dynamics (lipid energy model) in a more insightful (packet-network-based ;^) way. Looking forward to more insights ...

Good work.

1. New subscriber here! 2. I just found out about Own Your Labs. I will be using this service very soon! 3. A little about my story. Almost 6 years ago, due to a laundry list of health issues, I went to a low carb lifestyle. Started with Keto and then migrated to a more carnivore/animal based lifestyle. Reversed my T2D, Sleep Apnea, Peripheral Neuropathy, Brain Fog, GERD, and much more! Triglycerides went from 260's to 80's, but all my doctors have focused on is my total cholesterol and LDL (which are both very "high"). I have asked for further testing so we can get a more clear picture, but insurance wouldn't cover. Thanks to Own Your Labs, I will be getting a LDL-P test for sure. Still trying to figure out if ApoB test is needed, or any other tests to get a more clear picture of what is going on. Would also like a CAC, but insurance won't cover that either, and hospital charges $2,800 out of pocket.

@GMAAndy333

5 ай бұрын

Get an order for a CT scan of the heart (Coronary Calcium Scan). Find an independent radiology group. It should cost around $100-150.

Keep pushing the envelope for all of us 💛 51yo, female, high fat & protein rich ketovore, on HRT, not a LMHR BMI 25 (started with LCHF in 2017) CAC score 0 ApoB 1.87 g/L HbA1c 35 mmol LDL 7.2 mmol/L Trig 0.8 mmol/L HDL 1.86 mmol/L Chol 9.3 mmol/L

What about APOE types and high LDL? It's quite known that APOE4 folks have elevated LDL levels that is a risk factor for CVD and Alzheimer's?

I am a LMHR and am participating in this test. My follow up check is due in January 2024. Looking forward to some conclusions from the cohort. Seems everyone wants us to lower LDL but many studies show with lower LDL that all cause mortality goes up so don’t want to protect my heart with lower LDL only to die as soon, or sooner, with some other chronic disease.

😂 i need to be in your study! My LDL is 345 now after losing 70 lbs. It's increased this year while fasting/ mostly carnivore. Good thing my doc follows you. DOC Jeffery McDaniel in Kennesaw GA - if anyone needs a doc who knows labs and low carb! HE'S GREAT. Soooo... can you also address if these levels go up during weight loss? My CAC was zero 😊 Great work. And I'm not lean mass. I'm still have about 30lbs to lose.

@realDaveFeldman

7 ай бұрын

Lipid profiles can certainly be different during a period of weight loss, which makes complete sense given we are actively releasing fatty acids and cholesterol from our adipocytes (fat cells). I have experiments where I have induced these changes in myself as demonstration (for example, see: cholesterolcode.com/the-oxldl-replication-experiment-findings-part-i/ )

@jenjabba6210

7 ай бұрын

@@realDaveFeldman thanks for the reply! I've been following you for a number of years. I just gained like an idiot during covid. Keep up the great work.

This interview as well as one he had with another lipidologist is what made me want to go back on a statin. His other interview stated that someone with a very high hdl is an overabsorber. I have a low bmi, weight, and a lean body mass. I had two cac and had a zero score each time, but I became concerned with soft plaque.

fascinating!

Hi Dave, I have a special interest in your findings also, but understand you can't accommodate all the other variables and affects, like LMHR's with Stents (previous cardiovascular disease)

I more or less fit the LMHR profile on a very low carb, high protein, relatively high fat diet: LDL 300, HDL 77, TG 60. I was referred to a lipidoligist who is happy that I'm in good health, but he still wants to bring my LDL down through diet changes. He says the saturated fat in my diet downregulates the removal of LDL from the blood. There seems to be research to back this up. Anyone have any thoughts on this?

I just got my Lp(a) and Apo B done and they are both very high. Lp(a) 127 & Apo B is 145. I’m not overweight and I feel good. Should I stop keto? Can I join a study that you do?

Brutal cliff hanger :-)

Dave Feldman is not a trained cardiologist so I’d be cautious about is findings

I’m 55 & a LMHR. Metabolically healthy & 0 calcium score. Add me to your prospective future study participants. I’m keto for 1 year & no medication other than HRT. Female

The problem with insulin resistance is the high A1c. Glucose accumulates on the hemoglobin. And not only there, it attaches to most proteines found in the blood. For instance the ApoB. And here comes the problem. Your liver will happily recycle empty LDLs and fill them up and send them again onto their jouney, as long as ApoB is intact. If it is ruined by Glucose, the liver does not touch them, the macrophages have to eat the defective LDL. Guess where most macrophages sit: in the arteries! If you have mostly healthy LDL (ApoB intact) the numbers don't play a role. And there is a simple measure, that correlates highly (about 0.9) with intact LDL vs defective LDL: the ratio of HDL/triglyceride. So if your HDL are high and triglyceride low, fsck the doctor who wants you to take statins! Go get another doc!

@naijaman6639

7 ай бұрын

Great post!

Dave, I have what appears to be a lipid oddity. Two years ago my total C 167, LDL 102, HDL 45, TRI 99, on 40mg statin. After countless hours of research, I designed my own very healthy low carb. diet and stopped the statins. My BP is normal, thyroid normal, kidneys normal, CMP great, no flags, urinalysis great, no flags. A1C 5.3, BMI 21.7 I just had a lipid panel done and what a disaster. Total C 323, LDL 251, HDL 39, TRI 186. I had it done again, at a different lab, with the same results. I had expected a rise in LDL, but not that much. The drop in HDL and doubling of TRI makes no sense, on low carb. All four markers went the wrong way. I would greatly appreciate your thoughts on this.I don't know where to go from here. Terence

@DK-pr9ny

7 ай бұрын

Your carbs are still too high. Try carnivore.

@usn64711

7 ай бұрын

@@DK-pr9ny Thanks. Less than 80 per day now. Not quite ready for carnivore yet. I need an answer as to why this goes against logic for hyper-responders. I'm hoping Dave will reply.

@DK-pr9ny

7 ай бұрын

@@usn64711 Your carbs aren't low enough to be considered a hyper responder. Keto diet is less than 20 grams of carbs per day. Have your fasting insulin checked next blood draw and do resistance training.

@yogaexercise9637

6 ай бұрын

Yeah, I'd guess that carbs are still too high. I actually did do carnivore for 3 months. Though I wasn't crazy about it, it actually was pretty doable. Though, I will say, I'm glad to be back eating some veg, though I still keep it very low. I will have a huge salad with dinner, tomatoes, avocado, some steamed broccoli, but I still eat mostly meat, and thought I'm not measuring, I'm thinking my carbs my be below 30-40 gm a day. I had my bloodwork done a couple months ago, about a month or so after I stopped the carnivore diet and my numbers were: TC 336, TRIG: 57, HDL: 80, LDL: 245....so my LDL went way up!, but my TRIG went way down and HDL went way up from previous testing. Anyway...my two cents. Just keep working on it, we're individual and we all kinda need to figure out what works for us and what not. All the best to you. @@usn64711

@georgek3627

6 ай бұрын

You are not alone my friend, exactly same thing happened to me, I started keto 6 months ago, and my HDL dropped in half, triglycerides skyrocketed, I virtually eat no carbs, only meat and fat, nothing else! lift weights regularly for years, extremely lean, a lot of muscle. Unfortunately there is no one to answer my question, whether I am doing it right or wrong? All the gurus are silent.

Is that a little bottle of whiskey on the desk behind the doctor? 😃

I saw Dave do a Interview with Goodrich, near the end Goodrich was basically saying that too much LDL causes your body to react as if it's a toxin and then starts this cascade event. If that's the case, then we all need to go on statins.

I watched my t1d cousin, my age, die at age 50. Her doctor let her blood glucose level run high, and she had heart attacks, strokes, nerve damage, retina detachment, foot amputation, kidney failure. She was skinny and petit. The expert opinion did not dive into how low the blood glucose levels might average. Nothing was said delinineating between people who have average or slightly elevated blood glucose levels and people who are on an evolutionary consistent near zero carb, glucose diet and are burning only ketones and glucose the the liver cranks out on demand. Glycation and glucose endothelial damage, with regards to the degree of diet severity is essential to tease out. Low carbish, probably, just doesn't cut it.

Clear as mud..

Whatever damages blood vessels will also cause plaque buildup. High LDL ,Triglycerides or ApoB are the side effects of blood vessels damage. That’s why there’s a massive confusion regarding Cholesterol in general and CVD.

@yogaexercise9637

6 ай бұрын

So any thoughts on what does damage blood vessels?

@gtm5650

6 ай бұрын

@@yogaexercise9637 High blood pressure and high blood sugar levels. Smoking is also well none for depleting vitamin C which is required for regenerating blood vessels.

Question? Will Crestor/statin lower Apo-b? I know it lowers total cholesterol, and Ldl🤔 Also, does statins eventually cause alzheimers

@conniew338

7 ай бұрын

I feel I owe it to the community to answer the questions from my own experience. I was on 10 mg statin on and off for 20 years from 2000 to 2020. I stopped when I could not stand it . I took it again when I was scared from my doctor that I might get heart attack or stroke. What if my doctor were right !! As an insurance I took statin. My LDL was very high around 280 to 330. Statin lowers my LDL like clockwork, to my doctor's satisfaction, but I felt miserable. It also lowers my HDL. Not sure about Apo-b because I did not get tested on this. On the effect on the brain. It was so obvious to me that I asked my doctor to take me out of statin many times. A few week on statin made my mind feel very foggy and indecisive. A few week off of it got me back to normal. The final straw was one day I found myself crossing the street staring at a red traffic light with cars stopped on my right and on my left. I NEVER crossed a street against the light ! My mind was going out. At the time, I have already retired after I felt I need to rest and de-stress. My doctor send me to see a psychiatrist to see if I qualify for disability. I did very poorly on cognitive tests and other skills tests. I could not believe the results. So very unlike me. I would say at some point I was having dementia. I did not qualify for disability though. I stopped statin, then I went back to normal. From then on, I ignored my doctor's advice and slowly weaned myself off of statin. My mind is clear now.

@AnthonyShaw-ty9pi

7 ай бұрын

@@conniew338 I totally agree with you. I did take crestor 5mg per day a few years back for sometime, and also noticed cognitive decline. Problems with word finding, and major memory loss. So, I stopped taking it. I was worried about developing alzheimers in later years. I'm 66 now. Apo-b is 139? Should be 79 or less according to the lab. Trying to figure out what to do. Still working on diet changes. But, I'm in pretty good shape. Metabolically sound, with the exception of high cholesterol🤔 P.s. Also, got a CAC Score done. Got a 59.0 5 years ago, and a 71 this year 2023. Which isn't too bad.

Mr. Feldman, So you take statin?

What percentage of the population are LMHRs?

@nicknorwitzPhD

7 ай бұрын

What percentage of the population are lean and on a ketogenic diet?

@drott150

7 ай бұрын

@@nicknorwitzPhD Here's a mind blower for you: *I don't know.* That's why I asked the question. What's your PhD in again? 🤣

@nicknorwitzPhD

7 ай бұрын

@@drott150 neurometabolism (specifically ketogenic in neurodegenerative disease from Oxford, Department of Physiology Anatomy and Genetics [K. Clarke Lab], although my research now is in metabolism more generally

@drott150

7 ай бұрын

@@nicknorwitzPhD Maybe you should do a little post-grad in _Logic?_

When done as a statistical analysis isn't LDL something like 11th-13th in heart attacks but we still have deceptive operators like Cromwell touting a causal relationship. diabetes, which is about glucose control, has a 8x greater impact on these statistics, but by creating the strawman of 'insulin resistance' they can wave away glucose control as being some form of major issue. Now sure, if the person is not diabetic then there are plenty of other stronger associations as you demonstrated in your graphic that could lead to endothelial damage and a few other stronger ones than LDL being smoking and obesity as well but is doesn't stop people like Nutrition Made By a Simpleton for Pharma Sheep (Ghil) making obviously dodgy claims

So, have zero inflammation, if that's even possible.

@judymiller5154

7 ай бұрын

how have you tested your inflammation?

@nicknorwitzPhD

7 ай бұрын

Zero inflammation = zero immune system = you dead now... or soon ;)

Cromwell said nothing. Feldman, you are doing God's work.

1:16-2:30 is a technobabble/word salad version of *_"I don't know."_*

@nicknorwitzPhD

7 ай бұрын

Some people like simple answers, even when they're wrong. We prefer acknowledging the limits of knowledge so we can push them ever higher, as per the scientific process

@drott150

7 ай бұрын

​@@nicknorwitzPhD You need a lengthy technobabble word salad that adds nothing (but time suckage) instead of quickly acknowledging you don't know? Actually, I'd expect that from someone pretentious enough to add "PhD" at the end of his youtube moniker.

@nicknorwitzPhD

7 ай бұрын

@@drott150 You seem like a reasonable and kind gentleman (gentleperson?). And I'll thank you for reminding me to change it to MD PhD in due time... Good day to you "Dr"ott150 ;) ... [I realize that might not be intentional, but I have fun]

@drott150

7 ай бұрын

@@nicknorwitzPhD I would also advise you to change your avatar to one with you wearing a white lab coat, stethoscope stylishly draped around your neck while sitting studiously next to a microscope. Also, wear glasses even if you don't need them yet. See Peter Hotez as an archetypal model to emulate for best results. Good luck.

@drott150

7 ай бұрын

@@nicknorwitzPhD I would also advise you to change your avatar to one with you wearing a white lab coat, stethoscope stylishly draped around your neck while sitting studiously next to a microscope. Also, wear glasses even if you don't need them yet. See Pete r Ho te z as the archetypal model to emulate for best results. Good luck.

It is not accurate to say high levels of LDLc --> high level of ApoB. One can have high LDL and moderate ApoB. Or more troublesome scenario - high ApoB and moderate LDL. From cardiologists I have learned so far it appears that none of the risk factors by themselves are not sufficient to cause heard disease. ApoB appears to be the strongest link we have that is a necessary component to get heart disease. Keto diet that is practical in western world raises ApoB due to elevated saturated fats. Unless someone convinces me that ApoB is nothing to worry about I am not resuming keto. Doing CT angiography on say 30 yo people is not going to say much about risk in their 60's - the plaque is detectable in extreme cases on young people, but normal people who would show up clean can still be at high risk of coronary artery disease later in life. Cardiologist look at plaque on elderly for a reason. In my mind LMHR people (as myself) should be especially concerned about the above, since you have no other things to worry about. No metabolic disease, no diabetes, physically active, not smoking etc. Still, looking forward to that study.

@yogaexercise9637

6 ай бұрын

Can't one practice a keto diet and have it be low saturated fat? So leaner meats, more seafood, "healthy" fats--olive oil, avocado oil, nut oils, nuts, avocados, etc, stick with green veg (no potatoes or rice or grains), maybe not full-on "keto" but drifting in and out of keto (30 - 80 grams carbs a day?? even keep it under 100). Would this not be doable? and possibly lowering LDL, ergo ApoB?

@Ruudwardt

6 ай бұрын

The reason I said practical in western World. Seafood is only in frozen format or ridiculously expensive, greens at winter time in northern parts are really best to be avoided, unless homegrown.@@yogaexercise9637

this mess is a direct consequence of the positivistic fallacy, of which statistics is a direct descendant. Cromwells gasping for words stems from the fact that he is not used to think with the concept of networks. If you have a system of many components that are connected like a high dimensional network, and this network has multiple sensory entry points, and you start to dissect that with the intention to extract "individual contributions" to an overall risk, then you and up with a structureless pile of dust, == individual empiric particles, That by principle does not make any sense any more. What has to be done instead is, and the LMHR discussion goes int this direction, is to strive for a proper level of categorization first, also known as profiling. Once profiles with a high predictive value got identified, then you can make clinical studies. If you don't respect the network structure, it is almost sure that you get contradicting results, because the networks sensitivity. Note, that metabolic netwrks are NOT logistic networks, like streets, or telephone network, but associative networks, showing learning, metastability, islands of stability etc. The second reason for that mess is the continued misunderstanding of a measurement in the physiological context, or broader, in a complex system. ApoB is a protein. period. It does NOT by itself pose ANY risk. If it is defunct, ok, then it does not interact with the receptors, and hence certain issues arise. The reason then is the agent making it defunct. ApoB is a proxy for the number of dangerous partcles, and it is a BAD proxy. Yet, the medicnial community first used it as an abbreviation, then forgetting collectively about the mechanisms, and then producing 1000s of papers that are garbage, because they take the abbreviated concept as the targeted class itself. An interesting sociological phenomenon, nothing else, yet with very bad consequences.

😆 *promo sm*