In this month’s “Hot Topic,” Elitza Theel, Ph.D., will discuss the overutilization of IgM serologic testing for Herpes Simplex virus and the recommendation by multiple agencies, including the CDC and the Infectious Diseases Society of America, to avoid using this test for clinical decision-making purposes. As a result of these recommendations and data generated at Mayo Clinic, Dr. Theel will summarize why HSV IgM testing will no longer be offered through Mayo Clinic Laboratories.