Cystic Fibrosis (CF) is an autosomal recessive genetic disease that affects the lungs. It is characterized by thick and sticky mucus due to a defective gene. It occurs due to a mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. It can be treated by gene therapy using DNase. DNase is a DNA-destroying enzyme that breaks DNA strands that remained by dying cells. DNase I reduce sputum viscosity in the lungs of CF patients as viscous sputum causes recurrent infections and affects lung function.
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