Crispr-Cas9 explained: the biggest revolution in gene editing

Ғылым және технология

Professor Jennifer Doudna, one the pioneers of Crispr-Cas9 gene editing explains how this important discovery enables precise changes to our DNA , which can be used to correct mutations that cause genetic disease and completely eradicate it from a germline. Doudna raises the 4 key issues of debate around this revolutionary discovery and suggests what will have the most immediate impact.
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Пікірлер: 146

  • @chidubem826
    @chidubem8264 жыл бұрын

    For her to have had that dream, her subconscious might have been telling her that this could go wrong.

  • @danny-mf9ct

    @danny-mf9ct

    3 жыл бұрын

    Haha you can say that again , I think her concious mind could tell her that as well

  • @reneeliverson8413

    @reneeliverson8413

    2 жыл бұрын

    Yes that is exactly what I'm thinking. Maybe if she had a better dream with a better example then I would consider gene editing but for now I'm not sure.

  • @joanneg7646

    @joanneg7646

    2 жыл бұрын

    Exactly what i thought

  • @chidubem826

    @chidubem826

    2 жыл бұрын

    @@joanneg7646 could be a warning that a rogue government will try and take over the technology once it's perfected - perhaps to create enhanced super soldiers

  • @FrankDenada

    @FrankDenada

    2 ай бұрын

    Agreed

  • @doghouse010
    @doghouse0105 жыл бұрын

    The lighting guy should get an award

  • @ravehz8917
    @ravehz89175 жыл бұрын

    We kept telling ourselves it would take thousands of years to evolve and now we can do that in a couple years

  • @sandracaldwellcooper9289
    @sandracaldwellcooper92895 жыл бұрын

    One problem with all such breakthroughs is the industrial military complex. As soon as a benign technical/biological advancement comes out, they always find a way to weaponize it. Science fiction eventually becomes science fact. I agree that one way to combat this eventuality is make it transparent to everyone. There the issue becomes is it true transparency or is it opaque transparency? For now, I will adopt an attitude of wait and see. "The answers are out there."

  • @nicktaylor5264

    @nicktaylor5264

    4 жыл бұрын

    It's quite often the military that's paying for the research in the first place... which isn't necessarily a bad thing... although there are some quite serious flaws in that approach, granted.

  • @jarrettporst4799

    @jarrettporst4799

    4 жыл бұрын

    Sandra Caldwell Cooper not a bad thing, as long as everyone has it. If everyone is superhuman, then we’re all still the same.

  • @chidubem826

    @chidubem826

    4 жыл бұрын

    @@jarrettporst4799 "And when everyone's super, no one will be." - Syndrome (Incredibles)

  • @lynpierson8797

    @lynpierson8797

    Жыл бұрын

    I agree on that

  • @familymanof6169

    @familymanof6169

    Жыл бұрын

    Definitely opaque if your talking about the us government!

  • @92DDO
    @92DDO5 жыл бұрын

    Amazing and dangerous all in one.

  • @NickZhu50581203

    @NickZhu50581203

    3 жыл бұрын

    technology is unconscious, human mind is the problem

  • @BrendanClearyMadFood
    @BrendanClearyMadFood5 жыл бұрын

    Bang on. We just discussed the very subject last night. But my idea is to score some goals on viruses first

  • @sevengenerations8879
    @sevengenerations88795 жыл бұрын

    No matter how accurate or precise genetic modification/engineering becomes (and CRISPR is over-rated in that respect*), these scientists tend to ignore one basic reality about gene editing: genes exist in an ecosystem; a network that is dynamic, fluid, always in flux. Any modification, no matter the technique, no matter how "precise", will impact that network in some unexpected, unanticipated way that will likely result in unwanted mutations. That's the science. That is the science that is ignored all the time. While Doudna gets credit for raising ethical concerns (after the fact), she seems to have never been outspoken about the intrinsic flaws about gene editing in general. Where there is money to be made .... . *see, for example, "God’s Red Pencil? CRISPR and the Three Myths of Precise Genome Editing," by Jonathan Latham, PhD, Independent Science News, April 25, 2016

  • @gomy7777

    @gomy7777

    4 жыл бұрын

    If we were living in a perfect world you would be totally right but we are not! already there is so many people suffering from hunger around the world and things are not getting better but they will get worse as climate is changing and there is not enough time for plants and animals to adopt to new climate. In this changing/ endanger world, CRISPR is our friend, helping us to protect the organisms around us and to protect and feed ourselves.

  • @kylestanley7843

    @kylestanley7843

    3 жыл бұрын

    I'd like to add to what the person above me said by saying that it's still worth a shot. Trial and error is surprisingly effective sometimes, and with our current world we don't have many other options in the long term.

  • @atti1120

    @atti1120

    2 жыл бұрын

    Well the same applies to natural mutations and induced mutations by breeding. What one has to realize is that the crops we have now are so far removed from what they were naturally, so we already crossed this line a long time ago. But you are right, keep artificially selecting for growth, then taste or disease resistance will not be selected for, and those qualities are washed out

  • @benjamiah
    @benjamiah4 жыл бұрын

    The possible nefarious implications of this technology is rather scary .....a brave new world!

  • @englandsensation
    @englandsensation5 жыл бұрын

    Fascinating and terrifiyng at the same time.

  • @Jumpingjackflash123

    @Jumpingjackflash123

    Жыл бұрын

    I don’t see how it’s terrifying. We’re evolving as a species. This was bound to happen. We have the ability to act as gods. We can usher in heaven on earth. Exactly how it should be, No disease or famine.

  • @williamjayaraj2244
    @williamjayaraj22443 жыл бұрын

    Greatest invention of all in the recent times in chemistry that will revolutionise the medical system itself in the near future . Congratulations to Professor Jennifer Doudna and Immanualle Charpentier. Best wishes.

  • @reneeliverson8413

    @reneeliverson8413

    2 жыл бұрын

    *Emmanuelle

  • @mbnyc5401

    @mbnyc5401

    2 жыл бұрын

    Or potentially destroy mankind.

  • @moringaottawa
    @moringaottawa5 ай бұрын

    2:59 thank you for this

  • @glenn.grispen6946
    @glenn.grispen69463 жыл бұрын

    Covid19 brought me here.

  • @c-light7624
    @c-light76245 жыл бұрын

    The cost and access ... a discussion we should be having? Couldn’t that be a cut and dry answer? Those pioneers who developed certain medical advancements and stated they should not be administered for profit, guess what happened and who doesn’t have access. Greed is paramount in healthcare and not answering that question is very telling.

  • @lynpierson8797
    @lynpierson8797 Жыл бұрын

    Is this available now? I have read this can help with Chronic lymphocytic leukemia

  • @mrsmithlocksmiths
    @mrsmithlocksmiths3 жыл бұрын

    If CRISPR-Cas9 can cut the 'intruder' DNA code, allowing it to be replaced with the "correct" sequence - does every variation of cancer have the same genetic address? Like a MAC address? Shouldn't genetic editing be used for life threatening illnesses more than it is already?

  • @61tree_VR_Gliding
    @61tree_VR_Gliding5 жыл бұрын

    I think someone used Crispr gene editing on the camera editing.

  • @janedoe2119
    @janedoe21194 жыл бұрын

    In a world like that where morality is subjective what do you think the outcome will be?

  • @MoreChannelNoise
    @MoreChannelNoise4 жыл бұрын

    Scientists often say this will probably happen within the next decade and then 30 years later we are still waiting. In the 1960's and 70's I would watch programs on how great eveything would be in the year 2000 + and here we are in 2020 and all that's changed is TV. sets have gotten bigger and we have the internet.

  • @tranhai8895

    @tranhai8895

    3 жыл бұрын

    oh really?

  • @lionsden5123

    @lionsden5123

    3 жыл бұрын

    If you really think the only thing that’s changed is TV, then perhaps it’d be worthwhile looking at current medical and technological advances that would be nothing short of a magic trick to someone from the 60’s.

  • @Jumpingjackflash123

    @Jumpingjackflash123

    Жыл бұрын

    Right. We were suppose to have flying cars by now but all we got was the shake weight and tik tok dances. We’re highly optimistic in our world views. I think within 50 years it’ll be fully commercialized

  • @_unopablo
    @_unopablo3 жыл бұрын

    What a Future.

  • @familymanof6169
    @familymanof6169 Жыл бұрын

    Have you given any thought to what WILL INEVITABLY GO WRONG?!

  • @madhudivakaran8434
    @madhudivakaran84342 жыл бұрын

    Is there any research in Multiple lipoma.

  • @Redumbrellayellow
    @Redumbrellayellow3 жыл бұрын

    And now she has won Nobel prize 😎

  • @hope3761
    @hope37612 жыл бұрын

    So is the Cas 9 in the C experimental shot ?

  • @user-yl4ow2lz7z
    @user-yl4ow2lz7z5 ай бұрын

    They cured my cough and leg problems

  • @BOSWAHANA81
    @BOSWAHANA815 жыл бұрын

    Okay, now tell me where can i download this gene editing tool, it's looks awesome..

  • @RUS38

    @RUS38

    5 жыл бұрын

    You don't need to. It's already installed. Most people just live their lives not knowing what tools they have preinstalled at birth and they die without ever using them. What a waste of life.

  • @HardKore5250

    @HardKore5250

    5 жыл бұрын

    More proof of no god

  • @praveendhule5151
    @praveendhule51512 ай бұрын

    Hallo madam I'm from india.its available in India and wts is the cost

  • @lostcause1281
    @lostcause12815 жыл бұрын

    I'm all for this new tech! Are you too? 😋

  • @krystalphan8871

    @krystalphan8871

    5 жыл бұрын

    I don't think it's completely beneficial but its potential is phonomenal

  • @dwnld31

    @dwnld31

    5 жыл бұрын

    @@SusanPDavis pfft, as if we'll buy it

  • @mexdal

    @mexdal

    5 жыл бұрын

    @@SusanPDavis SCAM!!!

  • @a.i.dimmer4616

    @a.i.dimmer4616

    4 жыл бұрын

    @@SusanPDavis ur d kind of dna i wanna eliminate in this world

  • @DadYT
    @DadYT5 жыл бұрын

    Let's make humans great again

  • @jamesryan6224

    @jamesryan6224

    5 жыл бұрын

    They never were great. -Andrew Cuomo

  • @a.i.dimmer4616

    @a.i.dimmer4616

    4 жыл бұрын

    i think ur dumb

  • @Duelli75
    @Duelli754 жыл бұрын

    Well, this and the "Learning Machines" are out there now. I wonder when the quantum computing takes off. Is it possible to calculate the outcome of gen editing for all life on earth? Since they are teasing quantum computing makes password hacking take hours not eons?

  • @kylestanley7843

    @kylestanley7843

    3 жыл бұрын

    I often wonder what a simulation ran by a supercomputer would do to help us. Sometimes they show us things we don't expect.

  • @user-lk8fq7zc7e
    @user-lk8fq7zc7e4 жыл бұрын

    Yes it's very important to cure generic diseases. And also be accessible to every class of people around. We are waiting for a treatment for muscular distrophy on our family. Hope it's very soon to approach.

  • @DGill48
    @DGill485 жыл бұрын

    We have had the power to remove my favorite invasive species in the western hemisphere....Aedes Egypti mosquitoes ..... no more Zika, yellow fever, dengue, etc. But we don't. Please explain to me.

  • @Dasani_water_drinker

    @Dasani_water_drinker

    3 жыл бұрын

    Cause your Gov and every Gov on earth put those squitos there

  • @Kikilang60
    @Kikilang604 жыл бұрын

    Stand aside Crispr-Cas9, because a new technique has come along. It's called Prime editing, and it works much better the then crispr.

  • @emilie6466

    @emilie6466

    Жыл бұрын

    Prime editing is Cas9…

  • @maxfarmiloe5208
    @maxfarmiloe52085 жыл бұрын

    O brave new world, That has such people in’t!

  • @lauraanderson7358
    @lauraanderson73585 жыл бұрын

    moral imperative to use technology for the benefits of humans

  • @jasonvanderloew3078
    @jasonvanderloew30785 жыл бұрын

    Definitely a future of Divergents?

  • @nicktaylor5264
    @nicktaylor52644 жыл бұрын

    re: "Number 4 : Engagement - it's incredibly important that citizens everywhere have a voice in deciding how to use powerful technologies like Crispr" Seriously? The same citizens that voted for trump, Brexit, Bolsanaro, Erdogan, that maniac from the Philippines, and whoever's running India right now? That epic % of the population who are rabidly denying climate-science? Citizens are too easily manipulated for direct-democracy - especially over something like this. We need democratically appointed representatives... but representatives who are strictly banned from taking ANY corporate money. The idea that citizens should have a say kindof highlights the fact that our democracies are chronically dysfunctional right now - mainly due to wealth-inequality, aka capitalism.

  • @sparkee666
    @sparkee6665 жыл бұрын

    As long as it doesm't go the way of eugenics in good with it.

  • @uyenhuynh1492
    @uyenhuynh14925 жыл бұрын

    Is this the same as GMO?

  • @aldovirooo

    @aldovirooo

    5 жыл бұрын

    Gwen Huynh yes this is about genetically modifying organisms, but that is a wide umbrella concept, this video is about a specific method

  • @Dasani_water_drinker

    @Dasani_water_drinker

    3 жыл бұрын

    Sort of. Gmos are done seed level- gene editing can happen at all levels of existence in humans

  • @ASLUHLUHCE
    @ASLUHLUHCE5 жыл бұрын

    2:35 She's either lying or naive. It is currently physically possible, and our understanding of the genome will not stop progressing. Therefore, designer babies/post-human species are inevitable (unless an extinction even occurs beforehand).

  • @blacksheepshepherd
    @blacksheepshepherd Жыл бұрын

    When will we start seeing X-Men and metahumans?

  • @sudipaich7617
    @sudipaich76173 жыл бұрын

    Salute u mam🙏

  • @notsewdarb9972
    @notsewdarb99722 жыл бұрын

    Now watch this: @

  • @hartartiste7650
    @hartartiste765010 ай бұрын

    I honestly believe that I am being used as a test subject for this bio-hacking technology. It's causing remote neural paralysis and transhuman symptoms. Where can we go to report highly strange events to our health w/o being disregarded by physicians who were trained prior to these factors? We have a huge reputation in the world for studying torture and its effects and the applications of this technology require these methods. For pain is what opens up the neurons for the damage and thus "repair" and altering of our nervous systems towards being hooked up to the internet of all things

  • @NaturalMystic71
    @NaturalMystic713 жыл бұрын

    If you people in the comments think these people want to prevent disease you are extremely naive.

  • @uskyusky
    @uskyusky2 жыл бұрын

    Thank you very much for developing Crispr. best regards Dr. Mengele

  • @saritaverma6832
    @saritaverma68322 жыл бұрын

    Casper + telomeres+silent RNA+tumar cell +noxa =

  • @Content4free78
    @Content4free78 Жыл бұрын

    i'd use Crispr Gene Editing to create mutant animals.

  • @maelschuffenecker6459
    @maelschuffenecker64592 жыл бұрын

    i rien compris but c'est cool

  • @taodelorme8879

    @taodelorme8879

    2 жыл бұрын

    La même Roya

  • @maelschuffenecker6459

    @maelschuffenecker6459

    2 жыл бұрын

    You want evoluate the human race with me ?

  • @importantname
    @importantname5 жыл бұрын

    lol - the human species is not trustworthy, though there are some humans who are reasonably reliable.

  • @HardKore5250

    @HardKore5250

    5 жыл бұрын

    David Boson What about nanotechnology instead using nanobots to repair the body that could be safer?

  • @MefizTofelFolk
    @MefizTofelFolk5 жыл бұрын

    Don't be a idiots, this technology is almost the only way to management the impact of human kind or at least of that what the origin is the human. That kind of impact is not natural and our respond will be in the same way.

  • @joeyjojojrshabadoo7462
    @joeyjojojrshabadoo74625 жыл бұрын

    "the simple answer is... no" Lol, nice reality check.

  • @patrickrkruger

    @patrickrkruger

    5 жыл бұрын

    Until A. I. and Quantum Computing are advanced enough for a property three way to produce the first human from nothing. I said three way, hehe

  • @HardKore5250

    @HardKore5250

    5 жыл бұрын

    Patrick Kruger So it’s possible to create a human from nothing?

  • @jormungandr2376

    @jormungandr2376

    5 жыл бұрын

    Not neccessarily, she did not deny that it's possible to design a human. If you watched other videos of her and doctor Church, you'll figure out that it's more than possible. What she was referring to are these two thing: - In the end she said in the "short run". - Also, designing a human doesn't neccessarily mean we have the ability to design everything, rather that doesn't matter, if we can do that for attractiveness and IQ that's what should matter. But you can;t fully design a human.

  • @HardKore5250

    @HardKore5250

    5 жыл бұрын

    Ahmad Raza Unless matter and antimatter came naturally for the reason we exist.

  • @GM-7777
    @GM-77775 жыл бұрын

    Adolf Hitler?! I think that says it all...

  • @18890426

    @18890426

    5 жыл бұрын

    What do u mean?? What does that say??

  • @GM-7777

    @GM-7777

    5 жыл бұрын

    She was saying how she had a dream about Hitler and he explained to her how Crispr would work. Very creepy

  • @andis9076
    @andis90763 жыл бұрын

    GMO....

  • @kylestanley7843

    @kylestanley7843

    3 жыл бұрын

    What a buzz word. It's harmless.

  • @madman026
    @madman0265 жыл бұрын

    well folks its either this or merge with machine i choose this

  • @kahvac

    @kahvac

    4 жыл бұрын

    We shall have both....

  • @madamadam5951
    @madamadam59515 жыл бұрын

    Genetically engineered medical treatment is good, but changing the unborn baby should be illegal. The movie Hanna come to mind, a genetically engineered girl made to be a better soldier, less empathy stronger smarter, it’s inhuman to impose such curses to someone who never wanted or asked for any of it.

  • @danielthunder9876

    @danielthunder9876

    5 жыл бұрын

    They are only talking about editing unborn children for genetic defects. Like cystic fibrosis ect. These are also easily identified as they know the exact gene that causes it. Modifying for complex things like stronger smarter ect is far more difficult as we don't even currently know what genes effect this. Maybe a problem in 50 years, but not now or the next couple of decades.

  • @HardKore5250

    @HardKore5250

    5 жыл бұрын

    Daniel thunder There is a brain chip for super intelligence.

  • @Jumpingjackflash123

    @Jumpingjackflash123

    Жыл бұрын

    I never wanted to be the way I am. Nor did I wanna be born. What’s the difference?

  • @maelschuffenecker6459
    @maelschuffenecker64592 жыл бұрын

    Je pense qu'il faudrait faire évoluer la race humaine grâce a sa

  • @Davidblaine18
    @Davidblaine182 жыл бұрын

    Evil

  • @raskult

    @raskult

    2 жыл бұрын

    This is in the vax

  • @valirosca2693
    @valirosca26932 жыл бұрын

    SATANIC

  • @Leezeo
    @Leezeo2 жыл бұрын

    To late

  • @askingwhy123
    @askingwhy1235 жыл бұрын

    Arguments from "It's too complicated to ..." have a terrible track record. There are many, many things that are common today that are "too complicated" for people to do, like Amazon recommendations or indexing the internet. If Professor Doudna wanted to be the least bit credible, she should argue that "Designing a person violates physical law in this way: ..." or "Not only conventional computers-but quantum computers as well-can be mathematically proven to be unable to design a human." Anything else is just wishful thinking. Her certainty is particularly regrettable since she could only plausibly make that claim if she *knew how humans work* -- everything else is a guess, and a likely bad one at that.

  • @brothermichael2833
    @brothermichael28332 жыл бұрын

    Stop talking and show me the procedure in real life with no animations.

  • @joncabotxox9389
    @joncabotxox93893 жыл бұрын

    The dream..... hahaha. BS

  • @li1295
    @li12953 жыл бұрын

    Don't.like.this.at.all

  • @__BD__________8

    @__BD__________8

    Жыл бұрын

    Why

  • @soggybread423
    @soggybread4235 жыл бұрын

    never show in my feed again .

  • @stormynight9663
    @stormynight9663Ай бұрын

    First find a solution for white hairs. Then talk about designer babies.

  • @gregsmith4527
    @gregsmith45275 жыл бұрын

    This women looks weird...creepy

  • @a-note76

    @a-note76

    5 жыл бұрын

    greg smith another Elizabeth Holmes lol

  • @34SlaveofAllah
    @34SlaveofAllah5 жыл бұрын

    The threat of the male race

  • @danielthunder9876

    @danielthunder9876

    5 жыл бұрын

    Males are not a race.

  • @__BD__________8

    @__BD__________8

    Жыл бұрын

    How

  • @AsseriHolopainen987654321
    @AsseriHolopainen9876543215 ай бұрын

    🇫🇮❤️❤️🇫🇮👍

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