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Clear explanation. Thanks for helping us with these issues ! 🤓

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This video was so damn conceptual. Loved it. Keep it up man! You doing great

Wow, best explanation ever. Thank you!

BEST CORI CYCLE EXPLANATION ON YT THANK YOUUUU

very simplified and clear enough! thank you for your efforts.. please keep going

EXCELLENT explanation... understood perfectly ... God bless you!

HI SIR. awesome lecture you explainded the reason behind these steps, cleared so many of my doubts. thank you from the bottom of my heart. please continue the good work. you rock champ

Thank you so much, so clear, and so useful.

Immensely useful ! Thank you!

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Well Explained.Thank you!

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Very clear explanation

Is the pyruvate to lactate formation in the presence of LDH a proton consuming or proton releasing reaction? What is the latest research on this?

Thank you

Excellent

thank you!!

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worth to watch

Liver has high oxygen meaning ETC can proceed hence the high levels of NAD in the liver. Writing this down helps my thought process so i might as well share it ! Pls correct me if im wrong and b nice abt it

Thanks - but one thing I don't understand is why lactic acid production causes an increase in acidity when the reaction that turns pyruvate into lactate is a h+ ion acceptor? Lactate then dissociates, but is the net effect an increase in h+? From what I am reading lactate is an important fuel, especially for the heart and brain, and not just in hypoxic conditions.

@ralphhancock7449

6 жыл бұрын

Hi Joe, just stumbled in to this presentation and I can't answer your question, but I think this article does: www.ncbi.nlm.nih.gov/pmc/articles/PMC4343186/

@ittimani

5 жыл бұрын

Hi JJ and Ralph see Understanding Lactate - Paul Marik from Royal North Shore Hospital & UTS smacc.net.au/2016/05/understanding-lactate-paul-marik/ Acidosis is caused by reactions other than lactate production. Every time ATP is broken down to ADP and Pi, a proton is released. Lactate saves the day by becoming Lactic acid and removing the proton.

Solid video, but I think there’s a mistake towards end? On the skeletal muscle side NADH is getting oxidized and on the liver side, it shows NAD+ getting reduced for the same reaction

@CosmoH0103

4 жыл бұрын

Because the reaction is going in the opposite direction.

why doesnt the regenerated pyruvate from the lactic acid go into the mitochondria for cellular respiration? going all the way back into glucose via gluconeogenesis seems inefficient.

can we supplement mtc1? what increases it?

Does lactic acid exist in human metabolism? What is the latest research on this?

Is the cori cycle the same as homolactic fermention?

Are lactate levels increased in T2 diabetics? If so, what is preventing pyruvate (for glycolysis) from entering the TCA/Kerb Cycle?

@marky5493

Жыл бұрын

Yes, inflammation in diebetics restricts blood flow(oxygen),leading to hypoxic areas which make the cori system work harder,to clear the lactic acid being formed. You can have both anorobic and areorobic energy production happening at the same time in your body, the problems start happening when it becomes more anaerobic for longer periods. Hope that helps

when pyruvate is converted to lactate, why there is a proton released? I think the proton should on the pyruvate side.

How much atps are formed in fermintation??

Hi sir my son is 2 and half years suffering from elivated lactatic acid ( IEM) by birth what is life sir my son tell me pls 🙏

@mahanteshgouri2931

2 жыл бұрын

Explain me sir my son problem life long ya some time

Maybe I understood your explanation wrongly, but the truth is that lactate is produced as a buffer for protons generated in non-mitochondrial ATP production (Robergs et. al). otherwise good!

How does pyruvate overcome pyruvate kinase, since that enzyme only proceeds in one direction?

@jjmedicine

6 жыл бұрын

You're right. Pyruvate kinase is an irreversible enzyme, so the cell needs to bypass that step in order to "recycle" pyruvate back to glucose. I talk about this in detail in my Gluconeogenesis video - but briefly, the cell uses pyruvate carboxylase to convert pyruvate to oxaloacetate in the mitochondria. Oxaloacetate gets converted to malate by malate dehydrogenase, and that malate leaves the mitochondria and enters the cytosol. In the cytosol, malate gets converted back to oxaloacetate by malate dehydrogenase again, and then the oxaloacetate gets converted to phosphoenolpyruvate by PEP carboxykinase. There are two other irreversible steps in the glycolysis pathway that are also bypassed by the cell - please check out my Gluconeogenesis video for more details on that. Hope that explanation helps :)

Can cori cycle result in liver glycogen formation?

didn't get, where exactly came a proton H+ in reaction "from pyruvate to lactat". can someone provide a link with an explanation of mechanism this reaction?

@ivanmateev

3 жыл бұрын

I think he got it wrong with the H+. H+ should have come from the Glycolisis. Glucose forms 2 pyruvates, 2H+ and the electrons from the H go to NAD+ to NADH. Those H+ cause acidic conditions and need to be taken care of. In absence of oxygene, they join the pyruvate to form Lactic Acid. Correct if I am wrong. I'm still getting to know this stuff.

@ivanmateev

3 жыл бұрын

Form wikipedia/glycolisis: "The overall process of glycolysis is: Glucose + 2 NAD+ + 2 ADP + 2 Pi → 2 pyruvate + 2 NADH + 2 H+ + 2 ATP"

@ivanmateev

3 жыл бұрын

And then: Pyruvate + NADH + H+ → lactate + NAD+. I don't think H+ gets into the bloodstream. Never found a source telling MCT1 is resposible for that. Lactic fermentation is the process to get rid of H+ and recover NAD+ from NADH

5:52

Does the transformation of lactic acid back to glucose require oxygen? It is not mentioned here. Thank you very much.

@komakecherick7438

3 жыл бұрын

this was nice explanation

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