This is brilliant! Having animations and a voiceover is so much easier to understand than static diagrams and walls of text. Thank you!

@jjmedicine

3 жыл бұрын

You're very welcome!

This video is amazing. Very informative and clear explanations. Thank you so much!

This tremendously helped me to understand insulin resistance pathogenesis. Many thanks, that’s a gold content!!

I like your videos you explanation is quite simple and easy to remember thank you so much for such a great work

Thank you very much. Extremely well-done explanations.

Thank you so much. You made this topic easier!

I love your videos and how you make sense of all the detailed information in the end! I also love the tool you use to draw your very comprehensive pathways, if you don't mind telling us what software you are using, i would like to use it for my own pathways. Thank you very much!

The best ever teaching style soo good!

Thanks a lot, I love your explainations. One of my favorite channels⚘️.

Great video! Huge help learning cell signaling pathways and cancer cascades

Great video. Helped tremendously!

Thank you for very clear presentation.

this helped me alot, thanks JJ medicine!!

Thanks for the simplistic explanation

Very good explaining and fully understanding

this video literally helped me understand a whole subtopic of my biochem project. thank you so much!!

@hrishabhupadhyay751

4 жыл бұрын

Aleida M what project did you make?

@aleidam2485

4 жыл бұрын

@@hrishabhupadhyay751 it was about insulin but i didnt really understood how the signaling cascade was explained in my coursework and this vid really helped

Thank you so much for this video!

Thank you so much ..really it is so helpful

This is PERFECT

It was really helpful ,thank you sir

Very helpful, thank you!

Thank you!! Very clearly explained. I now understand what GLUT4 translocation means. :)

You just saved my life!

looove your videos !

I just gave my cell signaling final exam yesterday and struggled with an essay question about insulin signaling. Today I discovered this helpful video. You can imagine my frustration.

Very good explanation!

Thank you so much for this

very clear and good one

Thank you!

Helpful video many thanks sir

very helpful 😍thank you.

Great video!

Thank you so much 👏🏻

great video!

Wonderful!

Thank you 🌸🌸

Excellent presentation. Could you please tell the book you followed to make this presentation ? It would be very very helpful for me.

GOOD JOB Thank you

great, thanks!

This has been very helpful. Can u please share your reference? (P.S I wish I can cite your video but I need a book or a paper for an educational project). thank you

Wowwww thanks!!!

You are the best

thank you !!

I SUBSCRIBED!

Thank you

thank you

please continue with Claire de lune ♡♡ we miss youu

Thanks

prior to phosphorylation, don't they need to dimerize? I thought that was the conformational change that occurs as a result of insulin binding

What about the pathway that activates protein phosphatase 1 tho? I was waiting for you to comment on this very enzyme : (.

thank u

REQUEST: could you please continue this video with an explanation of how insulin resistance occurs. Thanks.

@kmcveigh100

3 жыл бұрын

Anthony Mak, I second this request. Specifically how Diacylglycerol could interrupt this signaling cascade?

@carolinaguerra6726

2 жыл бұрын

Please how is insulina resistan ocurrs

Brilliant and very helpful. Could have been a bit more smooth but wonderful explanation nonetheless.

Wow. So molecular

So understanding insulin resistance, I've been trying to find research on this, insulin is just don't trigger the cascade at the insulin receptor site? or it triggers but connects and doesn't trigger the AKT to inhibit the AS16 so GLUT 4 is unable to open the channel for glucose uptake. Is it autoimmune, is the body creating antibodies that latch onto the insulin to make is less effective?

Great Video! What program did you use to make this?

@LikeTheVik

4 жыл бұрын

probably powerpoint

@gamingrex2930

4 жыл бұрын

Most likely powerpoint, but any drawing software can do the same. Just create shapes and colour them. Then group them together and drag them around.

mTOR tore my brain

So AKT is activated and glycogen synthesis is allowed to take place because AKT is stopping GSK3 from blocking GS, correct? This happens during the translocation of GLUT4?

Also, where is insulin resistance found in this? Is it a lack of receptors, lack of PDK1, IRS1/2, etc?

You should have mentioned that P110 is the catalytic part of PI3K while p85 is the regulatory one of it

Isn't the PI3K present inside IRS ? Plz clear it out.

Exactly How does increased pip3 recruit and activate pdk1/AKT?

Once IRS1/2 is activated, you better have your taxes ready.

during 7.25 hesaid that AKT is inhibiting the inhibitor means you activate the glycogen synthesis. so it means AKT has two roles which are inhibiting and phosphorylates the GSK3 ? is it???

@samanthal9114

5 жыл бұрын

No, AKT is inhibiting GSK3, which results in GS being turned on. AKT (serine/threonine-specific protein kinase) phosphorylates GSK3 at the inhibitory residue at serine-9 in GSK-3β & serine-21 in GSK-3α and thus makes it more difficult for GS3K to bind it's substrate and therefore reduces catalytic activity. So, AKT (Which is a serine phosphatase), phosphorylates these residues and decreases GSK3 activity. Glycogen Synthase (GS) is directly regulated by GSK3. GSK3 phosphorylates GS at inhibitory residues and therefore inactivate GS and turn off glycogen synthesis. Because GSK3 is inhibited, and not there to turn off GS, GS becomes activated as a result. I know it’s really easy to think about phosphorylation as only being “on” but a lot of inhibitory sites are also activated. The easiest way I remember it is ON-OFF-ON for AKT-GSK3-GS. Its an on sandwich.

@nordiniadriana7966

5 жыл бұрын

@@samanthal9114 wow, cool. Thankss !!

Sorry, could you explain me the pathway of PKB?

So how is this affected by insulin resistance?

What happens when a lectin sticks to the insulin receptor?

Please can you give me the source of this information ?

What app do u use to make this video ?

Your description of the islets is true for mice, but not for humans. Humans there is a more even distribution of alpha and beta cells throughout the islet

Anyone could explain me the IRS4 signaling cascade?

despite all these molecules the whole picture still is unknown how Insulin affect other cellular structures and cells. More discoveries are needed to understand it

@8:00 is he saying "REB" proteins?

Akt inactivate AS160???

wait a minute so the protein as160 actually anhibits the transportation og GLUT4? i dont get it? i thought it was the opposite. plz can someone esplain me?

Great video. Just one thing, if you could please try to talk somewhat a tiny bit more clearly, it would make everything perfect. :)

Insulin is much more than just controlling glucose. This is just ridiculous. What about MAPK pathway? What about de novo lipogenesis and fat storage?

0:25

@JacindaRivera

4 жыл бұрын

3:14

@JacindaRivera

4 жыл бұрын

3:45

@JacindaRivera

4 жыл бұрын

4:30

@JacindaRivera

4 жыл бұрын

7:42

you did not mention the role of PKB.

@CGStep

5 жыл бұрын

AKT is PKB

@brandongarrison1005

5 жыл бұрын

PKB actually IS Akt. I found that out too from my own question.

Hi JJ, do you have a mail adress?? Thanks

way to badly planned, very hard to follow along when you jump back and forth