Conférence : Les 3 prix Nobel 2016 de chimie, Jean-Pierre Sauvage, James Fraser Stoddart et Bernard L. Feringa, à l’Académie des sciences
Lien de la conférence : www.academie-sciences.fr/fr/Co...
00:00:00 Introduction
00:00:43 Topology : the science of infinitely deformable objects
00:02:57 Chemical topology : Frisch and Wasserman
00:04:52 a [2]catenane
00:07:01 The long travel from «Inorganic Photochemistry» to Catenanes, Molecular Topology and Molecular Machines
00:07:57 A very important photoactive transition metal complex : Ru[bipy]32+
00:08:35 From ruthenium to copper
00:08:53 The «story» behind the discovery
00:09:49 copper[I]-templated synthesis of catenanes and knots
00:10:26 The first practical synthesis of catenanes
00:11:12 Transition metal templated synthesis of a [2]catenane
00:11:41 "entwining" two ligands around a copper[I] centre
00:12:28 Double cyclisation reaction leading to the [2]catenane
00:13:02 Strategy A
00:13:47 Strategy B
00:15:37 Catenanes and Knots are very common in biology : proteins, DNA, viruses
00:15:55 From a «simple» [2]catenane to more complex topologies
00:16:26 Molecular Machines
00:16:39 In biology, molecular motions are ubiquitous and vital. Two examples of biologically essential molecular machines
00:17:46 Catenanes and Rotaxanes in motion : Towards Molecular Machines
00:18:41 rotation of a ring within another ring [no directionality]
00:22:54 Contractile and extensible molecular systems : Towards artificial muscles contraction and extension of a sarcomere
00:23:42 A synthetic "molecular muscle" [2]rotaxane dimer
00:24:21 A huge «thank you» to the members of our team "Laboratoire de Chimie Organo-Minérale"
00:26:34 A few old and less old pictures
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