CRMO is an autoinflammatory bone disorder that almost exclusively affects the skeletally immature -- children and adolescents. CRMO often resolves once they reach skeletal maturity. Since CRMO is a diagnosis of exclusion, biopsies, MRIs and genetic testing are often needed to rule out more serious causes of symptoms (e.g., bone pain, weakness, weight loss), such as leukemia, lymphoma, bacterial osteomyelitis, Ewing sarcoma and Langerhan’s cell histiocytosis.
In this video, Associate Professor of Orthopedic Surgery Nathan Donaldson, DO, discusses the use of radiographs and MRIs for imaging and the importance of biopsies to confirm CRMO diagnosis. CRMO treatment options include NSAIDs, methotrexate, TNF inhibitors or biphosphanates with a goal of being pain-free for 6 months prior to stopping treatment.
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