What do you think?

@darkhorseman8263

2 жыл бұрын

I think caloric restriction is overblown, and we're just eating unnatural foods in the wrong amounts. A high protein diet decreases lifespan but boosts fertility. A high protein diet with sufficient amounts of good cholesterol boosts fertility with no lifespan restriction. Amino acid balance, good fats, oils, and cholesterol that aren't oxidised, Carb Restriction, and supplementing co factors, while precisely regulating exogenous signalling molecules with the right foods we evolved to eat, is more important.

@rigeus

2 жыл бұрын

Pontzer, see for example Energy Constraint as a Novel Mechanism Linking Exercise and Health or his book (Burn), in his Constrained TEE model for energy compensation has also argumented that the body will react to prolonged (months) calories deficit and exercise with a reduced immune response, among others. But fasting now and then should not have an effect, it takes some weeks or even months until the body starts to adapt. Some quotes from the above article: "Chronic exercise thus suppresses other physiological activity, including immunity, reproduction, and stress response. This exercise-induced downregulation improves health at moderate levels of physical activity but can be detrimental at extreme workloads." "Indeed, a large body of evidence shows that exercise has suppressive effects on physiological activity throughout the body, including the immune system, HPA axis, SNS, and reproductive system." "It is notable that the systemic suppressive effects of exercise outlined in this study are similar in many ways to those observed with caloric restriction" Must say, I don't have the know-how to understand all the details but I get the big picture.

@lennihe

2 жыл бұрын

Well, of course Sheekey the Scientist would like to see more data! XD After all, science is never settled, there are just different levels of uncertainty. I suspect that cyclical CR would be the way forward, long enough to be beneficial, short enough to reduce risk. Not sure how to balance it though. I think I need more data... ;)

Thanks you helping to keep us up to date on the newest research, evidence, and data around longevity, aging, rejuvenation, and biotechnology.

Always enjoy your presentations! Thanks,

Superb piece, as usual!!

I enjoy your deep, technical explanations! You are the only speaker where I don’t need to increase the presenter’s speed.

Gosh darn it. I knew I should have picked caloric restriction over intermittent fasting for my biochem class' paper. Then I could have used this paper! Still super cool to learn how the circadian clock genes are interconnected with mTOR, sirtuins, and AMPK tho!

The issue I see with cleric restriction question mark is the fact that you are low in energy. Plus I see them with such low body fat that their bodies have no energy to function. It may also reduce sexual activity? The other research I have looked into was constant headaches and Been able to be agitated more often and easily. So there are benefits but there are other issues with this.

With the increase in the mobilization of fat, could you think of a reason why the body would down regulate anti inflammatory factors? What happens then when fat stores reaches a new equilibrium?

Not beling able to read either study fully; I'd say it simply shows that losing weight is beneficial. It said non-obese individuals. The 'average' American is quite overweight. 2 years is a short amount of time, I'd suspect, to see negative health effects (if any) since they most likely had a lot of weight to lose. Losing weight has already been shown to improve thymic function so no surprise there. I am impressed that the study changed the calories based off the subjects changing weight. Agreed it would have been great to see the individual subject's data! Thanks for the video! Hope your PhD program is going well. I just got accepted to grad school and can't wait! Love your videos!

cool video

I've embarked on a less calories in, more energy out system. The last month I have experienced drastic results in my weight drop. I've went down from 263 to 245 lbs. My overall goal is 215 lbs. I'll admit, I at times get irritatible with caloric restrictions throughout the day, I just keep in mind the weight I've dropped, and all the energy I feel each day.

sorry about my previous post. your channel is very useful and I realy enjoy this. I love you💖💖. forgive me please.

More (good) data collection is always the answer. To assess individuals meaningfully you might need several factors of magnitude more info. Say, their full genetic profile, as much as you can know about how they were expressing before the trial and after. Their skeletal makeup, body composition, etc. I hope we're going in the direction where that becomes practical. I know some organizations are trying to take that approach in smaller studies, but we're also talking about $5000 per patient just for the beginning and end tests, much less anything in-between (which we'd also want). We need better (and cheaper) testing technologies to make conclusions drawn about an individual as accurate as conclusions drawn about the average in a population.

Thanks for the update. Despite the new data, my own cost/benefit analysis still comes up with a resounding “NO” to calorie restriction, especially other techniques such as time restricted feeding (without actively seeking >20% caloric reduction) can provide similar benefits without the side effect. In addition, people at my age group (over 50) should also be cognizant about maintaining or even increasing muscle and bone mass to counter the effect of sarcopenia and CR is not conducive of achieving this goal.

@scotlandtheinsane3359

2 жыл бұрын

Sarcopenia is a problem for the over 65s not people in their 50s though.. But I agree that TRF seems more promising especially following the work of Satchin Panda and colleagues in relation to the diseases of aging. I still do long water fasts for other reasons but keep my calories to satiety in normal circumstances. Although I do keto and there's a further reduction in what 'satiety' actually means there...

@monnoo8221

8 ай бұрын

@@scotlandtheinsane3359 Sarcopenia is the end stage of a decade long ms-management of muscle mass, that is too little protein intake and to little exercise. The loss of muscle mass starts in the 40ies. If aged 65+, it is very difficult to build muscle mass, if there was a long phase of miss-mgmt. Not only the mass is reduced, the remaining muscle also gets dysfunctional.

@scotlandtheinsane3359

8 ай бұрын

@@monnoo8221 Yeah, I know it's a serious problem. But I disagree that people in their 40s should worry too much about fasting (occasionally) because of it. It's how we evolved after all. It's why something like ketosis exists so like with everything a moderate approach is probably for the best.

@monnoo8221

8 ай бұрын

@@scotlandtheinsane3359 I never went to the gym until the age of 53... it was the last call. More on the skinny side, i gained around 6 pounds of muscle mass since then. Most of it in the last 4 years, which is still a very low rate. And still with moderate protein intake. So I am happy to counteract the general trend. i believe, that "age" is not a risk factor for sarcopenia. Loosing mindfulness is.

How do you establish a baseline for calorific intake to study? Most western diets I imagine have at least a 40% excess of calories as compared to the evolutionary optimized diet of our ancestors from say 50,000 years ago. So, is this actually CR or just optimized nutrition?

@gabrieltorres5732

2 жыл бұрын

That’s why you don’t eat all that processed foods; eat meat, vegetables, and fruits only. Eat the food God gave us and this calorie restriction she is talking about here will actually work.

@AlexEats

Жыл бұрын

Depends how active you are. If you work a desk job with moderate activity level you don’t need more than 2k a day

Any nutritional long term study in humans can not be RCT. However, a well controlled crossover-reverse study measuring granular metabolome and integrative physiological marker, together with genome activity based on biopsies could be done, and imho that's the only way which is feasible. That cant be done on a lot of people though, yet, 50..100 participants would be enough. Te concept of caloric restriction lacks a proper operationalization. often it is assumed that people are "heavy", bmi >25 or waist height ratio >0.6. What's about people with bmi

I believe that aging speed is almost purely genetic, my grandfather lived up to 99 years old and his daily breakfast was sweetened coffee and cookies, no matter how much he ate he stayed always skinny. My father has 3 meals per day, he eats candy almost every day, and he looks 20 years younger. (We love candy) I am trying to eat 2 meals per day but I just feel hungry within 4 hours after eating. @_@ it is painful. I'm 5'7 - 123 pounds is this method risky for me?

@mikestock969

8 ай бұрын

Just a suggestion, Perhaps you can pick a day to have a cheat day, meaning you can eat what you want. That way your body won't feel deprived. Hope that helps.

This morning I got up and put my daughter to school then left for the gym. I trained legs, fasted, for 3 full hours. Then, I got on the Arc Trainer for 600 calories followed by 3 full on sprints. I just got home from the gym. It's 1:56 here in Florida. I still haven't eaten yet. Trying to decide if I should eat or go for a walk in the sun. Oh, I'm almost 57, 160 lbs, less than 10% body fat by DEXA and Inject 90g Stelara every 8 weeks due to sever inflammatory conditions.

@AlexEats

Жыл бұрын

Keep it up 👍

I wonder if high protein but within lower carb diet consumed in a time restricted eating window such as 16:8 or 20:4 would negate the benefits on longevity? For example, I need to gain weight to stop and hopefully reverse muscle loss. So I have high protein (30% macros = 80-90g per day = over 1.5g per current kg of weight) BUT I do nit want to accelerate cellular aging. I wonder how best to balance this

@gabrieltorres5732

2 жыл бұрын

Low carb is the only way to achieve weight loss, low carb increases longevity. Try eating only meat for a few days and you will gain muscle for sure.

@stefanisilva2493

9 ай бұрын

@@gabrieltorres5732 Not at all. Low csrb means high cortisol, which is a disaster specially for women. I saw healthy, lean females with pré diabetic sugar levels due to body compensation for a low carb diet. Is not that simple, unfortunately.

caloric restriction via intermittent fasting is good or bad?

@gribbler1695

Жыл бұрын

This may give you some insight. kzread.info/dash/bejne/kZWDydNtadO8g8Y.html

@AlexEats

Жыл бұрын

Sure but how much are you eating a day and how much of that energy are you exerting out

Adam and Eve should’ve never ate the damn apple

So its better to be obesse