Calcineurin Inhibitors (Tacrolimus and Cyclosporine) IL2 - Mechanism of action, adverse effects

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"Calcineurin inhibitors such as tacrolimus and cyclosporine are immunosuppressants. They are used mainly to prevent organ transplant rejection in combination with mycophenolate and steroids as well used in severe atopic dermatitis. They are not really used as much for rheumatologic conditions any more, possibly for lupus nephritis. Calcineurin inhibitors are also used for the treatment of graft versus host disease in bone marrow transplant recipients. Calcineurin inhibitors inhibit the synthesis of IL2."
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Пікірлер: 41

  • @JohnDoe-ob4mr
    @JohnDoe-ob4mr3 жыл бұрын

    Highly appreciate those like you who do not subject people to a 20 second intro for a serious study topic

  • @onghanhlookatandfollowme299
    @onghanhlookatandfollowme2993 жыл бұрын

    We should also know the mnemonic: Hot T Bone stEAk Hot (fever) = IL-1 T cell simulator = IL-2 Bone marrow stimulator (sim to GM-CSF) = IL-3 IgE = IL-4 and IgA = IL-5 Thanks for the short and very informative video. I have just subscribed. Btw, please share with me what apps or softwares that you use to draw, to make your videos? Thanks!

  • @thivz6630

    @thivz6630

    Жыл бұрын

    Thank you for this

  • @vishu1992
    @vishu19923 ай бұрын

    Awesome! Very clear and easy explanation.

  • @GiAndrei97
    @GiAndrei97 Жыл бұрын

    thank you for your very simple explaination

  • @aramhakobyan8549
    @aramhakobyan85493 жыл бұрын

    Thank you so much for the video,Found very useful for my Pharmacy study..

  • @686afroman
    @686afroman3 жыл бұрын

    Hello Armando, I came here because I wanted to comment in a recent video, so it’s more probable, that you will read it. I needed to understand how do interact Calcium levels, vitamin D and PTH, so I went to your video, which explains it. I have multiple sclerosis and I’m following a therapy called Coimbra Protocol, which is based in a few pillars: - Ultra high Dosis of vitamin D3 (50.000 units in my case to set my immune system back to “default”) - Very low calcium diet (to avoid to much calcium to filter) - More than 2,5 L of liquids per day (to avoid high concentration in Urine) - Regular sport (to build bone tissue up) - Avoid stress and unhealthy food My question is, *why, when a low level of Calcium in blood stimulates the production, did my PTH level increased from 21 pg/ml to 31?* The second time I checked this value, it only increased from 19,5 to 21 in the same time frame. I ate a bit more calcium-rich food in this time, so my body should have absorbed way more calcium. I just don’t get it A video about the coimbra protocol, how it works and what are its dangers, would be really nice. I can provide you with sources of information, if you want ;) I also would share it, with MS-Groups of Facebook, because it would be reeeeeally interesting to see how it works internally.

  • @davidcotton6797
    @davidcotton67973 жыл бұрын

    Filling some of the gap of sketchy pharm. Nice!

  • @ibadullahtahir7541
    @ibadullahtahir75413 жыл бұрын

    T hanks armando hasudungan channel.

  • @misbah2905
    @misbah29053 жыл бұрын

    Wow ,! Its fun way to learn . Thank you sir

  • @malakali537
    @malakali5373 жыл бұрын

    Amazing video, Thank you

  • @thom8303
    @thom83032 жыл бұрын

    Amazing. Do you have a video on mycophenolate, azathioprine, and other immunosuppressants?

  • @sodik2888
    @sodik28883 жыл бұрын

    Thanks , you're awesome♥️

  • @learningsciencechannel1894
    @learningsciencechannel18943 жыл бұрын

    Very informative😊

  • @sabirbabor
    @sabirbabor3 жыл бұрын

    I have watched your videos for the past 10 years. I just realised that I have not clicked the subscribe button 😅😅😅 sorry, the progress is amazing. It almost feels like seeing someone grow.

  • @SchuppenTV
    @SchuppenTV Жыл бұрын

    Bro you can see the matrix...this channel is insanely great....

  • @saraheady6813
    @saraheady6813Ай бұрын

    life-saving video

  • @medicalbiochemistry_
    @medicalbiochemistry_3 жыл бұрын

    Well explained

  • @che5ana359
    @che5ana3593 жыл бұрын

    Wowwwwwwwie😍. Thankyou sir!

  • @user-ul2sd8yc3g
    @user-ul2sd8yc3g2 жыл бұрын

    Amazing 👏🏻

  • @NERVESMEDICINE616
    @NERVESMEDICINE6163 жыл бұрын

    Wow , amazing

  • @MoMo-rk9xh
    @MoMo-rk9xh Жыл бұрын

    Thanks you so much

  • @someonehere7146
    @someonehere71463 жыл бұрын

    thank you

  • @drugvash4899
    @drugvash48992 жыл бұрын

    Super!!!

  • @pierregullam7636
    @pierregullam76363 жыл бұрын

    Keep it up ❤❤❤

  • @ranamohamed594
    @ranamohamed5943 жыл бұрын

    What's your effect or tools to make this video plz 😍😍😍

  • @sagardabary7168
    @sagardabary71683 жыл бұрын

    sir please make the full digation video

  • @dailydoseofmedicinee
    @dailydoseofmedicinee3 жыл бұрын

    Mechanism of action of calcineurin inhibitors is suppressing synthesis of pro-inflammatory cytokines. In the cytoplasm of the target cells, pimecrolimus and tacrolimus bind to the intracellular protein macrophilin-12, also called FKBP (FK506-binding protein). Similarly, cyclosporine A binds to cyclophilin.👍

  • @shashibhushansharma5320
    @shashibhushansharma53203 жыл бұрын

    Plz upload physics and chemistry lecture

  • @HarmanOberoi
    @HarmanOberoi3 жыл бұрын

    Thank you for accepting the request on posting a videos on immunosuppressants, even if you haven't read my previous comment..still thanks😇❤

  • @angelasoledadlugo7800
    @angelasoledadlugo78003 жыл бұрын

    Genial

  • @aniketgaikwad6058
    @aniketgaikwad60583 жыл бұрын

    Best

  • @vishal223165
    @vishal2231653 жыл бұрын

    Sir , I am teaching in Jr. College so need to take online classes coz of this pandemic. Can you plz tell me what have you used here to get such screen.? Is it a App? Of Device ? My issue is we don't get clearly when i stand in front of board and teach. So this way of yours is best . Can you guide plz

  • @gilbertchristoper2748
    @gilbertchristoper27483 жыл бұрын

    Can you also make a video about Tuberculosis please? The pathophysiology is very complex and difficult to understand by reading alone

  • @ediye2905
    @ediye29053 жыл бұрын

    👏👏

  • @pakhareprashant9473
    @pakhareprashant94733 жыл бұрын

    Millions subs ..still less likes

  • @Tony.250
    @Tony.25010 ай бұрын

    🌹🌹

  • @catherinethorstenberg8957
    @catherinethorstenberg89572 жыл бұрын

    I looked up this video just to find out how to pronounce tacrolimus