I hated it when my workplace eliminated sick days and clumped together sick days and vacation days into one category- paid days off. So most employees avoided using a day off if they were sick, why waste a potential vacation day staying home sick? More coworkers came to work sick spreading whatever they had.

@Sharla1213

4 ай бұрын

What a load of crap. I hope they change it back.

We need better sick leave policies.

Paxlovid: despite being available in the USA, most are NOT getting it. Elsewhere in the world it's pretty much unavailable.

@paulam3987

4 ай бұрын

The interactions of Pax with other meds and conditions have meant additional steps to get the product in hand. These steps have created obstacles for some. In the acute phase of the pandemic, these steps were streamlined. Now, that's all gone. 😢

@sciencefliestothemoon2305

3 ай бұрын

Wut? Every person within the risk group in my family got it, and even their friends did. But that's the EU for you

@WillNewcomb

3 ай бұрын

@@sciencefliestothemoon2305 Friends in the Netherlands & UK say it's pretty impossible to get.

Fever as a proxy for contagiousness (or surrogate) is AWFUL, I'm sorry. I've had covid twice and never had a fever. I did however feel awful.

He didn’t get to the root of the problem. That the CDC made a decision not due to science but due to business and public pressure.

@file1271

4 ай бұрын

But that's also due to large parts of society somehow (politically lubricated?) have lost faith in the CDC. A tail wagging the dog moment of sorts. But also, the CDC cannot simply dictate, it must engage & react to how society/public health is operating. What will it take to put the CDC back into commonly positive reception? Hard to say. Usually dire emergencies are where much conjecture & naysaying gets wiped away out of a simplified dire need for help.

@file1271

4 ай бұрын

Or a really helpful & widespread marketing campaign to help shift/repair public perception.....but that also starts with education....and we're off to the races! Quite the mixed bag this beloved country of ours.

Just want to thank you guys (again) for discussing this subject in such a way that us non-virologists can understand and put into action what we should do when he get Covid or any other respiratory disease. Vincent you are great at asking Paul questions that we lay people would want to ask him and he is terrific at answering in a concise, under stable, and lucid way. Thank you! Kudos!

Fever: 30% patients NEVER have a fever!!!

@AMRosa10

4 ай бұрын

True. But also people who are asymptomatic likely are not aware that they are infected, so they are not staying home from work or school. And, as we are not regularly testing people, most asymptomatic infections won't be detected either. The CDC guideline relates to when someone who has symptomatic COVID can return to normal activity. Prior guidelines were based on a set number days (5-10 days after symptom onset, were, I believe the prior recommendations), but as Dr. Offit said, not everyone's immune system responds the same way, so this recommendation tries to address that by tying the recommendation to the subsiding of an objectively verifiable symptom. Hypothetically, at this point, a person should no longer be producing infective viral particles, and as a result can return to normal activities with relative safety, especially if the follow the recommendation of masking in public for an additional 5 days.

@denisegaur

4 ай бұрын

Neither myself nor my husband has ever had a fever with multiple Covid infections. My fil DID develop a fever initial 5 days but then it was gone, swapped w/ SOB for 3 days until 2nd day to hospital er. They did NOT test or treat for any respiratory virus, just chest x ray and sent home. Only to decompress 20 hrs later taken to different er where he fell unresponsive and was intubated. That was Feb 27, he never regained consciousness although able to breathe w/o vent but lymphocytes never came back up, thrombocytopenia which is viral induced was not adequately managed by treating CC MD, platelets down to 13000 which seized his heart from lack of blood, oozing out his vessels instead with purple petechiae and purpura over his entire body. Husband asking why 0 viral respiratory panel to start Doc said why WASTE the money?! AS PART OF THE DIFFERENTIAL AND TREATMENT I yelled on the phone to my husband. He was given ZERO antivirals nor even steroid let alone IVIG to control sky high Sed rate, tanked platelets ITP. He died Friday, ashes and bones were spsead into Ganges river this Sunday morning. Needless death, clinically presenting as Covid, not treated appropriately nor counted as a Covid death. I trust NOBODY now.😷✌

@jedadruled984

4 ай бұрын

Boosters, we need Boosters.

@sprout2580

4 ай бұрын

I've had symptomatic COVID twice without fever.

@AMRosa10

4 ай бұрын

@@sprout2580 Were you taking antipyretic medications (Tylenol, Advil, Aleve, NyQuil, etc.) or on steroidal anti-inflammatories for another condition at signs of symptom onset? Because if you were/are, then that could contribute to fever not being a symptom, as those medications could have suppressed it.

My son was working at restraunt. He was told to slap on madk and go to work.

@kristoffer428

4 ай бұрын

That's insane..

Some of us were saying this from the very beginning. Welcome to the party finally!

Omicron was a LAV and enabled these changes. But that story, like the origin of the original strain, will likely never be publicly told.

We need to change our insurance system in the US so that when a CDC recommendation uses “may” instead of “should” the insurance will STILL cover it. I believe that the language of “should” might be to ensure insurance coverage for those that take advantage of the option to receive the additional dose. Those that don’t want it, regardless of the language, will still not bother getting the extra dose. I think it’s just to help make sure it’s covered.

My daughter and I have Von Willebrands disease. We can't take paxlovid. My 22 year old has had 7 vaccines. She has Vwd. Eds and Pots. Should she get another vaccine?

Is Offit recommending seniors NOT take their covid boosters?

I think if you are aboe to write prescriptions, you should understand the mechanism of action and a bit more than just the basics of how things work. This wait and see thing has killed how many people ? And the sick shit is these folk’s families still had to pay for the wack doctors and meds given to late.

Thanks as always!

There is a bill in North Carolina to make wearing a mask EVER to be illegal.

Gracias Pablo Cómo se está dispensando Paxlovid en las farmacias Tras más de 250 envases entregados en las boticas de Andalucía y 116 en Cataluña, ¿está habiendo dificultades? También lo hacen en Navarra y Aragón, junto a hospitales. 1369 Pesos para el tratamiento de cinco días. Gracias ❤

@Henry-fk7cq

3 ай бұрын

PESOS? Spain uses only Euros. The locations you mention are all in Spaon. You're over twenty five years in the past.

He's not interested in communicating about current studies (obviously). Or even possible complications of Long Covid. Of course, it's not/never has been "just" about severe disease. Listening to him, you'd think so, tho.

How is it that you’re most contagious a day or two before symptoms? Aren’t some of the symptoms what transmit the disease? Love the show, thanks!

@wallacegrommet9343

4 ай бұрын

By symptoms, are you referring to flu-like symptoms like tiredness, fever, and congestion? Covid-related damage such as hemorrhage, loss of lung function, and the concomitant low oxygen blood levels were often not experienced until many days into the infection

@AlbertMark-nb9zo

4 ай бұрын

Many of the symptoms are the result of the body actually fighting the virus.

@gribbler1695

4 ай бұрын

‘Asymptomatic’ cases may include very mild symptoms that may occur but are unnoticed, and is when viral load increases very quickly, peaking at symptom onset.

@kristoffer428

4 ай бұрын

Coughing and sneezing helps disperse more virus particles for sure but you exhale virus laden aerosols just by breathing when you're contagious

I have a great deal of respect for both of you and have learned a lot during the past few years, so thank you! Question about Paxlovid. Isn’t it true that it has never been studied for efficacy in people who have either had the vaccine and natural infection?

Off topic but the iPhones, maybe other smart phones with artificial intelligence could learn to recognize Koplik spots which might give people a heads up on a measles infection.

@sciencefliestothemoon2305

3 ай бұрын

Already too late, measles contagious days before they appear, and 5 days before a rash appears

@stonecookie

3 ай бұрын

@@sciencefliestothemoon2305 I said a "heads up" meaning that the diagnosis of measles could be made before the rash. If Koplik spots appear a couple days before the rash, but after symptoms onset, the time that people could be alerted to having measles would be roughly cut in half. That prodrome period when a person is infectious but not having the rash, could mean taking that 4-5 day period before the onset of the macopapular rash and making the diagnosis by smartphone and telemedicine and AI when Koplik spots first appear. But it would mean that people would have to start looking in their mouths in a mirror or with the phone for a 2-4 days when they got cold and flu- like signs and symptoms like a sore throat, runny nose, cough, conjunctivitis, or fever. Parents, however, should not probe the mouths of their infants and small children as this could cause laryngeal spasm. A gentle, non invasive look that does not agitate or distress the child would probably be OK but it would need guidelines. A daily check of the mouth at the inside of the cheeks near the back teeth (molars) seems doable, guidelines and phone apps could be developed.

@stonecookie

3 ай бұрын

@@sciencefliestothemoon2305 I said it an App could give us a heads up, Koplik spots are highly indicative of measles and appear during the prodrome period about 2-4 days after symptom onset. So there is an opportunity to diagnose measles with a smart phone photo. It could cut the time before diagnosis roughly in half. AI can learn to recognize Koplik spots if people are uncertain. we would need to make a habit of doing taking a few photos when getting sick. This is a rephrasing of my earlier reply which somehow got deleted.

May be must avoid to use antipiretics If SARS COV2 infection occur? May be fever have anti SARS COV2 effect? May be mask wearing maintain and increase upper respiratory temperature ?

@traianliviudanciu8665

4 ай бұрын

At TWiV 659 at min29 Christian Drosten suggest that SARS COV2 better replicate at very low tissue temperature

@MRCAGR1

4 ай бұрын

If you have a fever then that is the immune system responding to any infection, it is part of the inflammatory response. This is why it is recommended that children are not given antipyretics unless they’re in discomfort.

@traianliviudanciu8665

4 ай бұрын

@@MRCAGR1 fever and Covid19 fobia induced exces of antipiretics use

@traianliviudanciu8665

4 ай бұрын

@@MRCAGR1 fever can be induced by many factors Interferon induce fever also

@traianliviudanciu8665

4 ай бұрын

@@MRCAGR1 did we know all pyrogenic factors ?

Everybody can benefit from them reasoning through what infectious disease guidelines are best. The wisdom of these two lifetimes are here free for only a few minutes of my time.

We don't play covid at our house

So... I never had any Flu vaccine ever.... and I never had any Covid-19 "vaccine" ever. I am 67. I had my last flu more than 40 years ago and my last cold even longer ago than that. Never had any Covid-19 that I can remember. Am I at risk?

@MRCAGR1

4 ай бұрын

You are fortunate that your immune system is what it is. I’ve never had flu, and I am a similar age to you. We would have been exposed to the flu in 1968/69 and again in 1972/73 during the pandemics/epidemics.

@jaykanta4326

4 ай бұрын

Today on "what is survival bias".

@wednesdayschild3627

4 ай бұрын

May the odds always be in your favor. The hunger games

@wallacegrommet9343

4 ай бұрын

Some people do have better immune systems, with inherited immunity to common illnesses. There are even mutations that confer immunity to HIV! Rare, but not unheard of. You are what is referred to as a “Superavoider”

@SGtheSavage

4 ай бұрын

I've never had any vaccines and rarely get sick. But I worked in the most toxic places you can imagine and exposed to alot. I worked in the environmental emergency waste response field. Feed your immune system daily and allow yourself to be exposed to the world best health care ever known.